Table 3.
Open in new tab

Comparison of MGMTp Methylation Classification

MGMTp classification based on cutoff of 1.27
Nordic/NOA8/RTNordic/NOA8/TMZCE.6/RTCE6/RT + TMZ
MGMTp status
(original procedure and cutoff, 1)		Unmethylated
(N = 105)		Methylated
(N = 91)		Unmethylated
(N = 87)		Methylated
(N = 46)		Unmethylated
(N = 91)		Methylated
(N = 84)		Unmethylated
(N = 85)		Methylated
(N = 98)
Unmethylated103 (98.1%)5 (5.5%)86 (98.9%)0 (0%)89 (97.8%)7 (8.3%)85 (100%)8 (8.2%)
Methylated2 (1.9%)86 (94.5%)1 (1.1%)46 (100%)2 (2.2%)77 (91.7%)0 (0%)90 (91.8%)
Kappa (95% CI)0.93 (0.86–0.97)0.98 (0.92–1.00)0.90 (0.81–0.95)0.91 (0.83–0.96)
MGMTp classification based on cutoff of 1.27
Nordic/NOA8/RTNordic/NOA8/TMZCE.6/RTCE6/RT + TMZ
MGMTp status
(original procedure and cutoff, 1)		Unmethylated
(N = 105)		Methylated
(N = 91)		Unmethylated
(N = 87)		Methylated
(N = 46)		Unmethylated
(N = 91)		Methylated
(N = 84)		Unmethylated
(N = 85)		Methylated
(N = 98)
Unmethylated103 (98.1%)5 (5.5%)86 (98.9%)0 (0%)89 (97.8%)7 (8.3%)85 (100%)8 (8.2%)
Methylated2 (1.9%)86 (94.5%)1 (1.1%)46 (100%)2 (2.2%)77 (91.7%)0 (0%)90 (91.8%)
Kappa (95% CI)0.93 (0.86–0.97)0.98 (0.92–1.00)0.90 (0.81–0.95)0.91 (0.83–0.96)
Table 3.
Open in new tab

Comparison of MGMTp Methylation Classification

MGMTp classification based on cutoff of 1.27
Nordic/NOA8/RTNordic/NOA8/TMZCE.6/RTCE6/RT + TMZ
MGMTp status
(original procedure and cutoff, 1)		Unmethylated
(N = 105)		Methylated
(N = 91)		Unmethylated
(N = 87)		Methylated
(N = 46)		Unmethylated
(N = 91)		Methylated
(N = 84)		Unmethylated
(N = 85)		Methylated
(N = 98)
Unmethylated103 (98.1%)5 (5.5%)86 (98.9%)0 (0%)89 (97.8%)7 (8.3%)85 (100%)8 (8.2%)
Methylated2 (1.9%)86 (94.5%)1 (1.1%)46 (100%)2 (2.2%)77 (91.7%)0 (0%)90 (91.8%)
Kappa (95% CI)0.93 (0.86–0.97)0.98 (0.92–1.00)0.90 (0.81–0.95)0.91 (0.83–0.96)
MGMTp classification based on cutoff of 1.27
Nordic/NOA8/RTNordic/NOA8/TMZCE.6/RTCE6/RT + TMZ
MGMTp status
(original procedure and cutoff, 1)		Unmethylated
(N = 105)		Methylated
(N = 91)		Unmethylated
(N = 87)		Methylated
(N = 46)		Unmethylated
(N = 91)		Methylated
(N = 84)		Unmethylated
(N = 85)		Methylated
(N = 98)
Unmethylated103 (98.1%)5 (5.5%)86 (98.9%)0 (0%)89 (97.8%)7 (8.3%)85 (100%)8 (8.2%)
Methylated2 (1.9%)86 (94.5%)1 (1.1%)46 (100%)2 (2.2%)77 (91.7%)0 (0%)90 (91.8%)
Kappa (95% CI)0.93 (0.86–0.97)0.98 (0.92–1.00)0.90 (0.81–0.95)0.91 (0.83–0.96)
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