| . | Arm 1, patient 1 . | Arm 2, patient 2 . | Arm 2, patient 3 . |
|---|---|---|---|
| Day of reaction | C1D1 | C1D1 | C1D1 |
| Timing (hours) | 4.8 | 1 | 5 |
| CTCAE Grade | Grade 2 | Grade 2 | Grade 2 |
| Symptoms | Urticaria, hives, nasal congestion, and sneezing | Chills and rigors | Back pain, rigors, and fever |
| Emergency medications | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV |
| Diphenhydramine 50 mg IV | Diphenhydramine 25 mg IV | Diphenhydramine 25 mg IV | |
| Tylenol 650 mg PO | Hydromorphone 0.2 mg IV | Morphine 2 mg | |
| Subsequent Dara-SQ doses | No reactions with future doses | Premedication omitted after 6 doses (C2D15) with no further reactions | Premedication omitted after 8 doses (C3D1) with no further reactions |
| . | Arm 1, patient 1 . | Arm 2, patient 2 . | Arm 2, patient 3 . |
|---|---|---|---|
| Day of reaction | C1D1 | C1D1 | C1D1 |
| Timing (hours) | 4.8 | 1 | 5 |
| CTCAE Grade | Grade 2 | Grade 2 | Grade 2 |
| Symptoms | Urticaria, hives, nasal congestion, and sneezing | Chills and rigors | Back pain, rigors, and fever |
| Emergency medications | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV |
| Diphenhydramine 50 mg IV | Diphenhydramine 25 mg IV | Diphenhydramine 25 mg IV | |
| Tylenol 650 mg PO | Hydromorphone 0.2 mg IV | Morphine 2 mg | |
| Subsequent Dara-SQ doses | No reactions with future doses | Premedication omitted after 6 doses (C2D15) with no further reactions | Premedication omitted after 8 doses (C3D1) with no further reactions |
Abbreviations: C, cycle; D, day.
| . | Arm 1, patient 1 . | Arm 2, patient 2 . | Arm 2, patient 3 . |
|---|---|---|---|
| Day of reaction | C1D1 | C1D1 | C1D1 |
| Timing (hours) | 4.8 | 1 | 5 |
| CTCAE Grade | Grade 2 | Grade 2 | Grade 2 |
| Symptoms | Urticaria, hives, nasal congestion, and sneezing | Chills and rigors | Back pain, rigors, and fever |
| Emergency medications | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV |
| Diphenhydramine 50 mg IV | Diphenhydramine 25 mg IV | Diphenhydramine 25 mg IV | |
| Tylenol 650 mg PO | Hydromorphone 0.2 mg IV | Morphine 2 mg | |
| Subsequent Dara-SQ doses | No reactions with future doses | Premedication omitted after 6 doses (C2D15) with no further reactions | Premedication omitted after 8 doses (C3D1) with no further reactions |
| . | Arm 1, patient 1 . | Arm 2, patient 2 . | Arm 2, patient 3 . |
|---|---|---|---|
| Day of reaction | C1D1 | C1D1 | C1D1 |
| Timing (hours) | 4.8 | 1 | 5 |
| CTCAE Grade | Grade 2 | Grade 2 | Grade 2 |
| Symptoms | Urticaria, hives, nasal congestion, and sneezing | Chills and rigors | Back pain, rigors, and fever |
| Emergency medications | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV | Hydrocortisone 100 mg IV |
| Diphenhydramine 50 mg IV | Diphenhydramine 25 mg IV | Diphenhydramine 25 mg IV | |
| Tylenol 650 mg PO | Hydromorphone 0.2 mg IV | Morphine 2 mg | |
| Subsequent Dara-SQ doses | No reactions with future doses | Premedication omitted after 6 doses (C2D15) with no further reactions | Premedication omitted after 8 doses (C3D1) with no further reactions |
Abbreviations: C, cycle; D, day.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
