| . | 2019 n = 19 317 . | 2020 n = 8954 . | 2021 n = 15 754 . | 2022 n = 29 173 . | Total N = 73 198 . |
|---|---|---|---|---|---|
| Treatment failure, n (%) (antibiotic prescription associated with AOM diagnosis code between 3 and 14 days after index visit) | 116 (0.6) | 37 (0.4) | 87 (0.6) | 166 (0.6) | 406 (0.6) |
| Treatment failure with index antibiotic prescription (n = 61 612) | 95 (0.6) | 34 (0.5) | 80 (0.6) | 150 (0.6) | 359 (0.6) |
| Treatment failure with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 3 (1.0) | 1 (0.2) | 14 (0.9) | 21 (0.7) |
| Treatment failure with 7-day index antibiotic prescription (n = 12 060) | 13 (0.7) | 6 (0.6) | 20 (0.8) | 54 (0.8) | 93 (0.8) |
| Treatment failure with 10-day index antibiotic prescription (n = 45 689) | 79 (0.6) | 23 (0.4) | 56 (0.6) | 79 (0.5) | 237 (0.5) |
| Treatment failure with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Treatment failure with NO index antibiotic prescription (n = 11 586) | 21 (0.7) | 3 (0.2) | 7 (0.3) | 16 (0.4) | 47 (0.4) |
| Recurrence, n (%) (antibiotic prescription associated with AOM diagnosis code between 15 and 30 days after index visit) | 153 (0.8) | 32 (0.4) | 107 (0.7) | 220 (0.8) | 512 (0.7) |
| Recurrence with index antibiotic prescription (n = 61 612) | 141 (0.9) | 30 (0.4) | 99 (0.7) | 199 (0.8) | 469 (0.8) |
| Recurrence with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 1 (0.3) | 2 (0.3) | 8 (0.5) | 14 (0.4) |
| Recurrence with 7-day index antibiotic prescription (n = 12 060) | 21 (1) | 4 (0.4) | 21 (0.8) | 69 (1) | 115 (1.0) |
| Recurrence with 10-day index antibiotic prescription (n = 45 689) | 114 (0.9) | 23 (0.4) | 72 (0.7) | 121 (0.7) | 330 (0.7) |
| Recurrence with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Recurrence with NO index antibiotic prescription (n = 11 586) | 12 (0.4) | 2 (0.1) | 8 (0.3) | 21 (0.5) | 43 (0.4) |
| Office visit for AOM within 30 days after index visit, n (%) | 838 (4) | 318 (4) | 692 (4) | 1523 (5) | 3371 (5) |
| ED or urgent-care visit for AOM within 30 days after index visit, n (%) | 1048 (5) | 382 (4) | 907 (6) | 1712 (6) | 4049 (6) |
| Hospitalized day of or within 30 days after index visit, n (%) | 68 (0.4) | 27 (0.3) | 58 (0.4) | 106 (0.4) | 259 (0.4) |
| C. difficile test performed, n (%) | 2 (0.01) | 0 (0) | 4 (0.03) | 5 (0.02) | 1 (0.02) |
| C. difficile test positive, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Any adverse drug event, n (%) | 524 (3) | 166 (2) | 443 (3) | 755 (3) | 1888 (3) |
| Diarrhea | 19 (0.1) | 2 (0.02) | 9 (0.1) | 20 (0.1) | 50 (0.1) |
| Vomiting | 26 (0.1) | 7 (0.1) | 25 (0.2) | 38 (0.1) | 96 (0.1) |
| Candidiasis | 4 (0.02) | 3 (0.04) | 7 (0.05) | 13 (0.05) | 27 (0.04) |
| Noncandidal rash | 45 (0.2) | 15 (0.2) | 34 (0.2) | 48 (0.2) | 142 (0.2) |
| Other and unspecified Allergy | 6 (0.03) | 2 (0.02) | 2 (0.01) | 5 (0.02) | 15 (0.02) |
| Mastoiditis, n (%) | 5 (0.03) | 1 (0.01) | 3 (0.02) | 7 (0.02) | 16 (0.02) |
| . | 2019 n = 19 317 . | 2020 n = 8954 . | 2021 n = 15 754 . | 2022 n = 29 173 . | Total N = 73 198 . |
|---|---|---|---|---|---|
| Treatment failure, n (%) (antibiotic prescription associated with AOM diagnosis code between 3 and 14 days after index visit) | 116 (0.6) | 37 (0.4) | 87 (0.6) | 166 (0.6) | 406 (0.6) |
| Treatment failure with index antibiotic prescription (n = 61 612) | 95 (0.6) | 34 (0.5) | 80 (0.6) | 150 (0.6) | 359 (0.6) |
| Treatment failure with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 3 (1.0) | 1 (0.2) | 14 (0.9) | 21 (0.7) |
| Treatment failure with 7-day index antibiotic prescription (n = 12 060) | 13 (0.7) | 6 (0.6) | 20 (0.8) | 54 (0.8) | 93 (0.8) |
| Treatment failure with 10-day index antibiotic prescription (n = 45 689) | 79 (0.6) | 23 (0.4) | 56 (0.6) | 79 (0.5) | 237 (0.5) |
| Treatment failure with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Treatment failure with NO index antibiotic prescription (n = 11 586) | 21 (0.7) | 3 (0.2) | 7 (0.3) | 16 (0.4) | 47 (0.4) |
| Recurrence, n (%) (antibiotic prescription associated with AOM diagnosis code between 15 and 30 days after index visit) | 153 (0.8) | 32 (0.4) | 107 (0.7) | 220 (0.8) | 512 (0.7) |
| Recurrence with index antibiotic prescription (n = 61 612) | 141 (0.9) | 30 (0.4) | 99 (0.7) | 199 (0.8) | 469 (0.8) |
| Recurrence with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 1 (0.3) | 2 (0.3) | 8 (0.5) | 14 (0.4) |
| Recurrence with 7-day index antibiotic prescription (n = 12 060) | 21 (1) | 4 (0.4) | 21 (0.8) | 69 (1) | 115 (1.0) |
| Recurrence with 10-day index antibiotic prescription (n = 45 689) | 114 (0.9) | 23 (0.4) | 72 (0.7) | 121 (0.7) | 330 (0.7) |
| Recurrence with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Recurrence with NO index antibiotic prescription (n = 11 586) | 12 (0.4) | 2 (0.1) | 8 (0.3) | 21 (0.5) | 43 (0.4) |
| Office visit for AOM within 30 days after index visit, n (%) | 838 (4) | 318 (4) | 692 (4) | 1523 (5) | 3371 (5) |
| ED or urgent-care visit for AOM within 30 days after index visit, n (%) | 1048 (5) | 382 (4) | 907 (6) | 1712 (6) | 4049 (6) |
| Hospitalized day of or within 30 days after index visit, n (%) | 68 (0.4) | 27 (0.3) | 58 (0.4) | 106 (0.4) | 259 (0.4) |
| C. difficile test performed, n (%) | 2 (0.01) | 0 (0) | 4 (0.03) | 5 (0.02) | 1 (0.02) |
| C. difficile test positive, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Any adverse drug event, n (%) | 524 (3) | 166 (2) | 443 (3) | 755 (3) | 1888 (3) |
| Diarrhea | 19 (0.1) | 2 (0.02) | 9 (0.1) | 20 (0.1) | 50 (0.1) |
| Vomiting | 26 (0.1) | 7 (0.1) | 25 (0.2) | 38 (0.1) | 96 (0.1) |
| Candidiasis | 4 (0.02) | 3 (0.04) | 7 (0.05) | 13 (0.05) | 27 (0.04) |
| Noncandidal rash | 45 (0.2) | 15 (0.2) | 34 (0.2) | 48 (0.2) | 142 (0.2) |
| Other and unspecified Allergy | 6 (0.03) | 2 (0.02) | 2 (0.01) | 5 (0.02) | 15 (0.02) |
| Mastoiditis, n (%) | 5 (0.03) | 1 (0.01) | 3 (0.02) | 7 (0.02) | 16 (0.02) |
| . | 2019 n = 19 317 . | 2020 n = 8954 . | 2021 n = 15 754 . | 2022 n = 29 173 . | Total N = 73 198 . |
|---|---|---|---|---|---|
| Treatment failure, n (%) (antibiotic prescription associated with AOM diagnosis code between 3 and 14 days after index visit) | 116 (0.6) | 37 (0.4) | 87 (0.6) | 166 (0.6) | 406 (0.6) |
| Treatment failure with index antibiotic prescription (n = 61 612) | 95 (0.6) | 34 (0.5) | 80 (0.6) | 150 (0.6) | 359 (0.6) |
| Treatment failure with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 3 (1.0) | 1 (0.2) | 14 (0.9) | 21 (0.7) |
| Treatment failure with 7-day index antibiotic prescription (n = 12 060) | 13 (0.7) | 6 (0.6) | 20 (0.8) | 54 (0.8) | 93 (0.8) |
| Treatment failure with 10-day index antibiotic prescription (n = 45 689) | 79 (0.6) | 23 (0.4) | 56 (0.6) | 79 (0.5) | 237 (0.5) |
| Treatment failure with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Treatment failure with NO index antibiotic prescription (n = 11 586) | 21 (0.7) | 3 (0.2) | 7 (0.3) | 16 (0.4) | 47 (0.4) |
| Recurrence, n (%) (antibiotic prescription associated with AOM diagnosis code between 15 and 30 days after index visit) | 153 (0.8) | 32 (0.4) | 107 (0.7) | 220 (0.8) | 512 (0.7) |
| Recurrence with index antibiotic prescription (n = 61 612) | 141 (0.9) | 30 (0.4) | 99 (0.7) | 199 (0.8) | 469 (0.8) |
| Recurrence with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 1 (0.3) | 2 (0.3) | 8 (0.5) | 14 (0.4) |
| Recurrence with 7-day index antibiotic prescription (n = 12 060) | 21 (1) | 4 (0.4) | 21 (0.8) | 69 (1) | 115 (1.0) |
| Recurrence with 10-day index antibiotic prescription (n = 45 689) | 114 (0.9) | 23 (0.4) | 72 (0.7) | 121 (0.7) | 330 (0.7) |
| Recurrence with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Recurrence with NO index antibiotic prescription (n = 11 586) | 12 (0.4) | 2 (0.1) | 8 (0.3) | 21 (0.5) | 43 (0.4) |
| Office visit for AOM within 30 days after index visit, n (%) | 838 (4) | 318 (4) | 692 (4) | 1523 (5) | 3371 (5) |
| ED or urgent-care visit for AOM within 30 days after index visit, n (%) | 1048 (5) | 382 (4) | 907 (6) | 1712 (6) | 4049 (6) |
| Hospitalized day of or within 30 days after index visit, n (%) | 68 (0.4) | 27 (0.3) | 58 (0.4) | 106 (0.4) | 259 (0.4) |
| C. difficile test performed, n (%) | 2 (0.01) | 0 (0) | 4 (0.03) | 5 (0.02) | 1 (0.02) |
| C. difficile test positive, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Any adverse drug event, n (%) | 524 (3) | 166 (2) | 443 (3) | 755 (3) | 1888 (3) |
| Diarrhea | 19 (0.1) | 2 (0.02) | 9 (0.1) | 20 (0.1) | 50 (0.1) |
| Vomiting | 26 (0.1) | 7 (0.1) | 25 (0.2) | 38 (0.1) | 96 (0.1) |
| Candidiasis | 4 (0.02) | 3 (0.04) | 7 (0.05) | 13 (0.05) | 27 (0.04) |
| Noncandidal rash | 45 (0.2) | 15 (0.2) | 34 (0.2) | 48 (0.2) | 142 (0.2) |
| Other and unspecified Allergy | 6 (0.03) | 2 (0.02) | 2 (0.01) | 5 (0.02) | 15 (0.02) |
| Mastoiditis, n (%) | 5 (0.03) | 1 (0.01) | 3 (0.02) | 7 (0.02) | 16 (0.02) |
| . | 2019 n = 19 317 . | 2020 n = 8954 . | 2021 n = 15 754 . | 2022 n = 29 173 . | Total N = 73 198 . |
|---|---|---|---|---|---|
| Treatment failure, n (%) (antibiotic prescription associated with AOM diagnosis code between 3 and 14 days after index visit) | 116 (0.6) | 37 (0.4) | 87 (0.6) | 166 (0.6) | 406 (0.6) |
| Treatment failure with index antibiotic prescription (n = 61 612) | 95 (0.6) | 34 (0.5) | 80 (0.6) | 150 (0.6) | 359 (0.6) |
| Treatment failure with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 3 (1.0) | 1 (0.2) | 14 (0.9) | 21 (0.7) |
| Treatment failure with 7-day index antibiotic prescription (n = 12 060) | 13 (0.7) | 6 (0.6) | 20 (0.8) | 54 (0.8) | 93 (0.8) |
| Treatment failure with 10-day index antibiotic prescription (n = 45 689) | 79 (0.6) | 23 (0.4) | 56 (0.6) | 79 (0.5) | 237 (0.5) |
| Treatment failure with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Treatment failure with NO index antibiotic prescription (n = 11 586) | 21 (0.7) | 3 (0.2) | 7 (0.3) | 16 (0.4) | 47 (0.4) |
| Recurrence, n (%) (antibiotic prescription associated with AOM diagnosis code between 15 and 30 days after index visit) | 153 (0.8) | 32 (0.4) | 107 (0.7) | 220 (0.8) | 512 (0.7) |
| Recurrence with index antibiotic prescription (n = 61 612) | 141 (0.9) | 30 (0.4) | 99 (0.7) | 199 (0.8) | 469 (0.8) |
| Recurrence with 5-day index antibiotic prescription (n = 3144) | 3 (0.5) | 1 (0.3) | 2 (0.3) | 8 (0.5) | 14 (0.4) |
| Recurrence with 7-day index antibiotic prescription (n = 12 060) | 21 (1) | 4 (0.4) | 21 (0.8) | 69 (1) | 115 (1.0) |
| Recurrence with 10-day index antibiotic prescription (n = 45 689) | 114 (0.9) | 23 (0.4) | 72 (0.7) | 121 (0.7) | 330 (0.7) |
| Recurrence with 14-day index antibiotic prescription (n = 72) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Recurrence with NO index antibiotic prescription (n = 11 586) | 12 (0.4) | 2 (0.1) | 8 (0.3) | 21 (0.5) | 43 (0.4) |
| Office visit for AOM within 30 days after index visit, n (%) | 838 (4) | 318 (4) | 692 (4) | 1523 (5) | 3371 (5) |
| ED or urgent-care visit for AOM within 30 days after index visit, n (%) | 1048 (5) | 382 (4) | 907 (6) | 1712 (6) | 4049 (6) |
| Hospitalized day of or within 30 days after index visit, n (%) | 68 (0.4) | 27 (0.3) | 58 (0.4) | 106 (0.4) | 259 (0.4) |
| C. difficile test performed, n (%) | 2 (0.01) | 0 (0) | 4 (0.03) | 5 (0.02) | 1 (0.02) |
| C. difficile test positive, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Any adverse drug event, n (%) | 524 (3) | 166 (2) | 443 (3) | 755 (3) | 1888 (3) |
| Diarrhea | 19 (0.1) | 2 (0.02) | 9 (0.1) | 20 (0.1) | 50 (0.1) |
| Vomiting | 26 (0.1) | 7 (0.1) | 25 (0.2) | 38 (0.1) | 96 (0.1) |
| Candidiasis | 4 (0.02) | 3 (0.04) | 7 (0.05) | 13 (0.05) | 27 (0.04) |
| Noncandidal rash | 45 (0.2) | 15 (0.2) | 34 (0.2) | 48 (0.2) | 142 (0.2) |
| Other and unspecified Allergy | 6 (0.03) | 2 (0.02) | 2 (0.01) | 5 (0.02) | 15 (0.02) |
| Mastoiditis, n (%) | 5 (0.03) | 1 (0.01) | 3 (0.02) | 7 (0.02) | 16 (0.02) |
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
