Table 2 Open in new tab Association...

Population	Test of association	Test of heterogeneity
Pooled	Allele contrast (T vs. C)	1.023	0.898–1.166	0.728	R	0.016	59.2
Heterozygote (TC vs. CC)	1.204	0.982–1.476	0.075	R	0.024	56.6
Homozygote (TT vs. CC)	1.087	0.806–1.443	0.611	F	0.221	26.1
Dominant (TT/TC vs. CC)	1.166	0.961–1.414	0.119	R	0.022	55.4
Recessive (TT vs. TC/CC)	0.853	0.676–1.078	0.183	F	0.350	10.2
Caucasians	Allele contrast (T vs. C)	0.896	0.764–1.079	0.172	F	0.108	47.3
Heterozygote (TC vs. CC)	0.982	0.764–1.262	0.888	F	0.099	48.8
Homozygote (TT vs. CC)	0.863	0.605–1.231	0.416	F	0.424	0.0
Dominant (TT/TC vs. CC)	0.926	0.764–1.210	0.793	F	0.115	43.6
Recessive (TT vs. TC/CC)	0.879	0.735–1.050	0.156	F	0.5	0.413
Hispanics	Allele contrast (T vs. C)	1.395	1.059–1.836	0.018^∗	F	0.365	0.0
Heterozygote (TC vs. CC)	1.254	1.049–1.498	0.013^∗	F	0.929	0.0
Homozygote (TT vs. CC)	1.849	1.001–3.416	0.049^∗	F	0.415	0.0
Dominant (TT/TC vs. CC)	1.742	1.174–2.538	0.006	F	0.764	0.0
Recessive (TT vs. TC/CC)	1.228	0.763–1.976	0.397	R	0.140	54.2
Asians	Allele contrast (T vs. C)	1.262	0.831–1.915	0.275	F	1	0
Heterozygote (TC vs. CC)	1.293	1.025–1.632	0.030^∗	F	1	0
Homozygote (TT vs. CC)	1.412	0.557–3.581	0.468	F	1	0
Dominant (TT/TC vs. CC)	1.293	1.025–1.632	0.030	F	1	0
Recessive (TT vs. TC/CC)	0.880	0.446–1.735	0.712	F	1	0

Population

Test of association

Test of heterogeneity

Model

95% CI

Pvalue

Model

Pvalue

I² (%)

Pooled

Allele contrast (T vs. C)

1.023

0.898–1.166

0.728

0.016

59.2

Heterozygote (TC vs. CC)

1.204

0.982–1.476

0.075

0.024

56.6

Homozygote (TT vs. CC)

1.087

0.806–1.443

0.611

0.221

26.1

Dominant (TT/TC vs. CC)

1.166

0.961–1.414

0.119

0.022

55.4

Recessive (TT vs. TC/CC)

0.853

0.676–1.078

0.183

0.350

10.2

Caucasians

Allele contrast (T vs. C)

0.896

0.764–1.079

0.172

0.108

47.3

Heterozygote (TC vs. CC)

0.982

0.764–1.262

0.888

0.099

48.8

Homozygote (TT vs. CC)

0.863

0.605–1.231

0.416

0.424

0.0

Dominant (TT/TC vs. CC)

0.926

0.764–1.210

0.793

0.115

43.6

Recessive (TT vs. TC/CC)

0.879

0.735–1.050

0.156

0.5

0.413

Hispanics

Allele contrast (T vs. C)

1.395

1.059–1.836

0.018^∗

0.365

0.0

Heterozygote (TC vs. CC)

1.254

1.049–1.498

0.013^∗

0.929

0.0

Homozygote (TT vs. CC)

1.849

1.001–3.416

0.049^∗

0.415

0.0

Dominant (TT/TC vs. CC)

1.742

1.174–2.538

0.006

0.764

0.0

Recessive (TT vs. TC/CC)

1.228

0.763–1.976

0.397

0.140

54.2

Asians

Allele contrast (T vs. C)

1.262

0.831–1.915

0.275

Heterozygote (TC vs. CC)

1.293

1.025–1.632

0.030^∗

Homozygote (TT vs. CC)

1.412

0.557–3.581

0.468

Dominant (TT/TC vs. CC)

1.293

1.025–1.632

0.030

Recessive (TT vs. TC/CC)

0.880

0.446–1.735

0.712

Population	Test of association	Test of heterogeneity
Pooled	Allele contrast (T vs. C)	1.023	0.898–1.166	0.728	R	0.016	59.2
Heterozygote (TC vs. CC)	1.204	0.982–1.476	0.075	R	0.024	56.6
Homozygote (TT vs. CC)	1.087	0.806–1.443	0.611	F	0.221	26.1
Dominant (TT/TC vs. CC)	1.166	0.961–1.414	0.119	R	0.022	55.4
Recessive (TT vs. TC/CC)	0.853	0.676–1.078	0.183	F	0.350	10.2
Caucasians	Allele contrast (T vs. C)	0.896	0.764–1.079	0.172	F	0.108	47.3
Heterozygote (TC vs. CC)	0.982	0.764–1.262	0.888	F	0.099	48.8
Homozygote (TT vs. CC)	0.863	0.605–1.231	0.416	F	0.424	0.0
Dominant (TT/TC vs. CC)	0.926	0.764–1.210	0.793	F	0.115	43.6
Recessive (TT vs. TC/CC)	0.879	0.735–1.050	0.156	F	0.5	0.413
Hispanics	Allele contrast (T vs. C)	1.395	1.059–1.836	0.018^∗	F	0.365	0.0
Heterozygote (TC vs. CC)	1.254	1.049–1.498	0.013^∗	F	0.929	0.0
Homozygote (TT vs. CC)	1.849	1.001–3.416	0.049^∗	F	0.415	0.0
Dominant (TT/TC vs. CC)	1.742	1.174–2.538	0.006	F	0.764	0.0
Recessive (TT vs. TC/CC)	1.228	0.763–1.976	0.397	R	0.140	54.2
Asians	Allele contrast (T vs. C)	1.262	0.831–1.915	0.275	F	1	0
Heterozygote (TC vs. CC)	1.293	1.025–1.632	0.030^∗	F	1	0
Homozygote (TT vs. CC)	1.412	0.557–3.581	0.468	F	1	0
Dominant (TT/TC vs. CC)	1.293	1.025–1.632	0.030	F	1	0
Recessive (TT vs. TC/CC)	0.880	0.446–1.735	0.712	F	1	0

Table 2

Open in new tab

Association outcome between VDR FokI polymorphism and IDD

Population	Test of association				Test of heterogeneity
Population	Model	OR	95% CI	Pvalue	Model	Pvalue	I² (%)
Pooled	Allele contrast (T vs. C)	1.023	0.898–1.166	0.728	R	0.016	59.2
	Heterozygote (TC vs. CC)	1.204	0.982–1.476	0.075	R	0.024	56.6
	Homozygote (TT vs. CC)	1.087	0.806–1.443	0.611	F	0.221	26.1
	Dominant (TT/TC vs. CC)	1.166	0.961–1.414	0.119	R	0.022	55.4
	Recessive (TT vs. TC/CC)	0.853	0.676–1.078	0.183	F	0.350	10.2
Caucasians	Allele contrast (T vs. C)	0.896	0.764–1.079	0.172	F	0.108	47.3
	Heterozygote (TC vs. CC)	0.982	0.764–1.262	0.888	F	0.099	48.8
	Homozygote (TT vs. CC)	0.863	0.605–1.231	0.416	F	0.424	0.0
	Dominant (TT/TC vs. CC)	0.926	0.764–1.210	0.793	F	0.115	43.6
	Recessive (TT vs. TC/CC)	0.879	0.735–1.050	0.156	F	0.5	0.413
Hispanics	Allele contrast (T vs. C)	1.395	1.059–1.836	0.018^∗	F	0.365	0.0
	Heterozygote (TC vs. CC)	1.254	1.049–1.498	0.013^∗	F	0.929	0.0
	Homozygote (TT vs. CC)	1.849	1.001–3.416	0.049^∗	F	0.415	0.0
	Dominant (TT/TC vs. CC)	1.742	1.174–2.538	0.006	F	0.764	0.0
	Recessive (TT vs. TC/CC)	1.228	0.763–1.976	0.397	R	0.140	54.2
Asians	Allele contrast (T vs. C)	1.262	0.831–1.915	0.275	F	1	0
	Heterozygote (TC vs. CC)	1.293	1.025–1.632	0.030^∗	F	1	0
	Homozygote (TT vs. CC)	1.412	0.557–3.581	0.468	F	1	0
	Dominant (TT/TC vs. CC)	1.293	1.025–1.632	0.030	F	1	0
	Recessive (TT vs. TC/CC)	0.880	0.446–1.735	0.712	F	1	0

Population	Test of association				Test of heterogeneity
Population	Model	OR	95% CI	Pvalue	Model	Pvalue	I² (%)
Pooled	Allele contrast (T vs. C)	1.023	0.898–1.166	0.728	R	0.016	59.2
	Heterozygote (TC vs. CC)	1.204	0.982–1.476	0.075	R	0.024	56.6
	Homozygote (TT vs. CC)	1.087	0.806–1.443	0.611	F	0.221	26.1
	Dominant (TT/TC vs. CC)	1.166	0.961–1.414	0.119	R	0.022	55.4
	Recessive (TT vs. TC/CC)	0.853	0.676–1.078	0.183	F	0.350	10.2
Caucasians	Allele contrast (T vs. C)	0.896	0.764–1.079	0.172	F	0.108	47.3
	Heterozygote (TC vs. CC)	0.982	0.764–1.262	0.888	F	0.099	48.8
	Homozygote (TT vs. CC)	0.863	0.605–1.231	0.416	F	0.424	0.0
	Dominant (TT/TC vs. CC)	0.926	0.764–1.210	0.793	F	0.115	43.6
	Recessive (TT vs. TC/CC)	0.879	0.735–1.050	0.156	F	0.5	0.413
Hispanics	Allele contrast (T vs. C)	1.395	1.059–1.836	0.018^∗	F	0.365	0.0
	Heterozygote (TC vs. CC)	1.254	1.049–1.498	0.013^∗	F	0.929	0.0
	Homozygote (TT vs. CC)	1.849	1.001–3.416	0.049^∗	F	0.415	0.0
	Dominant (TT/TC vs. CC)	1.742	1.174–2.538	0.006	F	0.764	0.0
	Recessive (TT vs. TC/CC)	1.228	0.763–1.976	0.397	R	0.140	54.2
Asians	Allele contrast (T vs. C)	1.262	0.831–1.915	0.275	F	1	0
	Heterozygote (TC vs. CC)	1.293	1.025–1.632	0.030^∗	F	1	0
	Homozygote (TT vs. CC)	1.412	0.557–3.581	0.468	F	1	0
	Dominant (TT/TC vs. CC)	1.293	1.025–1.632	0.030	F	1	0
	Recessive (TT vs. TC/CC)	0.880	0.446–1.735	0.712	F	1	0

Note: VDR, vitamin D receptor; IDD, intervertebral disk degeneration; OR, odds ratio; CI, confidence interval. F and R refer to the fixed inverse variance and random inverse variance, respectively. Significant association is indicated with asterisk.

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