Table 3. Open in new tab Logistic...

	Univariable	Multivariable^a
Baseline IUS findings
IBUS-SAS	0.97	0.96-0.99	0.001
Bowel wall thickness (mm)	0.77	0.60-1.00	0.051
Bowel wall stratification (normal)	0.71	0.51-0.97	0.034
Color doppler signal (absent)	0.60	0.35-1.01	0.053
Inflammatory mesenteric fat (absent)	0.52	0.35-0.75	0.001	0.52	0.35-0.75	0.001
Validation variables^b
Accuracy				60.5%
AUC				0.70
Postinduction IUS findings
IBUS-SAS	0.92	0.89-0.96	<0.001
Δ IBUS-SAS^c	0.98	0.96-0.99	0.024
Bowel wall thickness (mm)	0.23	0.13-0.39	<0.001	0.23	0.13-0.39	<0.001
Δ Bowel wall thickness (mm)^c	0.56	0.41-0.76	<0.001
Bowel wall stratification (normal)	0.44	0.29-0.67	<0.001
Color doppler signal (absent)	0.19	0.10-0.37	<0.001
Inflammatory mesenteric fat (absent)	0.16	0.06-0.44	<0.001
Validation variables^b
Accuracy				73.7%
AUC				0.84

	Univariable	Multivariable^a
Baseline IUS findings
IBUS-SAS	0.97	0.96-0.99	0.001
Bowel wall thickness (mm)	0.77	0.60-1.00	0.051
Bowel wall stratification (normal)	0.71	0.51-0.97	0.034
Color doppler signal (absent)	0.60	0.35-1.01	0.053
Inflammatory mesenteric fat (absent)	0.52	0.35-0.75	0.001	0.52	0.35-0.75	0.001
Validation variables^b
Accuracy				60.5%
AUC				0.70
Postinduction IUS findings
IBUS-SAS	0.92	0.89-0.96	<0.001
Δ IBUS-SAS^c	0.98	0.96-0.99	0.024
Bowel wall thickness (mm)	0.23	0.13-0.39	<0.001	0.23	0.13-0.39	<0.001
Δ Bowel wall thickness (mm)^c	0.56	0.41-0.76	<0.001
Bowel wall stratification (normal)	0.44	0.29-0.67	<0.001
Color doppler signal (absent)	0.19	0.10-0.37	<0.001
Inflammatory mesenteric fat (absent)	0.16	0.06-0.44	<0.001
Validation variables^b
Accuracy				73.7%
AUC				0.84

Table 3.

Logistic regression analysis showing optimal baseline and postinduction IUS findings associated with transmural healing at visit 2 (44-56 weeks).

	Univariable			Multivariable^a
Predictors (reference)	OR	95% CI	P	OR	95% CI	P
Baseline IUS findings
IBUS-SAS	0.97	0.96-0.99	0.001
Bowel wall thickness (mm)	0.77	0.60-1.00	0.051
Bowel wall stratification (normal)	0.71	0.51-0.97	0.034
Color doppler signal (absent)	0.60	0.35-1.01	0.053
Inflammatory mesenteric fat (absent)	0.52	0.35-0.75	0.001	0.52	0.35-0.75	0.001
Validation variables^b
Accuracy				60.5%
AUC				0.70
Postinduction IUS findings
IBUS-SAS	0.92	0.89-0.96	<0.001
Δ IBUS-SAS^c	0.98	0.96-0.99	0.024
Bowel wall thickness (mm)	0.23	0.13-0.39	<0.001	0.23	0.13-0.39	<0.001
Δ Bowel wall thickness (mm)^c	0.56	0.41-0.76	<0.001
Bowel wall stratification (normal)	0.44	0.29-0.67	<0.001
Color doppler signal (absent)	0.19	0.10-0.37	<0.001
Inflammatory mesenteric fat (absent)	0.16	0.06-0.44	<0.001
Validation variables^b
Accuracy				73.7%
AUC				0.84

	Univariable			Multivariable^a
Predictors (reference)	OR	95% CI	P	OR	95% CI	P
Baseline IUS findings
IBUS-SAS	0.97	0.96-0.99	0.001
Bowel wall thickness (mm)	0.77	0.60-1.00	0.051
Bowel wall stratification (normal)	0.71	0.51-0.97	0.034
Color doppler signal (absent)	0.60	0.35-1.01	0.053
Inflammatory mesenteric fat (absent)	0.52	0.35-0.75	0.001	0.52	0.35-0.75	0.001
Validation variables^b
Accuracy				60.5%
AUC				0.70
Postinduction IUS findings
IBUS-SAS	0.92	0.89-0.96	<0.001
Δ IBUS-SAS^c	0.98	0.96-0.99	0.024
Bowel wall thickness (mm)	0.23	0.13-0.39	<0.001	0.23	0.13-0.39	<0.001
Δ Bowel wall thickness (mm)^c	0.56	0.41-0.76	<0.001
Bowel wall stratification (normal)	0.44	0.29-0.67	<0.001
Color doppler signal (absent)	0.19	0.10-0.37	<0.001
Inflammatory mesenteric fat (absent)	0.16	0.06-0.44	<0.001
Validation variables^b
Accuracy				73.7%
AUC				0.84

Abbreviations: IUS, intestinal ultrasound; OR, odds ratio; CI, confidence interval; IBUS-SAS, International Bowel Ultrasound Segmental Activity Score; AUC, area under the curve.

^aUsing the stepwise approach.

^bUsing the multifold cross-validation (10 times 5-fold cross-validation) approach.

^cChange from baseline value.

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