Table 2. Open in new tab Age-correlated...

Uniprot ID

Protein symbol (name)

P. adjusted

GV oocytes

P62195

PRS8 (26S proteasome regulatory subunit 8)

−0.71

0.030

P62258

1433E (14-3-3 protein epsilon)

−0.70

0.031

P11142

HSP7C (heat shock cognate 71 kDa protein)

−0.65

0.117

Q9UNS2

CSN3 (COP9 signalosome complex subunit 3)

−0.64

0.117

P09936

UCHL1 (ubiquitin carboxyl-terminal hydrolase isozyme L1)

−0.63

0.117

P17980

PRS6A (26S proteasome regulatory subunit 6A)

−0.62

0.117

P31948-2

STIP1 (stress-induced-phosphoprotein 1)

−0.62

0.117

Q96FJ2

DYL2 (dynein light chain 2, cytoplasmic)

−0.62

0.109

Q9UIC8

LCMT1 (leucine carboxyl methyltransferase 1)

−0.61

0.109

P47756-2

CAPZB (F-actin-capping protein subunit beta)

−0.61

0.119

Q02790

FKBP4 (peptidyl-prolyl cis-trans isomerase)

−0.58

0.148

Q99832

TCPH (T-complex protein 1 subunit eta)

−0.58

0.159

P35232

PHB1 (prohibitin 1)

0.57

0.180

Q9H3N1

TMX1 (thioredoxin-related transmembrane protein 1)

0.58

0.196

Q16891

MIC60 (MICOS complex subunit)

0.58

0.148

Q9UBS4

DJB11 (DnaJ homolog subfamily B member 11)

0.59

0.148

O75964

ATP5L (ATP synthase subunit g, mitochondrial)

0.60

0.119

O00592

PODXL (podocalyxin)

0.64

0.107

P18084

ITB5 (integrin beta-5)

0.65

0.139

Q5VV41

ARHGG (rho guanine nucleotide exchange factor 16)

0.81

0.004

MII oocytes

P01857

IGHG1 (immunoglobulin heavy constant gamma 1)

−0.69

0.047

Q6UB35

C1TM (monofunctional C1-tetrahydrofolate synthase, mitochondrial)

−0.69

0.071

Q14894

CRYM (ketimine reductase mu-crystallin)

−0.68

0.047

O60547

GMDS (GDP-mannose 4,6 dehydratase)

−0.61

0.145

Q9NQI0

DDX4 (probable ATP-dependent RNA helicase)

−0.60

0.160

P80723

BASP1 (brain acid soluble protein 1)

0.67

0.070

Q9UJS0

S2513 (electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial)

0.61

0.160

Table 2.

Open in new tab

Age-correlated proteins in germinal vesicle and MII human oocytes.

	Uniprot ID	Protein symbol (name)	R	P. adjusted
GV oocytes	P62195	PRS8 (26S proteasome regulatory subunit 8)	−0.71	0.030
	P62258	1433E (14-3-3 protein epsilon)	−0.70	0.031
	P11142	HSP7C (heat shock cognate 71 kDa protein)	−0.65	0.117
	Q9UNS2	CSN3 (COP9 signalosome complex subunit 3)	−0.64	0.117
	P09936	UCHL1 (ubiquitin carboxyl-terminal hydrolase isozyme L1)	−0.63	0.117
	P17980	PRS6A (26S proteasome regulatory subunit 6A)	−0.62	0.117
	P31948-2	STIP1 (stress-induced-phosphoprotein 1)	−0.62	0.117
	Q96FJ2	DYL2 (dynein light chain 2, cytoplasmic)	−0.62	0.109
	Q9UIC8	LCMT1 (leucine carboxyl methyltransferase 1)	−0.61	0.109
	P47756-2	CAPZB (F-actin-capping protein subunit beta)	−0.61	0.119
	Q02790	FKBP4 (peptidyl-prolyl cis-trans isomerase)	−0.58	0.148
	Q99832	TCPH (T-complex protein 1 subunit eta)	−0.58	0.159
	P35232	PHB1 (prohibitin 1)	0.57	0.180
	Q9H3N1	TMX1 (thioredoxin-related transmembrane protein 1)	0.58	0.196
	Q16891	MIC60 (MICOS complex subunit)	0.58	0.148
	Q9UBS4	DJB11 (DnaJ homolog subfamily B member 11)	0.59	0.148
	O75964	ATP5L (ATP synthase subunit g, mitochondrial)	0.60	0.119
	O00592	PODXL (podocalyxin)	0.64	0.107
	P18084	ITB5 (integrin beta-5)	0.65	0.139
	Q5VV41	ARHGG (rho guanine nucleotide exchange factor 16)	0.81	0.004
MII oocytes	P01857	IGHG1 (immunoglobulin heavy constant gamma 1)	−0.69	0.047
	Q6UB35	C1TM (monofunctional C1-tetrahydrofolate synthase, mitochondrial)	−0.69	0.071
	Q14894	CRYM (ketimine reductase mu-crystallin)	−0.68	0.047
	O60547	GMDS (GDP-mannose 4,6 dehydratase)	−0.61	0.145
	Q9NQI0	DDX4 (probable ATP-dependent RNA helicase)	−0.60	0.160
	P80723	BASP1 (brain acid soluble protein 1)	0.67	0.070
	Q9UJS0	S2513 (electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial)	0.61	0.160

	Uniprot ID	Protein symbol (name)	R	P. adjusted
GV oocytes	P62195	PRS8 (26S proteasome regulatory subunit 8)	−0.71	0.030
	P62258	1433E (14-3-3 protein epsilon)	−0.70	0.031
	P11142	HSP7C (heat shock cognate 71 kDa protein)	−0.65	0.117
	Q9UNS2	CSN3 (COP9 signalosome complex subunit 3)	−0.64	0.117
	P09936	UCHL1 (ubiquitin carboxyl-terminal hydrolase isozyme L1)	−0.63	0.117
	P17980	PRS6A (26S proteasome regulatory subunit 6A)	−0.62	0.117
	P31948-2	STIP1 (stress-induced-phosphoprotein 1)	−0.62	0.117
	Q96FJ2	DYL2 (dynein light chain 2, cytoplasmic)	−0.62	0.109
	Q9UIC8	LCMT1 (leucine carboxyl methyltransferase 1)	−0.61	0.109
	P47756-2	CAPZB (F-actin-capping protein subunit beta)	−0.61	0.119
	Q02790	FKBP4 (peptidyl-prolyl cis-trans isomerase)	−0.58	0.148
	Q99832	TCPH (T-complex protein 1 subunit eta)	−0.58	0.159
	P35232	PHB1 (prohibitin 1)	0.57	0.180
	Q9H3N1	TMX1 (thioredoxin-related transmembrane protein 1)	0.58	0.196
	Q16891	MIC60 (MICOS complex subunit)	0.58	0.148
	Q9UBS4	DJB11 (DnaJ homolog subfamily B member 11)	0.59	0.148
	O75964	ATP5L (ATP synthase subunit g, mitochondrial)	0.60	0.119
	O00592	PODXL (podocalyxin)	0.64	0.107
	P18084	ITB5 (integrin beta-5)	0.65	0.139
	Q5VV41	ARHGG (rho guanine nucleotide exchange factor 16)	0.81	0.004
MII oocytes	P01857	IGHG1 (immunoglobulin heavy constant gamma 1)	−0.69	0.047
	Q6UB35	C1TM (monofunctional C1-tetrahydrofolate synthase, mitochondrial)	−0.69	0.071
	Q14894	CRYM (ketimine reductase mu-crystallin)	−0.68	0.047
	O60547	GMDS (GDP-mannose 4,6 dehydratase)	−0.61	0.145
	Q9NQI0	DDX4 (probable ATP-dependent RNA helicase)	−0.60	0.160
	P80723	BASP1 (brain acid soluble protein 1)	0.67	0.070
	Q9UJS0	S2513 (electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial)	0.61	0.160

Spearman test: R≥ ǀ0.5|, P.adj ≤ 0.2; GV, germinal vesicle; MII, metaphase II.

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