Pretreatment Characteristics for Patients Stratified by MDASI-BT Cognitive Factor Baseline Scores in Quartile 1–3 (Lower Patient-Reported Cognitive Impairment) Versus Quartile 4 (Highest Patient-Reported Cognitive Impairment)
| Characteristics . | Less Severe Cognitive Impairment (Baseline Quartile 1–3 MDASI-BT Cognitive Factor Score), No. (%) . | Most Severe Cognitive Impairment (Baseline Quartile 4 MDASI-BT Cognitive Factor Score), No. (%) . | . |
|---|---|---|---|
| No. of patients | 368 (71.0%) | 150 (29.0) | |
| Assigned treatment group | 0.28 | ||
| WBRT | 177 (48.1) | 80 (53.3) | |
| HA-WBRT | 191 (51.9) | 70 (46.7) | |
| Age, y | 0.69 | ||
| Mean (SD) | 61.4 (11.4) | 60.9 (11.7) | |
| Sex | 0.14 | ||
| Male | 148 (40.2) | 71 (47.3) | |
| Female | 220 (59.8) | 79 (52.7) | |
| Race | 0.62 | ||
| American Indian/Alaska Native | 1 (0.3) | 2 (1.3) | |
| Asian | 6 (1.6) | 1 (0.7) | |
| Black or African American | 35(9.5) | 17 (11.3) | |
| White | 294 (79.9) | 117 (78.0) | |
| Unknown | 29 (7.9) | 11 (7.3) | |
| Not reported | 3 (0.8) | 2 (1.3) | |
| Karnofsky performance score | 0.02 | ||
| 70 | 64 (17.4) | 37 (24.7) | |
| 80 | 113 (30.7) | 43 (28.7) | |
| 90 | 123 (33.4) | 57 (38.0) | |
| 100 | 68 (18.5) | 13 (8.7) | |
| Karnofsky performance score | 0.28 | ||
| 70–80 | 177 (48.1) | 80 (53.3) | |
| 90–100 | 191 (51.9) | 70 (46.7) | |
| Neurologic function status | 0.002 | ||
| No neurologic symptoms: fully active at home/work without assistance | 183 (49.7) | 49 (32.7) | |
| Minor neurologic symptoms: fully active at home/work without assistance | 121 (32.9) | 57 (38.0) | |
| Moderate neurologic symptoms: fully active at home/work, but requires assistance | 32 (8.7) | 19 (12.7) | |
| Moderate neurologic symptoms: less than fully active at home/work and requires assistance | 16 (4.3) | 17 (11.3) | |
| Unknown | 14 (3.8) | 8 (5.3) | |
| Not reported | 2 (0.5) | 0 (0) | |
| RPA class | 0.66 | ||
| 1 | 52 (14.1) | 19 (12.7) | |
| 2 | 316 (85.9) | 131 (87.3) | |
| Education | 0.14 | ||
| ≤High school | 156 (42.4) | 68 (45.3) | |
| >High school | 200 (54.3) | 72 (48.0) | |
| Unknown | 12 (3.3) | 10 (6.7) | |
| Cognitive test, mean z score (SD) | |||
| HVLT-R total recall | –1.13 (1.24) | –1.71 (1.24) | <0.001 |
| HVLT-R delayed recall | –1.03 1.43) | –1.72 (1.51) | <0.001 |
| HVLT-R delayed recognition | –0.51 (1.34) | –1.07 (1.69) | <0.001 |
| TMT-A, s | –1.03 (2.33) | –1.81 (2.73) | 0.001 |
| TMT-B, s | –2.85 (7.52) | –4.51 (6.98) | 0.02 |
| COWA | –0.71 (1.15) | –1.11 (1.21) | <0.001 |
| CTB composite | –1.21 (1.79) | –1.99 (1.93) | <0.001 |
| MDASI-BT factors, mean raw score (SD) | |||
| Symptom severity | 1.31 (1.00) | 3.62 (1.36) | <0.001 |
| Symptom interference | 2.06 (2.14) | 4.58 (2.41) | <0.001 |
| Cognitive factor | 0.68 (0.67) | 4.07 (1.62) | <0.001 |
| Neurologic factor | 1.37 (1.56) | 3.63 (2.17) | <0.001 |
| Characteristics . | Less Severe Cognitive Impairment (Baseline Quartile 1–3 MDASI-BT Cognitive Factor Score), No. (%) . | Most Severe Cognitive Impairment (Baseline Quartile 4 MDASI-BT Cognitive Factor Score), No. (%) . | . |
|---|---|---|---|
| No. of patients | 368 (71.0%) | 150 (29.0) | |
| Assigned treatment group | 0.28 | ||
| WBRT | 177 (48.1) | 80 (53.3) | |
| HA-WBRT | 191 (51.9) | 70 (46.7) | |
| Age, y | 0.69 | ||
| Mean (SD) | 61.4 (11.4) | 60.9 (11.7) | |
| Sex | 0.14 | ||
| Male | 148 (40.2) | 71 (47.3) | |
| Female | 220 (59.8) | 79 (52.7) | |
| Race | 0.62 | ||
| American Indian/Alaska Native | 1 (0.3) | 2 (1.3) | |
| Asian | 6 (1.6) | 1 (0.7) | |
| Black or African American | 35(9.5) | 17 (11.3) | |
| White | 294 (79.9) | 117 (78.0) | |
| Unknown | 29 (7.9) | 11 (7.3) | |
| Not reported | 3 (0.8) | 2 (1.3) | |
| Karnofsky performance score | 0.02 | ||
| 70 | 64 (17.4) | 37 (24.7) | |
| 80 | 113 (30.7) | 43 (28.7) | |
| 90 | 123 (33.4) | 57 (38.0) | |
| 100 | 68 (18.5) | 13 (8.7) | |
| Karnofsky performance score | 0.28 | ||
| 70–80 | 177 (48.1) | 80 (53.3) | |
| 90–100 | 191 (51.9) | 70 (46.7) | |
| Neurologic function status | 0.002 | ||
| No neurologic symptoms: fully active at home/work without assistance | 183 (49.7) | 49 (32.7) | |
| Minor neurologic symptoms: fully active at home/work without assistance | 121 (32.9) | 57 (38.0) | |
| Moderate neurologic symptoms: fully active at home/work, but requires assistance | 32 (8.7) | 19 (12.7) | |
| Moderate neurologic symptoms: less than fully active at home/work and requires assistance | 16 (4.3) | 17 (11.3) | |
| Unknown | 14 (3.8) | 8 (5.3) | |
| Not reported | 2 (0.5) | 0 (0) | |
| RPA class | 0.66 | ||
| 1 | 52 (14.1) | 19 (12.7) | |
| 2 | 316 (85.9) | 131 (87.3) | |
| Education | 0.14 | ||
| ≤High school | 156 (42.4) | 68 (45.3) | |
| >High school | 200 (54.3) | 72 (48.0) | |
| Unknown | 12 (3.3) | 10 (6.7) | |
| Cognitive test, mean z score (SD) | |||
| HVLT-R total recall | –1.13 (1.24) | –1.71 (1.24) | <0.001 |
| HVLT-R delayed recall | –1.03 1.43) | –1.72 (1.51) | <0.001 |
| HVLT-R delayed recognition | –0.51 (1.34) | –1.07 (1.69) | <0.001 |
| TMT-A, s | –1.03 (2.33) | –1.81 (2.73) | 0.001 |
| TMT-B, s | –2.85 (7.52) | –4.51 (6.98) | 0.02 |
| COWA | –0.71 (1.15) | –1.11 (1.21) | <0.001 |
| CTB composite | –1.21 (1.79) | –1.99 (1.93) | <0.001 |
| MDASI-BT factors, mean raw score (SD) | |||
| Symptom severity | 1.31 (1.00) | 3.62 (1.36) | <0.001 |
| Symptom interference | 2.06 (2.14) | 4.58 (2.41) | <0.001 |
| Cognitive factor | 0.68 (0.67) | 4.07 (1.62) | <0.001 |
| Neurologic factor | 1.37 (1.56) | 3.63 (2.17) | <0.001 |
Pretreatment Characteristics for Patients Stratified by MDASI-BT Cognitive Factor Baseline Scores in Quartile 1–3 (Lower Patient-Reported Cognitive Impairment) Versus Quartile 4 (Highest Patient-Reported Cognitive Impairment)
| Characteristics . | Less Severe Cognitive Impairment (Baseline Quartile 1–3 MDASI-BT Cognitive Factor Score), No. (%) . | Most Severe Cognitive Impairment (Baseline Quartile 4 MDASI-BT Cognitive Factor Score), No. (%) . | . |
|---|---|---|---|
| No. of patients | 368 (71.0%) | 150 (29.0) | |
| Assigned treatment group | 0.28 | ||
| WBRT | 177 (48.1) | 80 (53.3) | |
| HA-WBRT | 191 (51.9) | 70 (46.7) | |
| Age, y | 0.69 | ||
| Mean (SD) | 61.4 (11.4) | 60.9 (11.7) | |
| Sex | 0.14 | ||
| Male | 148 (40.2) | 71 (47.3) | |
| Female | 220 (59.8) | 79 (52.7) | |
| Race | 0.62 | ||
| American Indian/Alaska Native | 1 (0.3) | 2 (1.3) | |
| Asian | 6 (1.6) | 1 (0.7) | |
| Black or African American | 35(9.5) | 17 (11.3) | |
| White | 294 (79.9) | 117 (78.0) | |
| Unknown | 29 (7.9) | 11 (7.3) | |
| Not reported | 3 (0.8) | 2 (1.3) | |
| Karnofsky performance score | 0.02 | ||
| 70 | 64 (17.4) | 37 (24.7) | |
| 80 | 113 (30.7) | 43 (28.7) | |
| 90 | 123 (33.4) | 57 (38.0) | |
| 100 | 68 (18.5) | 13 (8.7) | |
| Karnofsky performance score | 0.28 | ||
| 70–80 | 177 (48.1) | 80 (53.3) | |
| 90–100 | 191 (51.9) | 70 (46.7) | |
| Neurologic function status | 0.002 | ||
| No neurologic symptoms: fully active at home/work without assistance | 183 (49.7) | 49 (32.7) | |
| Minor neurologic symptoms: fully active at home/work without assistance | 121 (32.9) | 57 (38.0) | |
| Moderate neurologic symptoms: fully active at home/work, but requires assistance | 32 (8.7) | 19 (12.7) | |
| Moderate neurologic symptoms: less than fully active at home/work and requires assistance | 16 (4.3) | 17 (11.3) | |
| Unknown | 14 (3.8) | 8 (5.3) | |
| Not reported | 2 (0.5) | 0 (0) | |
| RPA class | 0.66 | ||
| 1 | 52 (14.1) | 19 (12.7) | |
| 2 | 316 (85.9) | 131 (87.3) | |
| Education | 0.14 | ||
| ≤High school | 156 (42.4) | 68 (45.3) | |
| >High school | 200 (54.3) | 72 (48.0) | |
| Unknown | 12 (3.3) | 10 (6.7) | |
| Cognitive test, mean z score (SD) | |||
| HVLT-R total recall | –1.13 (1.24) | –1.71 (1.24) | <0.001 |
| HVLT-R delayed recall | –1.03 1.43) | –1.72 (1.51) | <0.001 |
| HVLT-R delayed recognition | –0.51 (1.34) | –1.07 (1.69) | <0.001 |
| TMT-A, s | –1.03 (2.33) | –1.81 (2.73) | 0.001 |
| TMT-B, s | –2.85 (7.52) | –4.51 (6.98) | 0.02 |
| COWA | –0.71 (1.15) | –1.11 (1.21) | <0.001 |
| CTB composite | –1.21 (1.79) | –1.99 (1.93) | <0.001 |
| MDASI-BT factors, mean raw score (SD) | |||
| Symptom severity | 1.31 (1.00) | 3.62 (1.36) | <0.001 |
| Symptom interference | 2.06 (2.14) | 4.58 (2.41) | <0.001 |
| Cognitive factor | 0.68 (0.67) | 4.07 (1.62) | <0.001 |
| Neurologic factor | 1.37 (1.56) | 3.63 (2.17) | <0.001 |
| Characteristics . | Less Severe Cognitive Impairment (Baseline Quartile 1–3 MDASI-BT Cognitive Factor Score), No. (%) . | Most Severe Cognitive Impairment (Baseline Quartile 4 MDASI-BT Cognitive Factor Score), No. (%) . | . |
|---|---|---|---|
| No. of patients | 368 (71.0%) | 150 (29.0) | |
| Assigned treatment group | 0.28 | ||
| WBRT | 177 (48.1) | 80 (53.3) | |
| HA-WBRT | 191 (51.9) | 70 (46.7) | |
| Age, y | 0.69 | ||
| Mean (SD) | 61.4 (11.4) | 60.9 (11.7) | |
| Sex | 0.14 | ||
| Male | 148 (40.2) | 71 (47.3) | |
| Female | 220 (59.8) | 79 (52.7) | |
| Race | 0.62 | ||
| American Indian/Alaska Native | 1 (0.3) | 2 (1.3) | |
| Asian | 6 (1.6) | 1 (0.7) | |
| Black or African American | 35(9.5) | 17 (11.3) | |
| White | 294 (79.9) | 117 (78.0) | |
| Unknown | 29 (7.9) | 11 (7.3) | |
| Not reported | 3 (0.8) | 2 (1.3) | |
| Karnofsky performance score | 0.02 | ||
| 70 | 64 (17.4) | 37 (24.7) | |
| 80 | 113 (30.7) | 43 (28.7) | |
| 90 | 123 (33.4) | 57 (38.0) | |
| 100 | 68 (18.5) | 13 (8.7) | |
| Karnofsky performance score | 0.28 | ||
| 70–80 | 177 (48.1) | 80 (53.3) | |
| 90–100 | 191 (51.9) | 70 (46.7) | |
| Neurologic function status | 0.002 | ||
| No neurologic symptoms: fully active at home/work without assistance | 183 (49.7) | 49 (32.7) | |
| Minor neurologic symptoms: fully active at home/work without assistance | 121 (32.9) | 57 (38.0) | |
| Moderate neurologic symptoms: fully active at home/work, but requires assistance | 32 (8.7) | 19 (12.7) | |
| Moderate neurologic symptoms: less than fully active at home/work and requires assistance | 16 (4.3) | 17 (11.3) | |
| Unknown | 14 (3.8) | 8 (5.3) | |
| Not reported | 2 (0.5) | 0 (0) | |
| RPA class | 0.66 | ||
| 1 | 52 (14.1) | 19 (12.7) | |
| 2 | 316 (85.9) | 131 (87.3) | |
| Education | 0.14 | ||
| ≤High school | 156 (42.4) | 68 (45.3) | |
| >High school | 200 (54.3) | 72 (48.0) | |
| Unknown | 12 (3.3) | 10 (6.7) | |
| Cognitive test, mean z score (SD) | |||
| HVLT-R total recall | –1.13 (1.24) | –1.71 (1.24) | <0.001 |
| HVLT-R delayed recall | –1.03 1.43) | –1.72 (1.51) | <0.001 |
| HVLT-R delayed recognition | –0.51 (1.34) | –1.07 (1.69) | <0.001 |
| TMT-A, s | –1.03 (2.33) | –1.81 (2.73) | 0.001 |
| TMT-B, s | –2.85 (7.52) | –4.51 (6.98) | 0.02 |
| COWA | –0.71 (1.15) | –1.11 (1.21) | <0.001 |
| CTB composite | –1.21 (1.79) | –1.99 (1.93) | <0.001 |
| MDASI-BT factors, mean raw score (SD) | |||
| Symptom severity | 1.31 (1.00) | 3.62 (1.36) | <0.001 |
| Symptom interference | 2.06 (2.14) | 4.58 (2.41) | <0.001 |
| Cognitive factor | 0.68 (0.67) | 4.07 (1.62) | <0.001 |
| Neurologic factor | 1.37 (1.56) | 3.63 (2.17) | <0.001 |
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
