Table 2. Open in new tab Number of...

	Age 25–44 years	Age 45–64 years	Age 65–74 years	Age 75–84 years	Age ≥ 85 years
2007	172	47 (40–54)	1.3 (−0.9 to 3.6) P = .25	842	248 (231–265)	3.4 (2.4 to 4.3) P < .01	581	654 (601–707)	1.0 (0.3 to 1.7) P < .01	380	635 (571–699)	2.3 (0.7 to 4.0) P < .01	58	285 (212–358)	5.2 (2.3 to 8.3) P < .01
2008	154	42 (35–49)	965	276 (258–293)	620	678 (624–731)	398	657 (592–721)	66	307 (233–381)
2009	178	49 (42–56)	1024	284 (267–302)	704	745 (690–800)	427	699 (632–765)	67	295 (225–366)
2010	163	45 (38–52)	1065	288 (271–306)	693	711 (658–764)	448	724 (657–791)	81	339 (265–413)
2011	159	44 (37–51)	1189	316 (298–334)	755	746 (693–799)	465	741 (673–808)	123	494 (406–581)
2012	202	56 (48–64)	1176	311 (293–328)	811	757 (705–809)	528	829 (759–900)	111	425 (346–504)
2013	184	51 (43–58)	1269	333 (314–351)	849	752 (701–802)	523	808 (739–877)	121	445 (366–525)
2014	207	57 (49–65)	1252	326 (308–344)	869	737 (688–786)	528	800 (731–868)	131	466 (386–546)
2015	192	53 (45–60)	1329	343 (325–362)	948	773 (724–822)	578	861 (791–931)	117	403 (330–476)
2016	196	53 (46–61)	1397	358 (339–377)	1038	815 (765–864)	602	879 (809–950)	147	485 (407–564)
2017	202	54 (47–62)	1436	366 (347–385)	963	727 (681–773)	534	758 (694–822)	158	505 (426–583)
2018	199	52 (45–59)	1425	362 (343–381)	1043	760 (714–806)	589	808 (743–874)	156	484 (408–560)
2019	198	50 (43–57)	1490	378 (359–397)	1118	785 (739–831)	631	834 (769–899)	151	456 (383–529)

Age 25–44 years

Age 45–64 years

Age 65–74 years

Age 75–84 years

Age ≥ 85 years

Year

Count

Annual incidence (95% CI) -/Million

AAPC (95% CI),
P-value

Count

Crude annual incidence (95% CI)/Million

AAPC (95% CI)
P-value

Count

Annual incidence (95% CI) -/Million

AAPC (95% CI),
P-value

Count

Annual incidence (95% CI) -/Million

AAPC (%),
P-value

Count

Annual incidence (95% CI) -/Million

AAPC
(95% CI)
P-value

2007

172

47 (40–54)

1.3
(−0.9 to 3.6)
P = .25

842

248 (231–265)

3.4
(2.4 to 4.3)
P < .01

581

654 (601–707)

1.0
(0.3 to 1.7)
P < .01

380

635 (571–699)

2.3
(0.7 to 4.0)
P < .01

285 (212–358)

5.2
(2.3 to 8.3)
P < .01

2008

154

42 (35–49)

965

276 (258–293)

620

678 (624–731)

398

657 (592–721)

307 (233–381)

2009

178

49 (42–56)

1024

284 (267–302)

704

745 (690–800)

427

699 (632–765)

295 (225–366)

2010

163

45 (38–52)

1065

288 (271–306)

693

711 (658–764)

448

724 (657–791)

339 (265–413)

2011

159

44 (37–51)

1189

316 (298–334)

755

746 (693–799)

465

741 (673–808)

123

494 (406–581)

2012

202

56 (48–64)

1176

311 (293–328)

811

757 (705–809)

528

829 (759–900)

111

425 (346–504)

2013

184

51 (43–58)

1269

333 (314–351)

849

752 (701–802)

523

808 (739–877)

121

445 (366–525)

2014

207

57 (49–65)

1252

326 (308–344)

869

737 (688–786)

528

800 (731–868)

131

466 (386–546)

2015

192

53 (45–60)

1329

343 (325–362)

948

773 (724–822)

578

861 (791–931)

117

403 (330–476)

2016

196

53 (46–61)

1397

358 (339–377)

1038

815 (765–864)

602

879 (809–950)

147

485 (407–564)

2017

202

54 (47–62)

1436

366 (347–385)

963

727 (681–773)

534

758 (694–822)

158

505 (426–583)

2018

199

52 (45–59)

1425

362 (343–381)

1043

760 (714–806)

589

808 (743–874)

156

484 (408–560)

2019

198

50 (43–57)

1490

378 (359–397)

1118

785 (739–831)

631

834 (769–899)

151

456 (383–529)

	Age 25–44 years	Age 45–64 years	Age 65–74 years	Age 75–84 years	Age ≥ 85 years
2007	172	47 (40–54)	1.3 (−0.9 to 3.6) P = .25	842	248 (231–265)	3.4 (2.4 to 4.3) P < .01	581	654 (601–707)	1.0 (0.3 to 1.7) P < .01	380	635 (571–699)	2.3 (0.7 to 4.0) P < .01	58	285 (212–358)	5.2 (2.3 to 8.3) P < .01
2008	154	42 (35–49)	965	276 (258–293)	620	678 (624–731)	398	657 (592–721)	66	307 (233–381)
2009	178	49 (42–56)	1024	284 (267–302)	704	745 (690–800)	427	699 (632–765)	67	295 (225–366)
2010	163	45 (38–52)	1065	288 (271–306)	693	711 (658–764)	448	724 (657–791)	81	339 (265–413)
2011	159	44 (37–51)	1189	316 (298–334)	755	746 (693–799)	465	741 (673–808)	123	494 (406–581)
2012	202	56 (48–64)	1176	311 (293–328)	811	757 (705–809)	528	829 (759–900)	111	425 (346–504)
2013	184	51 (43–58)	1269	333 (314–351)	849	752 (701–802)	523	808 (739–877)	121	445 (366–525)
2014	207	57 (49–65)	1252	326 (308–344)	869	737 (688–786)	528	800 (731–868)	131	466 (386–546)
2015	192	53 (45–60)	1329	343 (325–362)	948	773 (724–822)	578	861 (791–931)	117	403 (330–476)
2016	196	53 (46–61)	1397	358 (339–377)	1038	815 (765–864)	602	879 (809–950)	147	485 (407–564)
2017	202	54 (47–62)	1436	366 (347–385)	963	727 (681–773)	534	758 (694–822)	158	505 (426–583)
2018	199	52 (45–59)	1425	362 (343–381)	1043	760 (714–806)	589	808 (743–874)	156	484 (408–560)
2019	198	50 (43–57)	1490	378 (359–397)	1118	785 (739–831)	631	834 (769–899)	151	456 (383–529)

	Males	Females
2007	1059	258 (242–273)	2.3 (1.0 to 3.6), P < .01	974	209 (196–223)	2.1 (1.3 to 2.9), P < .01
2008	1206	285 (269–301)	997	210 (197–223)
2009	1300	299 (283–315)	1100	226 (213–240)
2010	1365	303 (287–320)	1085	218 (205–231)
2011	1473	320 (304–337)	1218	238 (224–251)
2012	1548	329 (312–345)	1280	246 (232–260)
2013	1611	330 (314–346)	1335	250 (236–264)
2014	1622	324 (309–340)	1365	253 (240–267)
2015	1722	336 (320–352)	1442	261 (247–275)
2016	1921	364 (347–380)	1459	258 (245–275)
2017	1829	335 (319–350)	1464	257 (243–270)
2018	1912	339 (324–355)	1500	258 (245–272)
2019	1996	344 (329–359)	1592	268 (255–282)

Males

Females

Year

Count

Age-adjusted incidence (95% CI)—/Million

AAPC (95% CI),
P-value

Count

Age—standardized incidence (95% CI) -/Million

AAPC (95% CI),
P-value

2007

1059

258 (242–273)

2.3
(1.0 to 3.6),
P < .01

974

209 (196–223)

2.1
(1.3 to 2.9),
P < .01

2008

1206

285 (269–301)

997

210 (197–223)

2009

1300

299 (283–315)

1100

226 (213–240)

2010

1365

303 (287–320)

1085

218 (205–231)

2011

1473

320 (304–337)

1218

238 (224–251)

2012

1548

329 (312–345)

1280

246 (232–260)

2013

1611

330 (314–346)

1335

250 (236–264)

2014

1622

324 (309–340)

1365

253 (240–267)

2015

1722

336 (320–352)

1442

261 (247–275)

2016

1921

364 (347–380)

1459

258 (245–275)

2017

1829

335 (319–350)

1464

257 (243–270)

2018

1912

339 (324–355)

1500

258 (245–272)

2019

1996

344 (329–359)

1592

268 (255–282)

	Males	Females
2007	1059	258 (242–273)	2.3 (1.0 to 3.6), P < .01	974	209 (196–223)	2.1 (1.3 to 2.9), P < .01
2008	1206	285 (269–301)	997	210 (197–223)
2009	1300	299 (283–315)	1100	226 (213–240)
2010	1365	303 (287–320)	1085	218 (205–231)
2011	1473	320 (304–337)	1218	238 (224–251)
2012	1548	329 (312–345)	1280	246 (232–260)
2013	1611	330 (314–346)	1335	250 (236–264)
2014	1622	324 (309–340)	1365	253 (240–267)
2015	1722	336 (320–352)	1442	261 (247–275)
2016	1921	364 (347–380)	1459	258 (245–275)
2017	1829	335 (319–350)	1464	257 (243–270)
2018	1912	339 (324–355)	1500	258 (245–272)
2019	1996	344 (329–359)	1592	268 (255–282)

Table 2.

Open in new tab

Number of Cases, Annual Incidence, and Average Annual Percent Change (AAPC) in Incidence of Spine Metastasis by Age Groups and Sex

	Age 25–44 years			Age 45–64 years			Age 65–74 years			Age 75–84 years			Age ≥ 85 years
Year	Count	Annual incidence (95% CI) -/Million	AAPC (95% CI), P-value	Count	Crude annual incidence (95% CI)/Million	AAPC (95% CI) P-value	Count	Annual incidence (95% CI) -/Million	AAPC (95% CI), P-value	Count	Annual incidence (95% CI) -/Million	AAPC (%), P-value	Count	Annual incidence (95% CI) -/Million	AAPC (95% CI) P-value
2007	172	47 (40–54)	1.3 (−0.9 to 3.6) P = .25	842	248 (231–265)	3.4 (2.4 to 4.3) P < .01	581	654 (601–707)	1.0 (0.3 to 1.7) P < .01	380	635 (571–699)	2.3 (0.7 to 4.0) P < .01	58	285 (212–358)	5.2 (2.3 to 8.3) P < .01
2008	154	42 (35–49)		965	276 (258–293)		620	678 (624–731)		398	657 (592–721)		66	307 (233–381)
2009	178	49 (42–56)		1024	284 (267–302)		704	745 (690–800)		427	699 (632–765)		67	295 (225–366)
2010	163	45 (38–52)		1065	288 (271–306)		693	711 (658–764)		448	724 (657–791)		81	339 (265–413)
2011	159	44 (37–51)		1189	316 (298–334)		755	746 (693–799)		465	741 (673–808)		123	494 (406–581)
2012	202	56 (48–64)		1176	311 (293–328)		811	757 (705–809)		528	829 (759–900)		111	425 (346–504)
2013	184	51 (43–58)		1269	333 (314–351)		849	752 (701–802)		523	808 (739–877)		121	445 (366–525)
2014	207	57 (49–65)		1252	326 (308–344)		869	737 (688–786)		528	800 (731–868)		131	466 (386–546)
2015	192	53 (45–60)		1329	343 (325–362)		948	773 (724–822)		578	861 (791–931)		117	403 (330–476)
2016	196	53 (46–61)		1397	358 (339–377)		1038	815 (765–864)		602	879 (809–950)		147	485 (407–564)
2017	202	54 (47–62)		1436	366 (347–385)		963	727 (681–773)		534	758 (694–822)		158	505 (426–583)
2018	199	52 (45–59)		1425	362 (343–381)		1043	760 (714–806)		589	808 (743–874)		156	484 (408–560)
2019	198	50 (43–57)		1490	378 (359–397)		1118	785 (739–831)		631	834 (769–899)		151	456 (383–529)

	Age 25–44 years			Age 45–64 years			Age 65–74 years			Age 75–84 years			Age ≥ 85 years
Year	Count	Annual incidence (95% CI) -/Million	AAPC (95% CI), P-value	Count	Crude annual incidence (95% CI)/Million	AAPC (95% CI) P-value	Count	Annual incidence (95% CI) -/Million	AAPC (95% CI), P-value	Count	Annual incidence (95% CI) -/Million	AAPC (%), P-value	Count	Annual incidence (95% CI) -/Million	AAPC (95% CI) P-value
2007	172	47 (40–54)	1.3 (−0.9 to 3.6) P = .25	842	248 (231–265)	3.4 (2.4 to 4.3) P < .01	581	654 (601–707)	1.0 (0.3 to 1.7) P < .01	380	635 (571–699)	2.3 (0.7 to 4.0) P < .01	58	285 (212–358)	5.2 (2.3 to 8.3) P < .01
2008	154	42 (35–49)		965	276 (258–293)		620	678 (624–731)		398	657 (592–721)		66	307 (233–381)
2009	178	49 (42–56)		1024	284 (267–302)		704	745 (690–800)		427	699 (632–765)		67	295 (225–366)
2010	163	45 (38–52)		1065	288 (271–306)		693	711 (658–764)		448	724 (657–791)		81	339 (265–413)
2011	159	44 (37–51)		1189	316 (298–334)		755	746 (693–799)		465	741 (673–808)		123	494 (406–581)
2012	202	56 (48–64)		1176	311 (293–328)		811	757 (705–809)		528	829 (759–900)		111	425 (346–504)
2013	184	51 (43–58)		1269	333 (314–351)		849	752 (701–802)		523	808 (739–877)		121	445 (366–525)
2014	207	57 (49–65)		1252	326 (308–344)		869	737 (688–786)		528	800 (731–868)		131	466 (386–546)
2015	192	53 (45–60)		1329	343 (325–362)		948	773 (724–822)		578	861 (791–931)		117	403 (330–476)
2016	196	53 (46–61)		1397	358 (339–377)		1038	815 (765–864)		602	879 (809–950)		147	485 (407–564)
2017	202	54 (47–62)		1436	366 (347–385)		963	727 (681–773)		534	758 (694–822)		158	505 (426–583)
2018	199	52 (45–59)		1425	362 (343–381)		1043	760 (714–806)		589	808 (743–874)		156	484 (408–560)
2019	198	50 (43–57)		1490	378 (359–397)		1118	785 (739–831)		631	834 (769–899)		151	456 (383–529)

	Males			Females
Year	Count	Age-adjusted incidence (95% CI)—/Million	AAPC (95% CI), P-value	Count	Age—standardized incidence (95% CI) -/Million	AAPC (95% CI), P-value
2007	1059	258 (242–273)	2.3 (1.0 to 3.6), P < .01	974	209 (196–223)	2.1 (1.3 to 2.9), P < .01
2008	1206	285 (269–301)		997	210 (197–223)
2009	1300	299 (283–315)		1100	226 (213–240)
2010	1365	303 (287–320)		1085	218 (205–231)
2011	1473	320 (304–337)		1218	238 (224–251)
2012	1548	329 (312–345)		1280	246 (232–260)
2013	1611	330 (314–346)		1335	250 (236–264)
2014	1622	324 (309–340)		1365	253 (240–267)
2015	1722	336 (320–352)		1442	261 (247–275)
2016	1921	364 (347–380)		1459	258 (245–275)
2017	1829	335 (319–350)		1464	257 (243–270)
2018	1912	339 (324–355)		1500	258 (245–272)
2019	1996	344 (329–359)		1592	268 (255–282)

	Males			Females
Year	Count	Age-adjusted incidence (95% CI)—/Million	AAPC (95% CI), P-value	Count	Age—standardized incidence (95% CI) -/Million	AAPC (95% CI), P-value
2007	1059	258 (242–273)	2.3 (1.0 to 3.6), P < .01	974	209 (196–223)	2.1 (1.3 to 2.9), P < .01
2008	1206	285 (269–301)		997	210 (197–223)
2009	1300	299 (283–315)		1100	226 (213–240)
2010	1365	303 (287–320)		1085	218 (205–231)
2011	1473	320 (304–337)		1218	238 (224–251)
2012	1548	329 (312–345)		1280	246 (232–260)
2013	1611	330 (314–346)		1335	250 (236–264)
2014	1622	324 (309–340)		1365	253 (240–267)
2015	1722	336 (320–352)		1442	261 (247–275)
2016	1921	364 (347–380)		1459	258 (245–275)
2017	1829	335 (319–350)		1464	257 (243–270)
2018	1912	339 (324–355)		1500	258 (245–272)
2019	1996	344 (329–359)		1592	268 (255–282)

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