Median Estimate Parameter Values From the Monotherapy Studies With Ribavirin (RBV) or Interferon (IFN) Alfa
| Drug . | Model Fit . | Parameter, Mean ± SD . | ||||
|---|---|---|---|---|---|---|
| r2a . | kturn,b per d . | EC50c . | Hd . | POPMAX,e Log10 PFU/mL . | kdeath,f per d . | |
| RBV | 0.88 | 0.85 ± 0.39 | 142.70 ± 126.13 | 4.28 ± 1.14 | 8.54 ± 8.38 | 0.37 ± 0.54 |
| IFN alfa | 0.98 | 0.87 ± 3.04 | 2571.41 ± 860.98 | 1.24 ± 1.43 | 8.37 ± 8.45 | 0.37 ± 0.23 |
| Drug . | Model Fit . | Parameter, Mean ± SD . | ||||
|---|---|---|---|---|---|---|
| r2a . | kturn,b per d . | EC50c . | Hd . | POPMAX,e Log10 PFU/mL . | kdeath,f per d . | |
| RBV | 0.88 | 0.85 ± 0.39 | 142.70 ± 126.13 | 4.28 ± 1.14 | 8.54 ± 8.38 | 0.37 ± 0.54 |
| IFN alfa | 0.98 | 0.87 ± 3.04 | 2571.41 ± 860.98 | 1.24 ± 1.43 | 8.37 ± 8.45 | 0.37 ± 0.23 |
Abbreviation: PFU, plaque-forming units.
ar2 is coefficient of determination that quantifies goodness of fit.
bkturn is the first-order viral production rate constant for chikungunya virus.
c EC50 is the drug concentration of drug at which viral production rate constants are reduced by half. Data for RBV are in μg/mL, and data for IFN alfa are in IU/mL.
dH represents the Hill constant.
e POPMAX is the maximal amount of total viral burden.
fkdeath is the first-order rate of disintegration of infectious viral particle.
Median Estimate Parameter Values From the Monotherapy Studies With Ribavirin (RBV) or Interferon (IFN) Alfa
| Drug . | Model Fit . | Parameter, Mean ± SD . | ||||
|---|---|---|---|---|---|---|
| r2a . | kturn,b per d . | EC50c . | Hd . | POPMAX,e Log10 PFU/mL . | kdeath,f per d . | |
| RBV | 0.88 | 0.85 ± 0.39 | 142.70 ± 126.13 | 4.28 ± 1.14 | 8.54 ± 8.38 | 0.37 ± 0.54 |
| IFN alfa | 0.98 | 0.87 ± 3.04 | 2571.41 ± 860.98 | 1.24 ± 1.43 | 8.37 ± 8.45 | 0.37 ± 0.23 |
| Drug . | Model Fit . | Parameter, Mean ± SD . | ||||
|---|---|---|---|---|---|---|
| r2a . | kturn,b per d . | EC50c . | Hd . | POPMAX,e Log10 PFU/mL . | kdeath,f per d . | |
| RBV | 0.88 | 0.85 ± 0.39 | 142.70 ± 126.13 | 4.28 ± 1.14 | 8.54 ± 8.38 | 0.37 ± 0.54 |
| IFN alfa | 0.98 | 0.87 ± 3.04 | 2571.41 ± 860.98 | 1.24 ± 1.43 | 8.37 ± 8.45 | 0.37 ± 0.23 |
Abbreviation: PFU, plaque-forming units.
ar2 is coefficient of determination that quantifies goodness of fit.
bkturn is the first-order viral production rate constant for chikungunya virus.
c EC50 is the drug concentration of drug at which viral production rate constants are reduced by half. Data for RBV are in μg/mL, and data for IFN alfa are in IU/mL.
dH represents the Hill constant.
e POPMAX is the maximal amount of total viral burden.
fkdeath is the first-order rate of disintegration of infectious viral particle.
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