| Characteristic . | Control (n = 15) . | lpSMD (n = 25) . | rpSMD (n = 10) . | P-value . |
|---|---|---|---|---|
| Female | 10 (67%) | 13 (52%) | 8 (80%) | 0.28 |
| Education, years | 14 (13, 16) | 16 (14, 16) | 16 (13, 18) | 0.41 |
| Age at MRI, years | 60 (56, 64) | 64 (58, 69) | 68 (63, 71) | 0.05 |
| Handedness | 0.65 | |||
| Right | 21 (84%) | 9 (90%) | ||
| Left | 2 (8%) | 0 (0%) | ||
| Ambidextrous | 2 (8%) | 1 (10%) | ||
| Age at onset, years | 61 (54, 66) | 62 (58, 68) | 0.53 | |
| Disease duration, years | 3 (2, 5) | 4 (2, 5) | 0.71 | |
| Clinical/neuropsychological tests | ||||
| FAB (/18) | 15 (14, 17) | 18 (16, 18) | 0.03 | |
| FAB similarities (/3) | 2 (0, 3) | 3 (2, 3) | 0.07 | |
| FAB Luria (/3) | 3 (3, 3) | 3 (3, 3) | >0.99 | |
| UPDRS III (/148) | 0 (0,2) | 2 (0,4) | 0.20 | |
| WAB praxis (/60) | 59 (57, 60) | 60 (59, 60) | 0.07 | |
| NPI (/36) | 4 (2, 7) | 7 (3, 13) | 0.28 | |
| CBI-R (/180) | 35 (18, 51) | 40 (34, 61) | 0.58 | |
| CBI-R abnormal behaviour (/24) | 1 (0, 5) | 1 (1, 7) | 0.66 | |
| 20-BAS (/20) | 3 (1, 4) | 2 (1, 8) | 0.57 | |
| MoCA (/30) | 26 (24, 28) | 20 (18, 23) | 24 (20, 26) | 0.12a |
| Famous faces (/10) | 9 (7, 10) | 3 (1, 6) | 0.002 | |
| Auditory battery (/30) | 25 (21, 26) | 21 (17, 25) | 0.15 | |
| Pyramids & Palm trees (/52) | 41 (33, 47) | 41 (38, 42) | 0.76 | |
| Speech-language tests | ||||
| WAB-AQ (/100) | 86 (80, 93) | 93 (88, 96) | 0.04 | |
| SYDBAT naming (/30) | 6 (3, 17) | 11 (8, 12) | 0.29 | |
| SYDBAT semantic association (/30) | 19 (14, 22) | 15 (14, 18) | 0.17 | |
| Letter fluency (FAS) | 25 (15, 33) | 29 (18, 35) | 0.37 | |
| BDAE repetition (/10) | 8 (7, 10) | 9 (8, 10) | 0.25 | |
| Neuroimaging features | ||||
| Total intracranial volume, L | 1.5 (1.4, 1.6) | 1.5 (1.4, 1.7) | 1.4 (1.4, 1.5) | 0.22 |
| Total hippocampal volume, mL | 6.7 (6.4, 7.3) | 5.7 (5.2, 6.4) | 5.1 (4.8, 5.5) | 0.009a |
| Left hippocampal volume, mL | 3.3 (3.1, 3.6) | 2.4 (2.2, 3.0) | 2.8 (2.7, 2.9) | 0.06a |
| Right hippocampal volume, mL | 3.5 (3.2, 3.7) | 3.3 (3.0, 3.5) | 2.3 (2.2, 2.6) | <0.001a |
| Characteristic . | Control (n = 15) . | lpSMD (n = 25) . | rpSMD (n = 10) . | P-value . |
|---|---|---|---|---|
| Female | 10 (67%) | 13 (52%) | 8 (80%) | 0.28 |
| Education, years | 14 (13, 16) | 16 (14, 16) | 16 (13, 18) | 0.41 |
| Age at MRI, years | 60 (56, 64) | 64 (58, 69) | 68 (63, 71) | 0.05 |
| Handedness | 0.65 | |||
| Right | 21 (84%) | 9 (90%) | ||
| Left | 2 (8%) | 0 (0%) | ||
| Ambidextrous | 2 (8%) | 1 (10%) | ||
| Age at onset, years | 61 (54, 66) | 62 (58, 68) | 0.53 | |
| Disease duration, years | 3 (2, 5) | 4 (2, 5) | 0.71 | |
| Clinical/neuropsychological tests | ||||
| FAB (/18) | 15 (14, 17) | 18 (16, 18) | 0.03 | |
| FAB similarities (/3) | 2 (0, 3) | 3 (2, 3) | 0.07 | |
| FAB Luria (/3) | 3 (3, 3) | 3 (3, 3) | >0.99 | |
| UPDRS III (/148) | 0 (0,2) | 2 (0,4) | 0.20 | |
| WAB praxis (/60) | 59 (57, 60) | 60 (59, 60) | 0.07 | |
| NPI (/36) | 4 (2, 7) | 7 (3, 13) | 0.28 | |
| CBI-R (/180) | 35 (18, 51) | 40 (34, 61) | 0.58 | |
| CBI-R abnormal behaviour (/24) | 1 (0, 5) | 1 (1, 7) | 0.66 | |
| 20-BAS (/20) | 3 (1, 4) | 2 (1, 8) | 0.57 | |
| MoCA (/30) | 26 (24, 28) | 20 (18, 23) | 24 (20, 26) | 0.12a |
| Famous faces (/10) | 9 (7, 10) | 3 (1, 6) | 0.002 | |
| Auditory battery (/30) | 25 (21, 26) | 21 (17, 25) | 0.15 | |
| Pyramids & Palm trees (/52) | 41 (33, 47) | 41 (38, 42) | 0.76 | |
| Speech-language tests | ||||
| WAB-AQ (/100) | 86 (80, 93) | 93 (88, 96) | 0.04 | |
| SYDBAT naming (/30) | 6 (3, 17) | 11 (8, 12) | 0.29 | |
| SYDBAT semantic association (/30) | 19 (14, 22) | 15 (14, 18) | 0.17 | |
| Letter fluency (FAS) | 25 (15, 33) | 29 (18, 35) | 0.37 | |
| BDAE repetition (/10) | 8 (7, 10) | 9 (8, 10) | 0.25 | |
| Neuroimaging features | ||||
| Total intracranial volume, L | 1.5 (1.4, 1.6) | 1.5 (1.4, 1.7) | 1.4 (1.4, 1.5) | 0.22 |
| Total hippocampal volume, mL | 6.7 (6.4, 7.3) | 5.7 (5.2, 6.4) | 5.1 (4.8, 5.5) | 0.009a |
| Left hippocampal volume, mL | 3.3 (3.1, 3.6) | 2.4 (2.2, 3.0) | 2.8 (2.7, 2.9) | 0.06a |
| Right hippocampal volume, mL | 3.5 (3.2, 3.7) | 3.3 (3.0, 3.5) | 2.3 (2.2, 2.6) | <0.001a |
Data are shown as count (%) or median (Q1, Q3). P-values are from Fisher’s exact test, Kruskal–Wallis test or Wilcoxon rank-sum test, as appropriate. P-values less than 0.05 are considered significant and are shown in bold.
20-BAS, 20-item Behavioural Assessment Scale; AQ, aphasia quotient; BDAE, Boston Diagnostic Aphasia Examination; CBI-R, Cambridge Behavioural Inventory-Revised; FAB, Frontal Assessment Battery; MoCA, Montreal Cognitive Assessment; NPI, Neuropsychiatric Inventory; SYDBAT, Sydney Language Battery; UPDRS, Unified Parkinson’s Disease Rating Scale; WAB, Western Aphasia Battery.
aComparing semantic dementia groups.
| Characteristic . | Control (n = 15) . | lpSMD (n = 25) . | rpSMD (n = 10) . | P-value . |
|---|---|---|---|---|
| Female | 10 (67%) | 13 (52%) | 8 (80%) | 0.28 |
| Education, years | 14 (13, 16) | 16 (14, 16) | 16 (13, 18) | 0.41 |
| Age at MRI, years | 60 (56, 64) | 64 (58, 69) | 68 (63, 71) | 0.05 |
| Handedness | 0.65 | |||
| Right | 21 (84%) | 9 (90%) | ||
| Left | 2 (8%) | 0 (0%) | ||
| Ambidextrous | 2 (8%) | 1 (10%) | ||
| Age at onset, years | 61 (54, 66) | 62 (58, 68) | 0.53 | |
| Disease duration, years | 3 (2, 5) | 4 (2, 5) | 0.71 | |
| Clinical/neuropsychological tests | ||||
| FAB (/18) | 15 (14, 17) | 18 (16, 18) | 0.03 | |
| FAB similarities (/3) | 2 (0, 3) | 3 (2, 3) | 0.07 | |
| FAB Luria (/3) | 3 (3, 3) | 3 (3, 3) | >0.99 | |
| UPDRS III (/148) | 0 (0,2) | 2 (0,4) | 0.20 | |
| WAB praxis (/60) | 59 (57, 60) | 60 (59, 60) | 0.07 | |
| NPI (/36) | 4 (2, 7) | 7 (3, 13) | 0.28 | |
| CBI-R (/180) | 35 (18, 51) | 40 (34, 61) | 0.58 | |
| CBI-R abnormal behaviour (/24) | 1 (0, 5) | 1 (1, 7) | 0.66 | |
| 20-BAS (/20) | 3 (1, 4) | 2 (1, 8) | 0.57 | |
| MoCA (/30) | 26 (24, 28) | 20 (18, 23) | 24 (20, 26) | 0.12a |
| Famous faces (/10) | 9 (7, 10) | 3 (1, 6) | 0.002 | |
| Auditory battery (/30) | 25 (21, 26) | 21 (17, 25) | 0.15 | |
| Pyramids & Palm trees (/52) | 41 (33, 47) | 41 (38, 42) | 0.76 | |
| Speech-language tests | ||||
| WAB-AQ (/100) | 86 (80, 93) | 93 (88, 96) | 0.04 | |
| SYDBAT naming (/30) | 6 (3, 17) | 11 (8, 12) | 0.29 | |
| SYDBAT semantic association (/30) | 19 (14, 22) | 15 (14, 18) | 0.17 | |
| Letter fluency (FAS) | 25 (15, 33) | 29 (18, 35) | 0.37 | |
| BDAE repetition (/10) | 8 (7, 10) | 9 (8, 10) | 0.25 | |
| Neuroimaging features | ||||
| Total intracranial volume, L | 1.5 (1.4, 1.6) | 1.5 (1.4, 1.7) | 1.4 (1.4, 1.5) | 0.22 |
| Total hippocampal volume, mL | 6.7 (6.4, 7.3) | 5.7 (5.2, 6.4) | 5.1 (4.8, 5.5) | 0.009a |
| Left hippocampal volume, mL | 3.3 (3.1, 3.6) | 2.4 (2.2, 3.0) | 2.8 (2.7, 2.9) | 0.06a |
| Right hippocampal volume, mL | 3.5 (3.2, 3.7) | 3.3 (3.0, 3.5) | 2.3 (2.2, 2.6) | <0.001a |
| Characteristic . | Control (n = 15) . | lpSMD (n = 25) . | rpSMD (n = 10) . | P-value . |
|---|---|---|---|---|
| Female | 10 (67%) | 13 (52%) | 8 (80%) | 0.28 |
| Education, years | 14 (13, 16) | 16 (14, 16) | 16 (13, 18) | 0.41 |
| Age at MRI, years | 60 (56, 64) | 64 (58, 69) | 68 (63, 71) | 0.05 |
| Handedness | 0.65 | |||
| Right | 21 (84%) | 9 (90%) | ||
| Left | 2 (8%) | 0 (0%) | ||
| Ambidextrous | 2 (8%) | 1 (10%) | ||
| Age at onset, years | 61 (54, 66) | 62 (58, 68) | 0.53 | |
| Disease duration, years | 3 (2, 5) | 4 (2, 5) | 0.71 | |
| Clinical/neuropsychological tests | ||||
| FAB (/18) | 15 (14, 17) | 18 (16, 18) | 0.03 | |
| FAB similarities (/3) | 2 (0, 3) | 3 (2, 3) | 0.07 | |
| FAB Luria (/3) | 3 (3, 3) | 3 (3, 3) | >0.99 | |
| UPDRS III (/148) | 0 (0,2) | 2 (0,4) | 0.20 | |
| WAB praxis (/60) | 59 (57, 60) | 60 (59, 60) | 0.07 | |
| NPI (/36) | 4 (2, 7) | 7 (3, 13) | 0.28 | |
| CBI-R (/180) | 35 (18, 51) | 40 (34, 61) | 0.58 | |
| CBI-R abnormal behaviour (/24) | 1 (0, 5) | 1 (1, 7) | 0.66 | |
| 20-BAS (/20) | 3 (1, 4) | 2 (1, 8) | 0.57 | |
| MoCA (/30) | 26 (24, 28) | 20 (18, 23) | 24 (20, 26) | 0.12a |
| Famous faces (/10) | 9 (7, 10) | 3 (1, 6) | 0.002 | |
| Auditory battery (/30) | 25 (21, 26) | 21 (17, 25) | 0.15 | |
| Pyramids & Palm trees (/52) | 41 (33, 47) | 41 (38, 42) | 0.76 | |
| Speech-language tests | ||||
| WAB-AQ (/100) | 86 (80, 93) | 93 (88, 96) | 0.04 | |
| SYDBAT naming (/30) | 6 (3, 17) | 11 (8, 12) | 0.29 | |
| SYDBAT semantic association (/30) | 19 (14, 22) | 15 (14, 18) | 0.17 | |
| Letter fluency (FAS) | 25 (15, 33) | 29 (18, 35) | 0.37 | |
| BDAE repetition (/10) | 8 (7, 10) | 9 (8, 10) | 0.25 | |
| Neuroimaging features | ||||
| Total intracranial volume, L | 1.5 (1.4, 1.6) | 1.5 (1.4, 1.7) | 1.4 (1.4, 1.5) | 0.22 |
| Total hippocampal volume, mL | 6.7 (6.4, 7.3) | 5.7 (5.2, 6.4) | 5.1 (4.8, 5.5) | 0.009a |
| Left hippocampal volume, mL | 3.3 (3.1, 3.6) | 2.4 (2.2, 3.0) | 2.8 (2.7, 2.9) | 0.06a |
| Right hippocampal volume, mL | 3.5 (3.2, 3.7) | 3.3 (3.0, 3.5) | 2.3 (2.2, 2.6) | <0.001a |
Data are shown as count (%) or median (Q1, Q3). P-values are from Fisher’s exact test, Kruskal–Wallis test or Wilcoxon rank-sum test, as appropriate. P-values less than 0.05 are considered significant and are shown in bold.
20-BAS, 20-item Behavioural Assessment Scale; AQ, aphasia quotient; BDAE, Boston Diagnostic Aphasia Examination; CBI-R, Cambridge Behavioural Inventory-Revised; FAB, Frontal Assessment Battery; MoCA, Montreal Cognitive Assessment; NPI, Neuropsychiatric Inventory; SYDBAT, Sydney Language Battery; UPDRS, Unified Parkinson’s Disease Rating Scale; WAB, Western Aphasia Battery.
aComparing semantic dementia groups.
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