Table 1.

Characteristics of Individuals in the Cohort

UntreatedNMV-r Treated a
Pre–Omicron Era (n = 18 005)Omicron Era (n = 12 281)Omicron Era (n = 372)
Male8882 (49)5584 (45)161 (43)
Age, y, mean (SD)40.1 (15.9)44.7 (16.9)57.6 (14.9)
 <6516 749 (93)10 588 (86)246 (66)
 ≥651256 (7)1693 (14)126 (34)
Vaccinated: ≥1 SARS-CoV-2 vaccine1277 (7.1)6593 (54)272 (73)
Continuous 6-mo medical/pharmacy enrollment b5068 (26)3479 (28)131 (35)
High risk within those with 6-mo enrollment b,c2415 (48)1893 (54)96 (73)
Hospitalized within 30 d of index date154 (0.9)92 (0.8)1 (0.3)
Geographic region
 Northeast1754 (10)1047 (9)46 (12)
 Midwest1939 (11)1077 (9)13 (4)
 South12 091 (67)7735 (63)235 (63)
 West1387 (8)1897 (15)50 (13)
 Not available834 (5)525 (4)28 (8)
UntreatedNMV-r Treated a
Pre–Omicron Era (n = 18 005)Omicron Era (n = 12 281)Omicron Era (n = 372)
Male8882 (49)5584 (45)161 (43)
Age, y, mean (SD)40.1 (15.9)44.7 (16.9)57.6 (14.9)
 <6516 749 (93)10 588 (86)246 (66)
 ≥651256 (7)1693 (14)126 (34)
Vaccinated: ≥1 SARS-CoV-2 vaccine1277 (7.1)6593 (54)272 (73)
Continuous 6-mo medical/pharmacy enrollment b5068 (26)3479 (28)131 (35)
High risk within those with 6-mo enrollment b,c2415 (48)1893 (54)96 (73)
Hospitalized within 30 d of index date154 (0.9)92 (0.8)1 (0.3)
Geographic region
 Northeast1754 (10)1047 (9)46 (12)
 Midwest1939 (11)1077 (9)13 (4)
 South12 091 (67)7735 (63)235 (63)
 West1387 (8)1897 (15)50 (13)
 Not available834 (5)525 (4)28 (8)

Data are presented as No. (%) unless noted otherwise.

Abbreviation: NMV-r, nirmatrelvir/ritonavir.

aExcludes patients treated with other SARS-CoV-2 therapies.

bAllowed for a 30-day gap in coverage.

cHigh-risk status for progression to severe SARS-CoV-2 infection.

Table 1.

Characteristics of Individuals in the Cohort

UntreatedNMV-r Treated a
Pre–Omicron Era (n = 18 005)Omicron Era (n = 12 281)Omicron Era (n = 372)
Male8882 (49)5584 (45)161 (43)
Age, y, mean (SD)40.1 (15.9)44.7 (16.9)57.6 (14.9)
 <6516 749 (93)10 588 (86)246 (66)
 ≥651256 (7)1693 (14)126 (34)
Vaccinated: ≥1 SARS-CoV-2 vaccine1277 (7.1)6593 (54)272 (73)
Continuous 6-mo medical/pharmacy enrollment b5068 (26)3479 (28)131 (35)
High risk within those with 6-mo enrollment b,c2415 (48)1893 (54)96 (73)
Hospitalized within 30 d of index date154 (0.9)92 (0.8)1 (0.3)
Geographic region
 Northeast1754 (10)1047 (9)46 (12)
 Midwest1939 (11)1077 (9)13 (4)
 South12 091 (67)7735 (63)235 (63)
 West1387 (8)1897 (15)50 (13)
 Not available834 (5)525 (4)28 (8)
UntreatedNMV-r Treated a
Pre–Omicron Era (n = 18 005)Omicron Era (n = 12 281)Omicron Era (n = 372)
Male8882 (49)5584 (45)161 (43)
Age, y, mean (SD)40.1 (15.9)44.7 (16.9)57.6 (14.9)
 <6516 749 (93)10 588 (86)246 (66)
 ≥651256 (7)1693 (14)126 (34)
Vaccinated: ≥1 SARS-CoV-2 vaccine1277 (7.1)6593 (54)272 (73)
Continuous 6-mo medical/pharmacy enrollment b5068 (26)3479 (28)131 (35)
High risk within those with 6-mo enrollment b,c2415 (48)1893 (54)96 (73)
Hospitalized within 30 d of index date154 (0.9)92 (0.8)1 (0.3)
Geographic region
 Northeast1754 (10)1047 (9)46 (12)
 Midwest1939 (11)1077 (9)13 (4)
 South12 091 (67)7735 (63)235 (63)
 West1387 (8)1897 (15)50 (13)
 Not available834 (5)525 (4)28 (8)

Data are presented as No. (%) unless noted otherwise.

Abbreviation: NMV-r, nirmatrelvir/ritonavir.

aExcludes patients treated with other SARS-CoV-2 therapies.

bAllowed for a 30-day gap in coverage.

cHigh-risk status for progression to severe SARS-CoV-2 infection.

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