Table 2. Open in new tab AMR...

		City 2017–20 (2015–16)
penA (%)	Mosaic	4.3 (22.2)	8.3	0 (15.4)	13.8 (14.7)	8.2 (13.6)	6.3	13.3 (10.7)	15.4	7.7	16.0 (23.0)	10.0 (9.7)	9.0 (16.2)
A501 V/T	11.7 (2.0)	7.3	30.0 (4.8)	10.8 (13.2)	10.3 (6.8)	18.9	0 (7.1)	23.1	0	4 (0)	10.0 (0)	10.9 (4.6)
23S rRNA gene (%)^a	C2611T	3.2 (0)	6.3	0 (0)	4.6 (0)	20.6 (4.9)	14.7	6.7 (3.6)	15.4	0	33.3 (4.1)	2.0 (1.4)	12.0 (1.8)
gyrA (%)^b	S91	74.5 (44.4)	53.1	90.0 (53.8)	61.5 (77.9)	76.3 (67.0)	72.6	40.0 (64.3)	92.3	92.3	56.0 (59.5)	56.0 (22.2)	66.3 (54.7)
parC (%)^d	D86N	33.0 (0)	5.2	30.0 (2.9)	18.5 (2.9)^c	16.5 (1.9)	5.3	13.3 (3.6)	0	7.7	6.7 (1.4)	14.0 (2.8)	14.0 (2.0)
S87	41.5 (37.4)	40.6	60.0 (48.1)	40 (60.3)	45.4 (52.4)	38.9	26.7 (57.1)	84.6	84.6	50.7 (54.1)	42 (13.9)	44.3 (45.3)
E91	16.0 (15.2)	9.4	30.0 (4.8)	7.7 (26.5)	12.4 (13.6)	35.8	6.7 (17.9)	7.7	0	5.3 (5.4)	6.0 (4.2)	14.0 (11.7)
ponA (%)	L421P	43.6 (32.3)	49.0	70.0 (59.6)	61.5 (73.5)	64.9 (67.0)	70.5	33.3 (71.4)	100.0	84.6	62.7 (58.1)	54.0 (23.6)	59.1 (53.5)
mtrR (%)	−35 A-del. and/or G45D	30.9 (14.1)	29.2	20.0 (28.8)	41.5 (35.7)	30.9 (31.1)	50.5	6.7 (50.0)	61.5	0	42.7 (31.1)	26.0 (13.8)	32.4 (27.2)
Mosaic	9.6 (3.0)	3.1	10.0 (4.8)	7.7 (0)	9.3 (1.0)	2.1	6.7 (0)	0	0	8.0 (6.8)	0 (0)	5.8 (2.6)
mtr₁₂₀	0 (0)	0	0 (1.0)	1.5 (0)	2.0 (3.9)	0	0 (0)	0	0	0 (0)	0 (0)	0.5 (0.9)
mtrC (%)	Mosaic	8.5 (4.0)	3.1	10.0 (2.9)	9.2 (0)	9.3 (0)	2.1	6.7 (3.6)	0	0	8.0 (8.1)	0 (5.6)	5.8 (3.3)
GC-repeat deletion	2.1 (6.1)	12.5	0 (9.6)	9.2 (22.1)	15.5 (12.6)	8.4	6.7 (7.1)	0	0	9.3 (14.9)	8.0 (13.9)	8.8 (12.4)
mtrD (%)	Semi-mosaic	0 (1.0)	1.0	0 (0)	3.1 (0)	1.0 (0)	0	0 (0)	0	0	1.3 (0)	0 (0)	0.8 (0.2)
Mosaic	9.6 (3.0)	14.6	10.0 (10.6)	10.8 (7.4)	17.5 (5.8)	3.2	13.3 (7.1)	0	0	12 (12.2)	6 (11.1)	10.4 (8.0)
mtrE (%)	Mosaic	8.5 (4.0)	2.1	0 (3.8)	6.2 (7.4)	9.3 (5.8)	2.1	6.7 (3.6)	0	0	5.3 (17.6)	0 (11.1)	4.8 (1.1)
porB1b (%)	G101/A102	24.5 (33.3)	22.9	30.0 (29.8)	32.3 (38.2)	27.8 (38.8)	26.3	20 (35.7)	53.8	46.2	48.0 (51.4)	28.0 (29.2)	30.0 (36.3)
rpsJ (%)	V57M	98.9 (98.0)	87.5	90.0 (98.1)	83.1 (94.1)	95.9 (98.1)	92.6	93.3 (96.4)	92.3	100.0	88.0 (94.6)	90.0 (95.8)	91.7 (96.7)
**bla_TEM (%)**	β-lactamase	38.3 (20.2)	25.0	20.0 (42.3)	12.3 (41.2)	34.0 (36.9)	21.1	26.7 (25.0)	23.1	7.7	9.3 (17.6)	8.0 (11.1)	22.8 (28.8)
tetM (%)	tetM	39.4 (68.7)	32.3	20.0 (59.6)	18.5 (47.1)	30.9 (49.5)	34.7	26.7 (17.9)	23.1	7.7	21.3 (10.8)	20.0 (37.5)	28.7 (46.2)

City 2017–20 (2015–16)

Gene

AMR determinant

Manaus
94 (99)

Recife
96 (−)

Salvador
10 (104)

Brasilia
65 (68)

Belo Horizonte
97 (103)

Ribeirão Preto
95 (−)

São Paulo
15 (28)

San José dos Campos
13 (−)

Curitiba 13 (−)

Florianópolis 75 (74)

Porto Alegre
50 (72)

Total
623 (548)

penA (%)

Mosaic

4.3 (22.2)

8.3

0 (15.4)

13.8 (14.7)

8.2 (13.6)

6.3

13.3 (10.7)

15.4

7.7

16.0 (23.0)

10.0 (9.7)

9.0 (16.2)

A501 V/T

11.7 (2.0)

7.3

30.0 (4.8)

10.8 (13.2)

10.3 (6.8)

18.9

0 (7.1)

23.1

4 (0)

10.0 (0)

10.9 (4.6)

23S rRNA gene (%)^a

C2611T

3.2 (0)

6.3

0 (0)

4.6 (0)

20.6 (4.9)

14.7

6.7 (3.6)

15.4

33.3 (4.1)

2.0 (1.4)

12.0 (1.8)

gyrA (%)^b

S91

74.5 (44.4)

53.1

90.0 (53.8)

61.5 (77.9)

76.3 (67.0)

72.6

40.0 (64.3)

92.3

56.0 (59.5)

56.0 (22.2)

66.3 (54.7)

parC (%)^d

D86N

33.0 (0)

5.2

30.0 (2.9)

18.5 (2.9)^c

16.5 (1.9)

5.3

13.3 (3.6)

7.7

6.7 (1.4)

14.0 (2.8)

14.0 (2.0)

S87

41.5 (37.4)

40.6

60.0 (48.1)

40 (60.3)

45.4 (52.4)

38.9

26.7 (57.1)

84.6

50.7 (54.1)

42 (13.9)

44.3 (45.3)

E91

16.0 (15.2)

9.4

30.0 (4.8)

7.7 (26.5)

12.4 (13.6)

35.8

6.7 (17.9)

7.7

5.3 (5.4)

6.0 (4.2)

14.0 (11.7)

ponA (%)

L421P

43.6 (32.3)

49.0

70.0 (59.6)

61.5 (73.5)

64.9 (67.0)

70.5

33.3 (71.4)

100.0

84.6

62.7 (58.1)

54.0 (23.6)

59.1 (53.5)

mtrR (%)

−35 A-del. and/or G45D

30.9 (14.1)

29.2

20.0 (28.8)

41.5 (35.7)

30.9 (31.1)

50.5

6.7 (50.0)

61.5

42.7 (31.1)

26.0 (13.8)

32.4 (27.2)

Mosaic

9.6 (3.0)

3.1

10.0 (4.8)

7.7 (0)

9.3 (1.0)

2.1

6.7 (0)

8.0 (6.8)

0 (0)

5.8 (2.6)

mtr₁₂₀

0 (0)

0 (1.0)

1.5 (0)

2.0 (3.9)

0 (0)

0.5 (0.9)

mtrC (%)

Mosaic

8.5 (4.0)

3.1

10.0 (2.9)

9.2 (0)

9.3 (0)

2.1

6.7 (3.6)

8.0 (8.1)

0 (5.6)

5.8 (3.3)

GC-repeat deletion

2.1 (6.1)

12.5

0 (9.6)

9.2 (22.1)

15.5 (12.6)

8.4

6.7 (7.1)

9.3 (14.9)

8.0 (13.9)

8.8 (12.4)

mtrD (%)

Semi-mosaic

0 (1.0)

1.0

0 (0)

3.1 (0)

1.0 (0)

0 (0)

1.3 (0)

0 (0)

0.8 (0.2)

Mosaic

9.6 (3.0)

14.6

10.0 (10.6)

10.8 (7.4)

17.5 (5.8)

3.2

13.3 (7.1)

12 (12.2)

6 (11.1)

10.4 (8.0)

mtrE (%)

Mosaic

8.5 (4.0)

2.1

0 (3.8)

6.2 (7.4)

9.3 (5.8)

2.1

6.7 (3.6)

5.3 (17.6)

0 (11.1)

4.8 (1.1)

porB1b (%)

G101/A102

24.5 (33.3)

22.9

30.0 (29.8)

32.3 (38.2)

27.8 (38.8)

26.3

20 (35.7)

53.8

46.2

48.0 (51.4)

28.0 (29.2)

30.0 (36.3)

rpsJ (%)

V57M

98.9 (98.0)

87.5

90.0 (98.1)

83.1 (94.1)

95.9 (98.1)

92.6

93.3 (96.4)

92.3

100.0

88.0 (94.6)

90.0 (95.8)

91.7 (96.7)

bla_TEM (%)

β-lactamase

38.3 (20.2)

25.0

20.0 (42.3)

12.3 (41.2)

34.0 (36.9)

21.1

26.7 (25.0)

23.1

7.7

9.3 (17.6)

8.0 (11.1)

22.8 (28.8)

tetM (%)

tetM

39.4 (68.7)

32.3

20.0 (59.6)

18.5 (47.1)

30.9 (49.5)

34.7

26.7 (17.9)

23.1

7.7

21.3 (10.8)

20.0 (37.5)

28.7 (46.2)

		City 2017–20 (2015–16)
penA (%)	Mosaic	4.3 (22.2)	8.3	0 (15.4)	13.8 (14.7)	8.2 (13.6)	6.3	13.3 (10.7)	15.4	7.7	16.0 (23.0)	10.0 (9.7)	9.0 (16.2)
A501 V/T	11.7 (2.0)	7.3	30.0 (4.8)	10.8 (13.2)	10.3 (6.8)	18.9	0 (7.1)	23.1	0	4 (0)	10.0 (0)	10.9 (4.6)
23S rRNA gene (%)^a	C2611T	3.2 (0)	6.3	0 (0)	4.6 (0)	20.6 (4.9)	14.7	6.7 (3.6)	15.4	0	33.3 (4.1)	2.0 (1.4)	12.0 (1.8)
gyrA (%)^b	S91	74.5 (44.4)	53.1	90.0 (53.8)	61.5 (77.9)	76.3 (67.0)	72.6	40.0 (64.3)	92.3	92.3	56.0 (59.5)	56.0 (22.2)	66.3 (54.7)
parC (%)^d	D86N	33.0 (0)	5.2	30.0 (2.9)	18.5 (2.9)^c	16.5 (1.9)	5.3	13.3 (3.6)	0	7.7	6.7 (1.4)	14.0 (2.8)	14.0 (2.0)
S87	41.5 (37.4)	40.6	60.0 (48.1)	40 (60.3)	45.4 (52.4)	38.9	26.7 (57.1)	84.6	84.6	50.7 (54.1)	42 (13.9)	44.3 (45.3)
E91	16.0 (15.2)	9.4	30.0 (4.8)	7.7 (26.5)	12.4 (13.6)	35.8	6.7 (17.9)	7.7	0	5.3 (5.4)	6.0 (4.2)	14.0 (11.7)
ponA (%)	L421P	43.6 (32.3)	49.0	70.0 (59.6)	61.5 (73.5)	64.9 (67.0)	70.5	33.3 (71.4)	100.0	84.6	62.7 (58.1)	54.0 (23.6)	59.1 (53.5)
mtrR (%)	−35 A-del. and/or G45D	30.9 (14.1)	29.2	20.0 (28.8)	41.5 (35.7)	30.9 (31.1)	50.5	6.7 (50.0)	61.5	0	42.7 (31.1)	26.0 (13.8)	32.4 (27.2)
Mosaic	9.6 (3.0)	3.1	10.0 (4.8)	7.7 (0)	9.3 (1.0)	2.1	6.7 (0)	0	0	8.0 (6.8)	0 (0)	5.8 (2.6)
mtr₁₂₀	0 (0)	0	0 (1.0)	1.5 (0)	2.0 (3.9)	0	0 (0)	0	0	0 (0)	0 (0)	0.5 (0.9)
mtrC (%)	Mosaic	8.5 (4.0)	3.1	10.0 (2.9)	9.2 (0)	9.3 (0)	2.1	6.7 (3.6)	0	0	8.0 (8.1)	0 (5.6)	5.8 (3.3)
GC-repeat deletion	2.1 (6.1)	12.5	0 (9.6)	9.2 (22.1)	15.5 (12.6)	8.4	6.7 (7.1)	0	0	9.3 (14.9)	8.0 (13.9)	8.8 (12.4)
mtrD (%)	Semi-mosaic	0 (1.0)	1.0	0 (0)	3.1 (0)	1.0 (0)	0	0 (0)	0	0	1.3 (0)	0 (0)	0.8 (0.2)
Mosaic	9.6 (3.0)	14.6	10.0 (10.6)	10.8 (7.4)	17.5 (5.8)	3.2	13.3 (7.1)	0	0	12 (12.2)	6 (11.1)	10.4 (8.0)
mtrE (%)	Mosaic	8.5 (4.0)	2.1	0 (3.8)	6.2 (7.4)	9.3 (5.8)	2.1	6.7 (3.6)	0	0	5.3 (17.6)	0 (11.1)	4.8 (1.1)
porB1b (%)	G101/A102	24.5 (33.3)	22.9	30.0 (29.8)	32.3 (38.2)	27.8 (38.8)	26.3	20 (35.7)	53.8	46.2	48.0 (51.4)	28.0 (29.2)	30.0 (36.3)
rpsJ (%)	V57M	98.9 (98.0)	87.5	90.0 (98.1)	83.1 (94.1)	95.9 (98.1)	92.6	93.3 (96.4)	92.3	100.0	88.0 (94.6)	90.0 (95.8)	91.7 (96.7)
**bla_TEM (%)**	β-lactamase	38.3 (20.2)	25.0	20.0 (42.3)	12.3 (41.2)	34.0 (36.9)	21.1	26.7 (25.0)	23.1	7.7	9.3 (17.6)	8.0 (11.1)	22.8 (28.8)
tetM (%)	tetM	39.4 (68.7)	32.3	20.0 (59.6)	18.5 (47.1)	30.9 (49.5)	34.7	26.7 (17.9)	23.1	7.7	21.3 (10.8)	20.0 (37.5)	28.7 (46.2)

City 2017–20 (2015–16)

Gene

AMR determinant

Manaus
94 (99)

Recife
96 (−)

Salvador
10 (104)

Brasilia
65 (68)

Belo Horizonte
97 (103)

Ribeirão Preto
95 (−)

São Paulo
15 (28)

San José dos Campos
13 (−)

Curitiba 13 (−)

Florianópolis 75 (74)

Porto Alegre
50 (72)

Total
623 (548)

penA (%)

Mosaic

4.3 (22.2)

8.3

0 (15.4)

13.8 (14.7)

8.2 (13.6)

6.3

13.3 (10.7)

15.4

7.7

16.0 (23.0)

10.0 (9.7)

9.0 (16.2)

A501 V/T

11.7 (2.0)

7.3

30.0 (4.8)

10.8 (13.2)

10.3 (6.8)

18.9

0 (7.1)

23.1

4 (0)

10.0 (0)

10.9 (4.6)

23S rRNA gene (%)^a

C2611T

3.2 (0)

6.3

0 (0)

4.6 (0)

20.6 (4.9)

14.7

6.7 (3.6)

15.4

33.3 (4.1)

2.0 (1.4)

12.0 (1.8)

gyrA (%)^b

S91

74.5 (44.4)

53.1

90.0 (53.8)

61.5 (77.9)

76.3 (67.0)

72.6

40.0 (64.3)

92.3

56.0 (59.5)

56.0 (22.2)

66.3 (54.7)

parC (%)^d

D86N

33.0 (0)

5.2

30.0 (2.9)

18.5 (2.9)^c

16.5 (1.9)

5.3

13.3 (3.6)

7.7

6.7 (1.4)

14.0 (2.8)

14.0 (2.0)

S87

41.5 (37.4)

40.6

60.0 (48.1)

40 (60.3)

45.4 (52.4)

38.9

26.7 (57.1)

84.6

50.7 (54.1)

42 (13.9)

44.3 (45.3)

E91

16.0 (15.2)

9.4

30.0 (4.8)

7.7 (26.5)

12.4 (13.6)

35.8

6.7 (17.9)

7.7

5.3 (5.4)

6.0 (4.2)

14.0 (11.7)

ponA (%)

L421P

43.6 (32.3)

49.0

70.0 (59.6)

61.5 (73.5)

64.9 (67.0)

70.5

33.3 (71.4)

100.0

84.6

62.7 (58.1)

54.0 (23.6)

59.1 (53.5)

mtrR (%)

−35 A-del. and/or G45D

30.9 (14.1)

29.2

20.0 (28.8)

41.5 (35.7)

30.9 (31.1)

50.5

6.7 (50.0)

61.5

42.7 (31.1)

26.0 (13.8)

32.4 (27.2)

Mosaic

9.6 (3.0)

3.1

10.0 (4.8)

7.7 (0)

9.3 (1.0)

2.1

6.7 (0)

8.0 (6.8)

0 (0)

5.8 (2.6)

mtr₁₂₀

0 (0)

0 (1.0)

1.5 (0)

2.0 (3.9)

0 (0)

0.5 (0.9)

mtrC (%)

Mosaic

8.5 (4.0)

3.1

10.0 (2.9)

9.2 (0)

9.3 (0)

2.1

6.7 (3.6)

8.0 (8.1)

0 (5.6)

5.8 (3.3)

GC-repeat deletion

2.1 (6.1)

12.5

0 (9.6)

9.2 (22.1)

15.5 (12.6)

8.4

6.7 (7.1)

9.3 (14.9)

8.0 (13.9)

8.8 (12.4)

mtrD (%)

Semi-mosaic

0 (1.0)

1.0

0 (0)

3.1 (0)

1.0 (0)

0 (0)

1.3 (0)

0 (0)

0.8 (0.2)

Mosaic

9.6 (3.0)

14.6

10.0 (10.6)

10.8 (7.4)

17.5 (5.8)

3.2

13.3 (7.1)

12 (12.2)

6 (11.1)

10.4 (8.0)

mtrE (%)

Mosaic

8.5 (4.0)

2.1

0 (3.8)

6.2 (7.4)

9.3 (5.8)

2.1

6.7 (3.6)

5.3 (17.6)

0 (11.1)

4.8 (1.1)

porB1b (%)

G101/A102

24.5 (33.3)

22.9

30.0 (29.8)

32.3 (38.2)

27.8 (38.8)

26.3

20 (35.7)

53.8

46.2

48.0 (51.4)

28.0 (29.2)

30.0 (36.3)

rpsJ (%)

V57M

98.9 (98.0)

87.5

90.0 (98.1)

83.1 (94.1)

95.9 (98.1)

92.6

93.3 (96.4)

92.3

100.0

88.0 (94.6)

90.0 (95.8)

91.7 (96.7)

bla_TEM (%)

β-lactamase

38.3 (20.2)

25.0

20.0 (42.3)

12.3 (41.2)

34.0 (36.9)

21.1

26.7 (25.0)

23.1

7.7

9.3 (17.6)

8.0 (11.1)

22.8 (28.8)

tetM (%)

tetM

39.4 (68.7)

32.3

20.0 (59.6)

18.5 (47.1)

30.9 (49.5)

34.7

26.7 (17.9)

23.1

7.7

21.3 (10.8)

20.0 (37.5)

28.7 (46.2)

Table 2.

Open in new tab

AMR determinants in 11 cities across Brazil in 2017–20, compared to 2015–16²⁴

		City 2017–20 (2015–16)
Gene	AMR determinant	Manaus 94 (99)	Recife 96 (−)	Salvador 10 (104)	Brasilia 65 (68)	Belo Horizonte 97 (103)	Ribeirão Preto 95 (−)	São Paulo 15 (28)	San José dos Campos 13 (−)	Curitiba 13 (−)	Florianópolis 75 (74)	Porto Alegre 50 (72)	Total 623 (548)
penA (%)	Mosaic	4.3 (22.2)	8.3	0 (15.4)	13.8 (14.7)	8.2 (13.6)	6.3	13.3 (10.7)	15.4	7.7	16.0 (23.0)	10.0 (9.7)	9.0 (16.2)
penA (%)	A501 V/T	11.7 (2.0)	7.3	30.0 (4.8)	10.8 (13.2)	10.3 (6.8)	18.9	0 (7.1)	23.1	0	4 (0)	10.0 (0)	10.9 (4.6)
23S rRNA gene (%)^a	C2611T	3.2 (0)	6.3	0 (0)	4.6 (0)	20.6 (4.9)	14.7	6.7 (3.6)	15.4	0	33.3 (4.1)	2.0 (1.4)	12.0 (1.8)
gyrA (%)^b	S91	74.5 (44.4)	53.1	90.0 (53.8)	61.5 (77.9)	76.3 (67.0)	72.6	40.0 (64.3)	92.3	92.3	56.0 (59.5)	56.0 (22.2)	66.3 (54.7)
parC (%)^d	D86N	33.0 (0)	5.2	30.0 (2.9)	18.5 (2.9)^c	16.5 (1.9)	5.3	13.3 (3.6)	0	7.7	6.7 (1.4)	14.0 (2.8)	14.0 (2.0)
	S87	41.5 (37.4)	40.6	60.0 (48.1)	40 (60.3)	45.4 (52.4)	38.9	26.7 (57.1)	84.6	84.6	50.7 (54.1)	42 (13.9)	44.3 (45.3)
	E91	16.0 (15.2)	9.4	30.0 (4.8)	7.7 (26.5)	12.4 (13.6)	35.8	6.7 (17.9)	7.7	0	5.3 (5.4)	6.0 (4.2)	14.0 (11.7)
ponA (%)	L421P	43.6 (32.3)	49.0	70.0 (59.6)	61.5 (73.5)	64.9 (67.0)	70.5	33.3 (71.4)	100.0	84.6	62.7 (58.1)	54.0 (23.6)	59.1 (53.5)
mtrR (%)	−35 A-del. and/or G45D	30.9 (14.1)	29.2	20.0 (28.8)	41.5 (35.7)	30.9 (31.1)	50.5	6.7 (50.0)	61.5	0	42.7 (31.1)	26.0 (13.8)	32.4 (27.2)
	Mosaic	9.6 (3.0)	3.1	10.0 (4.8)	7.7 (0)	9.3 (1.0)	2.1	6.7 (0)	0	0	8.0 (6.8)	0 (0)	5.8 (2.6)
	mtr₁₂₀	0 (0)	0	0 (1.0)	1.5 (0)	2.0 (3.9)	0	0 (0)	0	0	0 (0)	0 (0)	0.5 (0.9)
mtrC (%)	Mosaic	8.5 (4.0)	3.1	10.0 (2.9)	9.2 (0)	9.3 (0)	2.1	6.7 (3.6)	0	0	8.0 (8.1)	0 (5.6)	5.8 (3.3)
mtrC (%)	GC-repeat deletion	2.1 (6.1)	12.5	0 (9.6)	9.2 (22.1)	15.5 (12.6)	8.4	6.7 (7.1)	0	0	9.3 (14.9)	8.0 (13.9)	8.8 (12.4)
mtrD (%)	Semi-mosaic	0 (1.0)	1.0	0 (0)	3.1 (0)	1.0 (0)	0	0 (0)	0	0	1.3 (0)	0 (0)	0.8 (0.2)
mtrD (%)	Mosaic	9.6 (3.0)	14.6	10.0 (10.6)	10.8 (7.4)	17.5 (5.8)	3.2	13.3 (7.1)	0	0	12 (12.2)	6 (11.1)	10.4 (8.0)
mtrE (%)	Mosaic	8.5 (4.0)	2.1	0 (3.8)	6.2 (7.4)	9.3 (5.8)	2.1	6.7 (3.6)	0	0	5.3 (17.6)	0 (11.1)	4.8 (1.1)
porB1b (%)	G101/A102	24.5 (33.3)	22.9	30.0 (29.8)	32.3 (38.2)	27.8 (38.8)	26.3	20 (35.7)	53.8	46.2	48.0 (51.4)	28.0 (29.2)	30.0 (36.3)
rpsJ (%)	V57M	98.9 (98.0)	87.5	90.0 (98.1)	83.1 (94.1)	95.9 (98.1)	92.6	93.3 (96.4)	92.3	100.0	88.0 (94.6)	90.0 (95.8)	91.7 (96.7)
**bla_TEM (%)**	β-lactamase	38.3 (20.2)	25.0	20.0 (42.3)	12.3 (41.2)	34.0 (36.9)	21.1	26.7 (25.0)	23.1	7.7	9.3 (17.6)	8.0 (11.1)	22.8 (28.8)
tetM (%)	tetM	39.4 (68.7)	32.3	20.0 (59.6)	18.5 (47.1)	30.9 (49.5)	34.7	26.7 (17.9)	23.1	7.7	21.3 (10.8)	20.0 (37.5)	28.7 (46.2)

		City 2017–20 (2015–16)
Gene	AMR determinant	Manaus 94 (99)	Recife 96 (−)	Salvador 10 (104)	Brasilia 65 (68)	Belo Horizonte 97 (103)	Ribeirão Preto 95 (−)	São Paulo 15 (28)	San José dos Campos 13 (−)	Curitiba 13 (−)	Florianópolis 75 (74)	Porto Alegre 50 (72)	Total 623 (548)
penA (%)	Mosaic	4.3 (22.2)	8.3	0 (15.4)	13.8 (14.7)	8.2 (13.6)	6.3	13.3 (10.7)	15.4	7.7	16.0 (23.0)	10.0 (9.7)	9.0 (16.2)
penA (%)	A501 V/T	11.7 (2.0)	7.3	30.0 (4.8)	10.8 (13.2)	10.3 (6.8)	18.9	0 (7.1)	23.1	0	4 (0)	10.0 (0)	10.9 (4.6)
23S rRNA gene (%)^a	C2611T	3.2 (0)	6.3	0 (0)	4.6 (0)	20.6 (4.9)	14.7	6.7 (3.6)	15.4	0	33.3 (4.1)	2.0 (1.4)	12.0 (1.8)
gyrA (%)^b	S91	74.5 (44.4)	53.1	90.0 (53.8)	61.5 (77.9)	76.3 (67.0)	72.6	40.0 (64.3)	92.3	92.3	56.0 (59.5)	56.0 (22.2)	66.3 (54.7)
parC (%)^d	D86N	33.0 (0)	5.2	30.0 (2.9)	18.5 (2.9)^c	16.5 (1.9)	5.3	13.3 (3.6)	0	7.7	6.7 (1.4)	14.0 (2.8)	14.0 (2.0)
	S87	41.5 (37.4)	40.6	60.0 (48.1)	40 (60.3)	45.4 (52.4)	38.9	26.7 (57.1)	84.6	84.6	50.7 (54.1)	42 (13.9)	44.3 (45.3)
	E91	16.0 (15.2)	9.4	30.0 (4.8)	7.7 (26.5)	12.4 (13.6)	35.8	6.7 (17.9)	7.7	0	5.3 (5.4)	6.0 (4.2)	14.0 (11.7)
ponA (%)	L421P	43.6 (32.3)	49.0	70.0 (59.6)	61.5 (73.5)	64.9 (67.0)	70.5	33.3 (71.4)	100.0	84.6	62.7 (58.1)	54.0 (23.6)	59.1 (53.5)
mtrR (%)	−35 A-del. and/or G45D	30.9 (14.1)	29.2	20.0 (28.8)	41.5 (35.7)	30.9 (31.1)	50.5	6.7 (50.0)	61.5	0	42.7 (31.1)	26.0 (13.8)	32.4 (27.2)
	Mosaic	9.6 (3.0)	3.1	10.0 (4.8)	7.7 (0)	9.3 (1.0)	2.1	6.7 (0)	0	0	8.0 (6.8)	0 (0)	5.8 (2.6)
	mtr₁₂₀	0 (0)	0	0 (1.0)	1.5 (0)	2.0 (3.9)	0	0 (0)	0	0	0 (0)	0 (0)	0.5 (0.9)
mtrC (%)	Mosaic	8.5 (4.0)	3.1	10.0 (2.9)	9.2 (0)	9.3 (0)	2.1	6.7 (3.6)	0	0	8.0 (8.1)	0 (5.6)	5.8 (3.3)
mtrC (%)	GC-repeat deletion	2.1 (6.1)	12.5	0 (9.6)	9.2 (22.1)	15.5 (12.6)	8.4	6.7 (7.1)	0	0	9.3 (14.9)	8.0 (13.9)	8.8 (12.4)
mtrD (%)	Semi-mosaic	0 (1.0)	1.0	0 (0)	3.1 (0)	1.0 (0)	0	0 (0)	0	0	1.3 (0)	0 (0)	0.8 (0.2)
mtrD (%)	Mosaic	9.6 (3.0)	14.6	10.0 (10.6)	10.8 (7.4)	17.5 (5.8)	3.2	13.3 (7.1)	0	0	12 (12.2)	6 (11.1)	10.4 (8.0)
mtrE (%)	Mosaic	8.5 (4.0)	2.1	0 (3.8)	6.2 (7.4)	9.3 (5.8)	2.1	6.7 (3.6)	0	0	5.3 (17.6)	0 (11.1)	4.8 (1.1)
porB1b (%)	G101/A102	24.5 (33.3)	22.9	30.0 (29.8)	32.3 (38.2)	27.8 (38.8)	26.3	20 (35.7)	53.8	46.2	48.0 (51.4)	28.0 (29.2)	30.0 (36.3)
rpsJ (%)	V57M	98.9 (98.0)	87.5	90.0 (98.1)	83.1 (94.1)	95.9 (98.1)	92.6	93.3 (96.4)	92.3	100.0	88.0 (94.6)	90.0 (95.8)	91.7 (96.7)
**bla_TEM (%)**	β-lactamase	38.3 (20.2)	25.0	20.0 (42.3)	12.3 (41.2)	34.0 (36.9)	21.1	26.7 (25.0)	23.1	7.7	9.3 (17.6)	8.0 (11.1)	22.8 (28.8)
tetM (%)	tetM	39.4 (68.7)	32.3	20.0 (59.6)	18.5 (47.1)	30.9 (49.5)	34.7	26.7 (17.9)	23.1	7.7	21.3 (10.8)	20.0 (37.5)	28.7 (46.2)

^aNo isolate with any mutation in 23S rRNA A2058 or A2059 was found.

^bTwo isolates from Recife and one isolate from Manaus had no mutation in S91 but only in D95N.

^cOne isolate had D86G.

^dNo isolate with S88 mutation was found in parC in 2017–20.

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