Clinical Characteristics and Outcomes of Patients With Diabetic Foot Osteomyelitis According to the Extent of Their Amputation
| Characteristic . | Major Amputation (n = 27) . | Minor Amputation (n = 74) . | P Value . |
|---|---|---|---|
| Age, y, median (IQR) | 66 (64–74) | 69 (58–79) | .94 |
| Sex, male | 14 (51.9) | 46 (62.3) | .37 |
| Body mass index, kg/m2, median (IQR) | 22.7 (20.5–26.5) | 23.4 (21.5–26.5) | .67 |
| Medical aid | 6 (22.2) | 23 (31.1) | .46 |
| Smokera | 12 (44.4) | 30 (42.6) | 1 |
| Medical condition | |||
| Coronary artery occlusive disease | 15 (55.6) | 35 (47.3) | .51 |
| Peripheral artery disease | 22 (88) | 54 (75.0) | .26 |
| Chronic kidney disease | 18 (72.0) | 55 (76.4) | .79 |
| PEDIS classification | .04 | ||
| Grade 2 | 2 (7.4) | 4 (5.4) | |
| Grade 3 | 15 (55.6) | 60 (81.1) | |
| Grade 4 | 10 (37.0) | 10 (13.5) | |
| ABI | .07 | ||
| >0.8 | 8 (33.3) | 34 (50.7) | |
| 0.6–0.79 | 4 (16.7) | 8 (11.9) | |
| 0.4–0.59 | 1 (4.2) | 11 (16.4) | |
| <0.39 | 11 (45.8) | 14 (20.9) | |
| Infection site | <.001 | ||
| Forefoot | 6 (22.2) | 63 (85.1) | |
| Midfoot | 8 (29.6) | 10 (13.5) | |
| Hindfoot | 13 (48.1) | 1 (1.4) | |
| Severity | |||
| Multiple ulcer | 14 (51.9) | 21 (28.4) | .03 |
| Residual infection | 3 (11.1) | 23 (31.1) | .06 |
| Duration of antibiotic therapy, d, median (IQR) | 12 (7–21) | 31 (14–50) | <.001 |
| Complete remission | 20 (74.1) | 40 (58.8) | .10 |
| Debridement | 8 (29.6) | 38 (51.4) | .07 |
| Amputation | 3 (11.1) | 25 (33.8) | .02 |
| CDI | 5 (19.2) | 9 (12.9) | .51 |
| MDRO infection/colonization | 5 (20) | 8 (11.4) | .32 |
| In-hospital mortality | 5 (29.4) | 6 (11.8) | .12 |
| Characteristic . | Major Amputation (n = 27) . | Minor Amputation (n = 74) . | P Value . |
|---|---|---|---|
| Age, y, median (IQR) | 66 (64–74) | 69 (58–79) | .94 |
| Sex, male | 14 (51.9) | 46 (62.3) | .37 |
| Body mass index, kg/m2, median (IQR) | 22.7 (20.5–26.5) | 23.4 (21.5–26.5) | .67 |
| Medical aid | 6 (22.2) | 23 (31.1) | .46 |
| Smokera | 12 (44.4) | 30 (42.6) | 1 |
| Medical condition | |||
| Coronary artery occlusive disease | 15 (55.6) | 35 (47.3) | .51 |
| Peripheral artery disease | 22 (88) | 54 (75.0) | .26 |
| Chronic kidney disease | 18 (72.0) | 55 (76.4) | .79 |
| PEDIS classification | .04 | ||
| Grade 2 | 2 (7.4) | 4 (5.4) | |
| Grade 3 | 15 (55.6) | 60 (81.1) | |
| Grade 4 | 10 (37.0) | 10 (13.5) | |
| ABI | .07 | ||
| >0.8 | 8 (33.3) | 34 (50.7) | |
| 0.6–0.79 | 4 (16.7) | 8 (11.9) | |
| 0.4–0.59 | 1 (4.2) | 11 (16.4) | |
| <0.39 | 11 (45.8) | 14 (20.9) | |
| Infection site | <.001 | ||
| Forefoot | 6 (22.2) | 63 (85.1) | |
| Midfoot | 8 (29.6) | 10 (13.5) | |
| Hindfoot | 13 (48.1) | 1 (1.4) | |
| Severity | |||
| Multiple ulcer | 14 (51.9) | 21 (28.4) | .03 |
| Residual infection | 3 (11.1) | 23 (31.1) | .06 |
| Duration of antibiotic therapy, d, median (IQR) | 12 (7–21) | 31 (14–50) | <.001 |
| Complete remission | 20 (74.1) | 40 (58.8) | .10 |
| Debridement | 8 (29.6) | 38 (51.4) | .07 |
| Amputation | 3 (11.1) | 25 (33.8) | .02 |
| CDI | 5 (19.2) | 9 (12.9) | .51 |
| MDRO infection/colonization | 5 (20) | 8 (11.4) | .32 |
| In-hospital mortality | 5 (29.4) | 6 (11.8) | .12 |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: ABI, ankle brachial index; CDI, Clostridioides difficile infection; IQR, interquartile range; MDRO, multidrug-resistant organism; PEDIS, perfusion, extent/size, depth/tissue loss, infection, and sensation.
aSmoker includes current smokers and ex-smokers.
Clinical Characteristics and Outcomes of Patients With Diabetic Foot Osteomyelitis According to the Extent of Their Amputation
| Characteristic . | Major Amputation (n = 27) . | Minor Amputation (n = 74) . | P Value . |
|---|---|---|---|
| Age, y, median (IQR) | 66 (64–74) | 69 (58–79) | .94 |
| Sex, male | 14 (51.9) | 46 (62.3) | .37 |
| Body mass index, kg/m2, median (IQR) | 22.7 (20.5–26.5) | 23.4 (21.5–26.5) | .67 |
| Medical aid | 6 (22.2) | 23 (31.1) | .46 |
| Smokera | 12 (44.4) | 30 (42.6) | 1 |
| Medical condition | |||
| Coronary artery occlusive disease | 15 (55.6) | 35 (47.3) | .51 |
| Peripheral artery disease | 22 (88) | 54 (75.0) | .26 |
| Chronic kidney disease | 18 (72.0) | 55 (76.4) | .79 |
| PEDIS classification | .04 | ||
| Grade 2 | 2 (7.4) | 4 (5.4) | |
| Grade 3 | 15 (55.6) | 60 (81.1) | |
| Grade 4 | 10 (37.0) | 10 (13.5) | |
| ABI | .07 | ||
| >0.8 | 8 (33.3) | 34 (50.7) | |
| 0.6–0.79 | 4 (16.7) | 8 (11.9) | |
| 0.4–0.59 | 1 (4.2) | 11 (16.4) | |
| <0.39 | 11 (45.8) | 14 (20.9) | |
| Infection site | <.001 | ||
| Forefoot | 6 (22.2) | 63 (85.1) | |
| Midfoot | 8 (29.6) | 10 (13.5) | |
| Hindfoot | 13 (48.1) | 1 (1.4) | |
| Severity | |||
| Multiple ulcer | 14 (51.9) | 21 (28.4) | .03 |
| Residual infection | 3 (11.1) | 23 (31.1) | .06 |
| Duration of antibiotic therapy, d, median (IQR) | 12 (7–21) | 31 (14–50) | <.001 |
| Complete remission | 20 (74.1) | 40 (58.8) | .10 |
| Debridement | 8 (29.6) | 38 (51.4) | .07 |
| Amputation | 3 (11.1) | 25 (33.8) | .02 |
| CDI | 5 (19.2) | 9 (12.9) | .51 |
| MDRO infection/colonization | 5 (20) | 8 (11.4) | .32 |
| In-hospital mortality | 5 (29.4) | 6 (11.8) | .12 |
| Characteristic . | Major Amputation (n = 27) . | Minor Amputation (n = 74) . | P Value . |
|---|---|---|---|
| Age, y, median (IQR) | 66 (64–74) | 69 (58–79) | .94 |
| Sex, male | 14 (51.9) | 46 (62.3) | .37 |
| Body mass index, kg/m2, median (IQR) | 22.7 (20.5–26.5) | 23.4 (21.5–26.5) | .67 |
| Medical aid | 6 (22.2) | 23 (31.1) | .46 |
| Smokera | 12 (44.4) | 30 (42.6) | 1 |
| Medical condition | |||
| Coronary artery occlusive disease | 15 (55.6) | 35 (47.3) | .51 |
| Peripheral artery disease | 22 (88) | 54 (75.0) | .26 |
| Chronic kidney disease | 18 (72.0) | 55 (76.4) | .79 |
| PEDIS classification | .04 | ||
| Grade 2 | 2 (7.4) | 4 (5.4) | |
| Grade 3 | 15 (55.6) | 60 (81.1) | |
| Grade 4 | 10 (37.0) | 10 (13.5) | |
| ABI | .07 | ||
| >0.8 | 8 (33.3) | 34 (50.7) | |
| 0.6–0.79 | 4 (16.7) | 8 (11.9) | |
| 0.4–0.59 | 1 (4.2) | 11 (16.4) | |
| <0.39 | 11 (45.8) | 14 (20.9) | |
| Infection site | <.001 | ||
| Forefoot | 6 (22.2) | 63 (85.1) | |
| Midfoot | 8 (29.6) | 10 (13.5) | |
| Hindfoot | 13 (48.1) | 1 (1.4) | |
| Severity | |||
| Multiple ulcer | 14 (51.9) | 21 (28.4) | .03 |
| Residual infection | 3 (11.1) | 23 (31.1) | .06 |
| Duration of antibiotic therapy, d, median (IQR) | 12 (7–21) | 31 (14–50) | <.001 |
| Complete remission | 20 (74.1) | 40 (58.8) | .10 |
| Debridement | 8 (29.6) | 38 (51.4) | .07 |
| Amputation | 3 (11.1) | 25 (33.8) | .02 |
| CDI | 5 (19.2) | 9 (12.9) | .51 |
| MDRO infection/colonization | 5 (20) | 8 (11.4) | .32 |
| In-hospital mortality | 5 (29.4) | 6 (11.8) | .12 |
Data are presented as No. (%) unless otherwise indicated.
Abbreviations: ABI, ankle brachial index; CDI, Clostridioides difficile infection; IQR, interquartile range; MDRO, multidrug-resistant organism; PEDIS, perfusion, extent/size, depth/tissue loss, infection, and sensation.
aSmoker includes current smokers and ex-smokers.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
