Univariable and Multivariable Random Intercepts Negative Binomial Regression of the Association Between Setting-Level Characteristics and All FEP, Non-affective Psychotic Disorders, and Affective Psychotic Disorders Incidence
| Setting-Level Variablea . | All FEP . | Non-affective Psychotic Disorders . | Affective Psychotic Disorders . | |||
|---|---|---|---|---|---|---|
| Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | |
| % owner-occupancy | 0.65 (0.56–0.75) | 0.76 (0.61–0.95) | 0.63 (0.55–0.72) | 0.68 (0.55–0.83) | 0.65 (0.43–0.99) | 1.07 (0.70–1.64) |
| % daily cannabis (controls)b | 1.34 (1.04–1.73) | 1.19 (0.96–1.48) | 1.38 (1.07–1.78) | 1.06 (0.86–1.30) | 1.18 (0.72–1.92) | 1.53 (1.02–2.31) |
| % high-potency cannabis (controls)b | 1.50 (1.23–1.82) | 1.03 (0.82–1.29) | 1.56 (1.31–1.87) | 1.12 (0.91–1.38) | 1.39 (0.88–2.20) | 0.82 (0.54–1.26) |
| % unemployment | 0.73 (0.58–0.92) | 0.94 (0.77–1.14) | 0.79 (0.60–1.03) | 1.11 (0.92–1.33) | 0.48 (0.35–0.65) | 0.48 (0.32–0.72) |
| Population density (people per km2) | 1.04 (0.78–1.38) | 0.92 (0.77–1.11) | 1.12 (0.84–1.49) | 0.97 (0.82–1.16) | 0.78 (0.49–1.24) | 0.80 (0.53–1.20) |
| Setting-Level Variablea . | All FEP . | Non-affective Psychotic Disorders . | Affective Psychotic Disorders . | |||
|---|---|---|---|---|---|---|
| Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | |
| % owner-occupancy | 0.65 (0.56–0.75) | 0.76 (0.61–0.95) | 0.63 (0.55–0.72) | 0.68 (0.55–0.83) | 0.65 (0.43–0.99) | 1.07 (0.70–1.64) |
| % daily cannabis (controls)b | 1.34 (1.04–1.73) | 1.19 (0.96–1.48) | 1.38 (1.07–1.78) | 1.06 (0.86–1.30) | 1.18 (0.72–1.92) | 1.53 (1.02–2.31) |
| % high-potency cannabis (controls)b | 1.50 (1.23–1.82) | 1.03 (0.82–1.29) | 1.56 (1.31–1.87) | 1.12 (0.91–1.38) | 1.39 (0.88–2.20) | 0.82 (0.54–1.26) |
| % unemployment | 0.73 (0.58–0.92) | 0.94 (0.77–1.14) | 0.79 (0.60–1.03) | 1.11 (0.92–1.33) | 0.48 (0.35–0.65) | 0.48 (0.32–0.72) |
| Population density (people per km2) | 1.04 (0.78–1.38) | 0.92 (0.77–1.11) | 1.12 (0.84–1.49) | 0.97 (0.82–1.16) | 0.78 (0.49–1.24) | 0.80 (0.53–1.20) |
Note: FEP, first-episode psychosis; IRR, incidence rate ratio.
Bold: P < .05 statistically significant.
aZ-standardized; IRR associated with 1 SD changes.
bSetting-level proportion of daily- or high-potency cannabis use reported by controls with multiple imputation and poststratification weights applied (see supplements 2 and 3 for methods).
cAdjusted for age, sex, age-sex interaction, migrant/ethnic group, and all other variables in the table.
Univariable and Multivariable Random Intercepts Negative Binomial Regression of the Association Between Setting-Level Characteristics and All FEP, Non-affective Psychotic Disorders, and Affective Psychotic Disorders Incidence
| Setting-Level Variablea . | All FEP . | Non-affective Psychotic Disorders . | Affective Psychotic Disorders . | |||
|---|---|---|---|---|---|---|
| Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | |
| % owner-occupancy | 0.65 (0.56–0.75) | 0.76 (0.61–0.95) | 0.63 (0.55–0.72) | 0.68 (0.55–0.83) | 0.65 (0.43–0.99) | 1.07 (0.70–1.64) |
| % daily cannabis (controls)b | 1.34 (1.04–1.73) | 1.19 (0.96–1.48) | 1.38 (1.07–1.78) | 1.06 (0.86–1.30) | 1.18 (0.72–1.92) | 1.53 (1.02–2.31) |
| % high-potency cannabis (controls)b | 1.50 (1.23–1.82) | 1.03 (0.82–1.29) | 1.56 (1.31–1.87) | 1.12 (0.91–1.38) | 1.39 (0.88–2.20) | 0.82 (0.54–1.26) |
| % unemployment | 0.73 (0.58–0.92) | 0.94 (0.77–1.14) | 0.79 (0.60–1.03) | 1.11 (0.92–1.33) | 0.48 (0.35–0.65) | 0.48 (0.32–0.72) |
| Population density (people per km2) | 1.04 (0.78–1.38) | 0.92 (0.77–1.11) | 1.12 (0.84–1.49) | 0.97 (0.82–1.16) | 0.78 (0.49–1.24) | 0.80 (0.53–1.20) |
| Setting-Level Variablea . | All FEP . | Non-affective Psychotic Disorders . | Affective Psychotic Disorders . | |||
|---|---|---|---|---|---|---|
| Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | Univariable IRR (95% CI) . | Multivariable IRR (95% CI)c . | |
| % owner-occupancy | 0.65 (0.56–0.75) | 0.76 (0.61–0.95) | 0.63 (0.55–0.72) | 0.68 (0.55–0.83) | 0.65 (0.43–0.99) | 1.07 (0.70–1.64) |
| % daily cannabis (controls)b | 1.34 (1.04–1.73) | 1.19 (0.96–1.48) | 1.38 (1.07–1.78) | 1.06 (0.86–1.30) | 1.18 (0.72–1.92) | 1.53 (1.02–2.31) |
| % high-potency cannabis (controls)b | 1.50 (1.23–1.82) | 1.03 (0.82–1.29) | 1.56 (1.31–1.87) | 1.12 (0.91–1.38) | 1.39 (0.88–2.20) | 0.82 (0.54–1.26) |
| % unemployment | 0.73 (0.58–0.92) | 0.94 (0.77–1.14) | 0.79 (0.60–1.03) | 1.11 (0.92–1.33) | 0.48 (0.35–0.65) | 0.48 (0.32–0.72) |
| Population density (people per km2) | 1.04 (0.78–1.38) | 0.92 (0.77–1.11) | 1.12 (0.84–1.49) | 0.97 (0.82–1.16) | 0.78 (0.49–1.24) | 0.80 (0.53–1.20) |
Note: FEP, first-episode psychosis; IRR, incidence rate ratio.
Bold: P < .05 statistically significant.
aZ-standardized; IRR associated with 1 SD changes.
bSetting-level proportion of daily- or high-potency cannabis use reported by controls with multiple imputation and poststratification weights applied (see supplements 2 and 3 for methods).
cAdjusted for age, sex, age-sex interaction, migrant/ethnic group, and all other variables in the table.
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