| . | BMI PRS . | Multiple trait PRS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Traits | PRS group | Case N (Prev.%) | OR (95% CI) | P | PRS group | Case N (Prev.%) | OR (95% CI) | P |
| Non-obese versus Obese by BMI | L | 1495 (21.43%) | 0.54 (0.51, 0.58) | 3.33 × 10−87 | L | 1898 (27.20%) | 0.74 (0.70, 0.79) | 4.32 × 10−25 |
| M (ref.) | 18,507 (33.16%) | - | - | M (ref.) | 18,566 (33.25%) | - | - | |
| H | 3353 (48.06%) | 1.90 (1.80, 2.00) | 4.13 × 10−135 | H | 2901 (41.58%) | 1.44 (1.36, 1.51) | 1.32 × 10−43 | |
| Non-obese versus Obese by WC | L | 1153 (18.01%) | 0.65 (0.61, 0.70) | 2.04 × 10−35 | L | 1368 (21.32%) | 0.79 (0.75, 0.85) | 1.37 × 10−12 |
| M (ref.) | 12,868 (25.06%) | - | - | M (ref.) | 12,889 (25.09%) | - | - | |
| H | 2223 (34.48%) | 1.60 (1.51, 1.69) | 9.20 × 10−61 | H | 1987 (30.97%) | 1.34 (1.27, 1.42) | 1.17 × 10−23 | |
| Non-obese vs. MHO+MUO | L | 1341 (21.27%) | 0.54 (0.51, 0.58) | 4.83 × 10−79 | L | 1701 (26.97%) | 0.74 (0.70, 0.78) | 5.60 × 10−24 |
| M (ref.) | 16,699 (33.02%) | - | - | M (ref.) | 16,766 (33.14%) | - | - | |
| H | 3066 (48.33%) | 1.93 (1.83, 2.03) | 1.64 × 10−129 | H | 2639 (41.69%) | 1.45 (1.38, 1.53) | 3.19 × 10−42 | |
| Non-obese versus MHO | L | 637 (11.37%) | 0.54 (0.50, 0.59) | 7.37 × 10−44 | L M (ref.) H | 883 (16.09%) | 0.80 (0.74, 0.86) | 7.88 × 10−9 |
| M (ref.) | 7967 (19.04%) | 8062 (19.25%) | - | - | ||||
| H | 1471 (30.97%) | 1.93 (1.81, 2.07) | 3.70 × 10−84 | 1130 (23.44%) | 1.29 (1.20, 1.39) | 2.23 × 10−12 | ||
| Non-obese versus MUO | L | 704 (12.42%) | 0.55 (0.50, 0.59) | 2.65 × 10−46 | L | 818 (15.08%) | 0.68 (0.63, 0.74) | 1.75 × 10−21 |
| M (ref.) | 8732 (20.49%) | M (ref.) | 8704 (20.47%) | - | - | |||
| H | 1595 (32.73%) | 1.93 (1.81, 2.06) | 1.46 × 10−86 | H | 1509 (29.02%) | 1.60 (1.50, 1.71) | 1.49× 10−45 | |
| MHO versus MUO | L | 704 (52.5%) | 0.99 (0.89, 1.11) | 0.90 | L | 818 (48.09%) | 0.85 (0.77, 0.94) | 1.19 × 10−3 |
| M (ref.) | 8732 (52.29%) | M (ref.) | 8704 (51.91%) | - | - | |||
| H | 1595 (52.02%) | 1.00 (0.92, 1.08) | 0.92 | H | 1509 (57.18%) | 1.25 (1.15, 1.36) | 1.36 × 10−7 | |
| . | BMI PRS . | Multiple trait PRS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Traits | PRS group | Case N (Prev.%) | OR (95% CI) | P | PRS group | Case N (Prev.%) | OR (95% CI) | P |
| Non-obese versus Obese by BMI | L | 1495 (21.43%) | 0.54 (0.51, 0.58) | 3.33 × 10−87 | L | 1898 (27.20%) | 0.74 (0.70, 0.79) | 4.32 × 10−25 |
| M (ref.) | 18,507 (33.16%) | - | - | M (ref.) | 18,566 (33.25%) | - | - | |
| H | 3353 (48.06%) | 1.90 (1.80, 2.00) | 4.13 × 10−135 | H | 2901 (41.58%) | 1.44 (1.36, 1.51) | 1.32 × 10−43 | |
| Non-obese versus Obese by WC | L | 1153 (18.01%) | 0.65 (0.61, 0.70) | 2.04 × 10−35 | L | 1368 (21.32%) | 0.79 (0.75, 0.85) | 1.37 × 10−12 |
| M (ref.) | 12,868 (25.06%) | - | - | M (ref.) | 12,889 (25.09%) | - | - | |
| H | 2223 (34.48%) | 1.60 (1.51, 1.69) | 9.20 × 10−61 | H | 1987 (30.97%) | 1.34 (1.27, 1.42) | 1.17 × 10−23 | |
| Non-obese vs. MHO+MUO | L | 1341 (21.27%) | 0.54 (0.51, 0.58) | 4.83 × 10−79 | L | 1701 (26.97%) | 0.74 (0.70, 0.78) | 5.60 × 10−24 |
| M (ref.) | 16,699 (33.02%) | - | - | M (ref.) | 16,766 (33.14%) | - | - | |
| H | 3066 (48.33%) | 1.93 (1.83, 2.03) | 1.64 × 10−129 | H | 2639 (41.69%) | 1.45 (1.38, 1.53) | 3.19 × 10−42 | |
| Non-obese versus MHO | L | 637 (11.37%) | 0.54 (0.50, 0.59) | 7.37 × 10−44 | L M (ref.) H | 883 (16.09%) | 0.80 (0.74, 0.86) | 7.88 × 10−9 |
| M (ref.) | 7967 (19.04%) | 8062 (19.25%) | - | - | ||||
| H | 1471 (30.97%) | 1.93 (1.81, 2.07) | 3.70 × 10−84 | 1130 (23.44%) | 1.29 (1.20, 1.39) | 2.23 × 10−12 | ||
| Non-obese versus MUO | L | 704 (12.42%) | 0.55 (0.50, 0.59) | 2.65 × 10−46 | L | 818 (15.08%) | 0.68 (0.63, 0.74) | 1.75 × 10−21 |
| M (ref.) | 8732 (20.49%) | M (ref.) | 8704 (20.47%) | - | - | |||
| H | 1595 (32.73%) | 1.93 (1.81, 2.06) | 1.46 × 10−86 | H | 1509 (29.02%) | 1.60 (1.50, 1.71) | 1.49× 10−45 | |
| MHO versus MUO | L | 704 (52.5%) | 0.99 (0.89, 1.11) | 0.90 | L | 818 (48.09%) | 0.85 (0.77, 0.94) | 1.19 × 10−3 |
| M (ref.) | 8732 (52.29%) | M (ref.) | 8704 (51.91%) | - | - | |||
| H | 1595 (52.02%) | 1.00 (0.92, 1.08) | 0.92 | H | 1509 (57.18%) | 1.25 (1.15, 1.36) | 1.36 × 10−7 | |
Traits
MHO vs. MUO. obese group comprising of MHO (control) vs. obese group comprising of MUO (case).
PRS group.
L, M, and H Low, Medium, and high PRS group of bottom decile, 2nd–9th decile, and top decile.
Statistical analyses.
OR and P odds ratio and significance level of PRS group from logistic model on obesity adjusted by age, sex, PRS group, and PC1–5.
| . | BMI PRS . | Multiple trait PRS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Traits | PRS group | Case N (Prev.%) | OR (95% CI) | P | PRS group | Case N (Prev.%) | OR (95% CI) | P |
| Non-obese versus Obese by BMI | L | 1495 (21.43%) | 0.54 (0.51, 0.58) | 3.33 × 10−87 | L | 1898 (27.20%) | 0.74 (0.70, 0.79) | 4.32 × 10−25 |
| M (ref.) | 18,507 (33.16%) | - | - | M (ref.) | 18,566 (33.25%) | - | - | |
| H | 3353 (48.06%) | 1.90 (1.80, 2.00) | 4.13 × 10−135 | H | 2901 (41.58%) | 1.44 (1.36, 1.51) | 1.32 × 10−43 | |
| Non-obese versus Obese by WC | L | 1153 (18.01%) | 0.65 (0.61, 0.70) | 2.04 × 10−35 | L | 1368 (21.32%) | 0.79 (0.75, 0.85) | 1.37 × 10−12 |
| M (ref.) | 12,868 (25.06%) | - | - | M (ref.) | 12,889 (25.09%) | - | - | |
| H | 2223 (34.48%) | 1.60 (1.51, 1.69) | 9.20 × 10−61 | H | 1987 (30.97%) | 1.34 (1.27, 1.42) | 1.17 × 10−23 | |
| Non-obese vs. MHO+MUO | L | 1341 (21.27%) | 0.54 (0.51, 0.58) | 4.83 × 10−79 | L | 1701 (26.97%) | 0.74 (0.70, 0.78) | 5.60 × 10−24 |
| M (ref.) | 16,699 (33.02%) | - | - | M (ref.) | 16,766 (33.14%) | - | - | |
| H | 3066 (48.33%) | 1.93 (1.83, 2.03) | 1.64 × 10−129 | H | 2639 (41.69%) | 1.45 (1.38, 1.53) | 3.19 × 10−42 | |
| Non-obese versus MHO | L | 637 (11.37%) | 0.54 (0.50, 0.59) | 7.37 × 10−44 | L M (ref.) H | 883 (16.09%) | 0.80 (0.74, 0.86) | 7.88 × 10−9 |
| M (ref.) | 7967 (19.04%) | 8062 (19.25%) | - | - | ||||
| H | 1471 (30.97%) | 1.93 (1.81, 2.07) | 3.70 × 10−84 | 1130 (23.44%) | 1.29 (1.20, 1.39) | 2.23 × 10−12 | ||
| Non-obese versus MUO | L | 704 (12.42%) | 0.55 (0.50, 0.59) | 2.65 × 10−46 | L | 818 (15.08%) | 0.68 (0.63, 0.74) | 1.75 × 10−21 |
| M (ref.) | 8732 (20.49%) | M (ref.) | 8704 (20.47%) | - | - | |||
| H | 1595 (32.73%) | 1.93 (1.81, 2.06) | 1.46 × 10−86 | H | 1509 (29.02%) | 1.60 (1.50, 1.71) | 1.49× 10−45 | |
| MHO versus MUO | L | 704 (52.5%) | 0.99 (0.89, 1.11) | 0.90 | L | 818 (48.09%) | 0.85 (0.77, 0.94) | 1.19 × 10−3 |
| M (ref.) | 8732 (52.29%) | M (ref.) | 8704 (51.91%) | - | - | |||
| H | 1595 (52.02%) | 1.00 (0.92, 1.08) | 0.92 | H | 1509 (57.18%) | 1.25 (1.15, 1.36) | 1.36 × 10−7 | |
| . | BMI PRS . | Multiple trait PRS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Traits | PRS group | Case N (Prev.%) | OR (95% CI) | P | PRS group | Case N (Prev.%) | OR (95% CI) | P |
| Non-obese versus Obese by BMI | L | 1495 (21.43%) | 0.54 (0.51, 0.58) | 3.33 × 10−87 | L | 1898 (27.20%) | 0.74 (0.70, 0.79) | 4.32 × 10−25 |
| M (ref.) | 18,507 (33.16%) | - | - | M (ref.) | 18,566 (33.25%) | - | - | |
| H | 3353 (48.06%) | 1.90 (1.80, 2.00) | 4.13 × 10−135 | H | 2901 (41.58%) | 1.44 (1.36, 1.51) | 1.32 × 10−43 | |
| Non-obese versus Obese by WC | L | 1153 (18.01%) | 0.65 (0.61, 0.70) | 2.04 × 10−35 | L | 1368 (21.32%) | 0.79 (0.75, 0.85) | 1.37 × 10−12 |
| M (ref.) | 12,868 (25.06%) | - | - | M (ref.) | 12,889 (25.09%) | - | - | |
| H | 2223 (34.48%) | 1.60 (1.51, 1.69) | 9.20 × 10−61 | H | 1987 (30.97%) | 1.34 (1.27, 1.42) | 1.17 × 10−23 | |
| Non-obese vs. MHO+MUO | L | 1341 (21.27%) | 0.54 (0.51, 0.58) | 4.83 × 10−79 | L | 1701 (26.97%) | 0.74 (0.70, 0.78) | 5.60 × 10−24 |
| M (ref.) | 16,699 (33.02%) | - | - | M (ref.) | 16,766 (33.14%) | - | - | |
| H | 3066 (48.33%) | 1.93 (1.83, 2.03) | 1.64 × 10−129 | H | 2639 (41.69%) | 1.45 (1.38, 1.53) | 3.19 × 10−42 | |
| Non-obese versus MHO | L | 637 (11.37%) | 0.54 (0.50, 0.59) | 7.37 × 10−44 | L M (ref.) H | 883 (16.09%) | 0.80 (0.74, 0.86) | 7.88 × 10−9 |
| M (ref.) | 7967 (19.04%) | 8062 (19.25%) | - | - | ||||
| H | 1471 (30.97%) | 1.93 (1.81, 2.07) | 3.70 × 10−84 | 1130 (23.44%) | 1.29 (1.20, 1.39) | 2.23 × 10−12 | ||
| Non-obese versus MUO | L | 704 (12.42%) | 0.55 (0.50, 0.59) | 2.65 × 10−46 | L | 818 (15.08%) | 0.68 (0.63, 0.74) | 1.75 × 10−21 |
| M (ref.) | 8732 (20.49%) | M (ref.) | 8704 (20.47%) | - | - | |||
| H | 1595 (32.73%) | 1.93 (1.81, 2.06) | 1.46 × 10−86 | H | 1509 (29.02%) | 1.60 (1.50, 1.71) | 1.49× 10−45 | |
| MHO versus MUO | L | 704 (52.5%) | 0.99 (0.89, 1.11) | 0.90 | L | 818 (48.09%) | 0.85 (0.77, 0.94) | 1.19 × 10−3 |
| M (ref.) | 8732 (52.29%) | M (ref.) | 8704 (51.91%) | - | - | |||
| H | 1595 (52.02%) | 1.00 (0.92, 1.08) | 0.92 | H | 1509 (57.18%) | 1.25 (1.15, 1.36) | 1.36 × 10−7 | |
Traits
MHO vs. MUO. obese group comprising of MHO (control) vs. obese group comprising of MUO (case).
PRS group.
L, M, and H Low, Medium, and high PRS group of bottom decile, 2nd–9th decile, and top decile.
Statistical analyses.
OR and P odds ratio and significance level of PRS group from logistic model on obesity adjusted by age, sex, PRS group, and PC1–5.
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