Table 2. Open in new tab Univariable...

	This work	Mehrabian et al.
MTR_{Amide,0.625µT}	12.8 [3.1] %	12.6 [3.9] %	.939	.939	0.51	188.2	9.0 [0.9] %	7.3 [1.4] %	<.0001	0.87	72.8
MTR_Amide,2.5µT	53.3 [8.4] %	55.1 [7.9] %	.973	.974	0.51	188.2	48.2 [2.2] %	42.2 [5.1] %	<.0001	0.88	67.3
MTR_NOE,0.625µT	14.4 [3.8] %	14.0 [3.6] %	.424	.452	0.55	187.6	10.2 [1.4] %	8.3 [1.6] %	<.0001	0.82	78.4
MTR_NOE,2.5µT	52.3 [8.9] %	52.4 [8.3] %	.744	.751	0.53	188.1	46.5 [2.7] %	41.2 [5.0] %	<.0001	0.83	77.9
MTR_{Asym,0.625µT}	−1.6 [0.94] %	−1.3 [0.69] %	.029	.068	0.63	184.7	−1.2 [1.3] %	−1.0 [1.2] %	.70	0.52	105
MTR_Asym,2.5µT	1.8 [1.3] %	2.1 [0.9] %	.319	.402	0.61	187.5	1.7 [1.5] %	1.2 [2.0] %	.23	0.58	103
T₁	1.95 [0.49] s	1.92 [0.42] s	.083	.106	0.56	185.5	1.77 [0.19] s	1.94 [0.32] s	.01	0.69	98.3
T₂	179 [82] ms	162 [88] ms	.433	.410	0.55	187.5	114 [26] ms	140 [34] ms	<.001	0.74	92.0
R·M_0B / R_A	0.8 [0.5]	0.8 [0.4]	.707	.636	0.46	188.0	1.4 [0.2]	1.2 [0.3]	.009	0.66	97.6
1 / (R_A·T_2A)	5.9 [2.7]	6.5 [2.9]	.030	.024	0.60	182.8	29 [4]	26 [6]	.005	0.73	96.6
AREX_{Amide,0.625µT}	0.040 [0.019] s^-1	0.040 [0.025] s^-1	.250	.250	0.55	186.8	2.1 [0.6] s^-1	1.5 [0.9] s^-1	0.002	0.81	94.7
AREX_Amide,2.5µT	0.23 [0.13] s⁻¹	0.25 [0.15] s⁻¹	.948	.948	0.51	188.2	7.6 [3.2] s⁻¹	5.8 [2.7] s⁻¹	.01	0.68	98.3
AREX_NOE,0.625µT	0.052 [0.020] s⁻¹	0.041 [0.024] s⁻¹	.874	.878	0.51	188.1	2.8 [1.2] s⁻¹	2.0 [0.7] s⁻¹	<.001	0.72	91.7
AREX_NOE,2.5µT	0.19 [0.13] s⁻¹	0.22 [0.12] s⁻¹	.670	.684	0.50	188.0	5.5 [2.5] s⁻¹	4.6 [2.0] s⁻¹	.09	0.62	102.1
rCBV	1.6 [1.3]	1.7 [1.6]	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
After application of PCA to MTR and AREX parameters:
MTRPC1	N/A	N/A	.922	.929	0.48	188.1	N/A	N/A	N/A	N/A	N/A
MTRPC2	N/A	N/A	.251	.296	0.57	187.1	N/A	N/A	N/A	N/A	N/A
AREXPC1	N/A	N/A	.066	.098	0.56	185.3	N/A	N/A	N/A	N/A	N/A
AREXPC2	N/A	N/A	.051	.054	0.62	184.2	N/A	N/A	N/A	N/A	N/A

This work

Mehrabian et al.

Parameter

Welch’s 2-sample t-test

Univariable logistic regression

Median value [IQR]

P-value

AUC

AIC

Median value [IQR]

P-value

AUC

AIC

MTR_{Amide,0.625µT}

12.8 [3.1] %

12.6 [3.9] %

.939

0.51

188.2

9.0 [0.9] %

7.3 [1.4] %

<.0001

0.87

72.8

MTR_Amide,2.5µT

53.3 [8.4] %

55.1 [7.9] %

.973

.974

0.51

188.2

48.2 [2.2] %

42.2 [5.1] %

<.0001

0.88

67.3

MTR_NOE,0.625µT

14.4 [3.8] %

14.0 [3.6] %

.424

.452

0.55

187.6

10.2 [1.4] %

8.3 [1.6] %

<.0001

0.82

78.4

MTR_NOE,2.5µT

52.3 [8.9] %

52.4 [8.3] %

.744

.751

0.53

188.1

46.5 [2.7] %

41.2 [5.0] %

<.0001

0.83

77.9

MTR_{Asym,0.625µT}

−1.6 [0.94] %

−1.3 [0.69] %

.029

.068

0.63

184.7

−1.2 [1.3] %

−1.0 [1.2] %

.70

0.52

105

MTR_Asym,2.5µT

1.8 [1.3] %

2.1 [0.9] %

.319

.402

0.61

187.5

1.7 [1.5] %

1.2 [2.0] %

.23

0.58

103

T₁

1.95 [0.49] s

1.92 [0.42] s

.083

.106

0.56

185.5

1.77 [0.19] s

1.94 [0.32] s

.01

0.69

98.3

T₂

179 [82] ms

162 [88] ms

.433

.410

0.55

187.5

114 [26] ms

140 [34] ms

<.001

0.74

92.0

R·M_0B / R_A

0.8 [0.5]

0.8 [0.4]

.707

.636

0.46

188.0

1.4 [0.2]

1.2 [0.3]

.009

0.66

97.6

1 / (R_A·T_2A)

5.9 [2.7]

6.5 [2.9]

.030

.024

0.60

182.8

29 [4]

26 [6]

.005

0.73

96.6

AREX_{Amide,0.625µT}

0.040 [0.019] s^-1

0.040 [0.025] s^-1

.250

0.55

186.8

2.1 [0.6] s^-1

1.5 [0.9] s^-1

0.002

0.81

94.7

AREX_Amide,2.5µT

0.23 [0.13] s⁻¹

0.25 [0.15] s⁻¹

.948

0.51

188.2

7.6 [3.2] s⁻¹

5.8 [2.7] s⁻¹

.01

0.68

98.3

AREX_NOE,0.625µT

0.052 [0.020] s⁻¹

0.041 [0.024] s⁻¹

.874

.878

0.51

188.1

2.8 [1.2] s⁻¹

2.0 [0.7] s⁻¹

<.001

0.72

91.7

AREX_NOE,2.5µT

0.19 [0.13] s⁻¹

0.22 [0.12] s⁻¹

.670

.684

0.50

188.0

5.5 [2.5] s⁻¹

4.6 [2.0] s⁻¹

.09

0.62

102.1

rCBV

1.6 [1.3]

1.7 [1.6]

N/A

After application of PCA to MTR and AREX parameters:

MTRPC1

N/A

.922

.929

0.48

188.1

N/A

MTRPC2

N/A

.251

.296

0.57

187.1

N/A

AREXPC1

N/A

.066

.098

0.56

185.3

N/A

AREXPC2

N/A

.051

.054

0.62

184.2

N/A

	This work	Mehrabian et al.
MTR_{Amide,0.625µT}	12.8 [3.1] %	12.6 [3.9] %	.939	.939	0.51	188.2	9.0 [0.9] %	7.3 [1.4] %	<.0001	0.87	72.8
MTR_Amide,2.5µT	53.3 [8.4] %	55.1 [7.9] %	.973	.974	0.51	188.2	48.2 [2.2] %	42.2 [5.1] %	<.0001	0.88	67.3
MTR_NOE,0.625µT	14.4 [3.8] %	14.0 [3.6] %	.424	.452	0.55	187.6	10.2 [1.4] %	8.3 [1.6] %	<.0001	0.82	78.4
MTR_NOE,2.5µT	52.3 [8.9] %	52.4 [8.3] %	.744	.751	0.53	188.1	46.5 [2.7] %	41.2 [5.0] %	<.0001	0.83	77.9
MTR_{Asym,0.625µT}	−1.6 [0.94] %	−1.3 [0.69] %	.029	.068	0.63	184.7	−1.2 [1.3] %	−1.0 [1.2] %	.70	0.52	105
MTR_Asym,2.5µT	1.8 [1.3] %	2.1 [0.9] %	.319	.402	0.61	187.5	1.7 [1.5] %	1.2 [2.0] %	.23	0.58	103
T₁	1.95 [0.49] s	1.92 [0.42] s	.083	.106	0.56	185.5	1.77 [0.19] s	1.94 [0.32] s	.01	0.69	98.3
T₂	179 [82] ms	162 [88] ms	.433	.410	0.55	187.5	114 [26] ms	140 [34] ms	<.001	0.74	92.0
R·M_0B / R_A	0.8 [0.5]	0.8 [0.4]	.707	.636	0.46	188.0	1.4 [0.2]	1.2 [0.3]	.009	0.66	97.6
1 / (R_A·T_2A)	5.9 [2.7]	6.5 [2.9]	.030	.024	0.60	182.8	29 [4]	26 [6]	.005	0.73	96.6
AREX_{Amide,0.625µT}	0.040 [0.019] s^-1	0.040 [0.025] s^-1	.250	.250	0.55	186.8	2.1 [0.6] s^-1	1.5 [0.9] s^-1	0.002	0.81	94.7
AREX_Amide,2.5µT	0.23 [0.13] s⁻¹	0.25 [0.15] s⁻¹	.948	.948	0.51	188.2	7.6 [3.2] s⁻¹	5.8 [2.7] s⁻¹	.01	0.68	98.3
AREX_NOE,0.625µT	0.052 [0.020] s⁻¹	0.041 [0.024] s⁻¹	.874	.878	0.51	188.1	2.8 [1.2] s⁻¹	2.0 [0.7] s⁻¹	<.001	0.72	91.7
AREX_NOE,2.5µT	0.19 [0.13] s⁻¹	0.22 [0.12] s⁻¹	.670	.684	0.50	188.0	5.5 [2.5] s⁻¹	4.6 [2.0] s⁻¹	.09	0.62	102.1
rCBV	1.6 [1.3]	1.7 [1.6]	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
After application of PCA to MTR and AREX parameters:
MTRPC1	N/A	N/A	.922	.929	0.48	188.1	N/A	N/A	N/A	N/A	N/A
MTRPC2	N/A	N/A	.251	.296	0.57	187.1	N/A	N/A	N/A	N/A	N/A
AREXPC1	N/A	N/A	.066	.098	0.56	185.3	N/A	N/A	N/A	N/A	N/A
AREXPC2	N/A	N/A	.051	.054	0.62	184.2	N/A	N/A	N/A	N/A	N/A

Table 2.

Open in new tab

Univariable analyses

	This work						Mehrabian et al.
Parameter	RN	TP	Welch’s 2-sample t-test	Univariable logistic regression			RN	TP	Univariable logistic regression
Parameter	Median value [IQR]		P-value	P-value	AUC	AIC	Median value [IQR]		P-value	AUC	AIC
MTR_{Amide,0.625µT}	12.8 [3.1] %	12.6 [3.9] %	.939	.939	0.51	188.2	9.0 [0.9] %	7.3 [1.4] %	<.0001	0.87	72.8
MTR_Amide,2.5µT	53.3 [8.4] %	55.1 [7.9] %	.973	.974	0.51	188.2	48.2 [2.2] %	42.2 [5.1] %	<.0001	0.88	67.3
MTR_NOE,0.625µT	14.4 [3.8] %	14.0 [3.6] %	.424	.452	0.55	187.6	10.2 [1.4] %	8.3 [1.6] %	<.0001	0.82	78.4
MTR_NOE,2.5µT	52.3 [8.9] %	52.4 [8.3] %	.744	.751	0.53	188.1	46.5 [2.7] %	41.2 [5.0] %	<.0001	0.83	77.9
MTR_{Asym,0.625µT}	−1.6 [0.94] %	−1.3 [0.69] %	.029	.068	0.63	184.7	−1.2 [1.3] %	−1.0 [1.2] %	.70	0.52	105
MTR_Asym,2.5µT	1.8 [1.3] %	2.1 [0.9] %	.319	.402	0.61	187.5	1.7 [1.5] %	1.2 [2.0] %	.23	0.58	103
T₁	1.95 [0.49] s	1.92 [0.42] s	.083	.106	0.56	185.5	1.77 [0.19] s	1.94 [0.32] s	.01	0.69	98.3
T₂	179 [82] ms	162 [88] ms	.433	.410	0.55	187.5	114 [26] ms	140 [34] ms	<.001	0.74	92.0
R·M_0B / R_A	0.8 [0.5]	0.8 [0.4]	.707	.636	0.46	188.0	1.4 [0.2]	1.2 [0.3]	.009	0.66	97.6
1 / (R_A·T_2A)	5.9 [2.7]	6.5 [2.9]	.030	.024	0.60	182.8	29 [4]	26 [6]	.005	0.73	96.6
AREX_{Amide,0.625µT}	0.040 [0.019] s^-1	0.040 [0.025] s^-1	.250	.250	0.55	186.8	2.1 [0.6] s^-1	1.5 [0.9] s^-1	0.002	0.81	94.7
AREX_Amide,2.5µT	0.23 [0.13] s⁻¹	0.25 [0.15] s⁻¹	.948	.948	0.51	188.2	7.6 [3.2] s⁻¹	5.8 [2.7] s⁻¹	.01	0.68	98.3
AREX_NOE,0.625µT	0.052 [0.020] s⁻¹	0.041 [0.024] s⁻¹	.874	.878	0.51	188.1	2.8 [1.2] s⁻¹	2.0 [0.7] s⁻¹	<.001	0.72	91.7
AREX_NOE,2.5µT	0.19 [0.13] s⁻¹	0.22 [0.12] s⁻¹	.670	.684	0.50	188.0	5.5 [2.5] s⁻¹	4.6 [2.0] s⁻¹	.09	0.62	102.1
rCBV	1.6 [1.3]	1.7 [1.6]	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
After application of PCA to MTR and AREX parameters:
MTRPC1	N/A	N/A	.922	.929	0.48	188.1	N/A	N/A	N/A	N/A	N/A
MTRPC2	N/A	N/A	.251	.296	0.57	187.1	N/A	N/A	N/A	N/A	N/A
AREXPC1	N/A	N/A	.066	.098	0.56	185.3	N/A	N/A	N/A	N/A	N/A
AREXPC2	N/A	N/A	.051	.054	0.62	184.2	N/A	N/A	N/A	N/A	N/A

	This work						Mehrabian et al.
Parameter	RN	TP	Welch’s 2-sample t-test	Univariable logistic regression			RN	TP	Univariable logistic regression
Parameter	Median value [IQR]		P-value	P-value	AUC	AIC	Median value [IQR]		P-value	AUC	AIC
MTR_{Amide,0.625µT}	12.8 [3.1] %	12.6 [3.9] %	.939	.939	0.51	188.2	9.0 [0.9] %	7.3 [1.4] %	<.0001	0.87	72.8
MTR_Amide,2.5µT	53.3 [8.4] %	55.1 [7.9] %	.973	.974	0.51	188.2	48.2 [2.2] %	42.2 [5.1] %	<.0001	0.88	67.3
MTR_NOE,0.625µT	14.4 [3.8] %	14.0 [3.6] %	.424	.452	0.55	187.6	10.2 [1.4] %	8.3 [1.6] %	<.0001	0.82	78.4
MTR_NOE,2.5µT	52.3 [8.9] %	52.4 [8.3] %	.744	.751	0.53	188.1	46.5 [2.7] %	41.2 [5.0] %	<.0001	0.83	77.9
MTR_{Asym,0.625µT}	−1.6 [0.94] %	−1.3 [0.69] %	.029	.068	0.63	184.7	−1.2 [1.3] %	−1.0 [1.2] %	.70	0.52	105
MTR_Asym,2.5µT	1.8 [1.3] %	2.1 [0.9] %	.319	.402	0.61	187.5	1.7 [1.5] %	1.2 [2.0] %	.23	0.58	103
T₁	1.95 [0.49] s	1.92 [0.42] s	.083	.106	0.56	185.5	1.77 [0.19] s	1.94 [0.32] s	.01	0.69	98.3
T₂	179 [82] ms	162 [88] ms	.433	.410	0.55	187.5	114 [26] ms	140 [34] ms	<.001	0.74	92.0
R·M_0B / R_A	0.8 [0.5]	0.8 [0.4]	.707	.636	0.46	188.0	1.4 [0.2]	1.2 [0.3]	.009	0.66	97.6
1 / (R_A·T_2A)	5.9 [2.7]	6.5 [2.9]	.030	.024	0.60	182.8	29 [4]	26 [6]	.005	0.73	96.6
AREX_{Amide,0.625µT}	0.040 [0.019] s^-1	0.040 [0.025] s^-1	.250	.250	0.55	186.8	2.1 [0.6] s^-1	1.5 [0.9] s^-1	0.002	0.81	94.7
AREX_Amide,2.5µT	0.23 [0.13] s⁻¹	0.25 [0.15] s⁻¹	.948	.948	0.51	188.2	7.6 [3.2] s⁻¹	5.8 [2.7] s⁻¹	.01	0.68	98.3
AREX_NOE,0.625µT	0.052 [0.020] s⁻¹	0.041 [0.024] s⁻¹	.874	.878	0.51	188.1	2.8 [1.2] s⁻¹	2.0 [0.7] s⁻¹	<.001	0.72	91.7
AREX_NOE,2.5µT	0.19 [0.13] s⁻¹	0.22 [0.12] s⁻¹	.670	.684	0.50	188.0	5.5 [2.5] s⁻¹	4.6 [2.0] s⁻¹	.09	0.62	102.1
rCBV	1.6 [1.3]	1.7 [1.6]	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
After application of PCA to MTR and AREX parameters:
MTRPC1	N/A	N/A	.922	.929	0.48	188.1	N/A	N/A	N/A	N/A	N/A
MTRPC2	N/A	N/A	.251	.296	0.57	187.1	N/A	N/A	N/A	N/A	N/A
AREXPC1	N/A	N/A	.066	.098	0.56	185.3	N/A	N/A	N/A	N/A	N/A
AREXPC2	N/A	N/A	.051	.054	0.62	184.2	N/A	N/A	N/A	N/A	N/A

The median and interquartile ranges are shown for the radiation necrosis (RN) and tumor progression (TP) cohorts for each parameter. Welch’s 2-sample t-test was computed for each parameter. Univariable logistic regression was performed where the area under the receiver-operating characteristic curve (AUC) and Akaike information criterion (AIC) were obtained for each parameter. The values from Mehrabian et al.²⁴ are also shown to allow for direct comparison of the results. Values with P-values below .05 are bolded.

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