Table 3: Open in new tab Univariable and...

Parameters	Univariable	Multivariable
Age (ref. <70 years)
≥70	1.14	0.71–1.76	0.563
Gender (ref. male)
Female	0.82	0.54–1.20	0.300
Histological type (ref. LG-TC)
HG-TC	1.35	0.65–2.49	0.391
NOS-TC	1.20	0.73–1.88	0.446
Resection status (ref. R2 non-resection)
R0	0.16	0.09–0.28	<0.001	0.27	0.15–0.48	<0.001
R1	0.42	0.23–0.77	<0.001	0.40	0.22–0.74	0.004
R2 sub-total	0.43	0.22–0.81	<0.001	0.38	0.20–0.72	0.003
Pathological Masaoka stage (ref. I–II)
II	3.72	1.94–7.88	<0.001	2.97	1.45–6.10	0.003
IV	7.81	4.16–16.3	<0.001	4.96	2.33–10.5	<0.001
Preoperative CT (ref. no)
Yes	1.96	1.28–2.92	0.002	1.27	0.81–1.98	0.295
Postoperative RT (ref. no)
Yes	1.18	0.81–1.72	0.377	1.05	0.72–1.54	0.793

Parameters	Univariable	Multivariable
Age (ref. <70 years)
≥70	1.14	0.71–1.76	0.563
Gender (ref. male)
Female	0.82	0.54–1.20	0.300
Histological type (ref. LG-TC)
HG-TC	1.35	0.65–2.49	0.391
NOS-TC	1.20	0.73–1.88	0.446
Resection status (ref. R2 non-resection)
R0	0.16	0.09–0.28	<0.001	0.27	0.15–0.48	<0.001
R1	0.42	0.23–0.77	<0.001	0.40	0.22–0.74	0.004
R2 sub-total	0.43	0.22–0.81	<0.001	0.38	0.20–0.72	0.003
Pathological Masaoka stage (ref. I–II)
II	3.72	1.94–7.88	<0.001	2.97	1.45–6.10	0.003
IV	7.81	4.16–16.3	<0.001	4.96	2.33–10.5	<0.001
Preoperative CT (ref. no)
Yes	1.96	1.28–2.92	0.002	1.27	0.81–1.98	0.295
Postoperative RT (ref. no)
Yes	1.18	0.81–1.72	0.377	1.05	0.72–1.54	0.793

Table 3:

Univariable and multivariable analyses of parameters influencing OS

Parameters	Univariable			Multivariable
Parameters	HR	95% CI	P	HR	95% CI	P
Age (ref. <70 years)
≥70	1.14	0.71–1.76	0.563
Gender (ref. male)
Female	0.82	0.54–1.20	0.300
Histological type (ref. LG-TC)
HG-TC	1.35	0.65–2.49	0.391
NOS-TC	1.20	0.73–1.88	0.446
Resection status (ref. R2 non-resection)
R0	0.16	0.09–0.28	<0.001	0.27	0.15–0.48	<0.001
R1	0.42	0.23–0.77	<0.001	0.40	0.22–0.74	0.004
R2 sub-total	0.43	0.22–0.81	<0.001	0.38	0.20–0.72	0.003
Pathological Masaoka stage (ref. I–II)
II	3.72	1.94–7.88	<0.001	2.97	1.45–6.10	0.003
IV	7.81	4.16–16.3	<0.001	4.96	2.33–10.5	<0.001
Preoperative CT (ref. no)
Yes	1.96	1.28–2.92	0.002	1.27	0.81–1.98	0.295
Postoperative RT (ref. no)
Yes	1.18	0.81–1.72	0.377	1.05	0.72–1.54	0.793

Parameters	Univariable			Multivariable
Parameters	HR	95% CI	P	HR	95% CI	P
Age (ref. <70 years)
≥70	1.14	0.71–1.76	0.563
Gender (ref. male)
Female	0.82	0.54–1.20	0.300
Histological type (ref. LG-TC)
HG-TC	1.35	0.65–2.49	0.391
NOS-TC	1.20	0.73–1.88	0.446
Resection status (ref. R2 non-resection)
R0	0.16	0.09–0.28	<0.001	0.27	0.15–0.48	<0.001
R1	0.42	0.23–0.77	<0.001	0.40	0.22–0.74	0.004
R2 sub-total	0.43	0.22–0.81	<0.001	0.38	0.20–0.72	0.003
Pathological Masaoka stage (ref. I–II)
II	3.72	1.94–7.88	<0.001	2.97	1.45–6.10	0.003
IV	7.81	4.16–16.3	<0.001	4.96	2.33–10.5	<0.001
Preoperative CT (ref. no)
Yes	1.96	1.28–2.92	0.002	1.27	0.81–1.98	0.295
Postoperative RT (ref. no)
Yes	1.18	0.81–1.72	0.377	1.05	0.72–1.54	0.793

OS: overall survival; HR: hazard ratio; CI: confidence interval; LG-TC: low-grade thymic carcinoma; HG-TC: high-grade thymic carcinoma; NOS-TC: thymic carcinoma, not otherwise specified; CT: chemotherapy; RT: radiotherapy.

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