Human gene expression correlations between CNR1 and markers for proliferation, inflammation, and oxidative phosphorylation in human plaques
. | . | All patients (n = 202) . | Female (n = 57) . | Male (n = 145) . | |||
---|---|---|---|---|---|---|---|
Function . | Marker gene . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . |
Proliferation | CSF1R | −0.22 | 0.001 | −0.25 | 0.061 | −0.2 | 0.017 |
CSF2 | −0.23 | 0.001 | −0.12 | 0.394 | −0.26 | 0.002 | |
MDM2 | 0.18 | 0.01 | 0.01 | 0.944 | 0.27 | ≤0.001 | |
MKI67 | −0.16 | 0.025 | −0.32 | 0.016 | −0.1 | 0.236 | |
STAT3 | 0.22 | 0.002 | −0.01 | 0.961 | 0.3 | ≤0.001 | |
TP53 | −0.21 | 0.002 | −0.17 | 0.206 | −0.21 | 0.013 | |
Inflammation | CCR5 | −0.21 | 0.003 | −0.23 | 0.084 | −0.2 | 0.019 |
CD74 | −0.33 | ≤0.001 | −0.24 | 0.076 | −0.36 | ≤0.001 | |
CEBPB | −0.38 | ≤0.001 | −0.31 | 0.018 | −0.39 | ≤0.001 | |
IL1B | −0.24 | ≤0.001 | −0.24 | 0.068 | −0.24 | 0.004 | |
IL6 | −0.26 | ≤0.001 | −0.16 | 0.229 | −0.3 | ≤0.001 | |
MIF | −0.15 | 0.034 | −0.08 | 0.531 | −0.17 | 0.036 | |
Oxidative phosphorylation | NDUFA6 | −0.36 | ≤0.001 | −0.1 | 0.448 | −0.47 | ≤0.001 |
SIRT4 | −0.15 | 0.031 | −0.16 | 0.241 | −0.15 | 0.067 |
. | . | All patients (n = 202) . | Female (n = 57) . | Male (n = 145) . | |||
---|---|---|---|---|---|---|---|
Function . | Marker gene . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . |
Proliferation | CSF1R | −0.22 | 0.001 | −0.25 | 0.061 | −0.2 | 0.017 |
CSF2 | −0.23 | 0.001 | −0.12 | 0.394 | −0.26 | 0.002 | |
MDM2 | 0.18 | 0.01 | 0.01 | 0.944 | 0.27 | ≤0.001 | |
MKI67 | −0.16 | 0.025 | −0.32 | 0.016 | −0.1 | 0.236 | |
STAT3 | 0.22 | 0.002 | −0.01 | 0.961 | 0.3 | ≤0.001 | |
TP53 | −0.21 | 0.002 | −0.17 | 0.206 | −0.21 | 0.013 | |
Inflammation | CCR5 | −0.21 | 0.003 | −0.23 | 0.084 | −0.2 | 0.019 |
CD74 | −0.33 | ≤0.001 | −0.24 | 0.076 | −0.36 | ≤0.001 | |
CEBPB | −0.38 | ≤0.001 | −0.31 | 0.018 | −0.39 | ≤0.001 | |
IL1B | −0.24 | ≤0.001 | −0.24 | 0.068 | −0.24 | 0.004 | |
IL6 | −0.26 | ≤0.001 | −0.16 | 0.229 | −0.3 | ≤0.001 | |
MIF | −0.15 | 0.034 | −0.08 | 0.531 | −0.17 | 0.036 | |
Oxidative phosphorylation | NDUFA6 | −0.36 | ≤0.001 | −0.1 | 0.448 | −0.47 | ≤0.001 |
SIRT4 | −0.15 | 0.031 | −0.16 | 0.241 | −0.15 | 0.067 |
Bulk RNA sequencing data from 202 patients undergoing carotid endarterectomy (CEA) were analysed.
Human gene expression correlations between CNR1 and markers for proliferation, inflammation, and oxidative phosphorylation in human plaques
. | . | All patients (n = 202) . | Female (n = 57) . | Male (n = 145) . | |||
---|---|---|---|---|---|---|---|
Function . | Marker gene . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . |
Proliferation | CSF1R | −0.22 | 0.001 | −0.25 | 0.061 | −0.2 | 0.017 |
CSF2 | −0.23 | 0.001 | −0.12 | 0.394 | −0.26 | 0.002 | |
MDM2 | 0.18 | 0.01 | 0.01 | 0.944 | 0.27 | ≤0.001 | |
MKI67 | −0.16 | 0.025 | −0.32 | 0.016 | −0.1 | 0.236 | |
STAT3 | 0.22 | 0.002 | −0.01 | 0.961 | 0.3 | ≤0.001 | |
TP53 | −0.21 | 0.002 | −0.17 | 0.206 | −0.21 | 0.013 | |
Inflammation | CCR5 | −0.21 | 0.003 | −0.23 | 0.084 | −0.2 | 0.019 |
CD74 | −0.33 | ≤0.001 | −0.24 | 0.076 | −0.36 | ≤0.001 | |
CEBPB | −0.38 | ≤0.001 | −0.31 | 0.018 | −0.39 | ≤0.001 | |
IL1B | −0.24 | ≤0.001 | −0.24 | 0.068 | −0.24 | 0.004 | |
IL6 | −0.26 | ≤0.001 | −0.16 | 0.229 | −0.3 | ≤0.001 | |
MIF | −0.15 | 0.034 | −0.08 | 0.531 | −0.17 | 0.036 | |
Oxidative phosphorylation | NDUFA6 | −0.36 | ≤0.001 | −0.1 | 0.448 | −0.47 | ≤0.001 |
SIRT4 | −0.15 | 0.031 | −0.16 | 0.241 | −0.15 | 0.067 |
. | . | All patients (n = 202) . | Female (n = 57) . | Male (n = 145) . | |||
---|---|---|---|---|---|---|---|
Function . | Marker gene . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . | Correlation coefficient . | P-value . |
Proliferation | CSF1R | −0.22 | 0.001 | −0.25 | 0.061 | −0.2 | 0.017 |
CSF2 | −0.23 | 0.001 | −0.12 | 0.394 | −0.26 | 0.002 | |
MDM2 | 0.18 | 0.01 | 0.01 | 0.944 | 0.27 | ≤0.001 | |
MKI67 | −0.16 | 0.025 | −0.32 | 0.016 | −0.1 | 0.236 | |
STAT3 | 0.22 | 0.002 | −0.01 | 0.961 | 0.3 | ≤0.001 | |
TP53 | −0.21 | 0.002 | −0.17 | 0.206 | −0.21 | 0.013 | |
Inflammation | CCR5 | −0.21 | 0.003 | −0.23 | 0.084 | −0.2 | 0.019 |
CD74 | −0.33 | ≤0.001 | −0.24 | 0.076 | −0.36 | ≤0.001 | |
CEBPB | −0.38 | ≤0.001 | −0.31 | 0.018 | −0.39 | ≤0.001 | |
IL1B | −0.24 | ≤0.001 | −0.24 | 0.068 | −0.24 | 0.004 | |
IL6 | −0.26 | ≤0.001 | −0.16 | 0.229 | −0.3 | ≤0.001 | |
MIF | −0.15 | 0.034 | −0.08 | 0.531 | −0.17 | 0.036 | |
Oxidative phosphorylation | NDUFA6 | −0.36 | ≤0.001 | −0.1 | 0.448 | −0.47 | ≤0.001 |
SIRT4 | −0.15 | 0.031 | −0.16 | 0.241 | −0.15 | 0.067 |
Bulk RNA sequencing data from 202 patients undergoing carotid endarterectomy (CEA) were analysed.
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