Details on the endocrine phenotype and other symptoms of 155 patients with ACT by age and sex
| . | Female . | Male . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | <8 years (n = 63) . | % . | ≥ 8 years (n = 47) . | % . | P value . | <9 years (n = 34) . | % . | ≥ 9 years (n = 11) . | % . | P value . |
| Virilization (female)/peripheral precocity (male) | ||||||||||
| Pubarche/excessive pubic hair | 43 | 68.3 | 22 | 46.8 | .024 | 19 | 55.9 | 3 | 27.3 | .166 |
| Clitoral hypertrophy | 31 | 49.2 | 6 | 12.8 | <.001 | — | — | — | ||
| Penile growth | — | — | — | 16 | 47.1 | 1 | 9.1 | .024 | ||
| Tall stature | 14 | 22.2 | 4 | 8.5 | .051 | 7 | 20.6 | 1 | 9.1 | .328 |
| Sweat odor | 10 | 15.9 | 7 | 14.9 | .985 | 4 | 11.8 | 1 | 9.1 | .704 |
| Deep voice | 4 | 6.3 | 12 | 25.5 | .007 | 3 | 8.8 | 0 | 0.0 | .298 |
| Greasy hair | 5 | 7.9 | 2 | 4.3 | .519 | 2 | 5.9 | 0 | 0.0 | .367 |
| Overlapping signs and symptoms of virilization (female)/peripheral precocity (male) and Cushing syndrome | ||||||||||
| Menstrual disorder (sec. amenorrhea) | 1 | 1.6 | 11 | 23.4 | <.001 | — | — | |||
| Acne | 14 | 22.2 | 17 | 36.2 | .110 | 11 | 32.4 | 1 | 9.1 | .087 |
| Hirsutism | 3 | 4.8 | 9 | 19.1 | .017 | 1 | 2.9 | 0 | 0 | .565 |
| Cushing syndrome | ||||||||||
| Cushingoid appearance | 3 | 4.8 | 5 | 10.6 | .240 | 3 | 8.8 | 3 | 27.3 | .118 |
| Weight gain/obesity | 20 | 31.7 | 16 | 34.0 | .915 | 8 | 23.5 | 5 | 45.5 | .153 |
| Hypertension | 13 | 20.6 | 17 | 36.2 | .075 | 7 | 20.6 | 4 | 36.4 | .372 |
| Tirednessa | 9 | 14.3 | 16 | 34.0 | .022 | 6 | 17.6 | 2 | 18.2 | .924 |
| Dizzinessb | 2 | 3.2 | 8 | 17.0 | .014 | 4 | 11.8 | 1 | 9.1 | .704 |
| Mood swings | 4 | 6.3 | 1 | 2.1 | .293 | 1 | 2.9 | 1 | 9.1 | .390 |
| No endocrine signs and symptoms | ||||||||||
| Phenotypic silent | 8 | 12.7 | 8 | 17.0 | .494 | 10 | 29.4 | 4 | 36.4 | .665 |
| Other symptoms | ||||||||||
| Abdominal/back pain | 6 | 9.5 | 12 | 25.5 | .028 | 3 | 8.8 | 6 | 54.5 | .003 |
| . | Female . | Male . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | <8 years (n = 63) . | % . | ≥ 8 years (n = 47) . | % . | P value . | <9 years (n = 34) . | % . | ≥ 9 years (n = 11) . | % . | P value . |
| Virilization (female)/peripheral precocity (male) | ||||||||||
| Pubarche/excessive pubic hair | 43 | 68.3 | 22 | 46.8 | .024 | 19 | 55.9 | 3 | 27.3 | .166 |
| Clitoral hypertrophy | 31 | 49.2 | 6 | 12.8 | <.001 | — | — | — | ||
| Penile growth | — | — | — | 16 | 47.1 | 1 | 9.1 | .024 | ||
| Tall stature | 14 | 22.2 | 4 | 8.5 | .051 | 7 | 20.6 | 1 | 9.1 | .328 |
| Sweat odor | 10 | 15.9 | 7 | 14.9 | .985 | 4 | 11.8 | 1 | 9.1 | .704 |
| Deep voice | 4 | 6.3 | 12 | 25.5 | .007 | 3 | 8.8 | 0 | 0.0 | .298 |
| Greasy hair | 5 | 7.9 | 2 | 4.3 | .519 | 2 | 5.9 | 0 | 0.0 | .367 |
| Overlapping signs and symptoms of virilization (female)/peripheral precocity (male) and Cushing syndrome | ||||||||||
| Menstrual disorder (sec. amenorrhea) | 1 | 1.6 | 11 | 23.4 | <.001 | — | — | |||
| Acne | 14 | 22.2 | 17 | 36.2 | .110 | 11 | 32.4 | 1 | 9.1 | .087 |
| Hirsutism | 3 | 4.8 | 9 | 19.1 | .017 | 1 | 2.9 | 0 | 0 | .565 |
| Cushing syndrome | ||||||||||
| Cushingoid appearance | 3 | 4.8 | 5 | 10.6 | .240 | 3 | 8.8 | 3 | 27.3 | .118 |
| Weight gain/obesity | 20 | 31.7 | 16 | 34.0 | .915 | 8 | 23.5 | 5 | 45.5 | .153 |
| Hypertension | 13 | 20.6 | 17 | 36.2 | .075 | 7 | 20.6 | 4 | 36.4 | .372 |
| Tirednessa | 9 | 14.3 | 16 | 34.0 | .022 | 6 | 17.6 | 2 | 18.2 | .924 |
| Dizzinessb | 2 | 3.2 | 8 | 17.0 | .014 | 4 | 11.8 | 1 | 9.1 | .704 |
| Mood swings | 4 | 6.3 | 1 | 2.1 | .293 | 1 | 2.9 | 1 | 9.1 | .390 |
| No endocrine signs and symptoms | ||||||||||
| Phenotypic silent | 8 | 12.7 | 8 | 17.0 | .494 | 10 | 29.4 | 4 | 36.4 | .665 |
| Other symptoms | ||||||||||
| Abdominal/back pain | 6 | 9.5 | 12 | 25.5 | .028 | 3 | 8.8 | 6 | 54.5 | .003 |
aIncluding reduced performance, weakness, and headache.
bIncluding nausea and vomiting.
Details on the endocrine phenotype and other symptoms of 155 patients with ACT by age and sex
| . | Female . | Male . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | <8 years (n = 63) . | % . | ≥ 8 years (n = 47) . | % . | P value . | <9 years (n = 34) . | % . | ≥ 9 years (n = 11) . | % . | P value . |
| Virilization (female)/peripheral precocity (male) | ||||||||||
| Pubarche/excessive pubic hair | 43 | 68.3 | 22 | 46.8 | .024 | 19 | 55.9 | 3 | 27.3 | .166 |
| Clitoral hypertrophy | 31 | 49.2 | 6 | 12.8 | <.001 | — | — | — | ||
| Penile growth | — | — | — | 16 | 47.1 | 1 | 9.1 | .024 | ||
| Tall stature | 14 | 22.2 | 4 | 8.5 | .051 | 7 | 20.6 | 1 | 9.1 | .328 |
| Sweat odor | 10 | 15.9 | 7 | 14.9 | .985 | 4 | 11.8 | 1 | 9.1 | .704 |
| Deep voice | 4 | 6.3 | 12 | 25.5 | .007 | 3 | 8.8 | 0 | 0.0 | .298 |
| Greasy hair | 5 | 7.9 | 2 | 4.3 | .519 | 2 | 5.9 | 0 | 0.0 | .367 |
| Overlapping signs and symptoms of virilization (female)/peripheral precocity (male) and Cushing syndrome | ||||||||||
| Menstrual disorder (sec. amenorrhea) | 1 | 1.6 | 11 | 23.4 | <.001 | — | — | |||
| Acne | 14 | 22.2 | 17 | 36.2 | .110 | 11 | 32.4 | 1 | 9.1 | .087 |
| Hirsutism | 3 | 4.8 | 9 | 19.1 | .017 | 1 | 2.9 | 0 | 0 | .565 |
| Cushing syndrome | ||||||||||
| Cushingoid appearance | 3 | 4.8 | 5 | 10.6 | .240 | 3 | 8.8 | 3 | 27.3 | .118 |
| Weight gain/obesity | 20 | 31.7 | 16 | 34.0 | .915 | 8 | 23.5 | 5 | 45.5 | .153 |
| Hypertension | 13 | 20.6 | 17 | 36.2 | .075 | 7 | 20.6 | 4 | 36.4 | .372 |
| Tirednessa | 9 | 14.3 | 16 | 34.0 | .022 | 6 | 17.6 | 2 | 18.2 | .924 |
| Dizzinessb | 2 | 3.2 | 8 | 17.0 | .014 | 4 | 11.8 | 1 | 9.1 | .704 |
| Mood swings | 4 | 6.3 | 1 | 2.1 | .293 | 1 | 2.9 | 1 | 9.1 | .390 |
| No endocrine signs and symptoms | ||||||||||
| Phenotypic silent | 8 | 12.7 | 8 | 17.0 | .494 | 10 | 29.4 | 4 | 36.4 | .665 |
| Other symptoms | ||||||||||
| Abdominal/back pain | 6 | 9.5 | 12 | 25.5 | .028 | 3 | 8.8 | 6 | 54.5 | .003 |
| . | Female . | Male . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | <8 years (n = 63) . | % . | ≥ 8 years (n = 47) . | % . | P value . | <9 years (n = 34) . | % . | ≥ 9 years (n = 11) . | % . | P value . |
| Virilization (female)/peripheral precocity (male) | ||||||||||
| Pubarche/excessive pubic hair | 43 | 68.3 | 22 | 46.8 | .024 | 19 | 55.9 | 3 | 27.3 | .166 |
| Clitoral hypertrophy | 31 | 49.2 | 6 | 12.8 | <.001 | — | — | — | ||
| Penile growth | — | — | — | 16 | 47.1 | 1 | 9.1 | .024 | ||
| Tall stature | 14 | 22.2 | 4 | 8.5 | .051 | 7 | 20.6 | 1 | 9.1 | .328 |
| Sweat odor | 10 | 15.9 | 7 | 14.9 | .985 | 4 | 11.8 | 1 | 9.1 | .704 |
| Deep voice | 4 | 6.3 | 12 | 25.5 | .007 | 3 | 8.8 | 0 | 0.0 | .298 |
| Greasy hair | 5 | 7.9 | 2 | 4.3 | .519 | 2 | 5.9 | 0 | 0.0 | .367 |
| Overlapping signs and symptoms of virilization (female)/peripheral precocity (male) and Cushing syndrome | ||||||||||
| Menstrual disorder (sec. amenorrhea) | 1 | 1.6 | 11 | 23.4 | <.001 | — | — | |||
| Acne | 14 | 22.2 | 17 | 36.2 | .110 | 11 | 32.4 | 1 | 9.1 | .087 |
| Hirsutism | 3 | 4.8 | 9 | 19.1 | .017 | 1 | 2.9 | 0 | 0 | .565 |
| Cushing syndrome | ||||||||||
| Cushingoid appearance | 3 | 4.8 | 5 | 10.6 | .240 | 3 | 8.8 | 3 | 27.3 | .118 |
| Weight gain/obesity | 20 | 31.7 | 16 | 34.0 | .915 | 8 | 23.5 | 5 | 45.5 | .153 |
| Hypertension | 13 | 20.6 | 17 | 36.2 | .075 | 7 | 20.6 | 4 | 36.4 | .372 |
| Tirednessa | 9 | 14.3 | 16 | 34.0 | .022 | 6 | 17.6 | 2 | 18.2 | .924 |
| Dizzinessb | 2 | 3.2 | 8 | 17.0 | .014 | 4 | 11.8 | 1 | 9.1 | .704 |
| Mood swings | 4 | 6.3 | 1 | 2.1 | .293 | 1 | 2.9 | 1 | 9.1 | .390 |
| No endocrine signs and symptoms | ||||||||||
| Phenotypic silent | 8 | 12.7 | 8 | 17.0 | .494 | 10 | 29.4 | 4 | 36.4 | .665 |
| Other symptoms | ||||||||||
| Abdominal/back pain | 6 | 9.5 | 12 | 25.5 | .028 | 3 | 8.8 | 6 | 54.5 | .003 |
aIncluding reduced performance, weakness, and headache.
bIncluding nausea and vomiting.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
