Multivariate Analysis of the Factors Associated With Survival Through 6 Months After Discharge Among Patients Presenting With Central Line–Associated Bloodstream Infections Present on Admission
| Factors . | Multivariate HR . | 95% CI . | P Value . |
|---|---|---|---|
| Age, y | |||
| 0–19 | 1 | … | … |
| 20–44 | 11.21 | (1.46–86.22) | .02 |
| 45–64 | 20.88 | (2.84–153.58) | .003 |
| ≥65 | 22.50 | (2.98–169.93) | .003 |
| Sex | |||
| Female | 1 | … | .36 |
| Male | 0.85 | (.60–1.20) | |
| Race | |||
| Non-Hispanic white | 1 | … | … |
| Non-Hispanic black | 1.15 | (.79–1.68) | .45 |
| Hispanic | 0.54 | (.13–2.31) | .41 |
| Other | 0.86 | (.33–2.20) | .75 |
| Insurance | |||
| Medicaid | 1 | … | … |
| Medicare | 1.25 | (.63–2.46) | .52 |
| Private | 1.26 | (.65–2.47) | .49 |
| Uninsured | 2.46 | (1.08–5.59) | .03 |
| VA/TRICARE/other governmental | 1.29 | (.40–4.19) | .67 |
| 30-d Readmission status of index admission | |||
| No | 1 | … | .07 |
| Yes | 1.38 | (.97–1.96) | |
| Presence of prior CLABSI | |||
| No | 1 | … | .06 |
| Yes | 0.78 | (.59–1.02) | |
| Chemotherapy within past 6 mo | |||
| No | 1 | … | .08 |
| Yes | 1.40 | (.96–2.06) | |
| Need for PN within past month | |||
| No | 1 | … | .14 |
| Yes | 0.64 | (.35–1.16) | |
| Enterobacterales | |||
| No | 1 | … | .89 |
| Yes | 1.03 | (.67–1.60) | |
| Coagulase-negative staphylococci | |||
| No | 1 | … | .94 |
| Yes | 0.98 | (.62–1.56) | |
| Staphylococcus aureus | |||
| No | 1 | … | .59 |
| Yes | 0.84 | (.44–1.59) | |
| Streptococcus | |||
| No | 1 | … | .16 |
| Yes | 1.40 | (.88–2.22) | |
| Non-Enterobacteriaceae GNR | |||
| No | 1 | … | .84 |
| Yes | 1.06 | (.59–1.92) | |
| Yeast | |||
| No | 1 | … | .21 |
| Yes | 1.58 | (.78–3.23) | |
| Anaerobes | |||
| No | 1 | … | .48 |
| Yes | .73 | (.30–1.74) | |
| MDRO | |||
| No | 1 | … | .35 |
| Yes | 1.32 | (.74–2.35) | |
| Removal of CVC during admission | |||
| No | 1 | … | .004 |
| Yes | 0.57 | (.39–.84) |
| Factors . | Multivariate HR . | 95% CI . | P Value . |
|---|---|---|---|
| Age, y | |||
| 0–19 | 1 | … | … |
| 20–44 | 11.21 | (1.46–86.22) | .02 |
| 45–64 | 20.88 | (2.84–153.58) | .003 |
| ≥65 | 22.50 | (2.98–169.93) | .003 |
| Sex | |||
| Female | 1 | … | .36 |
| Male | 0.85 | (.60–1.20) | |
| Race | |||
| Non-Hispanic white | 1 | … | … |
| Non-Hispanic black | 1.15 | (.79–1.68) | .45 |
| Hispanic | 0.54 | (.13–2.31) | .41 |
| Other | 0.86 | (.33–2.20) | .75 |
| Insurance | |||
| Medicaid | 1 | … | … |
| Medicare | 1.25 | (.63–2.46) | .52 |
| Private | 1.26 | (.65–2.47) | .49 |
| Uninsured | 2.46 | (1.08–5.59) | .03 |
| VA/TRICARE/other governmental | 1.29 | (.40–4.19) | .67 |
| 30-d Readmission status of index admission | |||
| No | 1 | … | .07 |
| Yes | 1.38 | (.97–1.96) | |
| Presence of prior CLABSI | |||
| No | 1 | … | .06 |
| Yes | 0.78 | (.59–1.02) | |
| Chemotherapy within past 6 mo | |||
| No | 1 | … | .08 |
| Yes | 1.40 | (.96–2.06) | |
| Need for PN within past month | |||
| No | 1 | … | .14 |
| Yes | 0.64 | (.35–1.16) | |
| Enterobacterales | |||
| No | 1 | … | .89 |
| Yes | 1.03 | (.67–1.60) | |
| Coagulase-negative staphylococci | |||
| No | 1 | … | .94 |
| Yes | 0.98 | (.62–1.56) | |
| Staphylococcus aureus | |||
| No | 1 | … | .59 |
| Yes | 0.84 | (.44–1.59) | |
| Streptococcus | |||
| No | 1 | … | .16 |
| Yes | 1.40 | (.88–2.22) | |
| Non-Enterobacteriaceae GNR | |||
| No | 1 | … | .84 |
| Yes | 1.06 | (.59–1.92) | |
| Yeast | |||
| No | 1 | … | .21 |
| Yes | 1.58 | (.78–3.23) | |
| Anaerobes | |||
| No | 1 | … | .48 |
| Yes | .73 | (.30–1.74) | |
| MDRO | |||
| No | 1 | … | .35 |
| Yes | 1.32 | (.74–2.35) | |
| Removal of CVC during admission | |||
| No | 1 | … | .004 |
| Yes | 0.57 | (.39–.84) |
Abbreviation: CI, confidence interval; CVC, central venous catheter; CLABSI, central line–associated bloodstream infection; CLABSI-POA, CLABSI present on admission; GNR, gram-negative rod; HR, hazard ratio; MDRO, multidrug-resistant organism; PN, parenteral nutrition; VA, Veterans Affairs.
Multivariate Analysis of the Factors Associated With Survival Through 6 Months After Discharge Among Patients Presenting With Central Line–Associated Bloodstream Infections Present on Admission
| Factors . | Multivariate HR . | 95% CI . | P Value . |
|---|---|---|---|
| Age, y | |||
| 0–19 | 1 | … | … |
| 20–44 | 11.21 | (1.46–86.22) | .02 |
| 45–64 | 20.88 | (2.84–153.58) | .003 |
| ≥65 | 22.50 | (2.98–169.93) | .003 |
| Sex | |||
| Female | 1 | … | .36 |
| Male | 0.85 | (.60–1.20) | |
| Race | |||
| Non-Hispanic white | 1 | … | … |
| Non-Hispanic black | 1.15 | (.79–1.68) | .45 |
| Hispanic | 0.54 | (.13–2.31) | .41 |
| Other | 0.86 | (.33–2.20) | .75 |
| Insurance | |||
| Medicaid | 1 | … | … |
| Medicare | 1.25 | (.63–2.46) | .52 |
| Private | 1.26 | (.65–2.47) | .49 |
| Uninsured | 2.46 | (1.08–5.59) | .03 |
| VA/TRICARE/other governmental | 1.29 | (.40–4.19) | .67 |
| 30-d Readmission status of index admission | |||
| No | 1 | … | .07 |
| Yes | 1.38 | (.97–1.96) | |
| Presence of prior CLABSI | |||
| No | 1 | … | .06 |
| Yes | 0.78 | (.59–1.02) | |
| Chemotherapy within past 6 mo | |||
| No | 1 | … | .08 |
| Yes | 1.40 | (.96–2.06) | |
| Need for PN within past month | |||
| No | 1 | … | .14 |
| Yes | 0.64 | (.35–1.16) | |
| Enterobacterales | |||
| No | 1 | … | .89 |
| Yes | 1.03 | (.67–1.60) | |
| Coagulase-negative staphylococci | |||
| No | 1 | … | .94 |
| Yes | 0.98 | (.62–1.56) | |
| Staphylococcus aureus | |||
| No | 1 | … | .59 |
| Yes | 0.84 | (.44–1.59) | |
| Streptococcus | |||
| No | 1 | … | .16 |
| Yes | 1.40 | (.88–2.22) | |
| Non-Enterobacteriaceae GNR | |||
| No | 1 | … | .84 |
| Yes | 1.06 | (.59–1.92) | |
| Yeast | |||
| No | 1 | … | .21 |
| Yes | 1.58 | (.78–3.23) | |
| Anaerobes | |||
| No | 1 | … | .48 |
| Yes | .73 | (.30–1.74) | |
| MDRO | |||
| No | 1 | … | .35 |
| Yes | 1.32 | (.74–2.35) | |
| Removal of CVC during admission | |||
| No | 1 | … | .004 |
| Yes | 0.57 | (.39–.84) |
| Factors . | Multivariate HR . | 95% CI . | P Value . |
|---|---|---|---|
| Age, y | |||
| 0–19 | 1 | … | … |
| 20–44 | 11.21 | (1.46–86.22) | .02 |
| 45–64 | 20.88 | (2.84–153.58) | .003 |
| ≥65 | 22.50 | (2.98–169.93) | .003 |
| Sex | |||
| Female | 1 | … | .36 |
| Male | 0.85 | (.60–1.20) | |
| Race | |||
| Non-Hispanic white | 1 | … | … |
| Non-Hispanic black | 1.15 | (.79–1.68) | .45 |
| Hispanic | 0.54 | (.13–2.31) | .41 |
| Other | 0.86 | (.33–2.20) | .75 |
| Insurance | |||
| Medicaid | 1 | … | … |
| Medicare | 1.25 | (.63–2.46) | .52 |
| Private | 1.26 | (.65–2.47) | .49 |
| Uninsured | 2.46 | (1.08–5.59) | .03 |
| VA/TRICARE/other governmental | 1.29 | (.40–4.19) | .67 |
| 30-d Readmission status of index admission | |||
| No | 1 | … | .07 |
| Yes | 1.38 | (.97–1.96) | |
| Presence of prior CLABSI | |||
| No | 1 | … | .06 |
| Yes | 0.78 | (.59–1.02) | |
| Chemotherapy within past 6 mo | |||
| No | 1 | … | .08 |
| Yes | 1.40 | (.96–2.06) | |
| Need for PN within past month | |||
| No | 1 | … | .14 |
| Yes | 0.64 | (.35–1.16) | |
| Enterobacterales | |||
| No | 1 | … | .89 |
| Yes | 1.03 | (.67–1.60) | |
| Coagulase-negative staphylococci | |||
| No | 1 | … | .94 |
| Yes | 0.98 | (.62–1.56) | |
| Staphylococcus aureus | |||
| No | 1 | … | .59 |
| Yes | 0.84 | (.44–1.59) | |
| Streptococcus | |||
| No | 1 | … | .16 |
| Yes | 1.40 | (.88–2.22) | |
| Non-Enterobacteriaceae GNR | |||
| No | 1 | … | .84 |
| Yes | 1.06 | (.59–1.92) | |
| Yeast | |||
| No | 1 | … | .21 |
| Yes | 1.58 | (.78–3.23) | |
| Anaerobes | |||
| No | 1 | … | .48 |
| Yes | .73 | (.30–1.74) | |
| MDRO | |||
| No | 1 | … | .35 |
| Yes | 1.32 | (.74–2.35) | |
| Removal of CVC during admission | |||
| No | 1 | … | .004 |
| Yes | 0.57 | (.39–.84) |
Abbreviation: CI, confidence interval; CVC, central venous catheter; CLABSI, central line–associated bloodstream infection; CLABSI-POA, CLABSI present on admission; GNR, gram-negative rod; HR, hazard ratio; MDRO, multidrug-resistant organism; PN, parenteral nutrition; VA, Veterans Affairs.
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