Table 3 Open in new tab Summary...

								Discovery dataset	KoGES_Affy	UKB_Chi	UKB_EUR
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	1.73 × 10⁻¹⁶	0.40	0.12	0.42	0.02	0.04	0.27	0.53	5.10 × 10⁻³²	0.09
										0.10			0.13		−0.30		0.08
2:25108197	rs1865689	ADCY3	T	C	0.43	0.62	0	3.52 × 10⁻¹⁰	0.49	0.08	0.49	3.45 × 10⁻⁴	0.12	-	-	-	-
										0.07			0.15	-	-	-	-
3:52893465	rs6798941	STIMATE	C	T	0.37	0.5	0	9.60 × 10⁻¹¹	0.42	0.07	0.42	0.02	−0.02	-	-	-	-
										0.08			0.11	-	-	-	-
6:20674691	rs9368219	CDKAL1	C	T	0.47	0.02	0	3.31 × 10⁻¹¹	5.12 × 10⁻³	−0.10	4.77 × 10⁻³	0.14	−0.04	3.31 × 10⁻⁷	−0.10	0	−0.04
										−0.05			−0.08		0.49		−0.02
8:19845376	rs7841189	LPL	C	T	0.12	0.62	0	2.08 × 10⁻¹⁷	0.00	0.10	2.97 × 10⁻¹⁸	0.02	−0.10	0.15	0.64	1.86 × 10⁻⁷⁴	0.17
										−0.13			−0.17		0.45		−0.12
11:27703480	rs35038967	BDNF-AS	T	A	0.45	0.02	0	1.02 × 10⁻¹¹	0.93	−0.08	0.92	0.05	−0.09	0.96	−0.04	5.93 × 10⁻²⁷	−0.07
										−0.08			−0.08		−0.05		−0.08
11:116526322	rs486394	LINC02702	A	C	0.12	0.56	0	2.67 × 10⁻⁹	3.55 × 10⁻⁹	−0.12	3.61 × 10⁻⁹	0.02	−0.06	-	-	-	-
										0.04			0.15	-	-	-	-
11:116651463	rs1942478	ZPR1	T	G	0.22	0.64	0	9.03 × 10⁻¹⁷	0.00	0.10	1.25 × 10⁻¹⁷	2.39 × 10⁻⁴	0.16	0.22	0.31	1.08 × 10⁻¹¹³	0.06
										−0.08			−0.13		−0.36		−0.03
11:116664776	rs1787680	APOA5	T	A	0.22	0.06	0	4.85 × 10⁻¹³	6.35 × 10⁻¹⁴	0.09	6.88 × 10⁻¹⁴	0.05	0.13	-	-	-	-
										−0.07			−0.04	-	-	-	-
11:116837089	rs78044162	SIK3	C	T	0.17	0.64	0	2.25 × 10⁻¹²	1.96 × 10⁻¹²	0.11	1.92 × 10⁻¹²	0.02	0.14	1.88 × 10⁻³	−0.08	5.74 × 10⁻⁴	0.06
										−0.05			−0.08		0.41		3.29 × 10⁻³
15:68123915	rs4776987	SKOR1	A	T	0.37	0.5	0	3.81 × 10⁻⁸	1.19 × 10⁻⁸	0.08	4.12 × 10⁻³	0.04	6.17 × 10⁻⁴	-	-	-	-
										0.03			0.10	-	-	-	-
16:56994528	rs17231506	CETP	C	T	0.17	0.26	0	1.13 × 10⁻¹⁹	0.00	0.13	3.96 × 10⁻²⁰	-	-	0.54	0.31	3.76 × 10⁻¹⁶⁹	0.10
										−0.08		-	-		−0.22		−0.07
18:57831468	rs633265	MC4R	G	T	0.28	0.66	0	1.07 × 10⁻¹⁸	0.41	0.10	0.40	0.02	0.02	-	-	-	-
										0.12			0.12	-	-	-	-

Discovery dataset

KoGES_Affy

UKB_Chi

UKB_EUR

CHR: BP

SNP

GENE

REF

ALT

MAF

HWE

LRT P

MUL P

BETA

EQ P

REP P

BETA

REP P

BETA

REP P

BETA

1:177873210

rs574367

SEC16B

0.25

0.74

1.73 × 10⁻¹⁶

0.40

0.12

0.42

0.02

0.04

0.27

0.53

5.10 × 10⁻³²

0.09

0.10

0.13

−0.30

0.08

2:25108197

rs1865689

ADCY3

0.43

0.62

3.52 × 10⁻¹⁰

0.49

0.08

0.49

3.45 × 10⁻⁴

0.12

0.07

0.15

3:52893465

rs6798941

STIMATE

0.37

0.5

9.60 × 10⁻¹¹

0.42

0.07

0.42

0.02

−0.02

0.08

0.11

6:20674691

rs9368219

CDKAL1

0.47

0.02

3.31 × 10⁻¹¹

5.12 × 10⁻³

−0.10

4.77 × 10⁻³

0.14

−0.04

3.31 × 10⁻⁷

−0.10

−0.04

−0.05

−0.08

0.49

−0.02

8:19845376

rs7841189

LPL

0.12

0.62

2.08 × 10⁻¹⁷

0.00

0.10

2.97 × 10⁻¹⁸

0.02

−0.10

0.15

0.64

1.86 × 10⁻⁷⁴

0.17

−0.13

−0.17

0.45

−0.12

11:27703480

rs35038967

BDNF-AS

0.45

0.02

1.02 × 10⁻¹¹

0.93

−0.08

0.92

0.05

−0.09

0.96

−0.04

5.93 × 10⁻²⁷

−0.07

−0.08

−0.05

−0.08

11:116526322

rs486394

LINC02702

0.12

0.56

2.67 × 10⁻⁹

3.55 × 10⁻⁹

−0.12

3.61 × 10⁻⁹

0.02

−0.06

0.04

0.15

11:116651463

rs1942478

ZPR1

0.22

0.64

9.03 × 10⁻¹⁷

0.00

0.10

1.25 × 10⁻¹⁷

2.39 × 10⁻⁴

0.16

0.22

0.31

1.08 × 10⁻¹¹³

0.06

−0.08

−0.13

−0.36

−0.03

11:116664776

rs1787680

APOA5

0.22

0.06

4.85 × 10⁻¹³

6.35 × 10⁻¹⁴

0.09

6.88 × 10⁻¹⁴

0.05

0.13

−0.07

−0.04

11:116837089

rs78044162

SIK3

0.17

0.64

2.25 × 10⁻¹²

1.96 × 10⁻¹²

0.11

1.92 × 10⁻¹²

0.02

0.14

1.88 × 10⁻³

−0.08

5.74 × 10⁻⁴

0.06

−0.05

−0.08

0.41

3.29 × 10⁻³

15:68123915

rs4776987

SKOR1

0.37

0.5

3.81 × 10⁻⁸

1.19 × 10⁻⁸

0.08

4.12 × 10⁻³

0.04

6.17 × 10⁻⁴

0.03

0.10

16:56994528

rs17231506

CETP

0.17

0.26

1.13 × 10⁻¹⁹

0.00

0.13

3.96 × 10⁻²⁰

0.54

0.31

3.76 × 10⁻¹⁶⁹

0.10

−0.08

−0.22

−0.07

18:57831468

rs633265

MC4R

0.28

0.66

1.07 × 10⁻¹⁸

0.41

0.10

0.40

0.02

0.12

								Discovery dataset	KoGES_Affy	UKB_Chi	UKB_EUR
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	1.73 × 10⁻¹⁶	0.40	0.12	0.42	0.02	0.04	0.27	0.53	5.10 × 10⁻³²	0.09
										0.10			0.13		−0.30		0.08
2:25108197	rs1865689	ADCY3	T	C	0.43	0.62	0	3.52 × 10⁻¹⁰	0.49	0.08	0.49	3.45 × 10⁻⁴	0.12	-	-	-	-
										0.07			0.15	-	-	-	-
3:52893465	rs6798941	STIMATE	C	T	0.37	0.5	0	9.60 × 10⁻¹¹	0.42	0.07	0.42	0.02	−0.02	-	-	-	-
										0.08			0.11	-	-	-	-
6:20674691	rs9368219	CDKAL1	C	T	0.47	0.02	0	3.31 × 10⁻¹¹	5.12 × 10⁻³	−0.10	4.77 × 10⁻³	0.14	−0.04	3.31 × 10⁻⁷	−0.10	0	−0.04
										−0.05			−0.08		0.49		−0.02
8:19845376	rs7841189	LPL	C	T	0.12	0.62	0	2.08 × 10⁻¹⁷	0.00	0.10	2.97 × 10⁻¹⁸	0.02	−0.10	0.15	0.64	1.86 × 10⁻⁷⁴	0.17
										−0.13			−0.17		0.45		−0.12
11:27703480	rs35038967	BDNF-AS	T	A	0.45	0.02	0	1.02 × 10⁻¹¹	0.93	−0.08	0.92	0.05	−0.09	0.96	−0.04	5.93 × 10⁻²⁷	−0.07
										−0.08			−0.08		−0.05		−0.08
11:116526322	rs486394	LINC02702	A	C	0.12	0.56	0	2.67 × 10⁻⁹	3.55 × 10⁻⁹	−0.12	3.61 × 10⁻⁹	0.02	−0.06	-	-	-	-
										0.04			0.15	-	-	-	-
11:116651463	rs1942478	ZPR1	T	G	0.22	0.64	0	9.03 × 10⁻¹⁷	0.00	0.10	1.25 × 10⁻¹⁷	2.39 × 10⁻⁴	0.16	0.22	0.31	1.08 × 10⁻¹¹³	0.06
										−0.08			−0.13		−0.36		−0.03
11:116664776	rs1787680	APOA5	T	A	0.22	0.06	0	4.85 × 10⁻¹³	6.35 × 10⁻¹⁴	0.09	6.88 × 10⁻¹⁴	0.05	0.13	-	-	-	-
										−0.07			−0.04	-	-	-	-
11:116837089	rs78044162	SIK3	C	T	0.17	0.64	0	2.25 × 10⁻¹²	1.96 × 10⁻¹²	0.11	1.92 × 10⁻¹²	0.02	0.14	1.88 × 10⁻³	−0.08	5.74 × 10⁻⁴	0.06
										−0.05			−0.08		0.41		3.29 × 10⁻³
15:68123915	rs4776987	SKOR1	A	T	0.37	0.5	0	3.81 × 10⁻⁸	1.19 × 10⁻⁸	0.08	4.12 × 10⁻³	0.04	6.17 × 10⁻⁴	-	-	-	-
										0.03			0.10	-	-	-	-
16:56994528	rs17231506	CETP	C	T	0.17	0.26	0	1.13 × 10⁻¹⁹	0.00	0.13	3.96 × 10⁻²⁰	-	-	0.54	0.31	3.76 × 10⁻¹⁶⁹	0.10
										−0.08		-	-		−0.22		−0.07
18:57831468	rs633265	MC4R	G	T	0.28	0.66	0	1.07 × 10⁻¹⁸	0.41	0.10	0.40	0.02	0.02	-	-	-	-
										0.12			0.12	-	-	-	-

Table 3

Open in new tab

Summary statistics of GWAS on discovery dataset; significant SNPs identified by GWASs on obesity

								Discovery dataset				KoGES_Affy		UKB_Chi		UKB_EUR
CHR: BP	SNP	GENE	REF	ALT	MAF	HWE	MR	LRT P	MUL P	BETA	EQ P	REP P	BETA	REP P	BETA	REP P	BETA
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	1.73 × 10⁻¹⁶	0.40	0.12	0.42	0.02	0.04	0.27	0.53	5.10 × 10⁻³²	0.09
										0.10			0.13		−0.30		0.08
2:25108197	rs1865689	ADCY3	T	C	0.43	0.62	0	3.52 × 10⁻¹⁰	0.49	0.08	0.49	3.45 × 10⁻⁴	0.12	-	-	-	-
										0.07			0.15	-	-	-	-
3:52893465	rs6798941	STIMATE	C	T	0.37	0.5	0	9.60 × 10⁻¹¹	0.42	0.07	0.42	0.02	−0.02	-	-	-	-
										0.08			0.11	-	-	-	-
6:20674691	rs9368219	CDKAL1	C	T	0.47	0.02	0	3.31 × 10⁻¹¹	5.12 × 10⁻³	−0.10	4.77 × 10⁻³	0.14	−0.04	3.31 × 10⁻⁷	−0.10	0	−0.04
										−0.05			−0.08		0.49		−0.02
8:19845376	rs7841189	LPL	C	T	0.12	0.62	0	2.08 × 10⁻¹⁷	0.00	0.10	2.97 × 10⁻¹⁸	0.02	−0.10	0.15	0.64	1.86 × 10⁻⁷⁴	0.17
										−0.13			−0.17		0.45		−0.12
11:27703480	rs35038967	BDNF-AS	T	A	0.45	0.02	0	1.02 × 10⁻¹¹	0.93	−0.08	0.92	0.05	−0.09	0.96	−0.04	5.93 × 10⁻²⁷	−0.07
										−0.08			−0.08		−0.05		−0.08
11:116526322	rs486394	LINC02702	A	C	0.12	0.56	0	2.67 × 10⁻⁹	3.55 × 10⁻⁹	−0.12	3.61 × 10⁻⁹	0.02	−0.06	-	-	-	-
										0.04			0.15	-	-	-	-
11:116651463	rs1942478	ZPR1	T	G	0.22	0.64	0	9.03 × 10⁻¹⁷	0.00	0.10	1.25 × 10⁻¹⁷	2.39 × 10⁻⁴	0.16	0.22	0.31	1.08 × 10⁻¹¹³	0.06
										−0.08			−0.13		−0.36		−0.03
11:116664776	rs1787680	APOA5	T	A	0.22	0.06	0	4.85 × 10⁻¹³	6.35 × 10⁻¹⁴	0.09	6.88 × 10⁻¹⁴	0.05	0.13	-	-	-	-
										−0.07			−0.04	-	-	-	-
11:116837089	rs78044162	SIK3	C	T	0.17	0.64	0	2.25 × 10⁻¹²	1.96 × 10⁻¹²	0.11	1.92 × 10⁻¹²	0.02	0.14	1.88 × 10⁻³	−0.08	5.74 × 10⁻⁴	0.06
										−0.05			−0.08		0.41		3.29 × 10⁻³
15:68123915	rs4776987	SKOR1	A	T	0.37	0.5	0	3.81 × 10⁻⁸	1.19 × 10⁻⁸	0.08	4.12 × 10⁻³	0.04	6.17 × 10⁻⁴	-	-	-	-
										0.03			0.10	-	-	-	-
16:56994528	rs17231506	CETP	C	T	0.17	0.26	0	1.13 × 10⁻¹⁹	0.00	0.13	3.96 × 10⁻²⁰	-	-	0.54	0.31	3.76 × 10⁻¹⁶⁹	0.10
										−0.08		-	-		−0.22		−0.07
18:57831468	rs633265	MC4R	G	T	0.28	0.66	0	1.07 × 10⁻¹⁸	0.41	0.10	0.40	0.02	0.02	-	-	-	-
										0.12			0.12	-	-	-	-

								Discovery dataset				KoGES_Affy		UKB_Chi		UKB_EUR
CHR: BP	SNP	GENE	REF	ALT	MAF	HWE	MR	LRT P	MUL P	BETA	EQ P	REP P	BETA	REP P	BETA	REP P	BETA
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	1.73 × 10⁻¹⁶	0.40	0.12	0.42	0.02	0.04	0.27	0.53	5.10 × 10⁻³²	0.09
										0.10			0.13		−0.30		0.08
2:25108197	rs1865689	ADCY3	T	C	0.43	0.62	0	3.52 × 10⁻¹⁰	0.49	0.08	0.49	3.45 × 10⁻⁴	0.12	-	-	-	-
										0.07			0.15	-	-	-	-
3:52893465	rs6798941	STIMATE	C	T	0.37	0.5	0	9.60 × 10⁻¹¹	0.42	0.07	0.42	0.02	−0.02	-	-	-	-
										0.08			0.11	-	-	-	-
6:20674691	rs9368219	CDKAL1	C	T	0.47	0.02	0	3.31 × 10⁻¹¹	5.12 × 10⁻³	−0.10	4.77 × 10⁻³	0.14	−0.04	3.31 × 10⁻⁷	−0.10	0	−0.04
										−0.05			−0.08		0.49		−0.02
8:19845376	rs7841189	LPL	C	T	0.12	0.62	0	2.08 × 10⁻¹⁷	0.00	0.10	2.97 × 10⁻¹⁸	0.02	−0.10	0.15	0.64	1.86 × 10⁻⁷⁴	0.17
										−0.13			−0.17		0.45		−0.12
11:27703480	rs35038967	BDNF-AS	T	A	0.45	0.02	0	1.02 × 10⁻¹¹	0.93	−0.08	0.92	0.05	−0.09	0.96	−0.04	5.93 × 10⁻²⁷	−0.07
										−0.08			−0.08		−0.05		−0.08
11:116526322	rs486394	LINC02702	A	C	0.12	0.56	0	2.67 × 10⁻⁹	3.55 × 10⁻⁹	−0.12	3.61 × 10⁻⁹	0.02	−0.06	-	-	-	-
										0.04			0.15	-	-	-	-
11:116651463	rs1942478	ZPR1	T	G	0.22	0.64	0	9.03 × 10⁻¹⁷	0.00	0.10	1.25 × 10⁻¹⁷	2.39 × 10⁻⁴	0.16	0.22	0.31	1.08 × 10⁻¹¹³	0.06
										−0.08			−0.13		−0.36		−0.03
11:116664776	rs1787680	APOA5	T	A	0.22	0.06	0	4.85 × 10⁻¹³	6.35 × 10⁻¹⁴	0.09	6.88 × 10⁻¹⁴	0.05	0.13	-	-	-	-
										−0.07			−0.04	-	-	-	-
11:116837089	rs78044162	SIK3	C	T	0.17	0.64	0	2.25 × 10⁻¹²	1.96 × 10⁻¹²	0.11	1.92 × 10⁻¹²	0.02	0.14	1.88 × 10⁻³	−0.08	5.74 × 10⁻⁴	0.06
										−0.05			−0.08		0.41		3.29 × 10⁻³
15:68123915	rs4776987	SKOR1	A	T	0.37	0.5	0	3.81 × 10⁻⁸	1.19 × 10⁻⁸	0.08	4.12 × 10⁻³	0.04	6.17 × 10⁻⁴	-	-	-	-
										0.03			0.10	-	-	-	-
16:56994528	rs17231506	CETP	C	T	0.17	0.26	0	1.13 × 10⁻¹⁹	0.00	0.13	3.96 × 10⁻²⁰	-	-	0.54	0.31	3.76 × 10⁻¹⁶⁹	0.10
										−0.08		-	-		−0.22		−0.07
18:57831468	rs633265	MC4R	G	T	0.28	0.66	0	1.07 × 10⁻¹⁸	0.41	0.10	0.40	0.02	0.02	-	-	-	-
										0.12			0.12	-	-	-	-

MR. SNP missing rate

For each SNPs, upper row and lower row represents the effects of MHO group and MUO group compared with the non-obese group, respectively.

MUL P. P-value from multinomial regression testing for SNP effect on MHO group and MUO group compared with the non-obese group, respectively.

EQ P. P-value from multinomial regression testing for equal SNP effect between MHO and MUO group.

REP P. P-value from replication.

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