| Township . | Bukit Batok . | Choa Chu Kang . | Tampines . | Yishun . |
|---|---|---|---|---|
| Intervention start date | EW23 2020 | EW20 2020 | EW39 2018 | EW27 2018 |
| Study end date | EW26 2022 | EW26 2022 | EW26 2022 | EW26 2022 |
| Intervention time (weeks) | 109 | 112 | 197 | 209 |
| Total township size (m2)& | 627 441 | 1 145 559 | 5 088 046 | 3 473 690 |
| Production approach** | IIT-SIT | IIT-SIT | High-fidelity sex-sorting&& | IIT-SIT |
| Frequency of release | Twice weekly | Twice weekly | Twice weekly | Twice weekly |
| Release strategy*** | Targeted# | Targeted | Expanding## | Expanding |
| Number of mosquitoes released | 1–7 wAlbB-SG males were released per study site resident per week | |||
| Total number of mosquitoes released (rounded to thousands) | 17 139 000 | 14 598 000 | 109 432 000 | 77 659 000 |
| Township population covered by release over study period | 40 132 | 64 672 | 272 048 | 231 020 |
| Township . | Bukit Batok . | Choa Chu Kang . | Tampines . | Yishun . |
|---|---|---|---|---|
| Intervention start date | EW23 2020 | EW20 2020 | EW39 2018 | EW27 2018 |
| Study end date | EW26 2022 | EW26 2022 | EW26 2022 | EW26 2022 |
| Intervention time (weeks) | 109 | 112 | 197 | 209 |
| Total township size (m2)& | 627 441 | 1 145 559 | 5 088 046 | 3 473 690 |
| Production approach** | IIT-SIT | IIT-SIT | High-fidelity sex-sorting&& | IIT-SIT |
| Frequency of release | Twice weekly | Twice weekly | Twice weekly | Twice weekly |
| Release strategy*** | Targeted# | Targeted | Expanding## | Expanding |
| Number of mosquitoes released | 1–7 wAlbB-SG males were released per study site resident per week | |||
| Total number of mosquitoes released (rounded to thousands) | 17 139 000 | 14 598 000 | 109 432 000 | 77 659 000 |
| Township population covered by release over study period | 40 132 | 64 672 | 272 048 | 231 020 |
Total area of public housing estates subject to release in respective townships in EW26 2022
*Computed as (sum of area of releases multiplied by weeks of release until end of study period) over (total area of township multiplied by total release weeks). Areas were considered covered once they receive at least 6 months of Wolbachia interventions
**The IIT-SIT approach and high-fidelity sex-sorting are detailed in Supplementary information section 1 and has been previously characterized10,13
***Denotes approach to releasing Wolbachia-infected males
Targeted approach that focused releases on areas with high Aedes aegypti abundance and persistent dengue transmission
Expanding (‘rolling’) approach where release sites were gradually expanded to adjacent neighbourhoods
IIT-SIT increasingly adopted into production protocol from August 2020 onwards
| Township . | Bukit Batok . | Choa Chu Kang . | Tampines . | Yishun . |
|---|---|---|---|---|
| Intervention start date | EW23 2020 | EW20 2020 | EW39 2018 | EW27 2018 |
| Study end date | EW26 2022 | EW26 2022 | EW26 2022 | EW26 2022 |
| Intervention time (weeks) | 109 | 112 | 197 | 209 |
| Total township size (m2)& | 627 441 | 1 145 559 | 5 088 046 | 3 473 690 |
| Production approach** | IIT-SIT | IIT-SIT | High-fidelity sex-sorting&& | IIT-SIT |
| Frequency of release | Twice weekly | Twice weekly | Twice weekly | Twice weekly |
| Release strategy*** | Targeted# | Targeted | Expanding## | Expanding |
| Number of mosquitoes released | 1–7 wAlbB-SG males were released per study site resident per week | |||
| Total number of mosquitoes released (rounded to thousands) | 17 139 000 | 14 598 000 | 109 432 000 | 77 659 000 |
| Township population covered by release over study period | 40 132 | 64 672 | 272 048 | 231 020 |
| Township . | Bukit Batok . | Choa Chu Kang . | Tampines . | Yishun . |
|---|---|---|---|---|
| Intervention start date | EW23 2020 | EW20 2020 | EW39 2018 | EW27 2018 |
| Study end date | EW26 2022 | EW26 2022 | EW26 2022 | EW26 2022 |
| Intervention time (weeks) | 109 | 112 | 197 | 209 |
| Total township size (m2)& | 627 441 | 1 145 559 | 5 088 046 | 3 473 690 |
| Production approach** | IIT-SIT | IIT-SIT | High-fidelity sex-sorting&& | IIT-SIT |
| Frequency of release | Twice weekly | Twice weekly | Twice weekly | Twice weekly |
| Release strategy*** | Targeted# | Targeted | Expanding## | Expanding |
| Number of mosquitoes released | 1–7 wAlbB-SG males were released per study site resident per week | |||
| Total number of mosquitoes released (rounded to thousands) | 17 139 000 | 14 598 000 | 109 432 000 | 77 659 000 |
| Township population covered by release over study period | 40 132 | 64 672 | 272 048 | 231 020 |
Total area of public housing estates subject to release in respective townships in EW26 2022
*Computed as (sum of area of releases multiplied by weeks of release until end of study period) over (total area of township multiplied by total release weeks). Areas were considered covered once they receive at least 6 months of Wolbachia interventions
**The IIT-SIT approach and high-fidelity sex-sorting are detailed in Supplementary information section 1 and has been previously characterized10,13
***Denotes approach to releasing Wolbachia-infected males
Targeted approach that focused releases on areas with high Aedes aegypti abundance and persistent dengue transmission
Expanding (‘rolling’) approach where release sites were gradually expanded to adjacent neighbourhoods
IIT-SIT increasingly adopted into production protocol from August 2020 onwards
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