Summary of pooled effect estimates and heterogeneity in the main analysis and sensitivity analyses stratified by endpoint
| Model . | Pooled OR [95% CI] . | I2% [95% CI] . | Excluded studies . |
|---|---|---|---|
| Stroke and systemic emboli | |||
| Main model | 0.81 [0.57, 1.15] | 21 [0, 53] | |
| Model 1 | 0.75 [0.60, 0.95] | 0 [0, 48] | Robinson et al.32 |
| Model 2 | 0.77 [0.61, 0.96] | 0 [0, 49] | Abdelnabi et al.,17 Robinson et al.32 |
| Model 3 | 0.72 [0.47, 1.08] | 0 [0, 52] | Abdelnabi et al.,17 Ali et al.,22 Bass et al.23 Herald et al.,27 Robinson et al.32 |
| Thrombus resolution | |||
| Main model | 1.2 [0.86, 1.54] | 18 [0, 55] | |
| Model 1 | 1.3 [1.05, 1.71] | 0 [0, 55] | Robinson et al.32 |
| Model 2 | 1.1 [0.9, 1.46] | 0 [0, 58] | Jones et al.,30 Robinson et al.,32 Zhang et al.37 |
| Death | |||
| Main model | 0.65 [0.46, 0.92] | 15 [0, 54] | |
| Model 1 | 0.84 [062, 1.14] | 0 [0,58] | Herald et al.27 |
| Major or clinically relevant non-major bleeding | |||
| Main model | 0.67 [0.47, 0.97] | 0 [0, 51] | |
| Model 1 | 0.61 [0.46, 0.81] | 0 [0, 52] | Herald et al.27 |
| Model 2 | 0.59 [0.46, 0.81] | 0 [0, 52] | Herald et al.,27 Mihm et al.31 |
| Model . | Pooled OR [95% CI] . | I2% [95% CI] . | Excluded studies . |
|---|---|---|---|
| Stroke and systemic emboli | |||
| Main model | 0.81 [0.57, 1.15] | 21 [0, 53] | |
| Model 1 | 0.75 [0.60, 0.95] | 0 [0, 48] | Robinson et al.32 |
| Model 2 | 0.77 [0.61, 0.96] | 0 [0, 49] | Abdelnabi et al.,17 Robinson et al.32 |
| Model 3 | 0.72 [0.47, 1.08] | 0 [0, 52] | Abdelnabi et al.,17 Ali et al.,22 Bass et al.23 Herald et al.,27 Robinson et al.32 |
| Thrombus resolution | |||
| Main model | 1.2 [0.86, 1.54] | 18 [0, 55] | |
| Model 1 | 1.3 [1.05, 1.71] | 0 [0, 55] | Robinson et al.32 |
| Model 2 | 1.1 [0.9, 1.46] | 0 [0, 58] | Jones et al.,30 Robinson et al.,32 Zhang et al.37 |
| Death | |||
| Main model | 0.65 [0.46, 0.92] | 15 [0, 54] | |
| Model 1 | 0.84 [062, 1.14] | 0 [0,58] | Herald et al.27 |
| Major or clinically relevant non-major bleeding | |||
| Main model | 0.67 [0.47, 0.97] | 0 [0, 51] | |
| Model 1 | 0.61 [0.46, 0.81] | 0 [0, 52] | Herald et al.27 |
| Model 2 | 0.59 [0.46, 0.81] | 0 [0, 52] | Herald et al.,27 Mihm et al.31 |
We conducted sensitivity analyses by removing studies or a set of studies found to have considerable high influence on the pooled effect estimate and/or heterogeneity as described in the Methods section and in Supplemental material online, Figure S3A–D. Studies, or a set of studies, are excluded and the effect estimates and heterogeneity are provided for these sensitivity models. Studies excluded for a respective model are shown in the right column.
Summary of pooled effect estimates and heterogeneity in the main analysis and sensitivity analyses stratified by endpoint
| Model . | Pooled OR [95% CI] . | I2% [95% CI] . | Excluded studies . |
|---|---|---|---|
| Stroke and systemic emboli | |||
| Main model | 0.81 [0.57, 1.15] | 21 [0, 53] | |
| Model 1 | 0.75 [0.60, 0.95] | 0 [0, 48] | Robinson et al.32 |
| Model 2 | 0.77 [0.61, 0.96] | 0 [0, 49] | Abdelnabi et al.,17 Robinson et al.32 |
| Model 3 | 0.72 [0.47, 1.08] | 0 [0, 52] | Abdelnabi et al.,17 Ali et al.,22 Bass et al.23 Herald et al.,27 Robinson et al.32 |
| Thrombus resolution | |||
| Main model | 1.2 [0.86, 1.54] | 18 [0, 55] | |
| Model 1 | 1.3 [1.05, 1.71] | 0 [0, 55] | Robinson et al.32 |
| Model 2 | 1.1 [0.9, 1.46] | 0 [0, 58] | Jones et al.,30 Robinson et al.,32 Zhang et al.37 |
| Death | |||
| Main model | 0.65 [0.46, 0.92] | 15 [0, 54] | |
| Model 1 | 0.84 [062, 1.14] | 0 [0,58] | Herald et al.27 |
| Major or clinically relevant non-major bleeding | |||
| Main model | 0.67 [0.47, 0.97] | 0 [0, 51] | |
| Model 1 | 0.61 [0.46, 0.81] | 0 [0, 52] | Herald et al.27 |
| Model 2 | 0.59 [0.46, 0.81] | 0 [0, 52] | Herald et al.,27 Mihm et al.31 |
| Model . | Pooled OR [95% CI] . | I2% [95% CI] . | Excluded studies . |
|---|---|---|---|
| Stroke and systemic emboli | |||
| Main model | 0.81 [0.57, 1.15] | 21 [0, 53] | |
| Model 1 | 0.75 [0.60, 0.95] | 0 [0, 48] | Robinson et al.32 |
| Model 2 | 0.77 [0.61, 0.96] | 0 [0, 49] | Abdelnabi et al.,17 Robinson et al.32 |
| Model 3 | 0.72 [0.47, 1.08] | 0 [0, 52] | Abdelnabi et al.,17 Ali et al.,22 Bass et al.23 Herald et al.,27 Robinson et al.32 |
| Thrombus resolution | |||
| Main model | 1.2 [0.86, 1.54] | 18 [0, 55] | |
| Model 1 | 1.3 [1.05, 1.71] | 0 [0, 55] | Robinson et al.32 |
| Model 2 | 1.1 [0.9, 1.46] | 0 [0, 58] | Jones et al.,30 Robinson et al.,32 Zhang et al.37 |
| Death | |||
| Main model | 0.65 [0.46, 0.92] | 15 [0, 54] | |
| Model 1 | 0.84 [062, 1.14] | 0 [0,58] | Herald et al.27 |
| Major or clinically relevant non-major bleeding | |||
| Main model | 0.67 [0.47, 0.97] | 0 [0, 51] | |
| Model 1 | 0.61 [0.46, 0.81] | 0 [0, 52] | Herald et al.27 |
| Model 2 | 0.59 [0.46, 0.81] | 0 [0, 52] | Herald et al.,27 Mihm et al.31 |
We conducted sensitivity analyses by removing studies or a set of studies found to have considerable high influence on the pooled effect estimate and/or heterogeneity as described in the Methods section and in Supplemental material online, Figure S3A–D. Studies, or a set of studies, are excluded and the effect estimates and heterogeneity are provided for these sensitivity models. Studies excluded for a respective model are shown in the right column.
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