Table 3. Open in new tab Disposition of...

Case

Pathogen(s)

Infection Type

Number 0f KT Detections Before Infection Onset

KT MPM Range Before Infection Onset

Days From HCT To KT Detection

Days From HCT To Infection Onset

Time To Infection Onset

Number Of Detections After Infection Onset

KT MPM Range After Infection Onset

Antimicrobials^a

LOS

Days Between Death and Infection Onset

Bordatella hinzii

Pneumonia

52–1100

100

N/A

Before infection onset but after KT detection
ciprofloxacin ppx (35)
TMP/SMX ppx (14)
After infection onset
cefepime (10)

Mycoplasma hominis

Pneumonia

N/A

Before infection onset but after KT detection
TMP/SMX (3)
——–
After infection onset:
TMP/SMX (160)

Alive at 12 mo post-HCT

Human mastadenovirus

Ileitis with diarrhea

341

140

155

N/A

After infection onset
Acyclovir (2)

Alive at 12 mo post-HCT

Escherichia coli
Enterococcus faecium

Peritonitis/intraperitoneal abscess

2
3

285–1823
71–439

29 and 15

N/A

Before infection onset but after KT detection:
Levofloxacin (1)
Cefepime (7)
Metronidazole (5)
Rifaximin (25)
Vancomycin (11)
Ciprofloxacin (2)
TMP/SMX (15)
———
After infection onset:
Ceftriaxone (5)
Vancomycin (8)
Ciprofloxacin (15)

42 + 15

HSV-2

Lesion on mons pubis

14–922

45–95

Before infection onset but after KT detection:
Acyclovir ppx (4)
—–
After infection onset:
Acyclovir (25)

Alive at 12 mo post-HCT

Table 3.

Open in new tab

Disposition of Participants Where Karius Test Provided Additive Diagnostic Value

Case	Pathogen(s)	Infection Type	Number 0f KT Detections Before Infection Onset	KT MPM Range Before Infection Onset	Days From HCT To KT Detection	Days From HCT To Infection Onset	Time To Infection Onset	Number Of Detections After Infection Onset	KT MPM Range After Infection Onset	Antimicrobials^a	LOS	Days Between Death and Infection Onset
1	Bordatella hinzii	Pneumonia	6	52–1100	43	100	57	0	N/A	Before infection onset but after KT detection ciprofloxacin ppx (35) TMP/SMX ppx (14) After infection onset cefepime (10)	11	11
2	Mycoplasma hominis	Pneumonia	1	61	15	18	3	0	N/A	Before infection onset but after KT detection TMP/SMX (3) ——– After infection onset: TMP/SMX (160)	29	Alive at 12 mo post-HCT
3	Human mastadenovirus	Ileitis with diarrhea	1	341	140	155	15	0	N/A	After infection onset Acyclovir (2)	2	Alive at 12 mo post-HCT
4	Escherichia coli Enterococcus faecium	Peritonitis/intraperitoneal abscess	2 3	285–1823 71–439	8	37	29 and 15	0	N/A	Before infection onset but after KT detection: Levofloxacin (1) Cefepime (7) Metronidazole (5) Rifaximin (25) Vancomycin (11) Ciprofloxacin (2) TMP/SMX (15) ——— After infection onset: Ceftriaxone (5) Vancomycin (8) Ciprofloxacin (15)	42 + 15	29
5	HSV-2	Lesion on mons pubis	2	14–922	8	21	13	2	45–95	Before infection onset but after KT detection: Acyclovir ppx (4) —– After infection onset: Acyclovir (25)	47	Alive at 12 mo post-HCT

Case	Pathogen(s)	Infection Type	Number 0f KT Detections Before Infection Onset	KT MPM Range Before Infection Onset	Days From HCT To KT Detection	Days From HCT To Infection Onset	Time To Infection Onset	Number Of Detections After Infection Onset	KT MPM Range After Infection Onset	Antimicrobials^a	LOS	Days Between Death and Infection Onset
1	Bordatella hinzii	Pneumonia	6	52–1100	43	100	57	0	N/A	Before infection onset but after KT detection ciprofloxacin ppx (35) TMP/SMX ppx (14) After infection onset cefepime (10)	11	11
2	Mycoplasma hominis	Pneumonia	1	61	15	18	3	0	N/A	Before infection onset but after KT detection TMP/SMX (3) ——– After infection onset: TMP/SMX (160)	29	Alive at 12 mo post-HCT
3	Human mastadenovirus	Ileitis with diarrhea	1	341	140	155	15	0	N/A	After infection onset Acyclovir (2)	2	Alive at 12 mo post-HCT
4	Escherichia coli Enterococcus faecium	Peritonitis/intraperitoneal abscess	2 3	285–1823 71–439	8	37	29 and 15	0	N/A	Before infection onset but after KT detection: Levofloxacin (1) Cefepime (7) Metronidazole (5) Rifaximin (25) Vancomycin (11) Ciprofloxacin (2) TMP/SMX (15) ——— After infection onset: Ceftriaxone (5) Vancomycin (8) Ciprofloxacin (15)	42 + 15	29
5	HSV-2	Lesion on mons pubis	2	14–922	8	21	13	2	45–95	Before infection onset but after KT detection: Acyclovir ppx (4) —– After infection onset: Acyclovir (25)	47	Alive at 12 mo post-HCT

Abbreviations: HCT, hematopoietic stem cell transplant; HSV-2, herpes simplex virus 2; KT, Karius test; LOS, length of stay; MPM, molecules per microliter; ppx, prophylaxis; TMP/SMX, trimethoprim/sulfamethoxazole.

^aBracketed text refers to number of days.

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