Table 3 Open in new tab Multivariable...

	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value
Age (years)	1.01	1.00–1.02	0.002	0.99	0.99–1.00	0.234	1.00	0.99–1.01	0.696
ASA class			0.012			0.280			0.408
I	0.846	0.72–1.00		1.00	0.84–1.19		0.97	0.80–1.18
II	0.813	0.71–0.93	0.91	0.78–1.06		0.90	0.77–1.06
III	Ref	Ref	Ref	Ref		Ref	Ref
Sex			0.005			0.011			0.054
Male	1.24	1.07–1.44		1.22	1.05–1.43		1.18	0.99–1.40
Female	Ref	Ref	Ref	Ref		Ref	Ref
Histologic type			0.495			0.163			0.106
AC	1.08	0.92–1.28	1.19	0.99–1.42		1.22	0.99–1.49
Other	1.15	0.91–1.45	1.21	0.93–1.56		1.30	0.98–1.71
SCC	Ref	Ref	Ref	Ref		Ref	Ref
cN stage			<0.001			<0.001			<0.001
0	0.41	0.28–0.61	0.43	0.29–0.65	0.37	0.24–0.57
1	0.55	0.38–0.80	0.56	0.38–0.84	0.53	0.35–0.79
2	0.60	0.41–0.89	0.64	0.42–0.95	0.54	0.35–0.82
3	Ref	Ref	Ref	Ref	Ref	Ref
Treatment protocol			<0.001			<0.001			<0.001
dCRT + salvage surgery	0.95	0.67–1.33	0.76	0.51–1.13	0.76	0.49–1.18
Upfront surgery	0.72	0.61–0.86	0.55	0.45–0.67	0.55	0.44–0.68
Surgery + adjuvant CT	1.39	1.10–1.77	1.58	1.24–2.00	1.53	1.19–1.98
nCRT + surgery	1.09	0.95–1.26	1.08	0.94–1.25	1.06	0.90–1.23
nCT + surgery	Ref	Ref	Ref	Ref	Ref	Ref
Postoperative complications*		<0.001		<0.001		<0.001
None or minor	0.57	0.50–0.64	0.77	0.68–0.88	0.74	0.64–0.86
Major	Ref	Ref	Ref	Ref	Ref	Ref

HR _adj

95% c.i.

P value

HR _adj

95% c.i.

P value

HR _adj

95% c.i.

P value

Overall survival (OS)

Disease-free survival (DFS)

Disease-specific survival (DSS)

Age (years)

1.01

1.00–1.02

0.002

0.99

0.99–1.00

0.234

1.00

0.99–1.01

0.696

ASA class

0.012

0.280

0.408

0.846

0.72–1.00

1.00

0.84–1.19

0.97

0.80–1.18

0.813

0.71–0.93

0.91

0.78–1.06

0.90

0.77–1.06

III

Ref

Sex

0.005

0.011

0.054

Male

1.24

1.07–1.44

1.22

1.05–1.43

1.18

0.99–1.40

Female

Ref

Histologic type

0.495

0.163

0.106

1.08

0.92–1.28

1.19

0.99–1.42

1.22

0.99–1.49

Other

1.15

0.91–1.45

1.21

0.93–1.56

1.30

0.98–1.71

SCC

Ref

cN stage

<0.001

0.41

0.28–0.61

0.43

0.29–0.65

0.37

0.24–0.57

0.55

0.38–0.80

0.56

0.38–0.84

0.53

0.35–0.79

0.60

0.41–0.89

0.64

0.42–0.95

0.54

0.35–0.82

Ref

Treatment protocol

<0.001

dCRT + salvage surgery

0.95

0.67–1.33

0.76

0.51–1.13

0.76

0.49–1.18

Upfront surgery

0.72

0.61–0.86

0.55

0.45–0.67

0.55

0.44–0.68

Surgery + adjuvant CT

1.39

1.10–1.77

1.58

1.24–2.00

1.53

1.19–1.98

nCRT + surgery

1.09

0.95–1.26

1.08

0.94–1.25

1.06

0.90–1.23

nCT + surgery

Ref

Postoperative
complications*

<0.001

None or minor

0.57

0.50–0.64

0.77

0.68–0.88

0.74

0.64–0.86

Major

Ref

	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value
Age (years)	1.01	1.00–1.02	0.002	0.99	0.99–1.00	0.234	1.00	0.99–1.01	0.696
ASA class			0.012			0.280			0.408
I	0.846	0.72–1.00		1.00	0.84–1.19		0.97	0.80–1.18
II	0.813	0.71–0.93	0.91	0.78–1.06		0.90	0.77–1.06
III	Ref	Ref	Ref	Ref		Ref	Ref
Sex			0.005			0.011			0.054
Male	1.24	1.07–1.44		1.22	1.05–1.43		1.18	0.99–1.40
Female	Ref	Ref	Ref	Ref		Ref	Ref
Histologic type			0.495			0.163			0.106
AC	1.08	0.92–1.28	1.19	0.99–1.42		1.22	0.99–1.49
Other	1.15	0.91–1.45	1.21	0.93–1.56		1.30	0.98–1.71
SCC	Ref	Ref	Ref	Ref		Ref	Ref
cN stage			<0.001			<0.001			<0.001
0	0.41	0.28–0.61	0.43	0.29–0.65	0.37	0.24–0.57
1	0.55	0.38–0.80	0.56	0.38–0.84	0.53	0.35–0.79
2	0.60	0.41–0.89	0.64	0.42–0.95	0.54	0.35–0.82
3	Ref	Ref	Ref	Ref	Ref	Ref
Treatment protocol			<0.001			<0.001			<0.001
dCRT + salvage surgery	0.95	0.67–1.33	0.76	0.51–1.13	0.76	0.49–1.18
Upfront surgery	0.72	0.61–0.86	0.55	0.45–0.67	0.55	0.44–0.68
Surgery + adjuvant CT	1.39	1.10–1.77	1.58	1.24–2.00	1.53	1.19–1.98
nCRT + surgery	1.09	0.95–1.26	1.08	0.94–1.25	1.06	0.90–1.23
nCT + surgery	Ref	Ref	Ref	Ref	Ref	Ref
Postoperative complications*		<0.001		<0.001		<0.001
None or minor	0.57	0.50–0.64	0.77	0.68–0.88	0.74	0.64–0.86
Major	Ref	Ref	Ref	Ref	Ref	Ref

Table 3

Open in new tab

Multivariable Cox analyses for overall, disease-free and disease-specific survival

	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value
	Overall survival (OS)			Disease-free survival (DFS)			Disease-specific survival (DSS)
Age (years)	1.01	1.00–1.02	0.002	0.99	0.99–1.00	0.234	1.00	0.99–1.01	0.696
ASA class			0.012			0.280			0.408
I	0.846	0.72–1.00		1.00	0.84–1.19		0.97	0.80–1.18
II	0.813	0.71–0.93		0.91	0.78–1.06		0.90	0.77–1.06
III	Ref	Ref		Ref	Ref		Ref	Ref
Sex			0.005			0.011			0.054
Male	1.24	1.07–1.44		1.22	1.05–1.43		1.18	0.99–1.40
Female	Ref	Ref		Ref	Ref		Ref	Ref
Histologic type			0.495			0.163			0.106
AC	1.08	0.92–1.28		1.19	0.99–1.42		1.22	0.99–1.49
Other	1.15	0.91–1.45		1.21	0.93–1.56		1.30	0.98–1.71
SCC	Ref	Ref		Ref	Ref		Ref	Ref
cN stage			<0.001			<0.001			<0.001
0	0.41	0.28–0.61		0.43	0.29–0.65		0.37	0.24–0.57
1	0.55	0.38–0.80		0.56	0.38–0.84		0.53	0.35–0.79
2	0.60	0.41–0.89		0.64	0.42–0.95		0.54	0.35–0.82
3	Ref	Ref		Ref	Ref		Ref	Ref
Treatment protocol			<0.001			<0.001			<0.001
dCRT + salvage surgery	0.95	0.67–1.33		0.76	0.51–1.13		0.76	0.49–1.18
Upfront surgery	0.72	0.61–0.86		0.55	0.45–0.67		0.55	0.44–0.68
Surgery + adjuvant CT	1.39	1.10–1.77		1.58	1.24–2.00		1.53	1.19–1.98
nCRT + surgery	1.09	0.95–1.26		1.08	0.94–1.25		1.06	0.90–1.23
nCT + surgery	Ref	Ref		Ref	Ref		Ref	Ref
Postoperative complications*			<0.001			<0.001			<0.001
None or minor	0.57	0.50–0.64		0.77	0.68–0.88		0.74	0.64–0.86
Major	Ref	Ref		Ref	Ref		Ref	Ref

	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value	HR _adj	95% c.i.	P value
	Overall survival (OS)			Disease-free survival (DFS)			Disease-specific survival (DSS)
Age (years)	1.01	1.00–1.02	0.002	0.99	0.99–1.00	0.234	1.00	0.99–1.01	0.696
ASA class			0.012			0.280			0.408
I	0.846	0.72–1.00		1.00	0.84–1.19		0.97	0.80–1.18
II	0.813	0.71–0.93		0.91	0.78–1.06		0.90	0.77–1.06
III	Ref	Ref		Ref	Ref		Ref	Ref
Sex			0.005			0.011			0.054
Male	1.24	1.07–1.44		1.22	1.05–1.43		1.18	0.99–1.40
Female	Ref	Ref		Ref	Ref		Ref	Ref
Histologic type			0.495			0.163			0.106
AC	1.08	0.92–1.28		1.19	0.99–1.42		1.22	0.99–1.49
Other	1.15	0.91–1.45		1.21	0.93–1.56		1.30	0.98–1.71
SCC	Ref	Ref		Ref	Ref		Ref	Ref
cN stage			<0.001			<0.001			<0.001
0	0.41	0.28–0.61		0.43	0.29–0.65		0.37	0.24–0.57
1	0.55	0.38–0.80		0.56	0.38–0.84		0.53	0.35–0.79
2	0.60	0.41–0.89		0.64	0.42–0.95		0.54	0.35–0.82
3	Ref	Ref		Ref	Ref		Ref	Ref
Treatment protocol			<0.001			<0.001			<0.001
dCRT + salvage surgery	0.95	0.67–1.33		0.76	0.51–1.13		0.76	0.49–1.18
Upfront surgery	0.72	0.61–0.86		0.55	0.45–0.67		0.55	0.44–0.68
Surgery + adjuvant CT	1.39	1.10–1.77		1.58	1.24–2.00		1.53	1.19–1.98
nCRT + surgery	1.09	0.95–1.26		1.08	0.94–1.25		1.06	0.90–1.23
nCT + surgery	Ref	Ref		Ref	Ref		Ref	Ref
Postoperative complications*			<0.001			<0.001			<0.001
None or minor	0.57	0.50–0.64		0.77	0.68–0.88		0.74	0.64–0.86
Major	Ref	Ref		Ref	Ref		Ref	Ref

HR_adj, adjusted hazard ratio; AC, adenocarcinoma; SCC, squamous cell carcinoma; (n)CT, (neoadjuvant)chemotherapy; (n/d)CRT, (neoadjuvant/definitive)chemoradiation; MIE, minimally invasive oesophagectomy; Ref, reference group. *Postoperative complications are graded according to the to the Clavien–Dindo scale¹⁶. Minor are considered as grade < IIIa and major as grade ≥ IIIa.

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