Table 2 Open in new tab fMRI activations...

Brain region	Lat.	Cluster size	Unc. P-value	SVC P-value	Peak T	Peak Z	X	Y	Z
*Increasing Relational Distance ([inf. 1 + inf. 2] > [2direct]) for both Genetic Groups and Exercising Conditions—**Fig. 3(A)
Precuneus	Right	799	<0.001		9.11	7.03	18	−52	14
Lingual gyrus	Left	576	<0.001		8.36	6.65	−24	−46	−8
Hippocampus	Left	<0.001	0.005	7.89	6.39	−18	−34	−12
Hippocampus	Right	1079	<0.001	<0.001	8.33	6.63	28	−44	−4
Parahippocampus	Right	<0.001		7.97	6.43	24	−36	−10
Calcarine gyrus	Left	495	<0.001		7.13	5.94	−16	−54	12
Occipital gyrus	Left	270	<0.001		4.80	4.36	−12	−86	−2
([control > risk] > [exercise > rest]) for all Relational Distance trials—Fig. 3(B)
Thalamus	Right	72	<0.001		4.99	4.49	10	−22	22
Left cerebellum IV–V	Left	27	<0.001		4.01	3.72	−6	−44	−12
Medial temporal lobe	Right	11	<0.001		3.54	3.33	32	−2	−26
[exercise > rest] in the control group for all Relational Distance trials—Fig. 3C
Parahippocampus	Left	18	<0.001		4.20	3.88	−30	−40	−4
Hippocampus	Right	17	<0.001	0.024	3.82	3.57	20	−16	−20
Angular gyrus	Right	44	<0.001		3.72	3.48	50	−64	32
Superior medial prefrontal gyrus	Right	39	<0.001		3.69	3.46	4	52	2
[exercise > rest] in the risk group for all Relational Distance trials
Middle frontal gyrus	Right	36	<0.001		4.39	4.033757	42	30	44
Whole-brain correlation between AEA changes and contrast [exercise > rest] in the control group for all Relational Distance trials—Fig. 4
Hippocampus	Right	13	<0.001	0.026	5.11	3.72	8	−14	−20

Brain region

Lat.

Cluster size

Unc. P-value

SVC P-value

Peak T

Peak Z

Increasing Relational Distance ([inf. 1 + inf. 2] > [2*direct]) for both Genetic Groups and Exercising Conditions—Fig. 3(A)

Precuneus

Right

799

<0.001

9.11

7.03

−52

Lingual gyrus

Left

576

<0.001

8.36

6.65

−24

−46

−8

Hippocampus

Left

<0.001

0.005

7.89

6.39

−18

−34

−12

Hippocampus

Right

1079

<0.001

8.33

6.63

−44

−4

Parahippocampus

Right

<0.001

7.97

6.43

−36

−10

Calcarine gyrus

Left

495

<0.001

7.13

5.94

−16

−54

Occipital gyrus

Left

270

<0.001

4.80

4.36

−12

−86

−2

([control > risk] > [exercise > rest]) for all Relational Distance trials—Fig. 3(B)

Thalamus

Right

<0.001

4.99

4.49

−22

Left cerebellum IV–V

Left

<0.001

4.01

3.72

−6

−44

−12

Medial temporal lobe

Right

<0.001

3.54

3.33

−2

−26

[exercise > rest] in the control group for all Relational Distance trials—Fig. 3C

Parahippocampus

Left

<0.001

4.20

3.88

−30

−40

−4

Hippocampus

Right

<0.001

0.024

3.82

3.57

−16

−20

Angular gyrus

Right

<0.001

3.72

3.48

−64

Superior medial prefrontal gyrus

Right

<0.001

3.69

3.46

[exercise > rest] in the risk group for all Relational Distance trials

Middle frontal gyrus

Right

<0.001

4.39

4.033757

Whole-brain correlation between AEA changes and contrast [exercise > rest] in the control group for all Relational Distance trials—Fig. 4

Hippocampus

Right

<0.001

0.026

5.11

3.72

−14

−20

Brain region	Lat.	Cluster size	Unc. P-value	SVC P-value	Peak T	Peak Z	X	Y	Z
*Increasing Relational Distance ([inf. 1 + inf. 2] > [2direct]) for both Genetic Groups and Exercising Conditions—**Fig. 3(A)
Precuneus	Right	799	<0.001		9.11	7.03	18	−52	14
Lingual gyrus	Left	576	<0.001		8.36	6.65	−24	−46	−8
Hippocampus	Left	<0.001	0.005	7.89	6.39	−18	−34	−12
Hippocampus	Right	1079	<0.001	<0.001	8.33	6.63	28	−44	−4
Parahippocampus	Right	<0.001		7.97	6.43	24	−36	−10
Calcarine gyrus	Left	495	<0.001		7.13	5.94	−16	−54	12
Occipital gyrus	Left	270	<0.001		4.80	4.36	−12	−86	−2
([control > risk] > [exercise > rest]) for all Relational Distance trials—Fig. 3(B)
Thalamus	Right	72	<0.001		4.99	4.49	10	−22	22
Left cerebellum IV–V	Left	27	<0.001		4.01	3.72	−6	−44	−12
Medial temporal lobe	Right	11	<0.001		3.54	3.33	32	−2	−26
[exercise > rest] in the control group for all Relational Distance trials—Fig. 3C
Parahippocampus	Left	18	<0.001		4.20	3.88	−30	−40	−4
Hippocampus	Right	17	<0.001	0.024	3.82	3.57	20	−16	−20
Angular gyrus	Right	44	<0.001		3.72	3.48	50	−64	32
Superior medial prefrontal gyrus	Right	39	<0.001		3.69	3.46	4	52	2
[exercise > rest] in the risk group for all Relational Distance trials
Middle frontal gyrus	Right	36	<0.001		4.39	4.033757	42	30	44
Whole-brain correlation between AEA changes and contrast [exercise > rest] in the control group for all Relational Distance trials—Fig. 4
Hippocampus	Right	13	<0.001	0.026	5.11	3.72	8	−14	−20

Table 2

Open in new tab

fMRI activations for the main contrasts of interest.

Brain region	Lat.	Cluster size	Unc. P-value	SVC P-value	Peak T	Peak Z	X	Y	Z
*Increasing Relational Distance ([inf. 1 + inf. 2] > [2direct]) for both Genetic Groups and Exercising Conditions—**Fig. 3(A)
Precuneus	Right	799	<0.001		9.11	7.03	18	−52	14
Lingual gyrus	Left	576	<0.001		8.36	6.65	−24	−46	−8
Hippocampus	Left	576	<0.001	0.005	7.89	6.39	−18	−34	−12
Hippocampus	Right	1079	<0.001	<0.001	8.33	6.63	28	−44	−4
Parahippocampus	Right	1079	<0.001		7.97	6.43	24	−36	−10
Calcarine gyrus	Left	495	<0.001		7.13	5.94	−16	−54	12
Occipital gyrus	Left	270	<0.001		4.80	4.36	−12	−86	−2
([control > risk] > [exercise > rest]) for all Relational Distance trials—Fig. 3(B)
Thalamus	Right	72	<0.001		4.99	4.49	10	−22	22
Left cerebellum IV–V	Left	27	<0.001		4.01	3.72	−6	−44	−12
Medial temporal lobe	Right	11	<0.001		3.54	3.33	32	−2	−26
[exercise > rest] in the control group for all Relational Distance trials—Fig. 3C
Parahippocampus	Left	18	<0.001		4.20	3.88	−30	−40	−4
Hippocampus	Right	17	<0.001	0.024	3.82	3.57	20	−16	−20
Angular gyrus	Right	44	<0.001		3.72	3.48	50	−64	32
Superior medial prefrontal gyrus	Right	39	<0.001		3.69	3.46	4	52	2
[exercise > rest] in the risk group for all Relational Distance trials
Middle frontal gyrus	Right	36	<0.001		4.39	4.033757	42	30	44
Whole-brain correlation between AEA changes and contrast [exercise > rest] in the control group for all Relational Distance trials—Fig. 4
Hippocampus	Right	13	<0.001	0.026	5.11	3.72	8	−14	−20

Brain region	Lat.	Cluster size	Unc. P-value	SVC P-value	Peak T	Peak Z	X	Y	Z
*Increasing Relational Distance ([inf. 1 + inf. 2] > [2direct]) for both Genetic Groups and Exercising Conditions—**Fig. 3(A)
Precuneus	Right	799	<0.001		9.11	7.03	18	−52	14
Lingual gyrus	Left	576	<0.001		8.36	6.65	−24	−46	−8
Hippocampus	Left	576	<0.001	0.005	7.89	6.39	−18	−34	−12
Hippocampus	Right	1079	<0.001	<0.001	8.33	6.63	28	−44	−4
Parahippocampus	Right	1079	<0.001		7.97	6.43	24	−36	−10
Calcarine gyrus	Left	495	<0.001		7.13	5.94	−16	−54	12
Occipital gyrus	Left	270	<0.001		4.80	4.36	−12	−86	−2
([control > risk] > [exercise > rest]) for all Relational Distance trials—Fig. 3(B)
Thalamus	Right	72	<0.001		4.99	4.49	10	−22	22
Left cerebellum IV–V	Left	27	<0.001		4.01	3.72	−6	−44	−12
Medial temporal lobe	Right	11	<0.001		3.54	3.33	32	−2	−26
[exercise > rest] in the control group for all Relational Distance trials—Fig. 3C
Parahippocampus	Left	18	<0.001		4.20	3.88	−30	−40	−4
Hippocampus	Right	17	<0.001	0.024	3.82	3.57	20	−16	−20
Angular gyrus	Right	44	<0.001		3.72	3.48	50	−64	32
Superior medial prefrontal gyrus	Right	39	<0.001		3.69	3.46	4	52	2
[exercise > rest] in the risk group for all Relational Distance trials
Middle frontal gyrus	Right	36	<0.001		4.39	4.033757	42	30	44
Whole-brain correlation between AEA changes and contrast [exercise > rest] in the control group for all Relational Distance trials—Fig. 4
Hippocampus	Right	13	<0.001	0.026	5.11	3.72	8	−14	−20

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