Clusters with significant relationships between metabolites and clinical outcomes
| . | Hem. . | Region . | MNI coordinates (peak signal) . | Cluster size (mm3) . | ||
|---|---|---|---|---|---|---|
| tCho | ||||||
| tCho × attention/WM | ||||||
| Cluster 1 (+) | bil | Frontal pole, sup. frontal gyrus and paracingulate gyrus | +2 | +34 | +42 | 1681 |
| tCho × language | ||||||
| Cluster 1 (+) | R | Postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital gyrus, intracalcarine cortex and occipital fusiform gyrus | +58 | −16 | +40 | 4488 |
| Cluster 2 (+) | L | Precentral gyrus, post. sup. temporal gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus and angular gyrus | −50 | −10 | +50 | 2820 |
| Cluster 3 (+) | R | Frontal pole, middle frontal gyrus, paracingulate gyrus, ant. corona radiata, ant. thalamic radiation and forceps minor | +16 | +40 | +24 | 2145 |
| Cluster 4 (+) | L | Frontal pole, middle frontal gyrus, inf. frontal gyrus (pars triangularis), genu of corpus callosum, ant. corona radiata, ant. thalamic radiation, forceps minor and inf. fronto-occipital fasc | −26 | +32 | +38 | 1775 |
| tCho × Proc. Speed | ||||||
| Cluster 1 (−) | R | Sup. frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +18 | −10 | +72 | 1717 |
| tCho × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +12 | +2 | +56 | 2859 |
| mIns | ||||||
| mIns × Language | ||||||
| Cluster 1 (+) | R | Precentral gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital cortex, inf. lateral occipital cortex and sup. longitudinal fasc. | +64 | −22 | +40 | 4682 |
| Cluster 2 (+) | L | Middle frontal gyrus, precentral gyrus, postcentral gyrus and CST | −62 | −22 | +48 | 1544 |
| mIns × Proc. Speed | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus and juxtapositional lobule (SMA) | +24 | −16 | +76 | 5017 |
| mIns × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +26 | −4 | +62 | 8625 |
| NAA | ||||||
| NAA × V/s function | ||||||
| Cluster 1 (+) | L | Post. sup. temporal gyrus, post. middle temporal gyrus, temporo-occipital middle temporal gyrus, temporo-occipital inf. temporal gyrus, temporal occipital fusiform cortex, post. thalamic radiation, sagittal stratum, inf. fronto-occipital fasc. and inf. longitudinal fasc. | −44 | −14 | −16 | 1829 |
| . | Hem. . | Region . | MNI coordinates (peak signal) . | Cluster size (mm3) . | ||
|---|---|---|---|---|---|---|
| tCho | ||||||
| tCho × attention/WM | ||||||
| Cluster 1 (+) | bil | Frontal pole, sup. frontal gyrus and paracingulate gyrus | +2 | +34 | +42 | 1681 |
| tCho × language | ||||||
| Cluster 1 (+) | R | Postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital gyrus, intracalcarine cortex and occipital fusiform gyrus | +58 | −16 | +40 | 4488 |
| Cluster 2 (+) | L | Precentral gyrus, post. sup. temporal gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus and angular gyrus | −50 | −10 | +50 | 2820 |
| Cluster 3 (+) | R | Frontal pole, middle frontal gyrus, paracingulate gyrus, ant. corona radiata, ant. thalamic radiation and forceps minor | +16 | +40 | +24 | 2145 |
| Cluster 4 (+) | L | Frontal pole, middle frontal gyrus, inf. frontal gyrus (pars triangularis), genu of corpus callosum, ant. corona radiata, ant. thalamic radiation, forceps minor and inf. fronto-occipital fasc | −26 | +32 | +38 | 1775 |
| tCho × Proc. Speed | ||||||
| Cluster 1 (−) | R | Sup. frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +18 | −10 | +72 | 1717 |
| tCho × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +12 | +2 | +56 | 2859 |
| mIns | ||||||
| mIns × Language | ||||||
| Cluster 1 (+) | R | Precentral gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital cortex, inf. lateral occipital cortex and sup. longitudinal fasc. | +64 | −22 | +40 | 4682 |
| Cluster 2 (+) | L | Middle frontal gyrus, precentral gyrus, postcentral gyrus and CST | −62 | −22 | +48 | 1544 |
| mIns × Proc. Speed | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus and juxtapositional lobule (SMA) | +24 | −16 | +76 | 5017 |
| mIns × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +26 | −4 | +62 | 8625 |
| NAA | ||||||
| NAA × V/s function | ||||||
| Cluster 1 (+) | L | Post. sup. temporal gyrus, post. middle temporal gyrus, temporo-occipital middle temporal gyrus, temporo-occipital inf. temporal gyrus, temporal occipital fusiform cortex, post. thalamic radiation, sagittal stratum, inf. fronto-occipital fasc. and inf. longitudinal fasc. | −44 | −14 | −16 | 1829 |
Only regions with at least 3% cluster overlap are reported. (+) positive association, (−) negative association.
ant., anterior; bil, bilateral; CST, corticospinal tract; fasc., fasciculus; Hem., hemisphere; L, left; post., posterior; Proc. speed, processing speed; R, right; SE, sleep efficiency; SMA, supplementary motor area; sup., superior; V/s, visuospatial; WM, working memory.
Clusters with significant relationships between metabolites and clinical outcomes
| . | Hem. . | Region . | MNI coordinates (peak signal) . | Cluster size (mm3) . | ||
|---|---|---|---|---|---|---|
| tCho | ||||||
| tCho × attention/WM | ||||||
| Cluster 1 (+) | bil | Frontal pole, sup. frontal gyrus and paracingulate gyrus | +2 | +34 | +42 | 1681 |
| tCho × language | ||||||
| Cluster 1 (+) | R | Postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital gyrus, intracalcarine cortex and occipital fusiform gyrus | +58 | −16 | +40 | 4488 |
| Cluster 2 (+) | L | Precentral gyrus, post. sup. temporal gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus and angular gyrus | −50 | −10 | +50 | 2820 |
| Cluster 3 (+) | R | Frontal pole, middle frontal gyrus, paracingulate gyrus, ant. corona radiata, ant. thalamic radiation and forceps minor | +16 | +40 | +24 | 2145 |
| Cluster 4 (+) | L | Frontal pole, middle frontal gyrus, inf. frontal gyrus (pars triangularis), genu of corpus callosum, ant. corona radiata, ant. thalamic radiation, forceps minor and inf. fronto-occipital fasc | −26 | +32 | +38 | 1775 |
| tCho × Proc. Speed | ||||||
| Cluster 1 (−) | R | Sup. frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +18 | −10 | +72 | 1717 |
| tCho × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +12 | +2 | +56 | 2859 |
| mIns | ||||||
| mIns × Language | ||||||
| Cluster 1 (+) | R | Precentral gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital cortex, inf. lateral occipital cortex and sup. longitudinal fasc. | +64 | −22 | +40 | 4682 |
| Cluster 2 (+) | L | Middle frontal gyrus, precentral gyrus, postcentral gyrus and CST | −62 | −22 | +48 | 1544 |
| mIns × Proc. Speed | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus and juxtapositional lobule (SMA) | +24 | −16 | +76 | 5017 |
| mIns × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +26 | −4 | +62 | 8625 |
| NAA | ||||||
| NAA × V/s function | ||||||
| Cluster 1 (+) | L | Post. sup. temporal gyrus, post. middle temporal gyrus, temporo-occipital middle temporal gyrus, temporo-occipital inf. temporal gyrus, temporal occipital fusiform cortex, post. thalamic radiation, sagittal stratum, inf. fronto-occipital fasc. and inf. longitudinal fasc. | −44 | −14 | −16 | 1829 |
| . | Hem. . | Region . | MNI coordinates (peak signal) . | Cluster size (mm3) . | ||
|---|---|---|---|---|---|---|
| tCho | ||||||
| tCho × attention/WM | ||||||
| Cluster 1 (+) | bil | Frontal pole, sup. frontal gyrus and paracingulate gyrus | +2 | +34 | +42 | 1681 |
| tCho × language | ||||||
| Cluster 1 (+) | R | Postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital gyrus, intracalcarine cortex and occipital fusiform gyrus | +58 | −16 | +40 | 4488 |
| Cluster 2 (+) | L | Precentral gyrus, post. sup. temporal gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus and angular gyrus | −50 | −10 | +50 | 2820 |
| Cluster 3 (+) | R | Frontal pole, middle frontal gyrus, paracingulate gyrus, ant. corona radiata, ant. thalamic radiation and forceps minor | +16 | +40 | +24 | 2145 |
| Cluster 4 (+) | L | Frontal pole, middle frontal gyrus, inf. frontal gyrus (pars triangularis), genu of corpus callosum, ant. corona radiata, ant. thalamic radiation, forceps minor and inf. fronto-occipital fasc | −26 | +32 | +38 | 1775 |
| tCho × Proc. Speed | ||||||
| Cluster 1 (−) | R | Sup. frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +18 | −10 | +72 | 1717 |
| tCho × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +12 | +2 | +56 | 2859 |
| mIns | ||||||
| mIns × Language | ||||||
| Cluster 1 (+) | R | Precentral gyrus, postcentral gyrus, ant. supramarginal gyrus, post. supramarginal gyrus, angular gyrus, sup. lateral occipital cortex, inf. lateral occipital cortex and sup. longitudinal fasc. | +64 | −22 | +40 | 4682 |
| Cluster 2 (+) | L | Middle frontal gyrus, precentral gyrus, postcentral gyrus and CST | −62 | −22 | +48 | 1544 |
| mIns × Proc. Speed | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus and juxtapositional lobule (SMA) | +24 | −16 | +76 | 5017 |
| mIns × SE | ||||||
| Cluster 1 (−) | bil | Sup. frontal gyrus, middle frontal gyrus, precentral gyrus and juxtapositional lobule (SMA) | +26 | −4 | +62 | 8625 |
| NAA | ||||||
| NAA × V/s function | ||||||
| Cluster 1 (+) | L | Post. sup. temporal gyrus, post. middle temporal gyrus, temporo-occipital middle temporal gyrus, temporo-occipital inf. temporal gyrus, temporal occipital fusiform cortex, post. thalamic radiation, sagittal stratum, inf. fronto-occipital fasc. and inf. longitudinal fasc. | −44 | −14 | −16 | 1829 |
Only regions with at least 3% cluster overlap are reported. (+) positive association, (−) negative association.
ant., anterior; bil, bilateral; CST, corticospinal tract; fasc., fasciculus; Hem., hemisphere; L, left; post., posterior; Proc. speed, processing speed; R, right; SE, sleep efficiency; SMA, supplementary motor area; sup., superior; V/s, visuospatial; WM, working memory.
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