Table 2. Open in new tab Cross-species...

		MEN1-PanNET mice^a
NDC80	Kinetochore protein NDC80	3.58	4.30	0.84	0.64-1.00
DEF8	Differentially expressed in FDCP 8 homolog	3.58	3.32	0.77	0.60-0.93
SPAG17	Sperm associated antigen 17	1.93	1.32	0.82	0.59-1.00
ATM	ATM serine/threonine kinase	1.54	1.99	0.66	0.50-0.82
IMMT	Inner membrane mitochondrial protein	1.36	2.95	0.77	0.57-0.96
DNAH6	Dynein axonemal heavy chain 6	1.32	1.55	0.69	0.50-0.88
DSP	Desmoplakin	1.31	1.57	0.77	0.49-1.00
CIT	Citron Rho-interacting serine/threonine kinase	1.22	6.16	0.75	0.56-0.94
C3	Complement C3	1.16	1.43	0.67	0.53-0.82
HRG	Histidine rich glycoprotein	1.15	1.24	0.66	0.49-0.82
F5	Coagulation factor V	1.14	1.26	0.75	0.60-0.89
CD79A	Cluster of differentiation CD79A	1.08	3.22	0.69	0.44-0.95
BDP1	B double prime 1	1.07	2.86	0.68	0.53-0.84
SERPINA11	Serpin family A member 11	1.06	1.44	0.75	0.60-0.90
PROS1	Coagulation regulator protein S	1.06	1.43	0.69	0.53-0.84
TARBP1	TAR (HIV-1) RNA binding protein 1	1.05	1.31	0.84	0.65-1.00
B2M	B2 microglobulin	1.02	1.25	0.68	0.52-0.84
SERPIND1	Serpin family D member 1	1.02	1.21	0.70	0.54-0.85
PROC	Protein C	1.00	1.23	0.68	0.53-0.84

MEN1-PanNET mice^a

8 month

12 month

Human MEN1 cohort

Protein

Description

Fold-change^a

AUC^b

95% CI

NDC80

Kinetochore protein NDC80

3.58

4.30

0.84

0.64-1.00

DEF8

Differentially expressed in FDCP 8 homolog

3.58

3.32

0.77

0.60-0.93

SPAG17

Sperm associated antigen 17

1.93

1.32

0.82

0.59-1.00

ATM

ATM serine/threonine kinase

1.54

1.99

0.66

0.50-0.82

IMMT

Inner membrane mitochondrial protein

1.36

2.95

0.77

0.57-0.96

DNAH6

Dynein axonemal heavy chain 6

1.32

1.55

0.69

0.50-0.88

DSP

Desmoplakin

1.31

1.57

0.77

0.49-1.00

CIT

Citron Rho-interacting serine/threonine kinase

1.22

6.16

0.75

0.56-0.94

Complement C3

1.16

1.43

0.67

0.53-0.82

HRG

Histidine rich glycoprotein

1.15

1.24

0.66

0.49-0.82

Coagulation factor V

1.14

1.26

0.75

0.60-0.89

CD79A

Cluster of differentiation CD79A

1.08

3.22

0.69

0.44-0.95

BDP1

B double prime 1

1.07

2.86

0.68

0.53-0.84

SERPINA11

Serpin family A member 11

1.06

1.44

0.75

0.60-0.90

PROS1

Coagulation regulator protein S

1.06

1.43

0.69

0.53-0.84

TARBP1

TAR (HIV-1) RNA binding protein 1

1.05

1.31

0.84

0.65-1.00

B2M

B2 microglobulin

1.02

1.25

0.68

0.52-0.84

SERPIND1

Serpin family D member 1

1.02

1.21

0.70

0.54-0.85

PROC

Protein C

1.00

1.23

0.68

0.53-0.84

		MEN1-PanNET mice^a
NDC80	Kinetochore protein NDC80	3.58	4.30	0.84	0.64-1.00
DEF8	Differentially expressed in FDCP 8 homolog	3.58	3.32	0.77	0.60-0.93
SPAG17	Sperm associated antigen 17	1.93	1.32	0.82	0.59-1.00
ATM	ATM serine/threonine kinase	1.54	1.99	0.66	0.50-0.82
IMMT	Inner membrane mitochondrial protein	1.36	2.95	0.77	0.57-0.96
DNAH6	Dynein axonemal heavy chain 6	1.32	1.55	0.69	0.50-0.88
DSP	Desmoplakin	1.31	1.57	0.77	0.49-1.00
CIT	Citron Rho-interacting serine/threonine kinase	1.22	6.16	0.75	0.56-0.94
C3	Complement C3	1.16	1.43	0.67	0.53-0.82
HRG	Histidine rich glycoprotein	1.15	1.24	0.66	0.49-0.82
F5	Coagulation factor V	1.14	1.26	0.75	0.60-0.89
CD79A	Cluster of differentiation CD79A	1.08	3.22	0.69	0.44-0.95
BDP1	B double prime 1	1.07	2.86	0.68	0.53-0.84
SERPINA11	Serpin family A member 11	1.06	1.44	0.75	0.60-0.90
PROS1	Coagulation regulator protein S	1.06	1.43	0.69	0.53-0.84
TARBP1	TAR (HIV-1) RNA binding protein 1	1.05	1.31	0.84	0.65-1.00
B2M	B2 microglobulin	1.02	1.25	0.68	0.52-0.84
SERPIND1	Serpin family D member 1	1.02	1.21	0.70	0.54-0.85
PROC	Protein C	1.00	1.23	0.68	0.53-0.84

Table 2.

Open in new tab

Cross-species intersection of plasma protein signatures of MEN1-related dpNET progression

		MEN1-PanNET mice^a
		8 month	12 month	Human MEN1 cohort
Protein	Description	Fold-change^a	Fold-change^a	AUC^b	95% CI
NDC80	Kinetochore protein NDC80	3.58	4.30	0.84	0.64-1.00
DEF8	Differentially expressed in FDCP 8 homolog	3.58	3.32	0.77	0.60-0.93
SPAG17	Sperm associated antigen 17	1.93	1.32	0.82	0.59-1.00
ATM	ATM serine/threonine kinase	1.54	1.99	0.66	0.50-0.82
IMMT	Inner membrane mitochondrial protein	1.36	2.95	0.77	0.57-0.96
DNAH6	Dynein axonemal heavy chain 6	1.32	1.55	0.69	0.50-0.88
DSP	Desmoplakin	1.31	1.57	0.77	0.49-1.00
CIT	Citron Rho-interacting serine/threonine kinase	1.22	6.16	0.75	0.56-0.94
C3	Complement C3	1.16	1.43	0.67	0.53-0.82
HRG	Histidine rich glycoprotein	1.15	1.24	0.66	0.49-0.82
F5	Coagulation factor V	1.14	1.26	0.75	0.60-0.89
CD79A	Cluster of differentiation CD79A	1.08	3.22	0.69	0.44-0.95
BDP1	B double prime 1	1.07	2.86	0.68	0.53-0.84
SERPINA11	Serpin family A member 11	1.06	1.44	0.75	0.60-0.90
PROS1	Coagulation regulator protein S	1.06	1.43	0.69	0.53-0.84
TARBP1	TAR (HIV-1) RNA binding protein 1	1.05	1.31	0.84	0.65-1.00
B2M	B2 microglobulin	1.02	1.25	0.68	0.52-0.84
SERPIND1	Serpin family D member 1	1.02	1.21	0.70	0.54-0.85
PROC	Protein C	1.00	1.23	0.68	0.53-0.84

		MEN1-PanNET mice^a
		8 month	12 month	Human MEN1 cohort
Protein	Description	Fold-change^a	Fold-change^a	AUC^b	95% CI
NDC80	Kinetochore protein NDC80	3.58	4.30	0.84	0.64-1.00
DEF8	Differentially expressed in FDCP 8 homolog	3.58	3.32	0.77	0.60-0.93
SPAG17	Sperm associated antigen 17	1.93	1.32	0.82	0.59-1.00
ATM	ATM serine/threonine kinase	1.54	1.99	0.66	0.50-0.82
IMMT	Inner membrane mitochondrial protein	1.36	2.95	0.77	0.57-0.96
DNAH6	Dynein axonemal heavy chain 6	1.32	1.55	0.69	0.50-0.88
DSP	Desmoplakin	1.31	1.57	0.77	0.49-1.00
CIT	Citron Rho-interacting serine/threonine kinase	1.22	6.16	0.75	0.56-0.94
C3	Complement C3	1.16	1.43	0.67	0.53-0.82
HRG	Histidine rich glycoprotein	1.15	1.24	0.66	0.49-0.82
F5	Coagulation factor V	1.14	1.26	0.75	0.60-0.89
CD79A	Cluster of differentiation CD79A	1.08	3.22	0.69	0.44-0.95
BDP1	B double prime 1	1.07	2.86	0.68	0.53-0.84
SERPINA11	Serpin family A member 11	1.06	1.44	0.75	0.60-0.90
PROS1	Coagulation regulator protein S	1.06	1.43	0.69	0.53-0.84
TARBP1	TAR (HIV-1) RNA binding protein 1	1.05	1.31	0.84	0.65-1.00
B2M	B2 microglobulin	1.02	1.25	0.68	0.52-0.84
SERPIND1	Serpin family D member 1	1.02	1.21	0.70	0.54-0.85
PROC	Protein C	1.00	1.23	0.68	0.53-0.84

Abbreviations: AUC, area under the receiver operating characteristics curve; CI, confidence interval; dpNET, duodenopancreatic neuroendocrine tumor.

^aFold change comparing plasma protein levels between cases (Men1^fl/flPdx1-Cre^Tg) and control (Men1^fl/fl) mice.

^bPredictive performance (AUC) for distinguishing cases from respective controls. Cases are defined as patients with MEN1 and liver metastases from a duodenopancreatic neuroendocrine tumor (dpNET). Controls are patients with MEN1 and a nonmetastatic (distant or regional) indolent dpNET or patients with MEN1 without a dpNET or other neuroendocrine tumor.

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