Risk-of-Bias (RoB) Assessment Ratings (n = 20) (Discontinued Trial Registries [n = 4] Not Assessed)
| Study ID . | Tool . | Tool scale39–42 . | Rating . |
|---|---|---|---|
| Alshammari et al, 2022 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| Badar et al, 2014 | RoB2.0 | Low RoB, some concerns, high RoB | High RoB |
| Christensen et al, 2022 | RoB2.0 | Low RoB, some concerns, high RoB | Some concerns |
| Kirkham et al, 2021 | NIH | Poor/fair/good quality | Good quality |
| Kirkham et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Kleckner et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Marinac et al, 2016 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Very high RoB |
| O’Donnell et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Palomar-Cros et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Low RoB |
| Vega et al, 2022 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Critical RoB |
| Yassin et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| NCT03523377 | RoB2.0 | Low RoB, some concerns, high RoB | Low RoB |
| NCT04626843 | NIH | Poor/fair/good quality | Good quality |
| NCT04708860 | NIH | Poor/fair/good quality | Good quality |
| NCT04783467 | RoB2.0 | Low RoB/some concerns/high RoB | High RoB |
| NCT05023967 | RoB2.0 | Low RoB/some concerns/high RoB | Low RoB |
| NCT05083416 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Serious RoB |
| NCT05259410 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
| NCT05312255 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Moderate RoB |
| NCT05722288 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
| Study ID . | Tool . | Tool scale39–42 . | Rating . |
|---|---|---|---|
| Alshammari et al, 2022 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| Badar et al, 2014 | RoB2.0 | Low RoB, some concerns, high RoB | High RoB |
| Christensen et al, 2022 | RoB2.0 | Low RoB, some concerns, high RoB | Some concerns |
| Kirkham et al, 2021 | NIH | Poor/fair/good quality | Good quality |
| Kirkham et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Kleckner et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Marinac et al, 2016 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Very high RoB |
| O’Donnell et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Palomar-Cros et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Low RoB |
| Vega et al, 2022 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Critical RoB |
| Yassin et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| NCT03523377 | RoB2.0 | Low RoB, some concerns, high RoB | Low RoB |
| NCT04626843 | NIH | Poor/fair/good quality | Good quality |
| NCT04708860 | NIH | Poor/fair/good quality | Good quality |
| NCT04783467 | RoB2.0 | Low RoB/some concerns/high RoB | High RoB |
| NCT05023967 | RoB2.0 | Low RoB/some concerns/high RoB | Low RoB |
| NCT05083416 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Serious RoB |
| NCT05259410 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
| NCT05312255 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Moderate RoB |
| NCT05722288 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
Risk-of-Bias (RoB) Assessment Ratings (n = 20) (Discontinued Trial Registries [n = 4] Not Assessed)
| Study ID . | Tool . | Tool scale39–42 . | Rating . |
|---|---|---|---|
| Alshammari et al, 2022 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| Badar et al, 2014 | RoB2.0 | Low RoB, some concerns, high RoB | High RoB |
| Christensen et al, 2022 | RoB2.0 | Low RoB, some concerns, high RoB | Some concerns |
| Kirkham et al, 2021 | NIH | Poor/fair/good quality | Good quality |
| Kirkham et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Kleckner et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Marinac et al, 2016 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Very high RoB |
| O’Donnell et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Palomar-Cros et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Low RoB |
| Vega et al, 2022 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Critical RoB |
| Yassin et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| NCT03523377 | RoB2.0 | Low RoB, some concerns, high RoB | Low RoB |
| NCT04626843 | NIH | Poor/fair/good quality | Good quality |
| NCT04708860 | NIH | Poor/fair/good quality | Good quality |
| NCT04783467 | RoB2.0 | Low RoB/some concerns/high RoB | High RoB |
| NCT05023967 | RoB2.0 | Low RoB/some concerns/high RoB | Low RoB |
| NCT05083416 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Serious RoB |
| NCT05259410 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
| NCT05312255 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Moderate RoB |
| NCT05722288 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
| Study ID . | Tool . | Tool scale39–42 . | Rating . |
|---|---|---|---|
| Alshammari et al, 2022 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| Badar et al, 2014 | RoB2.0 | Low RoB, some concerns, high RoB | High RoB |
| Christensen et al, 2022 | RoB2.0 | Low RoB, some concerns, high RoB | Some concerns |
| Kirkham et al, 2021 | NIH | Poor/fair/good quality | Good quality |
| Kirkham et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Kleckner et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Marinac et al, 2016 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Very high RoB |
| O’Donnell et al, 2022 | NIH | Poor/fair/good quality | Good quality |
| Palomar-Cros et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | Low RoB |
| Vega et al, 2022 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Critical RoB |
| Yassin et al, 2021 | ROBINS-E | Low RoB except for concerns about uncontrolled confounding/some concerns/high RoB/very high RoB | High RoB |
| NCT03523377 | RoB2.0 | Low RoB, some concerns, high RoB | Low RoB |
| NCT04626843 | NIH | Poor/fair/good quality | Good quality |
| NCT04708860 | NIH | Poor/fair/good quality | Good quality |
| NCT04783467 | RoB2.0 | Low RoB/some concerns/high RoB | High RoB |
| NCT05023967 | RoB2.0 | Low RoB/some concerns/high RoB | Low RoB |
| NCT05083416 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Serious RoB |
| NCT05259410 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
| NCT05312255 | ROBINS-I | Low RoB/moderate RoB/serious RoB/critical RoB/no information | Moderate RoB |
| NCT05722288 | RoB2.0 | Low RoB/some concerns/high RoB | Some concerns |
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