Case ID = case number assigned in chronological order; Lab ID = laboratory sample identifier; Date of isolation = day-month-year; Age of the case = years or months if <2 years of age; Country of birth = self-reported; Recent travel = foreign travel outside Chile within 30 days prior to clinical presentation; Presumed place of acquisition of infection = determination made by study team based on all available epidemiologic information collected through household investigations; Serum anti-Vi IgG titer = serum anti-Vi IgG titer measured in adult carriers, by enzyme-linked immunosorbent assay, using the US National Institutes of Health Reference Standard reagent Vi-IgG_R1; Follow-up period = the month of initial household investigation, lasting 2–4 weeks; Contacts sampled/total contacts = the number of household contacts who gave consent and stool specimens over the total number of household contacts reported (including absent or nonconsenting contacts); Sex = biological sex of household contact reported by self or family member; Age = age of contact reported by self or family member; Stool specimens (No. positive/No. tested) = the number of stool specimens positive for Salmonella Typhi by qPCR or culture over the total number of stool specimens collected; History/presence of gallstones = history or presence of gallstones (cholelithiasis), Yes (Y) or No (N), if yes then confirmed by ultrasound or cholecystectomy and date abbreviated into a 2-digit format (’YY).

Abbreviations: C, cholecystectomy; F, female; IgG, immunoglobulin G; M, male; qPCR, quantitative polymerase chain reaction.