Table 1
Open in new tab

Summary of demographic, clinical and imaging characteristics

CADASIL (n = 24)Control (n = 24)P-value
Demographics
 Age, (range)50.69 ± 12.45 (23–75)52.82 ± 11.26 (28–75)0.54
 Sex, n (%) female16 (67%)16 (67%)1.0
 Education in years14.70 ± 4.1717.09 ± 2.130.02*
Cognitive measures
 Clinical Dementia Rating (CDR) global score0.17 ± 0.240.02 ± 0.100.01*
 CDR Sum-of-Boxes0.54 ± 0.830.15 ± 0.500.01*
 Mini-Mental State Examination (MMSE) total score27.72 ± 2.4929.52 ± 0.590.02*
 Trail B Test Time (TRAILB) (sec)84.67 ± 65.7247.88 ± 14.69 
 Rey–Osterrieth Complex Figure Test recall at 10 min (Rey10 m)12.24 ± 2.1913.36 ± 2.080.09
Imaging characteristics
 Brain parenchymal fraction (BPF)0.77 ± 0.060.78 ± 0.030.54
 Total white matter hyperintensity (WMH) volume (mm3)12 723.27 ± 8334.021306.34 ± 7210.0000007*
 Enlarged perivascular spaces (ePVS) volume (mm3)547.75 ± 441.38487.88 ± 747.550.73
CADASIL (n = 24)Control (n = 24)P-value
Demographics
 Age, (range)50.69 ± 12.45 (23–75)52.82 ± 11.26 (28–75)0.54
 Sex, n (%) female16 (67%)16 (67%)1.0
 Education in years14.70 ± 4.1717.09 ± 2.130.02*
Cognitive measures
 Clinical Dementia Rating (CDR) global score0.17 ± 0.240.02 ± 0.100.01*
 CDR Sum-of-Boxes0.54 ± 0.830.15 ± 0.500.01*
 Mini-Mental State Examination (MMSE) total score27.72 ± 2.4929.52 ± 0.590.02*
 Trail B Test Time (TRAILB) (sec)84.67 ± 65.7247.88 ± 14.69 
 Rey–Osterrieth Complex Figure Test recall at 10 min (Rey10 m)12.24 ± 2.1913.36 ± 2.080.09
Imaging characteristics
 Brain parenchymal fraction (BPF)0.77 ± 0.060.78 ± 0.030.54
 Total white matter hyperintensity (WMH) volume (mm3)12 723.27 ± 8334.021306.34 ± 7210.0000007*
 Enlarged perivascular spaces (ePVS) volume (mm3)547.75 ± 441.38487.88 ± 747.550.73

Values are reported as mean ± standard deviation. Two-tailed Student’s t-tests or the non-parametric Wilcoxon rank sum was used for statistical comparison of continuous and nominal measures, and Chi-square tests were performed to compare group characteristics. *P-value < 0.05.

Table 1
Open in new tab

Summary of demographic, clinical and imaging characteristics

CADASIL (n = 24)Control (n = 24)P-value
Demographics
 Age, (range)50.69 ± 12.45 (23–75)52.82 ± 11.26 (28–75)0.54
 Sex, n (%) female16 (67%)16 (67%)1.0
 Education in years14.70 ± 4.1717.09 ± 2.130.02*
Cognitive measures
 Clinical Dementia Rating (CDR) global score0.17 ± 0.240.02 ± 0.100.01*
 CDR Sum-of-Boxes0.54 ± 0.830.15 ± 0.500.01*
 Mini-Mental State Examination (MMSE) total score27.72 ± 2.4929.52 ± 0.590.02*
 Trail B Test Time (TRAILB) (sec)84.67 ± 65.7247.88 ± 14.69 
 Rey–Osterrieth Complex Figure Test recall at 10 min (Rey10 m)12.24 ± 2.1913.36 ± 2.080.09
Imaging characteristics
 Brain parenchymal fraction (BPF)0.77 ± 0.060.78 ± 0.030.54
 Total white matter hyperintensity (WMH) volume (mm3)12 723.27 ± 8334.021306.34 ± 7210.0000007*
 Enlarged perivascular spaces (ePVS) volume (mm3)547.75 ± 441.38487.88 ± 747.550.73
CADASIL (n = 24)Control (n = 24)P-value
Demographics
 Age, (range)50.69 ± 12.45 (23–75)52.82 ± 11.26 (28–75)0.54
 Sex, n (%) female16 (67%)16 (67%)1.0
 Education in years14.70 ± 4.1717.09 ± 2.130.02*
Cognitive measures
 Clinical Dementia Rating (CDR) global score0.17 ± 0.240.02 ± 0.100.01*
 CDR Sum-of-Boxes0.54 ± 0.830.15 ± 0.500.01*
 Mini-Mental State Examination (MMSE) total score27.72 ± 2.4929.52 ± 0.590.02*
 Trail B Test Time (TRAILB) (sec)84.67 ± 65.7247.88 ± 14.69 
 Rey–Osterrieth Complex Figure Test recall at 10 min (Rey10 m)12.24 ± 2.1913.36 ± 2.080.09
Imaging characteristics
 Brain parenchymal fraction (BPF)0.77 ± 0.060.78 ± 0.030.54
 Total white matter hyperintensity (WMH) volume (mm3)12 723.27 ± 8334.021306.34 ± 7210.0000007*
 Enlarged perivascular spaces (ePVS) volume (mm3)547.75 ± 441.38487.88 ± 747.550.73

Values are reported as mean ± standard deviation. Two-tailed Student’s t-tests or the non-parametric Wilcoxon rank sum was used for statistical comparison of continuous and nominal measures, and Chi-square tests were performed to compare group characteristics. *P-value < 0.05.

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