Table 4 Open in new tab Receiver...

Table 4

Receiver operating curve (ROC) analysis and optimal cut-offs for multiple echocardiographic parameters commonly used in the evaluation of cardiac amyloidosis

	ROC AUC	Optimal cut-off	Sensitivity	Specificity	NPV	PPV	Accuracy
LV EF	0.56	54	0.60	0.48	0.30	0.76	0.55
LV EDVi	0.72	53	0.79	0.61	0.32	0.92	0.74
RWT	0.77	0.57	0.74	0.73	0.51	0.88	0.74
E/A	0.67	1.06	0.68	0.61	0.52	0.74	0.65
E/e′	0.62	18.4	0.38	0.73	0.32	0.80	0.50
LV GLS	0.57	−17.0	0.71	0.42	0.35	0.77	0.64
ASR	0.74	1.67	0.72	0.66	0.50	0.84	0.74
TAPSE	0.69	18.1	0.67	0.62	0.39	0.83	0.64
RV FAC	0.68	33	0.55	0.73	0.34	0.85	0.58
LAS	0.68	11	0.52	0.73	0.34	0.84	0.55
EF/LS	0.55	3.4	0.51	0.59	0.31	0.77	0.56
LVMi/LS	0.56	6.4	0.66	0.50	0.22	0.87	0.66
AMYLI	0.74	7.8	0.76	0.65	0.51	0.83	0.73
MCF	0.68	26	0.68	0.65	0.26	0.92	0.68

	ROC AUC	Optimal cut-off	Sensitivity	Specificity	NPV	PPV	Accuracy
LV EF	0.56	54	0.60	0.48	0.30	0.76	0.55
LV EDVi	0.72	53	0.79	0.61	0.32	0.92	0.74
RWT	0.77	0.57	0.74	0.73	0.51	0.88	0.74
E/A	0.67	1.06	0.68	0.61	0.52	0.74	0.65
E/e′	0.62	18.4	0.38	0.73	0.32	0.80	0.50
LV GLS	0.57	−17.0	0.71	0.42	0.35	0.77	0.64
ASR	0.74	1.67	0.72	0.66	0.50	0.84	0.74
TAPSE	0.69	18.1	0.67	0.62	0.39	0.83	0.64
RV FAC	0.68	33	0.55	0.73	0.34	0.85	0.58
LAS	0.68	11	0.52	0.73	0.34	0.84	0.55
EF/LS	0.55	3.4	0.51	0.59	0.31	0.77	0.56
LVMi/LS	0.56	6.4	0.66	0.50	0.22	0.87	0.66
AMYLI	0.74	7.8	0.76	0.65	0.51	0.83	0.73
MCF	0.68	26	0.68	0.65	0.26	0.92	0.68

Parameters that showed highest accuracy (>0.70) are shown in bold.

LVEF, left ventricular ejection fraction; LVEDVi, left ventricular end-diastolic volume indexed; RWT, relative wall thickness; LV GLS, left ventricular global longitudinal strain; ASR, apical sparing ratio; LAS, left atrial strain; MCF, myocardial contraction fraction; ROC, receiver operating curve; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value.

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