Histologic Observations in Nonhuman Primates Inoculated via the Intranasal or Aerosol Route
| . | Intranasal Route . | Aerosol Route . | ||||||
|---|---|---|---|---|---|---|---|---|
| Lung Lobe: Observationa . | IN1 . | IN2 . | IN3 . | IN4 . | A1 . | A2 . | A3 . | A4 . |
| Right upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Right middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Right lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Left upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| Left middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Left lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| . | Intranasal Route . | Aerosol Route . | ||||||
|---|---|---|---|---|---|---|---|---|
| Lung Lobe: Observationa . | IN1 . | IN2 . | IN3 . | IN4 . | A1 . | A2 . | A3 . | A4 . |
| Right upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Right middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Right lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Left upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| Left middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Left lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
aObservation: 0, no lesions; 1, minimal lesions (1%–10%).
Histologic Observations in Nonhuman Primates Inoculated via the Intranasal or Aerosol Route
| . | Intranasal Route . | Aerosol Route . | ||||||
|---|---|---|---|---|---|---|---|---|
| Lung Lobe: Observationa . | IN1 . | IN2 . | IN3 . | IN4 . | A1 . | A2 . | A3 . | A4 . |
| Right upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Right middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Right lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Left upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| Left middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Left lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| . | Intranasal Route . | Aerosol Route . | ||||||
|---|---|---|---|---|---|---|---|---|
| Lung Lobe: Observationa . | IN1 . | IN2 . | IN3 . | IN4 . | A1 . | A2 . | A3 . | A4 . |
| Right upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Right middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Right lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Left upper | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| Left middle | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Left lower | ||||||||
| Pneumocyte hyperplasia | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Interstitial pneumonia | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
aObservation: 0, no lesions; 1, minimal lesions (1%–10%).
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