| Characteristic . | Example Populations . | Preferred Paradigm . |
|---|---|---|
| Reliable follow-up | Birth cohort stable OAT | 1. Standard 2-step Ab followed by HCV RNA |
| Short interaction with uncertain follow-up | Jail PWID Screening drive | 1. POC Ab → POC RNA 2. POC Ab → DBS collection |
| Very high prevalence | SIS Active PWID Prison (?) | 1. POC HCV RNA/(Core Ag) |
| Limited healthcare providers | Rural/remote Self-testing | 1. DBS → Ab and HCV RNA |
| Characteristic . | Example Populations . | Preferred Paradigm . |
|---|---|---|
| Reliable follow-up | Birth cohort stable OAT | 1. Standard 2-step Ab followed by HCV RNA |
| Short interaction with uncertain follow-up | Jail PWID Screening drive | 1. POC Ab → POC RNA 2. POC Ab → DBS collection |
| Very high prevalence | SIS Active PWID Prison (?) | 1. POC HCV RNA/(Core Ag) |
| Limited healthcare providers | Rural/remote Self-testing | 1. DBS → Ab and HCV RNA |
Abbreviations: Ab, antibody; Ag, antigen; DBS, dried blood spot; HCV, hepatitis C virus; OAT, opiate agonist therapy; POC, point of care; PWID, people who inject drugs; SIS, supervised injection site.
| Characteristic . | Example Populations . | Preferred Paradigm . |
|---|---|---|
| Reliable follow-up | Birth cohort stable OAT | 1. Standard 2-step Ab followed by HCV RNA |
| Short interaction with uncertain follow-up | Jail PWID Screening drive | 1. POC Ab → POC RNA 2. POC Ab → DBS collection |
| Very high prevalence | SIS Active PWID Prison (?) | 1. POC HCV RNA/(Core Ag) |
| Limited healthcare providers | Rural/remote Self-testing | 1. DBS → Ab and HCV RNA |
| Characteristic . | Example Populations . | Preferred Paradigm . |
|---|---|---|
| Reliable follow-up | Birth cohort stable OAT | 1. Standard 2-step Ab followed by HCV RNA |
| Short interaction with uncertain follow-up | Jail PWID Screening drive | 1. POC Ab → POC RNA 2. POC Ab → DBS collection |
| Very high prevalence | SIS Active PWID Prison (?) | 1. POC HCV RNA/(Core Ag) |
| Limited healthcare providers | Rural/remote Self-testing | 1. DBS → Ab and HCV RNA |
Abbreviations: Ab, antibody; Ag, antigen; DBS, dried blood spot; HCV, hepatitis C virus; OAT, opiate agonist therapy; POC, point of care; PWID, people who inject drugs; SIS, supervised injection site.
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