Table 3. Open in new tab Multivariate...

Variable	Malaria RDT Negative	Malaria RDT Positive	Interaction
Ct of EBOV RT-PCR (increasing, continuous)	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001
Age category, y
0–4	14.3 (3.5–58.5)	<.001	12.3 (3.2–47.7)	<.001	0.9 (.2–4.8)^a	.86
5–14	1 (Reference)		4.2 (1.7–10.1)	.002	4.2 (1.7–10.1)^a	.002
15–44	3.0 (1.5–5.9)	.002	2.6 (1.2–5.9)	.02	0.9 (.5–1.5)^a	.63
≥45	5.0 (2.4–10.5)	<.001	3.9 (1.5–10.2)	.006	0.8 (.3–1.7)^a	.52

Variable	Malaria RDT Negative	Malaria RDT Positive	Interaction
Ct of EBOV RT-PCR (increasing, continuous)	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001
Age category, y
0–4	14.3 (3.5–58.5)	<.001	12.3 (3.2–47.7)	<.001	0.9 (.2–4.8)^a	.86
5–14	1 (Reference)		4.2 (1.7–10.1)	.002	4.2 (1.7–10.1)^a	.002
15–44	3.0 (1.5–5.9)	.002	2.6 (1.2–5.9)	.02	0.9 (.5–1.5)^a	.63
≥45	5.0 (2.4–10.5)	<.001	3.9 (1.5–10.2)	.006	0.8 (.3–1.7)^a	.52

Table 3.

Multivariate Logistic Regression Analysis of the Association Between Age and Fatal Outcome, by Malaria Rapid Diagnostic Test (RDT) Result, and the Effect of Malaria per Age Group (Interaction) Among 1047 Patients With Ebola Virus Disease

Variable	Malaria RDT Negative		Malaria RDT Positive		Interaction
Variable	Full Model, OR for Fatal Outcome (95% CI)	P Value	Full Model, OR for Fatal Outcome (95% CI)	P Value	Full Model, OR for Fatal Outcome (95% CI)	P Value
Ct of EBOV RT-PCR (increasing, continuous)	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001
Age category, y
0–4	14.3 (3.5–58.5)	<.001	12.3 (3.2–47.7)	<.001	0.9 (.2–4.8)^a	.86
5–14	1 (Reference)		4.2 (1.7–10.1)	.002	4.2 (1.7–10.1)^a	.002
15–44	3.0 (1.5–5.9)	.002	2.6 (1.2–5.9)	.02	0.9 (.5–1.5)^a	.63
≥45	5.0 (2.4–10.5)	<.001	3.9 (1.5–10.2)	.006	0.8 (.3–1.7)^a	.52

Variable	Malaria RDT Negative		Malaria RDT Positive		Interaction
Variable	Full Model, OR for Fatal Outcome (95% CI)	P Value	Full Model, OR for Fatal Outcome (95% CI)	P Value	Full Model, OR for Fatal Outcome (95% CI)	P Value
Ct of EBOV RT-PCR (increasing, continuous)	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001	0.7 (.7–.7)	<.001
Age category, y
0–4	14.3 (3.5–58.5)	<.001	12.3 (3.2–47.7)	<.001	0.9 (.2–4.8)^a	.86
5–14	1 (Reference)		4.2 (1.7–10.1)	.002	4.2 (1.7–10.1)^a	.002
15–44	3.0 (1.5–5.9)	.002	2.6 (1.2–5.9)	.02	0.9 (.5–1.5)^a	.63
≥45	5.0 (2.4–10.5)	<.001	3.9 (1.5–10.2)	.006	0.8 (.3–1.7)^a	.52

Abbreviations: CI, confidence interval; Ct, cycle threshold; EBOV, Ebola virus; OR, odds ratio; RT-PCR, reverse transcription–polymerase chain reaction.

^a Estimates of the corresponding interaction terms are as follows: age 0–4 years: OR, 0.2 (95% CI, .1–1.4; P = .11); age 5–14 years: OR, 1 (reference); age 15–44 years: OR, 0.2 (95% CI, .1–.6; P = .003); and age ≥45 years: OR, 0.2 (95% CI, .1–.6; P = .006).

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