| Testing Modality . | Advantages . | Disadvantages . |
|---|---|---|
| Ab followed by reflex HCV RNA | Cost efficient Accurate | Loss to follow-up Burden on patient (time/anxiety) |
| Ab followed by core Ag | Cost efficient | Low sensitivity |
| POC Ab followed by POC HCV RNA | Rapid | Relatively costly Turnaround time |
| Immediate POC HCV RNA | Rapid | Costly except with very high prevalence |
| POC HCV Core Ag | Rapid Cost efficient | Not available—technically difficult |
| Testing Modality . | Advantages . | Disadvantages . |
|---|---|---|
| Ab followed by reflex HCV RNA | Cost efficient Accurate | Loss to follow-up Burden on patient (time/anxiety) |
| Ab followed by core Ag | Cost efficient | Low sensitivity |
| POC Ab followed by POC HCV RNA | Rapid | Relatively costly Turnaround time |
| Immediate POC HCV RNA | Rapid | Costly except with very high prevalence |
| POC HCV Core Ag | Rapid Cost efficient | Not available—technically difficult |
Abbreviations: Ab, antibody; Ag, antigen; HCV, hepatitis C virus; POC, point of care.
| Testing Modality . | Advantages . | Disadvantages . |
|---|---|---|
| Ab followed by reflex HCV RNA | Cost efficient Accurate | Loss to follow-up Burden on patient (time/anxiety) |
| Ab followed by core Ag | Cost efficient | Low sensitivity |
| POC Ab followed by POC HCV RNA | Rapid | Relatively costly Turnaround time |
| Immediate POC HCV RNA | Rapid | Costly except with very high prevalence |
| POC HCV Core Ag | Rapid Cost efficient | Not available—technically difficult |
| Testing Modality . | Advantages . | Disadvantages . |
|---|---|---|
| Ab followed by reflex HCV RNA | Cost efficient Accurate | Loss to follow-up Burden on patient (time/anxiety) |
| Ab followed by core Ag | Cost efficient | Low sensitivity |
| POC Ab followed by POC HCV RNA | Rapid | Relatively costly Turnaround time |
| Immediate POC HCV RNA | Rapid | Costly except with very high prevalence |
| POC HCV Core Ag | Rapid Cost efficient | Not available—technically difficult |
Abbreviations: Ab, antibody; Ag, antigen; HCV, hepatitis C virus; POC, point of care.
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