Thermodynamic parameters for the peptide-G4 interactions obtained by ITC at 25°C
| . | Myb397–415 . | MybA400 . | MybA412 . | |
|---|---|---|---|---|
| . | c-KIT2 . | HER2 . | c-KIT2 . | c-KIT2 . |
| Ka (M−1) | 5.0 (±0.3) ×106 | 1.0 (±0.1) ×107 | 7.3 (±1.3) ×106 | 5.3 (±0.8) ×106 |
| Kd (nM) | 200 (±12) | 100 (±10) | 137 (±24) | 187 (±28) |
| ΔG° (kJ mol−1) | –38.2 (±2.3) | –40.0 (±4.0) | –39.2 (±7.0) | –38.4 (±5.8) |
| ΔH° (kJ mol−1) | –47.4 (±0.8) | –64.4 (±1.1) | –60.2 (±2.0) | –58.8 (±1.4) |
| TΔS° (kJ mol−1) | –9.2 (±3.1) | –24.4 (±5.1) | –21.0 (±9.0) | –20.4 (±7.2) |
| n | 2 | 3 | 2 | 2 |
| . | Myb397–415 . | MybA400 . | MybA412 . | |
|---|---|---|---|---|
| . | c-KIT2 . | HER2 . | c-KIT2 . | c-KIT2 . |
| Ka (M−1) | 5.0 (±0.3) ×106 | 1.0 (±0.1) ×107 | 7.3 (±1.3) ×106 | 5.3 (±0.8) ×106 |
| Kd (nM) | 200 (±12) | 100 (±10) | 137 (±24) | 187 (±28) |
| ΔG° (kJ mol−1) | –38.2 (±2.3) | –40.0 (±4.0) | –39.2 (±7.0) | –38.4 (±5.8) |
| ΔH° (kJ mol−1) | –47.4 (±0.8) | –64.4 (±1.1) | –60.2 (±2.0) | –58.8 (±1.4) |
| TΔS° (kJ mol−1) | –9.2 (±3.1) | –24.4 (±5.1) | –21.0 (±9.0) | –20.4 (±7.2) |
| n | 2 | 3 | 2 | 2 |
Thermodynamic parameters for the peptide-G4 interactions obtained by ITC at 25°C
| . | Myb397–415 . | MybA400 . | MybA412 . | |
|---|---|---|---|---|
| . | c-KIT2 . | HER2 . | c-KIT2 . | c-KIT2 . |
| Ka (M−1) | 5.0 (±0.3) ×106 | 1.0 (±0.1) ×107 | 7.3 (±1.3) ×106 | 5.3 (±0.8) ×106 |
| Kd (nM) | 200 (±12) | 100 (±10) | 137 (±24) | 187 (±28) |
| ΔG° (kJ mol−1) | –38.2 (±2.3) | –40.0 (±4.0) | –39.2 (±7.0) | –38.4 (±5.8) |
| ΔH° (kJ mol−1) | –47.4 (±0.8) | –64.4 (±1.1) | –60.2 (±2.0) | –58.8 (±1.4) |
| TΔS° (kJ mol−1) | –9.2 (±3.1) | –24.4 (±5.1) | –21.0 (±9.0) | –20.4 (±7.2) |
| n | 2 | 3 | 2 | 2 |
| . | Myb397–415 . | MybA400 . | MybA412 . | |
|---|---|---|---|---|
| . | c-KIT2 . | HER2 . | c-KIT2 . | c-KIT2 . |
| Ka (M−1) | 5.0 (±0.3) ×106 | 1.0 (±0.1) ×107 | 7.3 (±1.3) ×106 | 5.3 (±0.8) ×106 |
| Kd (nM) | 200 (±12) | 100 (±10) | 137 (±24) | 187 (±28) |
| ΔG° (kJ mol−1) | –38.2 (±2.3) | –40.0 (±4.0) | –39.2 (±7.0) | –38.4 (±5.8) |
| ΔH° (kJ mol−1) | –47.4 (±0.8) | –64.4 (±1.1) | –60.2 (±2.0) | –58.8 (±1.4) |
| TΔS° (kJ mol−1) | –9.2 (±3.1) | –24.4 (±5.1) | –21.0 (±9.0) | –20.4 (±7.2) |
| n | 2 | 3 | 2 | 2 |
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