Outcome of Local Progression and Radiation Necrosis for Each Study Cohort Stratified by Maximal Dimension of Index Lesion
| Study cohort* . | Preoperative SRS dose (Gy) . | No. of patients enrolled . | No. with local progression . | No. with radiation necrosis . | No. with DLT . | Description of DLT . | Maximum tolerated dose . |
|---|---|---|---|---|---|---|---|
| >2–3 cm | 18 | 2 | 0 | 0 | 0 | Not reached | |
| 21 | 3 | 0 | 1 | 0 | |||
| >3–4 cm | 15 | 4 | 2 | 0 | 0 | 18 | |
| 18 | 9 | 0 | 0 | 0 | |||
| 21 | 5 | 1 | 1 | 2 | Grade 3 wound dehiscence and grade 3 wound infection | ||
| >4–6 cm | 12 | 2 | 2 | 0 | 0 | 18 | |
| 15 | 7 | 0 | 2 | 1 | Grade 4 hematoma | ||
| 18 | 4 | 1 | 0 | 0 |
| Study cohort* . | Preoperative SRS dose (Gy) . | No. of patients enrolled . | No. with local progression . | No. with radiation necrosis . | No. with DLT . | Description of DLT . | Maximum tolerated dose . |
|---|---|---|---|---|---|---|---|
| >2–3 cm | 18 | 2 | 0 | 0 | 0 | Not reached | |
| 21 | 3 | 0 | 1 | 0 | |||
| >3–4 cm | 15 | 4 | 2 | 0 | 0 | 18 | |
| 18 | 9 | 0 | 0 | 0 | |||
| 21 | 5 | 1 | 1 | 2 | Grade 3 wound dehiscence and grade 3 wound infection | ||
| >4–6 cm | 12 | 2 | 2 | 0 | 0 | 18 | |
| 15 | 7 | 0 | 2 | 1 | Grade 4 hematoma | ||
| 18 | 4 | 1 | 0 | 0 |
*Grouped by maximal dimension of index lesion.
Outcome of Local Progression and Radiation Necrosis for Each Study Cohort Stratified by Maximal Dimension of Index Lesion
| Study cohort* . | Preoperative SRS dose (Gy) . | No. of patients enrolled . | No. with local progression . | No. with radiation necrosis . | No. with DLT . | Description of DLT . | Maximum tolerated dose . |
|---|---|---|---|---|---|---|---|
| >2–3 cm | 18 | 2 | 0 | 0 | 0 | Not reached | |
| 21 | 3 | 0 | 1 | 0 | |||
| >3–4 cm | 15 | 4 | 2 | 0 | 0 | 18 | |
| 18 | 9 | 0 | 0 | 0 | |||
| 21 | 5 | 1 | 1 | 2 | Grade 3 wound dehiscence and grade 3 wound infection | ||
| >4–6 cm | 12 | 2 | 2 | 0 | 0 | 18 | |
| 15 | 7 | 0 | 2 | 1 | Grade 4 hematoma | ||
| 18 | 4 | 1 | 0 | 0 |
| Study cohort* . | Preoperative SRS dose (Gy) . | No. of patients enrolled . | No. with local progression . | No. with radiation necrosis . | No. with DLT . | Description of DLT . | Maximum tolerated dose . |
|---|---|---|---|---|---|---|---|
| >2–3 cm | 18 | 2 | 0 | 0 | 0 | Not reached | |
| 21 | 3 | 0 | 1 | 0 | |||
| >3–4 cm | 15 | 4 | 2 | 0 | 0 | 18 | |
| 18 | 9 | 0 | 0 | 0 | |||
| 21 | 5 | 1 | 1 | 2 | Grade 3 wound dehiscence and grade 3 wound infection | ||
| >4–6 cm | 12 | 2 | 2 | 0 | 0 | 18 | |
| 15 | 7 | 0 | 2 | 1 | Grade 4 hematoma | ||
| 18 | 4 | 1 | 0 | 0 |
*Grouped by maximal dimension of index lesion.
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