Echocardiographic parameters before and 1-year tafamidis treatment in patients with AF
| . | Baseline . | 1-year . | P-value . |
|---|---|---|---|
| 2D measurement | |||
| LVEDD (mm) | 44.3 ± 5.1 | 43.9 ± 5.3 | 0.5098 |
| LVESD (mm) | 35.6 ± 6.8 | 36.0 ± 7.4 | 0.6748 |
| IVS (mm) | 15.3 ± 2.9 | 15.4 ± 2.6 | 0.3559 |
| PW (mm) | 15.3 ± 2.5 | 15.6 ± 2.5 | 0.1723 |
| LVEF (%) | 47.3 ± 14.8 | 39.3 ± 13.9 | 0.0139 |
| LAD (mm) | 46.9 ± 4.6 | 47.9 ± 3.4 | 0.2956 |
| LA area (cm2) | 27.6 ± 5.9 | 28.5 ± 4.4 | 0.4650 |
| LAVI (mL/m2) | 57.6 ± 16.2 | 60.0 ± 13.9 | 0.5843 |
| Doppler measurement | |||
| E velocity (m/s) | 71.6 ± 18.4 | 67.6 ± 13.4 | 0.2860 |
| E′ lateral (m/s) | 5.2 ± 1.0 | 6.4 ± 3.8 | 0.3922 |
| E′ septal (m/s) | 3.8 ± 0.9 | 3.5 ± 1.0 | 0.4924 |
| Average E/E′ | 16.9 ± 5.0 | 17.9 ± 8.2 | 0.5487 |
| DT (ms) | 177.6 ± 35.3 | 146.4 ± 40.1 | 0.0402 |
| Speckle-tracking measurement | |||
| GLS 4ch (%) | −7.7 ± 1.8 | −6.9 ± 1.6 | 0.2919 |
| GLS 2ch (%) | −8.7 ± 2.8 | −6.5 ± 1.9 | 0.0014 |
| GLS apex (%) | −8.7 ± 2.3 | −6.7 ± 1.3 | 0.0364 |
| LAScd (%) | 5.1 ± 2.5 | 4.6 ± 2.2 | 0.2308 |
| LASct (%) | 0 (0–1) | 0 (0−2) | 0.5502 |
| RELAPS | 1.7 (1.6–1.8) | 2.2 (1.5–2.3) | 0.3051 |
| . | Baseline . | 1-year . | P-value . |
|---|---|---|---|
| 2D measurement | |||
| LVEDD (mm) | 44.3 ± 5.1 | 43.9 ± 5.3 | 0.5098 |
| LVESD (mm) | 35.6 ± 6.8 | 36.0 ± 7.4 | 0.6748 |
| IVS (mm) | 15.3 ± 2.9 | 15.4 ± 2.6 | 0.3559 |
| PW (mm) | 15.3 ± 2.5 | 15.6 ± 2.5 | 0.1723 |
| LVEF (%) | 47.3 ± 14.8 | 39.3 ± 13.9 | 0.0139 |
| LAD (mm) | 46.9 ± 4.6 | 47.9 ± 3.4 | 0.2956 |
| LA area (cm2) | 27.6 ± 5.9 | 28.5 ± 4.4 | 0.4650 |
| LAVI (mL/m2) | 57.6 ± 16.2 | 60.0 ± 13.9 | 0.5843 |
| Doppler measurement | |||
| E velocity (m/s) | 71.6 ± 18.4 | 67.6 ± 13.4 | 0.2860 |
| E′ lateral (m/s) | 5.2 ± 1.0 | 6.4 ± 3.8 | 0.3922 |
| E′ septal (m/s) | 3.8 ± 0.9 | 3.5 ± 1.0 | 0.4924 |
| Average E/E′ | 16.9 ± 5.0 | 17.9 ± 8.2 | 0.5487 |
| DT (ms) | 177.6 ± 35.3 | 146.4 ± 40.1 | 0.0402 |
| Speckle-tracking measurement | |||
| GLS 4ch (%) | −7.7 ± 1.8 | −6.9 ± 1.6 | 0.2919 |
| GLS 2ch (%) | −8.7 ± 2.8 | −6.5 ± 1.9 | 0.0014 |
| GLS apex (%) | −8.7 ± 2.3 | −6.7 ± 1.3 | 0.0364 |
| LAScd (%) | 5.1 ± 2.5 | 4.6 ± 2.2 | 0.2308 |
| LASct (%) | 0 (0–1) | 0 (0−2) | 0.5502 |
| RELAPS | 1.7 (1.6–1.8) | 2.2 (1.5–2.3) | 0.3051 |
DT, deceleration time; GLS, global longitudinal strain; IVS, interventricular septal; LA area, left atrial area; LAD, left atrial dimension; LAScd, left atrial conduit strain; LASct, left atrial contractile strain; LASr, left atrial reservoir strain; LAVI, left atrial volume index; LVDD, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVSD, left ventricular end-systolic diameter; PW, posterior wall; RELAPS, relative apical sparing.
Echocardiographic parameters before and 1-year tafamidis treatment in patients with AF
| . | Baseline . | 1-year . | P-value . |
|---|---|---|---|
| 2D measurement | |||
| LVEDD (mm) | 44.3 ± 5.1 | 43.9 ± 5.3 | 0.5098 |
| LVESD (mm) | 35.6 ± 6.8 | 36.0 ± 7.4 | 0.6748 |
| IVS (mm) | 15.3 ± 2.9 | 15.4 ± 2.6 | 0.3559 |
| PW (mm) | 15.3 ± 2.5 | 15.6 ± 2.5 | 0.1723 |
| LVEF (%) | 47.3 ± 14.8 | 39.3 ± 13.9 | 0.0139 |
| LAD (mm) | 46.9 ± 4.6 | 47.9 ± 3.4 | 0.2956 |
| LA area (cm2) | 27.6 ± 5.9 | 28.5 ± 4.4 | 0.4650 |
| LAVI (mL/m2) | 57.6 ± 16.2 | 60.0 ± 13.9 | 0.5843 |
| Doppler measurement | |||
| E velocity (m/s) | 71.6 ± 18.4 | 67.6 ± 13.4 | 0.2860 |
| E′ lateral (m/s) | 5.2 ± 1.0 | 6.4 ± 3.8 | 0.3922 |
| E′ septal (m/s) | 3.8 ± 0.9 | 3.5 ± 1.0 | 0.4924 |
| Average E/E′ | 16.9 ± 5.0 | 17.9 ± 8.2 | 0.5487 |
| DT (ms) | 177.6 ± 35.3 | 146.4 ± 40.1 | 0.0402 |
| Speckle-tracking measurement | |||
| GLS 4ch (%) | −7.7 ± 1.8 | −6.9 ± 1.6 | 0.2919 |
| GLS 2ch (%) | −8.7 ± 2.8 | −6.5 ± 1.9 | 0.0014 |
| GLS apex (%) | −8.7 ± 2.3 | −6.7 ± 1.3 | 0.0364 |
| LAScd (%) | 5.1 ± 2.5 | 4.6 ± 2.2 | 0.2308 |
| LASct (%) | 0 (0–1) | 0 (0−2) | 0.5502 |
| RELAPS | 1.7 (1.6–1.8) | 2.2 (1.5–2.3) | 0.3051 |
| . | Baseline . | 1-year . | P-value . |
|---|---|---|---|
| 2D measurement | |||
| LVEDD (mm) | 44.3 ± 5.1 | 43.9 ± 5.3 | 0.5098 |
| LVESD (mm) | 35.6 ± 6.8 | 36.0 ± 7.4 | 0.6748 |
| IVS (mm) | 15.3 ± 2.9 | 15.4 ± 2.6 | 0.3559 |
| PW (mm) | 15.3 ± 2.5 | 15.6 ± 2.5 | 0.1723 |
| LVEF (%) | 47.3 ± 14.8 | 39.3 ± 13.9 | 0.0139 |
| LAD (mm) | 46.9 ± 4.6 | 47.9 ± 3.4 | 0.2956 |
| LA area (cm2) | 27.6 ± 5.9 | 28.5 ± 4.4 | 0.4650 |
| LAVI (mL/m2) | 57.6 ± 16.2 | 60.0 ± 13.9 | 0.5843 |
| Doppler measurement | |||
| E velocity (m/s) | 71.6 ± 18.4 | 67.6 ± 13.4 | 0.2860 |
| E′ lateral (m/s) | 5.2 ± 1.0 | 6.4 ± 3.8 | 0.3922 |
| E′ septal (m/s) | 3.8 ± 0.9 | 3.5 ± 1.0 | 0.4924 |
| Average E/E′ | 16.9 ± 5.0 | 17.9 ± 8.2 | 0.5487 |
| DT (ms) | 177.6 ± 35.3 | 146.4 ± 40.1 | 0.0402 |
| Speckle-tracking measurement | |||
| GLS 4ch (%) | −7.7 ± 1.8 | −6.9 ± 1.6 | 0.2919 |
| GLS 2ch (%) | −8.7 ± 2.8 | −6.5 ± 1.9 | 0.0014 |
| GLS apex (%) | −8.7 ± 2.3 | −6.7 ± 1.3 | 0.0364 |
| LAScd (%) | 5.1 ± 2.5 | 4.6 ± 2.2 | 0.2308 |
| LASct (%) | 0 (0–1) | 0 (0−2) | 0.5502 |
| RELAPS | 1.7 (1.6–1.8) | 2.2 (1.5–2.3) | 0.3051 |
DT, deceleration time; GLS, global longitudinal strain; IVS, interventricular septal; LA area, left atrial area; LAD, left atrial dimension; LAScd, left atrial conduit strain; LASct, left atrial contractile strain; LASr, left atrial reservoir strain; LAVI, left atrial volume index; LVDD, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVSD, left ventricular end-systolic diameter; PW, posterior wall; RELAPS, relative apical sparing.
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