Correlation coefficients (and associated P-values) for associations between brain temperature and metabolites in ROIs and cognitive function and sleep outcomes
| . | . | Brain temperature . | tCho/tCr . | mIns/tCr . | NAA/tCr . |
|---|---|---|---|---|---|
| HVLT-based memory score | |||||
| L hippocampus | 0.350 (0.110) | −0.248 (0.265) | −0.400a (0.065) | −0.337 (0.125) | |
| R hippocampus | 0.063 (0.782) | −0.187 (0.405) | −0.409 (0.059) | −0.440 (0.040) | |
| Executive functioning domain | |||||
| L dlPFC | 0.288 (0.139) | 0.274a (0.217) | −0.081 (0.721) | 0.233a (0.296) | |
| R dlPFC | 0.184 (0.411) | −0.074a (0.744) | −0.123a (0.587) | −0.092 (0.685) | |
| Memory domain | |||||
| L hippocampus | 0.029 (0.899) | 0.051 (0.822) | −0.018a (0.938) | −0.459 (0.032) | |
| R hippocampus | −0.039 (0.862) | 0.007 (0.975) | −0.163 (0.470) | −0.311 (0.159) | |
| Processing speed domain | |||||
| L dlPFC | −0.004 (0.986) | −0.219a (0.327) | −0.076 (0.736) | −0.120a (0.595) | |
| R dlPFC | 0.130 (0.565) | −0.302a (0.172) | −0.236a (0.291) | −0.101 (0.655) | |
| SE | |||||
| L dlPFC | −0.042 (0.856) | 0.044a (0.849) | −0.098 (0.673) | −0.110a (0.634) | |
| R dlPFC | −0.206 (0.370) | −0.287a (0.207) | 0.068a (0.771) | −0.228 (0.321) | |
| L hippocampus | −0.012 (0.958) | −0.241 (0.292) | −0.271a (0.234) | −0.198 (0.390) | |
| R hippocampus | 0.056 (0.810) | −0.259 (0.257) | 0.040 (0.863) | −0.046 (0.844) | |
| L thalamus | −0.107 (0.644) | −0.401 (0.072) | −0.211 (0.359) | −0.233 (0.310) | |
| R thalamus | −0.038 (0.870) | −0.298 (0.190) | −0.249 (0.277) | −0.135 (0.559) | |
| N3 time | |||||
| L dlPFC | 0.178 (0.440) | 0.021a (0.929) | −0.126 (0.586) | −0.121a (0.602) | |
| R dlPFC | 0.152 (0.510) | 0.031a (0.893) | 0.006a (0.978) | −0.151 (0.514) | |
| L hippocampus | 0.151 (0.515) | −0.194 (0.400) | −0.017a (0.942) | −0.221 (0.335) | |
| R hippocampus | 0.445 (0.043) | 0.145 (0.530) | 0.229 (0.318) | −0.129 (0.577) | |
| L thalamus | 0.079 (0.732) | −0.320 (0.158) | 0.238 (0.298) | −0.008 (0.972) | |
| R thalamus | 0.143 (0.537) | −0.327 (0.148) | 0.222 (0.334) | −0.043 (0.852) | |
| N3% | |||||
| L dlPFC | 0.184 (0.424) | 0.100a (0.666) | −0.055 (0.813) | 0.058a (0.801) | |
| R dlPFC | 0.233 (0.310) | 0.127a (0.582) | 0.082a (0.724) | −0.065 (0.781) | |
| L hippocampus | 0.164 (0.477) | −0.139 (0.549) | 0.169a (0.464) | −0.199 (0.388) | |
| R hippocampus | 0.488 (0.025) | 0.252 (0.271) | 0.288 (0.205) | −0.102 (0.660) | |
| L thalamus | 0.106 (0.647) | −0.263 (0.249) | 0.358 (0.111) | 0.047 (0.840) | |
| R thalamus | 0.163 (0.480) | −0.291 (0.201) | 0.354 (0.115) | −0.007 (0.975) | |
| . | . | Brain temperature . | tCho/tCr . | mIns/tCr . | NAA/tCr . |
|---|---|---|---|---|---|
| HVLT-based memory score | |||||
| L hippocampus | 0.350 (0.110) | −0.248 (0.265) | −0.400a (0.065) | −0.337 (0.125) | |
| R hippocampus | 0.063 (0.782) | −0.187 (0.405) | −0.409 (0.059) | −0.440 (0.040) | |
| Executive functioning domain | |||||
| L dlPFC | 0.288 (0.139) | 0.274a (0.217) | −0.081 (0.721) | 0.233a (0.296) | |
| R dlPFC | 0.184 (0.411) | −0.074a (0.744) | −0.123a (0.587) | −0.092 (0.685) | |
| Memory domain | |||||
| L hippocampus | 0.029 (0.899) | 0.051 (0.822) | −0.018a (0.938) | −0.459 (0.032) | |
| R hippocampus | −0.039 (0.862) | 0.007 (0.975) | −0.163 (0.470) | −0.311 (0.159) | |
| Processing speed domain | |||||
| L dlPFC | −0.004 (0.986) | −0.219a (0.327) | −0.076 (0.736) | −0.120a (0.595) | |
| R dlPFC | 0.130 (0.565) | −0.302a (0.172) | −0.236a (0.291) | −0.101 (0.655) | |
| SE | |||||
| L dlPFC | −0.042 (0.856) | 0.044a (0.849) | −0.098 (0.673) | −0.110a (0.634) | |
| R dlPFC | −0.206 (0.370) | −0.287a (0.207) | 0.068a (0.771) | −0.228 (0.321) | |
| L hippocampus | −0.012 (0.958) | −0.241 (0.292) | −0.271a (0.234) | −0.198 (0.390) | |
| R hippocampus | 0.056 (0.810) | −0.259 (0.257) | 0.040 (0.863) | −0.046 (0.844) | |
| L thalamus | −0.107 (0.644) | −0.401 (0.072) | −0.211 (0.359) | −0.233 (0.310) | |
| R thalamus | −0.038 (0.870) | −0.298 (0.190) | −0.249 (0.277) | −0.135 (0.559) | |
| N3 time | |||||
| L dlPFC | 0.178 (0.440) | 0.021a (0.929) | −0.126 (0.586) | −0.121a (0.602) | |
| R dlPFC | 0.152 (0.510) | 0.031a (0.893) | 0.006a (0.978) | −0.151 (0.514) | |
| L hippocampus | 0.151 (0.515) | −0.194 (0.400) | −0.017a (0.942) | −0.221 (0.335) | |
| R hippocampus | 0.445 (0.043) | 0.145 (0.530) | 0.229 (0.318) | −0.129 (0.577) | |
| L thalamus | 0.079 (0.732) | −0.320 (0.158) | 0.238 (0.298) | −0.008 (0.972) | |
| R thalamus | 0.143 (0.537) | −0.327 (0.148) | 0.222 (0.334) | −0.043 (0.852) | |
| N3% | |||||
| L dlPFC | 0.184 (0.424) | 0.100a (0.666) | −0.055 (0.813) | 0.058a (0.801) | |
| R dlPFC | 0.233 (0.310) | 0.127a (0.582) | 0.082a (0.724) | −0.065 (0.781) | |
| L hippocampus | 0.164 (0.477) | −0.139 (0.549) | 0.169a (0.464) | −0.199 (0.388) | |
| R hippocampus | 0.488 (0.025) | 0.252 (0.271) | 0.288 (0.205) | −0.102 (0.660) | |
| L thalamus | 0.106 (0.647) | −0.263 (0.249) | 0.358 (0.111) | 0.047 (0.840) | |
| R thalamus | 0.163 (0.480) | −0.291 (0.201) | 0.354 (0.115) | −0.007 (0.975) | |
aSpearman’s ρ for non-normally distributed data. Correlation coefficients are Pearson’s r unless otherwise indicated. Domain scores are Z-scores.
L, left; R, right.
Correlation coefficients (and associated P-values) for associations between brain temperature and metabolites in ROIs and cognitive function and sleep outcomes
| . | . | Brain temperature . | tCho/tCr . | mIns/tCr . | NAA/tCr . |
|---|---|---|---|---|---|
| HVLT-based memory score | |||||
| L hippocampus | 0.350 (0.110) | −0.248 (0.265) | −0.400a (0.065) | −0.337 (0.125) | |
| R hippocampus | 0.063 (0.782) | −0.187 (0.405) | −0.409 (0.059) | −0.440 (0.040) | |
| Executive functioning domain | |||||
| L dlPFC | 0.288 (0.139) | 0.274a (0.217) | −0.081 (0.721) | 0.233a (0.296) | |
| R dlPFC | 0.184 (0.411) | −0.074a (0.744) | −0.123a (0.587) | −0.092 (0.685) | |
| Memory domain | |||||
| L hippocampus | 0.029 (0.899) | 0.051 (0.822) | −0.018a (0.938) | −0.459 (0.032) | |
| R hippocampus | −0.039 (0.862) | 0.007 (0.975) | −0.163 (0.470) | −0.311 (0.159) | |
| Processing speed domain | |||||
| L dlPFC | −0.004 (0.986) | −0.219a (0.327) | −0.076 (0.736) | −0.120a (0.595) | |
| R dlPFC | 0.130 (0.565) | −0.302a (0.172) | −0.236a (0.291) | −0.101 (0.655) | |
| SE | |||||
| L dlPFC | −0.042 (0.856) | 0.044a (0.849) | −0.098 (0.673) | −0.110a (0.634) | |
| R dlPFC | −0.206 (0.370) | −0.287a (0.207) | 0.068a (0.771) | −0.228 (0.321) | |
| L hippocampus | −0.012 (0.958) | −0.241 (0.292) | −0.271a (0.234) | −0.198 (0.390) | |
| R hippocampus | 0.056 (0.810) | −0.259 (0.257) | 0.040 (0.863) | −0.046 (0.844) | |
| L thalamus | −0.107 (0.644) | −0.401 (0.072) | −0.211 (0.359) | −0.233 (0.310) | |
| R thalamus | −0.038 (0.870) | −0.298 (0.190) | −0.249 (0.277) | −0.135 (0.559) | |
| N3 time | |||||
| L dlPFC | 0.178 (0.440) | 0.021a (0.929) | −0.126 (0.586) | −0.121a (0.602) | |
| R dlPFC | 0.152 (0.510) | 0.031a (0.893) | 0.006a (0.978) | −0.151 (0.514) | |
| L hippocampus | 0.151 (0.515) | −0.194 (0.400) | −0.017a (0.942) | −0.221 (0.335) | |
| R hippocampus | 0.445 (0.043) | 0.145 (0.530) | 0.229 (0.318) | −0.129 (0.577) | |
| L thalamus | 0.079 (0.732) | −0.320 (0.158) | 0.238 (0.298) | −0.008 (0.972) | |
| R thalamus | 0.143 (0.537) | −0.327 (0.148) | 0.222 (0.334) | −0.043 (0.852) | |
| N3% | |||||
| L dlPFC | 0.184 (0.424) | 0.100a (0.666) | −0.055 (0.813) | 0.058a (0.801) | |
| R dlPFC | 0.233 (0.310) | 0.127a (0.582) | 0.082a (0.724) | −0.065 (0.781) | |
| L hippocampus | 0.164 (0.477) | −0.139 (0.549) | 0.169a (0.464) | −0.199 (0.388) | |
| R hippocampus | 0.488 (0.025) | 0.252 (0.271) | 0.288 (0.205) | −0.102 (0.660) | |
| L thalamus | 0.106 (0.647) | −0.263 (0.249) | 0.358 (0.111) | 0.047 (0.840) | |
| R thalamus | 0.163 (0.480) | −0.291 (0.201) | 0.354 (0.115) | −0.007 (0.975) | |
| . | . | Brain temperature . | tCho/tCr . | mIns/tCr . | NAA/tCr . |
|---|---|---|---|---|---|
| HVLT-based memory score | |||||
| L hippocampus | 0.350 (0.110) | −0.248 (0.265) | −0.400a (0.065) | −0.337 (0.125) | |
| R hippocampus | 0.063 (0.782) | −0.187 (0.405) | −0.409 (0.059) | −0.440 (0.040) | |
| Executive functioning domain | |||||
| L dlPFC | 0.288 (0.139) | 0.274a (0.217) | −0.081 (0.721) | 0.233a (0.296) | |
| R dlPFC | 0.184 (0.411) | −0.074a (0.744) | −0.123a (0.587) | −0.092 (0.685) | |
| Memory domain | |||||
| L hippocampus | 0.029 (0.899) | 0.051 (0.822) | −0.018a (0.938) | −0.459 (0.032) | |
| R hippocampus | −0.039 (0.862) | 0.007 (0.975) | −0.163 (0.470) | −0.311 (0.159) | |
| Processing speed domain | |||||
| L dlPFC | −0.004 (0.986) | −0.219a (0.327) | −0.076 (0.736) | −0.120a (0.595) | |
| R dlPFC | 0.130 (0.565) | −0.302a (0.172) | −0.236a (0.291) | −0.101 (0.655) | |
| SE | |||||
| L dlPFC | −0.042 (0.856) | 0.044a (0.849) | −0.098 (0.673) | −0.110a (0.634) | |
| R dlPFC | −0.206 (0.370) | −0.287a (0.207) | 0.068a (0.771) | −0.228 (0.321) | |
| L hippocampus | −0.012 (0.958) | −0.241 (0.292) | −0.271a (0.234) | −0.198 (0.390) | |
| R hippocampus | 0.056 (0.810) | −0.259 (0.257) | 0.040 (0.863) | −0.046 (0.844) | |
| L thalamus | −0.107 (0.644) | −0.401 (0.072) | −0.211 (0.359) | −0.233 (0.310) | |
| R thalamus | −0.038 (0.870) | −0.298 (0.190) | −0.249 (0.277) | −0.135 (0.559) | |
| N3 time | |||||
| L dlPFC | 0.178 (0.440) | 0.021a (0.929) | −0.126 (0.586) | −0.121a (0.602) | |
| R dlPFC | 0.152 (0.510) | 0.031a (0.893) | 0.006a (0.978) | −0.151 (0.514) | |
| L hippocampus | 0.151 (0.515) | −0.194 (0.400) | −0.017a (0.942) | −0.221 (0.335) | |
| R hippocampus | 0.445 (0.043) | 0.145 (0.530) | 0.229 (0.318) | −0.129 (0.577) | |
| L thalamus | 0.079 (0.732) | −0.320 (0.158) | 0.238 (0.298) | −0.008 (0.972) | |
| R thalamus | 0.143 (0.537) | −0.327 (0.148) | 0.222 (0.334) | −0.043 (0.852) | |
| N3% | |||||
| L dlPFC | 0.184 (0.424) | 0.100a (0.666) | −0.055 (0.813) | 0.058a (0.801) | |
| R dlPFC | 0.233 (0.310) | 0.127a (0.582) | 0.082a (0.724) | −0.065 (0.781) | |
| L hippocampus | 0.164 (0.477) | −0.139 (0.549) | 0.169a (0.464) | −0.199 (0.388) | |
| R hippocampus | 0.488 (0.025) | 0.252 (0.271) | 0.288 (0.205) | −0.102 (0.660) | |
| L thalamus | 0.106 (0.647) | −0.263 (0.249) | 0.358 (0.111) | 0.047 (0.840) | |
| R thalamus | 0.163 (0.480) | −0.291 (0.201) | 0.354 (0.115) | −0.007 (0.975) | |
aSpearman’s ρ for non-normally distributed data. Correlation coefficients are Pearson’s r unless otherwise indicated. Domain scores are Z-scores.
L, left; R, right.
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