Table 3. Open in new tab Risk Factors...

	Posaconazole Level <1.8 µg/mL (n = 67)	Posaconazole Level ≥1.8 µg/mL (n = 31)		Multivariable Logistic Regression
Age, median (IQR), y	60.00 (53.00–68.00)	…	64.00 (57.00–69.00)	…	.206	…	…
Weight, median (IQR), kg	83.00 (68.20–93.00)	…	75.90 (61.10–91.70)	…	.148	0.99 (0.96–1.02)	.487
Weight >90 kg	19	28.4%	9	29.0%	.945	…	…
Height, median (IQR), cm	177.00 (168.00–182.00)	…	167.00 (160.00–177.00)	…	.004	…	…
IBW, median (IQR), kg	70.46 (62.34–76.80)	…	63.22 (52.38–72.28)	…	.003	…	…
IBW ≥60 kg	54	80.6%	16	51.6%	.003	0.26 (0.06–1.11)	.070
BMI, median (IQR), kg/m²	26.04 (23.49–30.30)	…	28.84 (23.71–30.55)	…	.529	…	…
Female gender	17	25.4%	16	51.6%	.011	0.90 (0.20–4.03)	0.895
AML	32	47.8%	15	48.4%	.954	…	…
Myeloid malignancy	47	70.1%	21	67.7%	.810	…	…
AlloSCT	32	47.8%	17	54.8%	.515	…	…
GI aGVHD	4	6.0%	6	19.4%	.068	3.80 (0.82–17.58)	.087
Interacting drug—any	55	82.1%	27	87.1%	.533	…	…
PPI	34	50.7%	17	54.8%	.706	…	…
Antacid, single agent	54	80.6%	26	83.9%	.697	…	…
Diarrhea	16	23.9%	5	16.1%	.384	…	…
Albumin ≤3 g/dL	37	55.2%	10	32.3%	.034	0.35 (0.13–0.94)	.036

Posaconazole Level <1.8 µg/mL
(n = 67)

Posaconazole Level ≥1.8 µg/mL
(n = 31)

Multivariable Logistic Regression

Risk Factor

P Value

OR (95% CI)

P Value

Age, median (IQR), y

60.00 (53.00–68.00)

…

64.00 (57.00–69.00)

…

.206

…

Weight, median (IQR), kg

83.00 (68.20–93.00)

…

75.90 (61.10–91.70)

…

.148

0.99 (0.96–1.02)

.487

Weight >90 kg

28.4%

29.0%

.945

…

Height, median (IQR), cm

177.00 (168.00–182.00)

…

167.00 (160.00–177.00)

…

.004

…

IBW, median (IQR), kg

70.46 (62.34–76.80)

…

63.22 (52.38–72.28)

…

.003

…

IBW ≥60 kg

80.6%

51.6%

.003

0.26 (0.06–1.11)

.070

BMI, median (IQR), kg/m²

26.04 (23.49–30.30)

…

28.84 (23.71–30.55)

…

.529

…

Female gender

25.4%

51.6%

.011

0.90 (0.20–4.03)

0.895

AML

47.8%

48.4%

.954

…

Myeloid malignancy

70.1%

67.7%

.810

…

AlloSCT

47.8%

54.8%

.515

…

GI aGVHD

6.0%

19.4%

.068

3.80 (0.82–17.58)

.087

Interacting drug—any

82.1%

87.1%

.533

…

PPI

50.7%

54.8%

.706

…

Antacid, single agent

80.6%

83.9%

.697

…

Diarrhea

23.9%

16.1%

.384

…

Albumin ≤3 g/dL

55.2%

32.3%

.034

0.35 (0.13–0.94)

.036

	Posaconazole Level <1.8 µg/mL (n = 67)	Posaconazole Level ≥1.8 µg/mL (n = 31)		Multivariable Logistic Regression
Age, median (IQR), y	60.00 (53.00–68.00)	…	64.00 (57.00–69.00)	…	.206	…	…
Weight, median (IQR), kg	83.00 (68.20–93.00)	…	75.90 (61.10–91.70)	…	.148	0.99 (0.96–1.02)	.487
Weight >90 kg	19	28.4%	9	29.0%	.945	…	…
Height, median (IQR), cm	177.00 (168.00–182.00)	…	167.00 (160.00–177.00)	…	.004	…	…
IBW, median (IQR), kg	70.46 (62.34–76.80)	…	63.22 (52.38–72.28)	…	.003	…	…
IBW ≥60 kg	54	80.6%	16	51.6%	.003	0.26 (0.06–1.11)	.070
BMI, median (IQR), kg/m²	26.04 (23.49–30.30)	…	28.84 (23.71–30.55)	…	.529	…	…
Female gender	17	25.4%	16	51.6%	.011	0.90 (0.20–4.03)	0.895
AML	32	47.8%	15	48.4%	.954	…	…
Myeloid malignancy	47	70.1%	21	67.7%	.810	…	…
AlloSCT	32	47.8%	17	54.8%	.515	…	…
GI aGVHD	4	6.0%	6	19.4%	.068	3.80 (0.82–17.58)	.087
Interacting drug—any	55	82.1%	27	87.1%	.533	…	…
PPI	34	50.7%	17	54.8%	.706	…	…
Antacid, single agent	54	80.6%	26	83.9%	.697	…	…
Diarrhea	16	23.9%	5	16.1%	.384	…	…
Albumin ≤3 g/dL	37	55.2%	10	32.3%	.034	0.35 (0.13–0.94)	.036

Table 3.

Open in new tab

Risk Factors for Subtherapeutic Posaconazole Concentrations for a Target Concentration ≥ 1.8 µg/mL

	Posaconazole Level <1.8 µg/mL (n = 67)		Posaconazole Level ≥1.8 µg/mL (n = 31)			Multivariable Logistic Regression
Risk Factor	Posaconazole Level <1.8 µg/mL (n = 67)		Posaconazole Level ≥1.8 µg/mL (n = 31)		P Value	OR (95% CI)	P Value
Age, median (IQR), y	60.00 (53.00–68.00)	…	64.00 (57.00–69.00)	…	.206	…	…
Weight, median (IQR), kg	83.00 (68.20–93.00)	…	75.90 (61.10–91.70)	…	.148	0.99 (0.96–1.02)	.487
Weight >90 kg	19	28.4%	9	29.0%	.945	…	…
Height, median (IQR), cm	177.00 (168.00–182.00)	…	167.00 (160.00–177.00)	…	.004	…	…
IBW, median (IQR), kg	70.46 (62.34–76.80)	…	63.22 (52.38–72.28)	…	.003	…	…
IBW ≥60 kg	54	80.6%	16	51.6%	.003	0.26 (0.06–1.11)	.070
BMI, median (IQR), kg/m²	26.04 (23.49–30.30)	…	28.84 (23.71–30.55)	…	.529	…	…
Female gender	17	25.4%	16	51.6%	.011	0.90 (0.20–4.03)	0.895
AML	32	47.8%	15	48.4%	.954	…	…
Myeloid malignancy	47	70.1%	21	67.7%	.810	…	…
AlloSCT	32	47.8%	17	54.8%	.515	…	…
GI aGVHD	4	6.0%	6	19.4%	.068	3.80 (0.82–17.58)	.087
Interacting drug—any	55	82.1%	27	87.1%	.533	…	…
PPI	34	50.7%	17	54.8%	.706	…	…
Antacid, single agent	54	80.6%	26	83.9%	.697	…	…
Diarrhea	16	23.9%	5	16.1%	.384	…	…
Albumin ≤3 g/dL	37	55.2%	10	32.3%	.034	0.35 (0.13–0.94)	.036

	Posaconazole Level <1.8 µg/mL (n = 67)		Posaconazole Level ≥1.8 µg/mL (n = 31)			Multivariable Logistic Regression
Risk Factor	Posaconazole Level <1.8 µg/mL (n = 67)		Posaconazole Level ≥1.8 µg/mL (n = 31)		P Value	OR (95% CI)	P Value
Age, median (IQR), y	60.00 (53.00–68.00)	…	64.00 (57.00–69.00)	…	.206	…	…
Weight, median (IQR), kg	83.00 (68.20–93.00)	…	75.90 (61.10–91.70)	…	.148	0.99 (0.96–1.02)	.487
Weight >90 kg	19	28.4%	9	29.0%	.945	…	…
Height, median (IQR), cm	177.00 (168.00–182.00)	…	167.00 (160.00–177.00)	…	.004	…	…
IBW, median (IQR), kg	70.46 (62.34–76.80)	…	63.22 (52.38–72.28)	…	.003	…	…
IBW ≥60 kg	54	80.6%	16	51.6%	.003	0.26 (0.06–1.11)	.070
BMI, median (IQR), kg/m²	26.04 (23.49–30.30)	…	28.84 (23.71–30.55)	…	.529	…	…
Female gender	17	25.4%	16	51.6%	.011	0.90 (0.20–4.03)	0.895
AML	32	47.8%	15	48.4%	.954	…	…
Myeloid malignancy	47	70.1%	21	67.7%	.810	…	…
AlloSCT	32	47.8%	17	54.8%	.515	…	…
GI aGVHD	4	6.0%	6	19.4%	.068	3.80 (0.82–17.58)	.087
Interacting drug—any	55	82.1%	27	87.1%	.533	…	…
PPI	34	50.7%	17	54.8%	.706	…	…
Antacid, single agent	54	80.6%	26	83.9%	.697	…	…
Diarrhea	16	23.9%	5	16.1%	.384	…	…
Albumin ≤3 g/dL	37	55.2%	10	32.3%	.034	0.35 (0.13–0.94)	.036

Abbreviations: AlloSCT, allogeneic stem cell transplant; AML, acute myeloid leukemia; BMI, body mass index; GI aGVHD, acute gastrointestinal graft-vs-host disease; IBW, ideal body weight; IQR, interquartile range; PPI, proton pump inhibitor.

This Feature Is Available To Subscribers Only