Table 1: Open in new tab Baseline data...

	Unmatched ( n = 310)	Matched ( n = 206)
Demographics and basic clinical data
Age (years)	83 ± 5	80 ± 10	<0.001	83 ± 5	83 ± 5	0.5
Male sex (%)	41	54	0.03	44	42	0.8
BMI (kg/m ² )	27 ± 5	27 ± 5	0.94	27 ± 5	27 ± 5	0.7
GFR (ml/min/1.73 m ² )	62 ± 26	60 ± 28	0.58	62 ± 27	62 ± 27	1.0
NYHA ≥ III (%)	91	93	0.44	91	91	1.0
STS-PROM (%)	7.70 ± 4.6	8.05 ± 6.0	0.56	7.95 ± 4.8	7.94 ± 5.3	1.0
Imaging and invasive measurements
P_mean (mmHg)	43 ± 16	41 ± 16	0.25	44 ± 16	42 ± 14	0.4
EF (%)	55 ± 11	51 ± 14	0.005	55 ± 11	55 ± 12	1.0
Interventricular septum (mm)	13 ± 2	13 ± 3	0.93	13 ± 2	13 ± 2	0.9
Agatston score (AU)	2849 ± 1416	2864 ± 1422	0.93	2777 ± 1377	2728 ± 1276	0.8
Effective system annulus (mm)	23.6 ± 2.0	24.3 ± 2.1	0.003	23.7 ± 2.0	23.8 ± 2.0	0.7
Clinical history
s. p. syncope (%)	13	17	0.35	14	16	0.5
s. p. cardiac decompensation (%)	34	40	0.23	34	36	0.8
IDDM (%)	6	6	0.85	8	6	0.6
COPD (%)	18	23	0.25	20	20	1.0
Atrial fibrillation (%)	40	32	0.19	37	39	0.8
Hypertension (%)	96	97	0.62	97	97	1.0
Hypercholesterolaemia (%)	41	51	0.09	48	48	0.9
CAD (%)	69	76	0.21	69	69	1.0
Myocardial infarction (%)	20	29	0.06	24	22	0.8
MR ≥ 2+ (%)	21	18	0.64	21	17	0.5
AR ≥ 2+ (%)	15	19	0.39	16	12	0.3
TR ≥ 2+ (%)	9	13	0.24	11	11	1.0
Stroke (%)	17	16	0.89	16	15	0.9
ICA stenosis (%)	12	19	0.10	15	14	0.7
Pacemaker (%)	14	17	0.46	15	15	0.8
PCI (%)	41	39	0.71	41	43	0.8
Prior CABG surgery (%)	22	34	0.03	24	23	0.9
Prior AVR surgery (%)	0	4	0.008	0	0	1.0

Unmatched ( n = 310)

Matched ( n = 206)

ACURATE ( n = 131)

SAPIEN ( n = 179)

P -values

ACURATE ( n = 103)

SAPIEN ( n = 103)

P -values

Demographics and basic clinical data

Age (years)

83 ± 5

80 ± 10

<0.001

83 ± 5

0.5

Male sex (%)

0.03

0.8

BMI (kg/m ² )

27 ± 5

0.94

27 ± 5

0.7

GFR (ml/min/1.73 m ² )

62 ± 26

60 ± 28

0.58

62 ± 27

1.0

NYHA ≥ III (%)

0.44

1.0

STS-PROM (%)

7.70 ± 4.6

8.05 ± 6.0

0.56

7.95 ± 4.8

7.94 ± 5.3

1.0

Imaging and invasive measurements

P_mean (mmHg)

43 ± 16

41 ± 16

0.25

44 ± 16

42 ± 14

0.4

EF (%)

55 ± 11

51 ± 14

0.005

55 ± 11

55 ± 12

1.0

Interventricular septum (mm)

13 ± 2

13 ± 3

0.93

13 ± 2

0.9

Agatston score (AU)

2849 ± 1416

2864 ± 1422

0.93

2777 ± 1377

2728 ± 1276

0.8

Effective system annulus (mm)

23.6 ± 2.0

24.3 ± 2.1

0.003

23.7 ± 2.0

23.8 ± 2.0

0.7

Clinical history

s. p. syncope (%)

0.35

0.5

s. p. cardiac decompensation (%)

0.23

0.8

IDDM (%)

0.85

0.6

COPD (%)

0.25

1.0

Atrial fibrillation (%)

0.19

0.8

Hypertension (%)

0.62

1.0

Hypercholesterolaemia (%)

0.09

0.9

CAD (%)

0.21

1.0

Myocardial infarction (%)

0.06

0.8

MR ≥ 2+ (%)

0.64

0.5

AR ≥ 2+ (%)

0.39

0.3

TR ≥ 2+ (%)

0.24

1.0

Stroke (%)

0.89

0.9

ICA stenosis (%)

0.10

0.7

Pacemaker (%)

0.46

0.8

PCI (%)

0.71

0.8

Prior CABG surgery (%)

0.03

0.9

Prior AVR surgery (%)

0.008

1.0

	Unmatched ( n = 310)	Matched ( n = 206)
Demographics and basic clinical data
Age (years)	83 ± 5	80 ± 10	<0.001	83 ± 5	83 ± 5	0.5
Male sex (%)	41	54	0.03	44	42	0.8
BMI (kg/m ² )	27 ± 5	27 ± 5	0.94	27 ± 5	27 ± 5	0.7
GFR (ml/min/1.73 m ² )	62 ± 26	60 ± 28	0.58	62 ± 27	62 ± 27	1.0
NYHA ≥ III (%)	91	93	0.44	91	91	1.0
STS-PROM (%)	7.70 ± 4.6	8.05 ± 6.0	0.56	7.95 ± 4.8	7.94 ± 5.3	1.0
Imaging and invasive measurements
P_mean (mmHg)	43 ± 16	41 ± 16	0.25	44 ± 16	42 ± 14	0.4
EF (%)	55 ± 11	51 ± 14	0.005	55 ± 11	55 ± 12	1.0
Interventricular septum (mm)	13 ± 2	13 ± 3	0.93	13 ± 2	13 ± 2	0.9
Agatston score (AU)	2849 ± 1416	2864 ± 1422	0.93	2777 ± 1377	2728 ± 1276	0.8
Effective system annulus (mm)	23.6 ± 2.0	24.3 ± 2.1	0.003	23.7 ± 2.0	23.8 ± 2.0	0.7
Clinical history
s. p. syncope (%)	13	17	0.35	14	16	0.5
s. p. cardiac decompensation (%)	34	40	0.23	34	36	0.8
IDDM (%)	6	6	0.85	8	6	0.6
COPD (%)	18	23	0.25	20	20	1.0
Atrial fibrillation (%)	40	32	0.19	37	39	0.8
Hypertension (%)	96	97	0.62	97	97	1.0
Hypercholesterolaemia (%)	41	51	0.09	48	48	0.9
CAD (%)	69	76	0.21	69	69	1.0
Myocardial infarction (%)	20	29	0.06	24	22	0.8
MR ≥ 2+ (%)	21	18	0.64	21	17	0.5
AR ≥ 2+ (%)	15	19	0.39	16	12	0.3
TR ≥ 2+ (%)	9	13	0.24	11	11	1.0
Stroke (%)	17	16	0.89	16	15	0.9
ICA stenosis (%)	12	19	0.10	15	14	0.7
Pacemaker (%)	14	17	0.46	15	15	0.8
PCI (%)	41	39	0.71	41	43	0.8
Prior CABG surgery (%)	22	34	0.03	24	23	0.9
Prior AVR surgery (%)	0	4	0.008	0	0	1.0

Table 1:

Open in new tab

Baseline data of patients before and after propensity score matching

	Unmatched ( n = 310)			Matched ( n = 206)
	ACURATE ( n = 131)	SAPIEN ( n = 179)	P -values	ACURATE ( n = 103)	SAPIEN ( n = 103)	P -values
Demographics and basic clinical data
Age (years)	83 ± 5	80 ± 10	<0.001	83 ± 5	83 ± 5	0.5
Male sex (%)	41	54	0.03	44	42	0.8
BMI (kg/m ² )	27 ± 5	27 ± 5	0.94	27 ± 5	27 ± 5	0.7
GFR (ml/min/1.73 m ² )	62 ± 26	60 ± 28	0.58	62 ± 27	62 ± 27	1.0
NYHA ≥ III (%)	91	93	0.44	91	91	1.0
STS-PROM (%)	7.70 ± 4.6	8.05 ± 6.0	0.56	7.95 ± 4.8	7.94 ± 5.3	1.0
Imaging and invasive measurements
P_mean (mmHg)	43 ± 16	41 ± 16	0.25	44 ± 16	42 ± 14	0.4
EF (%)	55 ± 11	51 ± 14	0.005	55 ± 11	55 ± 12	1.0
Interventricular septum (mm)	13 ± 2	13 ± 3	0.93	13 ± 2	13 ± 2	0.9
Agatston score (AU)	2849 ± 1416	2864 ± 1422	0.93	2777 ± 1377	2728 ± 1276	0.8
Effective system annulus (mm)	23.6 ± 2.0	24.3 ± 2.1	0.003	23.7 ± 2.0	23.8 ± 2.0	0.7
Clinical history
s. p. syncope (%)	13	17	0.35	14	16	0.5
s. p. cardiac decompensation (%)	34	40	0.23	34	36	0.8
IDDM (%)	6	6	0.85	8	6	0.6
COPD (%)	18	23	0.25	20	20	1.0
Atrial fibrillation (%)	40	32	0.19	37	39	0.8
Hypertension (%)	96	97	0.62	97	97	1.0
Hypercholesterolaemia (%)	41	51	0.09	48	48	0.9
CAD (%)	69	76	0.21	69	69	1.0
Myocardial infarction (%)	20	29	0.06	24	22	0.8
MR ≥ 2+ (%)	21	18	0.64	21	17	0.5
AR ≥ 2+ (%)	15	19	0.39	16	12	0.3
TR ≥ 2+ (%)	9	13	0.24	11	11	1.0
Stroke (%)	17	16	0.89	16	15	0.9
ICA stenosis (%)	12	19	0.10	15	14	0.7
Pacemaker (%)	14	17	0.46	15	15	0.8
PCI (%)	41	39	0.71	41	43	0.8
Prior CABG surgery (%)	22	34	0.03	24	23	0.9
Prior AVR surgery (%)	0	4	0.008	0	0	1.0

	Unmatched ( n = 310)			Matched ( n = 206)
	ACURATE ( n = 131)	SAPIEN ( n = 179)	P -values	ACURATE ( n = 103)	SAPIEN ( n = 103)	P -values
Demographics and basic clinical data
Age (years)	83 ± 5	80 ± 10	<0.001	83 ± 5	83 ± 5	0.5
Male sex (%)	41	54	0.03	44	42	0.8
BMI (kg/m ² )	27 ± 5	27 ± 5	0.94	27 ± 5	27 ± 5	0.7
GFR (ml/min/1.73 m ² )	62 ± 26	60 ± 28	0.58	62 ± 27	62 ± 27	1.0
NYHA ≥ III (%)	91	93	0.44	91	91	1.0
STS-PROM (%)	7.70 ± 4.6	8.05 ± 6.0	0.56	7.95 ± 4.8	7.94 ± 5.3	1.0
Imaging and invasive measurements
P_mean (mmHg)	43 ± 16	41 ± 16	0.25	44 ± 16	42 ± 14	0.4
EF (%)	55 ± 11	51 ± 14	0.005	55 ± 11	55 ± 12	1.0
Interventricular septum (mm)	13 ± 2	13 ± 3	0.93	13 ± 2	13 ± 2	0.9
Agatston score (AU)	2849 ± 1416	2864 ± 1422	0.93	2777 ± 1377	2728 ± 1276	0.8
Effective system annulus (mm)	23.6 ± 2.0	24.3 ± 2.1	0.003	23.7 ± 2.0	23.8 ± 2.0	0.7
Clinical history
s. p. syncope (%)	13	17	0.35	14	16	0.5
s. p. cardiac decompensation (%)	34	40	0.23	34	36	0.8
IDDM (%)	6	6	0.85	8	6	0.6
COPD (%)	18	23	0.25	20	20	1.0
Atrial fibrillation (%)	40	32	0.19	37	39	0.8
Hypertension (%)	96	97	0.62	97	97	1.0
Hypercholesterolaemia (%)	41	51	0.09	48	48	0.9
CAD (%)	69	76	0.21	69	69	1.0
Myocardial infarction (%)	20	29	0.06	24	22	0.8
MR ≥ 2+ (%)	21	18	0.64	21	17	0.5
AR ≥ 2+ (%)	15	19	0.39	16	12	0.3
TR ≥ 2+ (%)	9	13	0.24	11	11	1.0
Stroke (%)	17	16	0.89	16	15	0.9
ICA stenosis (%)	12	19	0.10	15	14	0.7
Pacemaker (%)	14	17	0.46	15	15	0.8
PCI (%)	41	39	0.71	41	43	0.8
Prior CABG surgery (%)	22	34	0.03	24	23	0.9
Prior AVR surgery (%)	0	4	0.008	0	0	1.0

CAD: coronary artery disease; ICA: internal carotid artery; s.p.: status post; AR: aortic valve regurgitation; AVR: aortic valve replacement; P_mean : mean transvalvular gradients; BMI: body mass index; CABG: coronary artery bypass crafting; COPD: chronic obstructive pulmonary disease; EF: left ventricular ejection fraction; GFR: glomerular filtration rate; HTN: arterial hypertension; IDDM: insulin-dependent diabetes mellitus; MR: mitral regurgitation; NYHA: New York Heart Association stages of heart failure; PAOD: peripheral arterial occlusive disease; PCI: percutaneous coronary intervention; STS-PROM: Society of Thoracic Surgeons risk predicted risk of mortality; TR: tricuspid regurgitation.

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