Table 2.
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PK Outcomes at infusion 4 and infusion 5.

VariableOverall (n = 128)Mono (n = 66)Combo (n = 62)P
Trough level infusion 4 (median [IQR])4.85 (2.30, 10.00)5.10 (2.40, 13.00)4.40 (2.30, 7.70)0.24
Clearance infusion4 (L/d, median [IQR])0.27 (0.22, 0.33)0.27 (0.21, 0.36)0.26 (0.22, 0.33)0.77
AUC infusion1-4 (µg*h/mL; median [IQR])85, 500 (67, 400; 107, 400)89, 700 (69, 000; 125, 500)81, 695.5 (66, 000; 101, 800)0.06
Trough level infusion 5 (median [IQR])4.80 (2.10, 8.80)4.05 (2.05, 7.75)5.85 (3.23, 9.40)0.14
Clearance infusion 5 (L/d, median [IQR])0.26 (0.21, 0.33)0.26 (0.21, 0.32)0.26 (0.22, 0.33)0.81
AUC infusion1-5 (µg*h/mL; median [IQR])113, 000 (89, 000; 137, 600)119, 200 (95, 000; 158, 400)108, 100 (83, 600; 132, 500)0.01
VariableOverall (n = 128)Mono (n = 66)Combo (n = 62)P
Trough level infusion 4 (median [IQR])4.85 (2.30, 10.00)5.10 (2.40, 13.00)4.40 (2.30, 7.70)0.24
Clearance infusion4 (L/d, median [IQR])0.27 (0.22, 0.33)0.27 (0.21, 0.36)0.26 (0.22, 0.33)0.77
AUC infusion1-4 (µg*h/mL; median [IQR])85, 500 (67, 400; 107, 400)89, 700 (69, 000; 125, 500)81, 695.5 (66, 000; 101, 800)0.06
Trough level infusion 5 (median [IQR])4.80 (2.10, 8.80)4.05 (2.05, 7.75)5.85 (3.23, 9.40)0.14
Clearance infusion 5 (L/d, median [IQR])0.26 (0.21, 0.33)0.26 (0.21, 0.32)0.26 (0.22, 0.33)0.81
AUC infusion1-5 (µg*h/mL; median [IQR])113, 000 (89, 000; 137, 600)119, 200 (95, 000; 158, 400)108, 100 (83, 600; 132, 500)0.01

Abbreviations: IQR, interquartile range. AUC; area under the curve PK; pharmacokinetic.

Table 2.
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PK Outcomes at infusion 4 and infusion 5.

VariableOverall (n = 128)Mono (n = 66)Combo (n = 62)P
Trough level infusion 4 (median [IQR])4.85 (2.30, 10.00)5.10 (2.40, 13.00)4.40 (2.30, 7.70)0.24
Clearance infusion4 (L/d, median [IQR])0.27 (0.22, 0.33)0.27 (0.21, 0.36)0.26 (0.22, 0.33)0.77
AUC infusion1-4 (µg*h/mL; median [IQR])85, 500 (67, 400; 107, 400)89, 700 (69, 000; 125, 500)81, 695.5 (66, 000; 101, 800)0.06
Trough level infusion 5 (median [IQR])4.80 (2.10, 8.80)4.05 (2.05, 7.75)5.85 (3.23, 9.40)0.14
Clearance infusion 5 (L/d, median [IQR])0.26 (0.21, 0.33)0.26 (0.21, 0.32)0.26 (0.22, 0.33)0.81
AUC infusion1-5 (µg*h/mL; median [IQR])113, 000 (89, 000; 137, 600)119, 200 (95, 000; 158, 400)108, 100 (83, 600; 132, 500)0.01
VariableOverall (n = 128)Mono (n = 66)Combo (n = 62)P
Trough level infusion 4 (median [IQR])4.85 (2.30, 10.00)5.10 (2.40, 13.00)4.40 (2.30, 7.70)0.24
Clearance infusion4 (L/d, median [IQR])0.27 (0.22, 0.33)0.27 (0.21, 0.36)0.26 (0.22, 0.33)0.77
AUC infusion1-4 (µg*h/mL; median [IQR])85, 500 (67, 400; 107, 400)89, 700 (69, 000; 125, 500)81, 695.5 (66, 000; 101, 800)0.06
Trough level infusion 5 (median [IQR])4.80 (2.10, 8.80)4.05 (2.05, 7.75)5.85 (3.23, 9.40)0.14
Clearance infusion 5 (L/d, median [IQR])0.26 (0.21, 0.33)0.26 (0.21, 0.32)0.26 (0.22, 0.33)0.81
AUC infusion1-5 (µg*h/mL; median [IQR])113, 000 (89, 000; 137, 600)119, 200 (95, 000; 158, 400)108, 100 (83, 600; 132, 500)0.01

Abbreviations: IQR, interquartile range. AUC; area under the curve PK; pharmacokinetic.

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