Table 2 Open in new tab Summary... | Oxford Academic

Table 2

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Summary statistics of GWAS on discovery dataset; significant SNPs identified by GWASs on BMI and WC

CHR: BP	SNP	GENE	REF	ALT	MAF	HWE	MR	TRAIT	BETA	SE	P	KoGES_Affy	UKB_Chi	UKB_EUR
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	BMI	0.06	0.006	3.03 × 10⁻²⁸	2.18 × 10⁻⁵	0.82	2.48 × 10⁻⁷⁰
								WC	0.04	0.005	7.15 × 10⁻¹⁴	2.33 × 10⁻³	0.86	4.89 × 10⁻⁵⁰
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	BMI	−0.07	0.008	2.94 × 10⁻¹⁷	-	0.70	1.23 × 10⁻⁷⁵
2:25133148	rs6744205	ADCY3	T	C	0.45	0.75	0	BMI	0.04	0.005	5.52 × 10⁻¹⁹	5.22 × 10⁻⁴	-	-
2:54240105	rs6715161	ACYP2	C	T	0.01	0.87	0	BMI	−0.17	0.024	2.70 × 10⁻¹²	-	-	9.32 × 10⁻⁵
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	WC	−0.05	0.008	3.74 × 10⁻¹⁰	-	0.90	6.57 × 10⁻⁵⁹
3:52893465	rs6798941	TMEM110	C	T	0.37	0.5	0	BMI	0.04	0.005	5.39 × 10⁻¹⁷	5.60 × 10⁻³	-	-
4:45182527	rs10938397	GNPDA2	A	G	0.28	0.48	0	BMI	0.04	0.005	7.76 × 10⁻¹²	0.07	0.19	6.11 × 10⁻⁴¹
								WC	0.03	0.005	8.19 × 10⁻⁹	0.04	0.35	8.14 × 10⁻²⁹
5:122750847	rs6595447	CEP120	T	C	0.32	0.81	0	BMI	−0.03	0.005	1.05 × 10⁻⁹	4.78 × 10⁻³	-	-
6:20686878	rs67131976	CDKAL1	C	T	0.46	0.03	0	BMI	−0.03	0.005	1.35 × 10⁻¹¹	0.05	0.20	1.06 × 10⁻⁶
								WC	−0.02	0.005	4.95 × 10⁻⁸	0.33	0.10	1.06 × 10⁻⁴
7:138817193	rs11525873	TTC26	T	C	0.29	0.31	0	BMI	−0.03	0.005	5.40 × 10⁻⁹	-	0.51	9.05 × 10⁻⁸
10:104222963	rs12570201	MFSD13A	T	C	0.25	0.45	0	BMI	−0.03	0.005	3.85 × 10⁻⁹	0.28	0.66	5.25 × 10⁻⁴
11:8612000	rs4418812	STK33	A	G	0.41	0.14	0	BMI	0.03	0.005	1.32 × 10⁻⁸	0.97	0.47	3.32 × 10⁻⁸
11:27704209	rs34379767	BDNF-AS	G	A	0.46	0.01	0	BMI	−0.05	0.005	8.08 × 10⁻²³	2.75 × 10⁻³	0.52	4.13 × 10⁻⁴⁵
16:20037123	rs57705530	GPR139	G	A	0.39	0.33	0	BMI	0.03	0.005	4.66 × 10⁻⁸	0.02	0.28	2.44 × 10⁻⁸
16:30093779	rs2278557	PPP4C	C	G	0.32	0.6	0	BMI	0.03	0.005	2.39 × 10⁻¹¹	7.86 × 10⁻³	0.53	4.53 × 10⁻²⁵
16:30068354	rs9939774	ALDOA	C	T	0.32	0.6	0	WC	0.03	0.005	8.96 × 10⁻¹¹	0.04	0.88	2.60 × 10⁻³⁰
18:57852587	rs476828	MC4R	T	C	0.27	0.53	0	BMI	0.07	0.005	1.65 × 10⁻³⁴	0.01	0.75	5.14 × 10⁻⁸⁵

CHR: BP	SNP	GENE	REF	ALT	MAF	HWE	MR	TRAIT	BETA	SE	P	KoGES_Affy	UKB_Chi	UKB_EUR
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	BMI	0.06	0.006	3.03 × 10⁻²⁸	2.18 × 10⁻⁵	0.82	2.48 × 10⁻⁷⁰
								WC	0.04	0.005	7.15 × 10⁻¹⁴	2.33 × 10⁻³	0.86	4.89 × 10⁻⁵⁰
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	BMI	−0.07	0.008	2.94 × 10⁻¹⁷	-	0.70	1.23 × 10⁻⁷⁵
2:25133148	rs6744205	ADCY3	T	C	0.45	0.75	0	BMI	0.04	0.005	5.52 × 10⁻¹⁹	5.22 × 10⁻⁴	-	-
2:54240105	rs6715161	ACYP2	C	T	0.01	0.87	0	BMI	−0.17	0.024	2.70 × 10⁻¹²	-	-	9.32 × 10⁻⁵
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	WC	−0.05	0.008	3.74 × 10⁻¹⁰	-	0.90	6.57 × 10⁻⁵⁹
3:52893465	rs6798941	TMEM110	C	T	0.37	0.5	0	BMI	0.04	0.005	5.39 × 10⁻¹⁷	5.60 × 10⁻³	-	-
4:45182527	rs10938397	GNPDA2	A	G	0.28	0.48	0	BMI	0.04	0.005	7.76 × 10⁻¹²	0.07	0.19	6.11 × 10⁻⁴¹
								WC	0.03	0.005	8.19 × 10⁻⁹	0.04	0.35	8.14 × 10⁻²⁹
5:122750847	rs6595447	CEP120	T	C	0.32	0.81	0	BMI	−0.03	0.005	1.05 × 10⁻⁹	4.78 × 10⁻³	-	-
6:20686878	rs67131976	CDKAL1	C	T	0.46	0.03	0	BMI	−0.03	0.005	1.35 × 10⁻¹¹	0.05	0.20	1.06 × 10⁻⁶
								WC	−0.02	0.005	4.95 × 10⁻⁸	0.33	0.10	1.06 × 10⁻⁴
7:138817193	rs11525873	TTC26	T	C	0.29	0.31	0	BMI	−0.03	0.005	5.40 × 10⁻⁹	-	0.51	9.05 × 10⁻⁸
10:104222963	rs12570201	MFSD13A	T	C	0.25	0.45	0	BMI	−0.03	0.005	3.85 × 10⁻⁹	0.28	0.66	5.25 × 10⁻⁴
11:8612000	rs4418812	STK33	A	G	0.41	0.14	0	BMI	0.03	0.005	1.32 × 10⁻⁸	0.97	0.47	3.32 × 10⁻⁸
11:27704209	rs34379767	BDNF-AS	G	A	0.46	0.01	0	BMI	−0.05	0.005	8.08 × 10⁻²³	2.75 × 10⁻³	0.52	4.13 × 10⁻⁴⁵
16:20037123	rs57705530	GPR139	G	A	0.39	0.33	0	BMI	0.03	0.005	4.66 × 10⁻⁸	0.02	0.28	2.44 × 10⁻⁸
16:30093779	rs2278557	PPP4C	C	G	0.32	0.6	0	BMI	0.03	0.005	2.39 × 10⁻¹¹	7.86 × 10⁻³	0.53	4.53 × 10⁻²⁵
16:30068354	rs9939774	ALDOA	C	T	0.32	0.6	0	WC	0.03	0.005	8.96 × 10⁻¹¹	0.04	0.88	2.60 × 10⁻³⁰
18:57852587	rs476828	MC4R	T	C	0.27	0.53	0	BMI	0.07	0.005	1.65 × 10⁻³⁴	0.01	0.75	5.14 × 10⁻⁸⁵

MR. SNP missing rate

KoGES_Affy, UKB_Chi, and UKB_EUR. Replication P-value on replication dataset.

Table 2

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Summary statistics of GWAS on discovery dataset; significant SNPs identified by GWASs on BMI and WC

CHR: BP	SNP	GENE	REF	ALT	MAF	HWE	MR	TRAIT	BETA	SE	P	KoGES_Affy	UKB_Chi	UKB_EUR
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	BMI	0.06	0.006	3.03 × 10⁻²⁸	2.18 × 10⁻⁵	0.82	2.48 × 10⁻⁷⁰
								WC	0.04	0.005	7.15 × 10⁻¹⁴	2.33 × 10⁻³	0.86	4.89 × 10⁻⁵⁰
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	BMI	−0.07	0.008	2.94 × 10⁻¹⁷	-	0.70	1.23 × 10⁻⁷⁵
2:25133148	rs6744205	ADCY3	T	C	0.45	0.75	0	BMI	0.04	0.005	5.52 × 10⁻¹⁹	5.22 × 10⁻⁴	-	-
2:54240105	rs6715161	ACYP2	C	T	0.01	0.87	0	BMI	−0.17	0.024	2.70 × 10⁻¹²	-	-	9.32 × 10⁻⁵
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	WC	−0.05	0.008	3.74 × 10⁻¹⁰	-	0.90	6.57 × 10⁻⁵⁹
3:52893465	rs6798941	TMEM110	C	T	0.37	0.5	0	BMI	0.04	0.005	5.39 × 10⁻¹⁷	5.60 × 10⁻³	-	-
4:45182527	rs10938397	GNPDA2	A	G	0.28	0.48	0	BMI	0.04	0.005	7.76 × 10⁻¹²	0.07	0.19	6.11 × 10⁻⁴¹
								WC	0.03	0.005	8.19 × 10⁻⁹	0.04	0.35	8.14 × 10⁻²⁹
5:122750847	rs6595447	CEP120	T	C	0.32	0.81	0	BMI	−0.03	0.005	1.05 × 10⁻⁹	4.78 × 10⁻³	-	-
6:20686878	rs67131976	CDKAL1	C	T	0.46	0.03	0	BMI	−0.03	0.005	1.35 × 10⁻¹¹	0.05	0.20	1.06 × 10⁻⁶
								WC	−0.02	0.005	4.95 × 10⁻⁸	0.33	0.10	1.06 × 10⁻⁴
7:138817193	rs11525873	TTC26	T	C	0.29	0.31	0	BMI	−0.03	0.005	5.40 × 10⁻⁹	-	0.51	9.05 × 10⁻⁸
10:104222963	rs12570201	MFSD13A	T	C	0.25	0.45	0	BMI	−0.03	0.005	3.85 × 10⁻⁹	0.28	0.66	5.25 × 10⁻⁴
11:8612000	rs4418812	STK33	A	G	0.41	0.14	0	BMI	0.03	0.005	1.32 × 10⁻⁸	0.97	0.47	3.32 × 10⁻⁸
11:27704209	rs34379767	BDNF-AS	G	A	0.46	0.01	0	BMI	−0.05	0.005	8.08 × 10⁻²³	2.75 × 10⁻³	0.52	4.13 × 10⁻⁴⁵
16:20037123	rs57705530	GPR139	G	A	0.39	0.33	0	BMI	0.03	0.005	4.66 × 10⁻⁸	0.02	0.28	2.44 × 10⁻⁸
16:30093779	rs2278557	PPP4C	C	G	0.32	0.6	0	BMI	0.03	0.005	2.39 × 10⁻¹¹	7.86 × 10⁻³	0.53	4.53 × 10⁻²⁵
16:30068354	rs9939774	ALDOA	C	T	0.32	0.6	0	WC	0.03	0.005	8.96 × 10⁻¹¹	0.04	0.88	2.60 × 10⁻³⁰
18:57852587	rs476828	MC4R	T	C	0.27	0.53	0	BMI	0.07	0.005	1.65 × 10⁻³⁴	0.01	0.75	5.14 × 10⁻⁸⁵

CHR: BP	SNP	GENE	REF	ALT	MAF	HWE	MR	TRAIT	BETA	SE	P	KoGES_Affy	UKB_Chi	UKB_EUR
1:177873210	rs574367	SEC16B	G	T	0.25	0.74	0	BMI	0.06	0.006	3.03 × 10⁻²⁸	2.18 × 10⁻⁵	0.82	2.48 × 10⁻⁷⁰
								WC	0.04	0.005	7.15 × 10⁻¹⁴	2.33 × 10⁻³	0.86	4.89 × 10⁻⁵⁰
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	BMI	−0.07	0.008	2.94 × 10⁻¹⁷	-	0.70	1.23 × 10⁻⁷⁵
2:25133148	rs6744205	ADCY3	T	C	0.45	0.75	0	BMI	0.04	0.005	5.52 × 10⁻¹⁹	5.22 × 10⁻⁴	-	-
2:54240105	rs6715161	ACYP2	C	T	0.01	0.87	0	BMI	−0.17	0.024	2.70 × 10⁻¹²	-	-	9.32 × 10⁻⁵
2:632101	rs11127486	TMEM18	T	C	0.09	0.82	0	WC	−0.05	0.008	3.74 × 10⁻¹⁰	-	0.90	6.57 × 10⁻⁵⁹
3:52893465	rs6798941	TMEM110	C	T	0.37	0.5	0	BMI	0.04	0.005	5.39 × 10⁻¹⁷	5.60 × 10⁻³	-	-
4:45182527	rs10938397	GNPDA2	A	G	0.28	0.48	0	BMI	0.04	0.005	7.76 × 10⁻¹²	0.07	0.19	6.11 × 10⁻⁴¹
								WC	0.03	0.005	8.19 × 10⁻⁹	0.04	0.35	8.14 × 10⁻²⁹
5:122750847	rs6595447	CEP120	T	C	0.32	0.81	0	BMI	−0.03	0.005	1.05 × 10⁻⁹	4.78 × 10⁻³	-	-
6:20686878	rs67131976	CDKAL1	C	T	0.46	0.03	0	BMI	−0.03	0.005	1.35 × 10⁻¹¹	0.05	0.20	1.06 × 10⁻⁶
								WC	−0.02	0.005	4.95 × 10⁻⁸	0.33	0.10	1.06 × 10⁻⁴
7:138817193	rs11525873	TTC26	T	C	0.29	0.31	0	BMI	−0.03	0.005	5.40 × 10⁻⁹	-	0.51	9.05 × 10⁻⁸
10:104222963	rs12570201	MFSD13A	T	C	0.25	0.45	0	BMI	−0.03	0.005	3.85 × 10⁻⁹	0.28	0.66	5.25 × 10⁻⁴
11:8612000	rs4418812	STK33	A	G	0.41	0.14	0	BMI	0.03	0.005	1.32 × 10⁻⁸	0.97	0.47	3.32 × 10⁻⁸
11:27704209	rs34379767	BDNF-AS	G	A	0.46	0.01	0	BMI	−0.05	0.005	8.08 × 10⁻²³	2.75 × 10⁻³	0.52	4.13 × 10⁻⁴⁵
16:20037123	rs57705530	GPR139	G	A	0.39	0.33	0	BMI	0.03	0.005	4.66 × 10⁻⁸	0.02	0.28	2.44 × 10⁻⁸
16:30093779	rs2278557	PPP4C	C	G	0.32	0.6	0	BMI	0.03	0.005	2.39 × 10⁻¹¹	7.86 × 10⁻³	0.53	4.53 × 10⁻²⁵
16:30068354	rs9939774	ALDOA	C	T	0.32	0.6	0	WC	0.03	0.005	8.96 × 10⁻¹¹	0.04	0.88	2.60 × 10⁻³⁰
18:57852587	rs476828	MC4R	T	C	0.27	0.53	0	BMI	0.07	0.005	1.65 × 10⁻³⁴	0.01	0.75	5.14 × 10⁻⁸⁵

MR. SNP missing rate

KoGES_Affy, UKB_Chi, and UKB_EUR. Replication P-value on replication dataset.