| Human Serum Used For Transfer . | Geomean Titer Post Transfer U/mL OspA ST2 IgG (Range) . | Infected/Totala . | P Value . | Tick Colonization . |
|---|---|---|---|---|
| 1:2 VLA15 immune serum pool | 693 (599–745) | 4/10 | .0108 | 53% |
| 1:4 VLA15 immune serum pool | 352 (302–388) | 4/9 | .0294 | 75% |
| 1:8 VLA15 immune serum pool | 178 (168–191) | 10/10 | ns | 94% |
| 1:16 VLA15 immune serum pool | 82 (71–95) | 8/8 | ns | 100% |
| Human nonimmune serum pool | 20b | 9/9 | n/a | 67% |
| Human Serum Used For Transfer . | Geomean Titer Post Transfer U/mL OspA ST2 IgG (Range) . | Infected/Totala . | P Value . | Tick Colonization . |
|---|---|---|---|---|
| 1:2 VLA15 immune serum pool | 693 (599–745) | 4/10 | .0108 | 53% |
| 1:4 VLA15 immune serum pool | 352 (302–388) | 4/9 | .0294 | 75% |
| 1:8 VLA15 immune serum pool | 178 (168–191) | 10/10 | ns | 94% |
| 1:16 VLA15 immune serum pool | 82 (71–95) | 8/8 | ns | 100% |
| Human nonimmune serum pool | 20b | 9/9 | n/a | 67% |
Abbreviations: IgG, immunoglobulin G; n/a, not applicable; ns, not significant; OspA, outer surface protein A.
aInfection was confirmed with at least one positive test (polymerase chain reaction, culture, serology).
bEnzyme-linked immunosorbent assay IgG titers measured below the lower limit of quantification of 40 U/mL were reported with 20 U/mL.
| Human Serum Used For Transfer . | Geomean Titer Post Transfer U/mL OspA ST2 IgG (Range) . | Infected/Totala . | P Value . | Tick Colonization . |
|---|---|---|---|---|
| 1:2 VLA15 immune serum pool | 693 (599–745) | 4/10 | .0108 | 53% |
| 1:4 VLA15 immune serum pool | 352 (302–388) | 4/9 | .0294 | 75% |
| 1:8 VLA15 immune serum pool | 178 (168–191) | 10/10 | ns | 94% |
| 1:16 VLA15 immune serum pool | 82 (71–95) | 8/8 | ns | 100% |
| Human nonimmune serum pool | 20b | 9/9 | n/a | 67% |
| Human Serum Used For Transfer . | Geomean Titer Post Transfer U/mL OspA ST2 IgG (Range) . | Infected/Totala . | P Value . | Tick Colonization . |
|---|---|---|---|---|
| 1:2 VLA15 immune serum pool | 693 (599–745) | 4/10 | .0108 | 53% |
| 1:4 VLA15 immune serum pool | 352 (302–388) | 4/9 | .0294 | 75% |
| 1:8 VLA15 immune serum pool | 178 (168–191) | 10/10 | ns | 94% |
| 1:16 VLA15 immune serum pool | 82 (71–95) | 8/8 | ns | 100% |
| Human nonimmune serum pool | 20b | 9/9 | n/a | 67% |
Abbreviations: IgG, immunoglobulin G; n/a, not applicable; ns, not significant; OspA, outer surface protein A.
aInfection was confirmed with at least one positive test (polymerase chain reaction, culture, serology).
bEnzyme-linked immunosorbent assay IgG titers measured below the lower limit of quantification of 40 U/mL were reported with 20 U/mL.
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