Table 2.

Summary of urothelial carcinoma clinical studies in urinary cfDNA

AuthorYearAssaySettingNSensitivity (%)SpecificityPFS hazard ratioLead timeReference
Chauhan2023Bespoke PCR (uCAPP-SeQ + ULP-WGS)MIBC7487NR3.00NRChauhan22
Zhang2023Bespoke PCR (PredicineBEACON)MIBC2010099%NRNRZhang23
Christensen2023Bespoke 50-gene PCRMIBC927265%NRNRChristensen24
AuthorYearAssaySettingNSensitivity (%)SpecificityPFS hazard ratioLead timeReference
Chauhan2023Bespoke PCR (uCAPP-SeQ + ULP-WGS)MIBC7487NR3.00NRChauhan22
Zhang2023Bespoke PCR (PredicineBEACON)MIBC2010099%NRNRZhang23
Christensen2023Bespoke 50-gene PCRMIBC927265%NRNRChristensen24

Abbreviations: CAPP-Seq, CAncer personalized profiling by deep sequencing; MIBC, muscle-invasive bladder cancer; MRD, molecular residual disease; NAC, neoadjuvant chemotherapy; NR, not reported; WES, whole exome sequencing; WGS, whole-genome sequencing.

Table 2.

Summary of urothelial carcinoma clinical studies in urinary cfDNA

AuthorYearAssaySettingNSensitivity (%)SpecificityPFS hazard ratioLead timeReference
Chauhan2023Bespoke PCR (uCAPP-SeQ + ULP-WGS)MIBC7487NR3.00NRChauhan22
Zhang2023Bespoke PCR (PredicineBEACON)MIBC2010099%NRNRZhang23
Christensen2023Bespoke 50-gene PCRMIBC927265%NRNRChristensen24
AuthorYearAssaySettingNSensitivity (%)SpecificityPFS hazard ratioLead timeReference
Chauhan2023Bespoke PCR (uCAPP-SeQ + ULP-WGS)MIBC7487NR3.00NRChauhan22
Zhang2023Bespoke PCR (PredicineBEACON)MIBC2010099%NRNRZhang23
Christensen2023Bespoke 50-gene PCRMIBC927265%NRNRChristensen24

Abbreviations: CAPP-Seq, CAncer personalized profiling by deep sequencing; MIBC, muscle-invasive bladder cancer; MRD, molecular residual disease; NAC, neoadjuvant chemotherapy; NR, not reported; WES, whole exome sequencing; WGS, whole-genome sequencing.

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