Table 4. Open in new tab Logistic...

Table 4.

Logistic regression analysis showing optimal baseline and postinduction IUS findings associated with segmental mucosal healing at visit-2 (44-56 weeks).

	Univariable			Multivariable^a
Predictors (reference)	OR	95% CI	P value	OR	95% CI	P
Baseline IUS findings
IBUS-SAS	0.97	0.95-0.99	<0.001	0.97	0.95-0.99	<0.001
Bowel wall thickness (mm)	0.64	0.48-0.85	0.002
Bowel wall stratification (normal)	0.67	0.48-0.94	0.019
Color doppler signal (absent)	0.46	0.26-0.80	0.006
Inflammatory mesenteric fat (absent)	0.51	0.35-0.74	<0.001
Validation variables^b
Accuracy					65.7%
AUC					0.73
Postinduction IUS findings
IBUS-SAS	0.94	0.91-0.96	<0.001	0.94	0.91-0.96	<0.001
Δ IBUS-SAS^c	0.98	0.97-1.00	0.024
Bowel wall thickness (mm)	0.34	0.22-0.52	<0.001
Δ Bowel wall thickness (mm)^c	0.79	0.61-1.02	0.074
Bowel wall stratification (normal)	0.44	0.29-0.66	<0.001
Color doppler signal (absent)	0.30	0.18-0.52	<0.001
Inflammatory mesenteric fat (absent)	0.14	0.05-0.38	<0.001
Validation variables^b
Accuracy					74.3%
AUC					0.80

	Univariable			Multivariable^a
Predictors (reference)	OR	95% CI	P value	OR	95% CI	P
Baseline IUS findings
IBUS-SAS	0.97	0.95-0.99	<0.001	0.97	0.95-0.99	<0.001
Bowel wall thickness (mm)	0.64	0.48-0.85	0.002
Bowel wall stratification (normal)	0.67	0.48-0.94	0.019
Color doppler signal (absent)	0.46	0.26-0.80	0.006
Inflammatory mesenteric fat (absent)	0.51	0.35-0.74	<0.001
Validation variables^b
Accuracy					65.7%
AUC					0.73
Postinduction IUS findings
IBUS-SAS	0.94	0.91-0.96	<0.001	0.94	0.91-0.96	<0.001
Δ IBUS-SAS^c	0.98	0.97-1.00	0.024
Bowel wall thickness (mm)	0.34	0.22-0.52	<0.001
Δ Bowel wall thickness (mm)^c	0.79	0.61-1.02	0.074
Bowel wall stratification (normal)	0.44	0.29-0.66	<0.001
Color doppler signal (absent)	0.30	0.18-0.52	<0.001
Inflammatory mesenteric fat (absent)	0.14	0.05-0.38	<0.001
Validation variables^b
Accuracy					74.3%
AUC					0.80

Abbreviations: IUS, intestinal ultrasound; OR, odds ratio; CI, confidence interval; IBUS-SAS, International Bowel Ultrasound Segmental Activity Score; AUC, area under the curve.

^aUsing the stepwise approach.

^bUsing the multi-fold cross-validation (10 times 5-fold cross-validation) approach.

^cChange from baseline value.

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