Baseline echocardiographic measurements according to the median baseline RVol/LAV ratio
| . | All patients (n = 567) . | RVol/LAV ≥ 0.67 (n = 284) . | RVol/LAV < 0.67 (n = 283) . | P-value . |
|---|---|---|---|---|
| EROA by PISA (cm²) | 0.40 ± 0.13 | 0.44 ± 0.13 | 0.36 ± 0.11 | <0.0001 |
| RVol by PISA (cm²) | 58.2 ± 18.3 | 67.3 ± 17.8 | 49.1 ± 13.9 | <0.0001 |
| Vena contracta (cm) | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.23 |
| Regurgitant fraction (%) | 36.2 ± 14.2 | 36.7 ± 14.3 | 35.8 ± 14.2 | 0.62 |
| LVEF (%) | 31.2 ± 9.3 | 31.6 ± 9.3 | 30.8 ± 9.4 | 0.31 |
| LVEF ≤ 40% | 441 (82.3) | 226 (83.4) | 215 (81.1) | 0.49 |
| LV GLS (%) | −11.95 ± 3.44 | −12.26 ± 3.44 | −11.62 ± 3.43 | 0.03 |
| LVEDVi (mL/m²) | 101.8 ± 35.0 | 98.5 ± 34.0 | 105.1 ± 35.8 | 0.03 |
| LVESVi (mL/m²) | 71.5 ± 29.7 | 68.5 ± 28.0 | 74.5 ± 31.0 | 0.02 |
| LV SVi (mL/m²) | 50.5 ± 16.9 | 51.2 ± 17.0 | 49.8 ± 16.8 | 0.32 |
| Left atrial volume (mL) | 91.2 ± 38.6 | 71.2 ± 20.9 | 111.2 ± 41.8 | <0.0001 |
| LAVi (mL/m2) | 48.3 ± 20.5 | 38.4 ± 11.2 | 58.2 ± 22.9 | <0.0001 |
| LA strain (%) | 12.7 ± 4.6 | 14.1 ± 4.8 | 11.3 ± 3.9 | <0.0001 |
| SPAP (mmHg) | 44.1 ± 13.4 | 44.2 ± 14.1 | 44.0 ± 12.7 | 0.90 |
| Tricuspid regurgitation ≥ 2+ | 90 (16.2) | 53 (19.1) | 37 (13.3) | 0.06 |
| RV fractional change area (%) | 32.0 ± 9.0 | 32.8 ± 8.6 | 31.2 ± 9.4 | 0.08 |
| RV free wall strain (%) | −17.8 ± 5.0 | −18.2 ± 4.9 | −17.4 ± 5.0 | 0.12 |
| . | All patients (n = 567) . | RVol/LAV ≥ 0.67 (n = 284) . | RVol/LAV < 0.67 (n = 283) . | P-value . |
|---|---|---|---|---|
| EROA by PISA (cm²) | 0.40 ± 0.13 | 0.44 ± 0.13 | 0.36 ± 0.11 | <0.0001 |
| RVol by PISA (cm²) | 58.2 ± 18.3 | 67.3 ± 17.8 | 49.1 ± 13.9 | <0.0001 |
| Vena contracta (cm) | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.23 |
| Regurgitant fraction (%) | 36.2 ± 14.2 | 36.7 ± 14.3 | 35.8 ± 14.2 | 0.62 |
| LVEF (%) | 31.2 ± 9.3 | 31.6 ± 9.3 | 30.8 ± 9.4 | 0.31 |
| LVEF ≤ 40% | 441 (82.3) | 226 (83.4) | 215 (81.1) | 0.49 |
| LV GLS (%) | −11.95 ± 3.44 | −12.26 ± 3.44 | −11.62 ± 3.43 | 0.03 |
| LVEDVi (mL/m²) | 101.8 ± 35.0 | 98.5 ± 34.0 | 105.1 ± 35.8 | 0.03 |
| LVESVi (mL/m²) | 71.5 ± 29.7 | 68.5 ± 28.0 | 74.5 ± 31.0 | 0.02 |
| LV SVi (mL/m²) | 50.5 ± 16.9 | 51.2 ± 17.0 | 49.8 ± 16.8 | 0.32 |
| Left atrial volume (mL) | 91.2 ± 38.6 | 71.2 ± 20.9 | 111.2 ± 41.8 | <0.0001 |
| LAVi (mL/m2) | 48.3 ± 20.5 | 38.4 ± 11.2 | 58.2 ± 22.9 | <0.0001 |
| LA strain (%) | 12.7 ± 4.6 | 14.1 ± 4.8 | 11.3 ± 3.9 | <0.0001 |
| SPAP (mmHg) | 44.1 ± 13.4 | 44.2 ± 14.1 | 44.0 ± 12.7 | 0.90 |
| Tricuspid regurgitation ≥ 2+ | 90 (16.2) | 53 (19.1) | 37 (13.3) | 0.06 |
| RV fractional change area (%) | 32.0 ± 9.0 | 32.8 ± 8.6 | 31.2 ± 9.4 | 0.08 |
| RV free wall strain (%) | −17.8 ± 5.0 | −18.2 ± 4.9 | −17.4 ± 5.0 | 0.12 |
Data are reported as mean ± SD, or n (%).
EROA, effective regurgitant orifice area; GLS, global longitudinal strain; LA, left atrium; LAV, left atrial volume; LV SVi, left ventricular stoke volume index; LVEDVi, left ventricular end-diastolic volume index; LVESVi, left ventricular end-systolic volume index; LVEF, left ventricular ejection fraction; LVMi, left ventricular mass index; MR, mitral regurgitation; PISA, proximal isovelocity surface area; RAVi, right atrial volume index; RV, right ventricle; RVol, regurgitant volume; SPAP, systolic pulmonary artery pressure.
Baseline echocardiographic measurements according to the median baseline RVol/LAV ratio
| . | All patients (n = 567) . | RVol/LAV ≥ 0.67 (n = 284) . | RVol/LAV < 0.67 (n = 283) . | P-value . |
|---|---|---|---|---|
| EROA by PISA (cm²) | 0.40 ± 0.13 | 0.44 ± 0.13 | 0.36 ± 0.11 | <0.0001 |
| RVol by PISA (cm²) | 58.2 ± 18.3 | 67.3 ± 17.8 | 49.1 ± 13.9 | <0.0001 |
| Vena contracta (cm) | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.23 |
| Regurgitant fraction (%) | 36.2 ± 14.2 | 36.7 ± 14.3 | 35.8 ± 14.2 | 0.62 |
| LVEF (%) | 31.2 ± 9.3 | 31.6 ± 9.3 | 30.8 ± 9.4 | 0.31 |
| LVEF ≤ 40% | 441 (82.3) | 226 (83.4) | 215 (81.1) | 0.49 |
| LV GLS (%) | −11.95 ± 3.44 | −12.26 ± 3.44 | −11.62 ± 3.43 | 0.03 |
| LVEDVi (mL/m²) | 101.8 ± 35.0 | 98.5 ± 34.0 | 105.1 ± 35.8 | 0.03 |
| LVESVi (mL/m²) | 71.5 ± 29.7 | 68.5 ± 28.0 | 74.5 ± 31.0 | 0.02 |
| LV SVi (mL/m²) | 50.5 ± 16.9 | 51.2 ± 17.0 | 49.8 ± 16.8 | 0.32 |
| Left atrial volume (mL) | 91.2 ± 38.6 | 71.2 ± 20.9 | 111.2 ± 41.8 | <0.0001 |
| LAVi (mL/m2) | 48.3 ± 20.5 | 38.4 ± 11.2 | 58.2 ± 22.9 | <0.0001 |
| LA strain (%) | 12.7 ± 4.6 | 14.1 ± 4.8 | 11.3 ± 3.9 | <0.0001 |
| SPAP (mmHg) | 44.1 ± 13.4 | 44.2 ± 14.1 | 44.0 ± 12.7 | 0.90 |
| Tricuspid regurgitation ≥ 2+ | 90 (16.2) | 53 (19.1) | 37 (13.3) | 0.06 |
| RV fractional change area (%) | 32.0 ± 9.0 | 32.8 ± 8.6 | 31.2 ± 9.4 | 0.08 |
| RV free wall strain (%) | −17.8 ± 5.0 | −18.2 ± 4.9 | −17.4 ± 5.0 | 0.12 |
| . | All patients (n = 567) . | RVol/LAV ≥ 0.67 (n = 284) . | RVol/LAV < 0.67 (n = 283) . | P-value . |
|---|---|---|---|---|
| EROA by PISA (cm²) | 0.40 ± 0.13 | 0.44 ± 0.13 | 0.36 ± 0.11 | <0.0001 |
| RVol by PISA (cm²) | 58.2 ± 18.3 | 67.3 ± 17.8 | 49.1 ± 13.9 | <0.0001 |
| Vena contracta (cm) | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.23 |
| Regurgitant fraction (%) | 36.2 ± 14.2 | 36.7 ± 14.3 | 35.8 ± 14.2 | 0.62 |
| LVEF (%) | 31.2 ± 9.3 | 31.6 ± 9.3 | 30.8 ± 9.4 | 0.31 |
| LVEF ≤ 40% | 441 (82.3) | 226 (83.4) | 215 (81.1) | 0.49 |
| LV GLS (%) | −11.95 ± 3.44 | −12.26 ± 3.44 | −11.62 ± 3.43 | 0.03 |
| LVEDVi (mL/m²) | 101.8 ± 35.0 | 98.5 ± 34.0 | 105.1 ± 35.8 | 0.03 |
| LVESVi (mL/m²) | 71.5 ± 29.7 | 68.5 ± 28.0 | 74.5 ± 31.0 | 0.02 |
| LV SVi (mL/m²) | 50.5 ± 16.9 | 51.2 ± 17.0 | 49.8 ± 16.8 | 0.32 |
| Left atrial volume (mL) | 91.2 ± 38.6 | 71.2 ± 20.9 | 111.2 ± 41.8 | <0.0001 |
| LAVi (mL/m2) | 48.3 ± 20.5 | 38.4 ± 11.2 | 58.2 ± 22.9 | <0.0001 |
| LA strain (%) | 12.7 ± 4.6 | 14.1 ± 4.8 | 11.3 ± 3.9 | <0.0001 |
| SPAP (mmHg) | 44.1 ± 13.4 | 44.2 ± 14.1 | 44.0 ± 12.7 | 0.90 |
| Tricuspid regurgitation ≥ 2+ | 90 (16.2) | 53 (19.1) | 37 (13.3) | 0.06 |
| RV fractional change area (%) | 32.0 ± 9.0 | 32.8 ± 8.6 | 31.2 ± 9.4 | 0.08 |
| RV free wall strain (%) | −17.8 ± 5.0 | −18.2 ± 4.9 | −17.4 ± 5.0 | 0.12 |
Data are reported as mean ± SD, or n (%).
EROA, effective regurgitant orifice area; GLS, global longitudinal strain; LA, left atrium; LAV, left atrial volume; LV SVi, left ventricular stoke volume index; LVEDVi, left ventricular end-diastolic volume index; LVESVi, left ventricular end-systolic volume index; LVEF, left ventricular ejection fraction; LVMi, left ventricular mass index; MR, mitral regurgitation; PISA, proximal isovelocity surface area; RAVi, right atrial volume index; RV, right ventricle; RVol, regurgitant volume; SPAP, systolic pulmonary artery pressure.
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