Table 1

Human gene expression correlations between CNR1 and markers for proliferation, inflammation, and oxidative phosphorylation in human plaques

All patients (n = 202)Female (n = 57)Male (n = 145)
FunctionMarker geneCorrelation coefficientP-valueCorrelation coefficientP-valueCorrelation coefficientP-value
ProliferationCSF1R−0.220.001−0.250.061−0.20.017
CSF2−0.230.001−0.120.394−0.260.002
MDM20.180.010.010.9440.27≤0.001
MKI67−0.160.025−0.320.016−0.10.236
STAT30.220.002−0.010.9610.3≤0.001
TP53−0.210.002−0.170.206−0.210.013
InflammationCCR5−0.210.003−0.230.084−0.20.019
CD74−0.33≤0.001−0.240.076−0.36≤0.001
CEBPB−0.38≤0.001−0.310.018−0.39≤0.001
IL1B−0.24≤0.001−0.240.068−0.240.004
IL6−0.26≤0.001−0.160.229−0.3≤0.001
MIF−0.150.034−0.080.531−0.170.036
Oxidative phosphorylationNDUFA6−0.36≤0.001−0.10.448−0.47≤0.001
SIRT4−0.150.031−0.160.241−0.150.067
All patients (n = 202)Female (n = 57)Male (n = 145)
FunctionMarker geneCorrelation coefficientP-valueCorrelation coefficientP-valueCorrelation coefficientP-value
ProliferationCSF1R−0.220.001−0.250.061−0.20.017
CSF2−0.230.001−0.120.394−0.260.002
MDM20.180.010.010.9440.27≤0.001
MKI67−0.160.025−0.320.016−0.10.236
STAT30.220.002−0.010.9610.3≤0.001
TP53−0.210.002−0.170.206−0.210.013
InflammationCCR5−0.210.003−0.230.084−0.20.019
CD74−0.33≤0.001−0.240.076−0.36≤0.001
CEBPB−0.38≤0.001−0.310.018−0.39≤0.001
IL1B−0.24≤0.001−0.240.068−0.240.004
IL6−0.26≤0.001−0.160.229−0.3≤0.001
MIF−0.150.034−0.080.531−0.170.036
Oxidative phosphorylationNDUFA6−0.36≤0.001−0.10.448−0.47≤0.001
SIRT4−0.150.031−0.160.241−0.150.067

Bulk RNA sequencing data from 202 patients undergoing carotid endarterectomy (CEA) were analysed.

Table 1

Human gene expression correlations between CNR1 and markers for proliferation, inflammation, and oxidative phosphorylation in human plaques

All patients (n = 202)Female (n = 57)Male (n = 145)
FunctionMarker geneCorrelation coefficientP-valueCorrelation coefficientP-valueCorrelation coefficientP-value
ProliferationCSF1R−0.220.001−0.250.061−0.20.017
CSF2−0.230.001−0.120.394−0.260.002
MDM20.180.010.010.9440.27≤0.001
MKI67−0.160.025−0.320.016−0.10.236
STAT30.220.002−0.010.9610.3≤0.001
TP53−0.210.002−0.170.206−0.210.013
InflammationCCR5−0.210.003−0.230.084−0.20.019
CD74−0.33≤0.001−0.240.076−0.36≤0.001
CEBPB−0.38≤0.001−0.310.018−0.39≤0.001
IL1B−0.24≤0.001−0.240.068−0.240.004
IL6−0.26≤0.001−0.160.229−0.3≤0.001
MIF−0.150.034−0.080.531−0.170.036
Oxidative phosphorylationNDUFA6−0.36≤0.001−0.10.448−0.47≤0.001
SIRT4−0.150.031−0.160.241−0.150.067
All patients (n = 202)Female (n = 57)Male (n = 145)
FunctionMarker geneCorrelation coefficientP-valueCorrelation coefficientP-valueCorrelation coefficientP-value
ProliferationCSF1R−0.220.001−0.250.061−0.20.017
CSF2−0.230.001−0.120.394−0.260.002
MDM20.180.010.010.9440.27≤0.001
MKI67−0.160.025−0.320.016−0.10.236
STAT30.220.002−0.010.9610.3≤0.001
TP53−0.210.002−0.170.206−0.210.013
InflammationCCR5−0.210.003−0.230.084−0.20.019
CD74−0.33≤0.001−0.240.076−0.36≤0.001
CEBPB−0.38≤0.001−0.310.018−0.39≤0.001
IL1B−0.24≤0.001−0.240.068−0.240.004
IL6−0.26≤0.001−0.160.229−0.3≤0.001
MIF−0.150.034−0.080.531−0.170.036
Oxidative phosphorylationNDUFA6−0.36≤0.001−0.10.448−0.47≤0.001
SIRT4−0.150.031−0.160.241−0.150.067

Bulk RNA sequencing data from 202 patients undergoing carotid endarterectomy (CEA) were analysed.

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