Table 2.

Rodent models of osteoporosis

ModelsMethodsSympathetic activationRef.
GonadectomyOvariectomy (OVX) or orchidectomy (ORX).Yes[48]
AgingNatural aging or using senescence accelerated-prone mice.
Drug inductionDaily intraperitoneal injection of dexamethasone (20 mg/kg) for 4 weeks.
DisuseTail suspension or hindlimb immobilization for 2 weeks.
Psychological stressExposure to various stressors or daily ISO induction (10 mg/kg) for 4 weeks.
Type 1 DiabetesDaily intraperitoneal injection of streptozotocin (50 mg/kg) for 5 days.
Type 2 DiabetesInduction of insulin resistance via high-fat diet or other means.Yes[85]
RadiationFocal radiation as a single dose of 20 Gy.Not investigated[86]
ModelsMethodsSympathetic activationRef.
GonadectomyOvariectomy (OVX) or orchidectomy (ORX).Yes[48]
AgingNatural aging or using senescence accelerated-prone mice.
Drug inductionDaily intraperitoneal injection of dexamethasone (20 mg/kg) for 4 weeks.
DisuseTail suspension or hindlimb immobilization for 2 weeks.
Psychological stressExposure to various stressors or daily ISO induction (10 mg/kg) for 4 weeks.
Type 1 DiabetesDaily intraperitoneal injection of streptozotocin (50 mg/kg) for 5 days.
Type 2 DiabetesInduction of insulin resistance via high-fat diet or other means.Yes[85]
RadiationFocal radiation as a single dose of 20 Gy.Not investigated[86]
Table 2.

Rodent models of osteoporosis

ModelsMethodsSympathetic activationRef.
GonadectomyOvariectomy (OVX) or orchidectomy (ORX).Yes[48]
AgingNatural aging or using senescence accelerated-prone mice.
Drug inductionDaily intraperitoneal injection of dexamethasone (20 mg/kg) for 4 weeks.
DisuseTail suspension or hindlimb immobilization for 2 weeks.
Psychological stressExposure to various stressors or daily ISO induction (10 mg/kg) for 4 weeks.
Type 1 DiabetesDaily intraperitoneal injection of streptozotocin (50 mg/kg) for 5 days.
Type 2 DiabetesInduction of insulin resistance via high-fat diet or other means.Yes[85]
RadiationFocal radiation as a single dose of 20 Gy.Not investigated[86]
ModelsMethodsSympathetic activationRef.
GonadectomyOvariectomy (OVX) or orchidectomy (ORX).Yes[48]
AgingNatural aging or using senescence accelerated-prone mice.
Drug inductionDaily intraperitoneal injection of dexamethasone (20 mg/kg) for 4 weeks.
DisuseTail suspension or hindlimb immobilization for 2 weeks.
Psychological stressExposure to various stressors or daily ISO induction (10 mg/kg) for 4 weeks.
Type 1 DiabetesDaily intraperitoneal injection of streptozotocin (50 mg/kg) for 5 days.
Type 2 DiabetesInduction of insulin resistance via high-fat diet or other means.Yes[85]
RadiationFocal radiation as a single dose of 20 Gy.Not investigated[86]
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