Simulation results of the JM and TS methods in case 2. Average is the average value of parameter estimates in 500 MC replications; SD is the MC standard deviation of the estimates across simulated data sets; is the mean of bootstrap standard deviations calculated on bootstrap samples for each MC sample; CP is the 95% coverage probability defined as the percentage of repetitions in which true value falls into the calculated confidence interval.
. | JM . | TS . | ||||||
---|---|---|---|---|---|---|---|---|
True . | . | SD . | . | CP . | . | SD . | . | CP . |
Survival | ||||||||
–0.4190 | 0.1564 | 0.1549 | 0.948 | –0.4222 | 0.1556 | 0.1537 | 0.936 | |
–0.1180 | 0.1397 | 0.1417 | 0.944 | –0.1202 | 0.1393 | 0.1410 | 0.942 | |
0.7195 | 0.1016 | 0.1013 | 0.946 | 0.7288 | 0.1015 | 0.1012 | 0.940 | |
0.2025 | 0.1327 | 0.1319 | 0.950 | 0.1994 | 0.1326 | 0.1319 | 0.948 | |
0.3221 | 0.2036 | 0.2138 | 0.946 | 0.3157 | 0.2032 | 0.2137 | 0.944 | |
0.3416 | 0.1441 | 0.1384 | 0.934 | 0.3236 | 0.1389 | 0.1332 | 0.920 | |
0.2037 | 0.0844 | 0.0827 | 0.932 | 0.1758 | 0.0845 | 0.0823 | 0.870 | |
Longitudinal | ||||||||
6.1932 | 0.1241 | 0.1242 | 0.946 | 6.1944 | 0.1242 | 0.1240 | 0.948 | |
4.4954 | 0.1212 | 0.1221 | 0.946 | 4.4947 | 0.1211 | 0.1221 | 0.948 | |
4.9946 | 0.1199 | 0.1223 | 0.940 | 4.9950 | 0.1199 | 0.1222 | 0.940 | |
4.6951 | 0.1231 | 0.1226 | 0.944 | 4.6936 | 0.1231 | 0.1228 | 0.944 | |
4.9950 | 0.1260 | 0.1264 | 0.944 | 4.9907 | 0.1262 | 0.1262 | 0.946 | |
4.4860 | 0.1278 | 0.1276 | 0.946 | 4.4851 | 0.1278 | 0.1277 | 0.946 | |
6.7988 | 0.1301 | 0.1276 | 0.942 | 6.7887 | 0.1301 | 0.1275 | 0.942 | |
4.1939 | 0.1214 | 0.1217 | 0.940 | 4.1935 | 0.1214 | 0.1216 | 0.940 | |
4.4935 | 0.1212 | 0.1222 | 0.936 | 4.4939 | 0.1212 | 0.1214 | 0.934 | |
4.0976 | 0.1234 | 0.1240 | 0.948 | 4.0968 | 0.1234 | 0.1238 | 0.944 | |
4.4911 | 0.1307 | 0.1316 | 0.944 | 4.4922 | 0.1308 | 0.1315 | 0.946 | |
4.1955 | 0.1353 | 0.1357 | 0.948 | 4.1950 | 0.1352 | 0.1354 | 0.946 | |
6.3959 | 0.1277 | 0.1278 | 0.950 | 6.3969 | 0.1278 | 0.1277 | 0.948 | |
4.4951 | 0.1209 | 0.1218 | 0.934 | 3.0124 | 0.1209 | 0.1218 | 0.934 | |
4.5925 | 0.1208 | 0.1217 | 0.936 | 4.5931 | 0.1208 | 0.1217 | 0.936 | |
4.0972 | 0.1246 | 0.1243 | 0.940 | 4.0961 | 0.1246 | 0.1245 | 0.940 | |
4.4901 | 0.1331 | 0.1330 | 0.942 | 4.4915 | 0.1332 | 0.1329 | 0.946 | |
4.2920 | 0.1331 | 0.1335 | 0.936 | 4.2914 | 0.1331 | 0.1335 | 0.938 | |
–0.0495 | 0.0084 | 0.0085 | 0.952 | –0.0496 | 0.0084 | 0.0085 | 0.952 | |
0.0297 | 0.0124 | 0.0111 | 0.948 | 0.0297 | 0.0124 | 0.0112 | 0.948 | |
0.0907 | 0.0172 | 0.0175 | 0.942 | 0.0908 | 0.0172 | 0.0175 | 0.940 | |
0.0801 | 0.0042 | 0.0042 | 0.948 | 0.0799 | 0.0042 | 0.0042 | 0.978 | |
0.1993 | 0.0062 | 0.0063 | 0.942 | 0.1995 | 0.0062 | 0.0064 | 0.946 | |
0.1994 | 0.0070 | 0.0069 | 0.954 | 0.1997 | 0.0071 | 0.0069 | 0.958 | |
0.3988 | 0.0160 | 0.0170 | 0.952 | 0.3993 | 0.0160 | 0.0170 | 0.952 | |
0.4975 | 0.0268 | 0.0263 | 0.954 | 0.4971 | 0.0268 | 0.0264 | 0.950 | |
0.2975 | 0.0320 | 0.0322 | 0.952 | 0.2976 | 0.0320 | 0.0323 | 0.952 | |
0.1764 | 0.0010 | 0.0010 | 0.930 | 0.1764 | 0.0010 | 0.0010 | 0.930 |
. | JM . | TS . | ||||||
---|---|---|---|---|---|---|---|---|
True . | . | SD . | . | CP . | . | SD . | . | CP . |
Survival | ||||||||
–0.4190 | 0.1564 | 0.1549 | 0.948 | –0.4222 | 0.1556 | 0.1537 | 0.936 | |
–0.1180 | 0.1397 | 0.1417 | 0.944 | –0.1202 | 0.1393 | 0.1410 | 0.942 | |
0.7195 | 0.1016 | 0.1013 | 0.946 | 0.7288 | 0.1015 | 0.1012 | 0.940 | |
0.2025 | 0.1327 | 0.1319 | 0.950 | 0.1994 | 0.1326 | 0.1319 | 0.948 | |
0.3221 | 0.2036 | 0.2138 | 0.946 | 0.3157 | 0.2032 | 0.2137 | 0.944 | |
0.3416 | 0.1441 | 0.1384 | 0.934 | 0.3236 | 0.1389 | 0.1332 | 0.920 | |
0.2037 | 0.0844 | 0.0827 | 0.932 | 0.1758 | 0.0845 | 0.0823 | 0.870 | |
Longitudinal | ||||||||
6.1932 | 0.1241 | 0.1242 | 0.946 | 6.1944 | 0.1242 | 0.1240 | 0.948 | |
4.4954 | 0.1212 | 0.1221 | 0.946 | 4.4947 | 0.1211 | 0.1221 | 0.948 | |
4.9946 | 0.1199 | 0.1223 | 0.940 | 4.9950 | 0.1199 | 0.1222 | 0.940 | |
4.6951 | 0.1231 | 0.1226 | 0.944 | 4.6936 | 0.1231 | 0.1228 | 0.944 | |
4.9950 | 0.1260 | 0.1264 | 0.944 | 4.9907 | 0.1262 | 0.1262 | 0.946 | |
4.4860 | 0.1278 | 0.1276 | 0.946 | 4.4851 | 0.1278 | 0.1277 | 0.946 | |
6.7988 | 0.1301 | 0.1276 | 0.942 | 6.7887 | 0.1301 | 0.1275 | 0.942 | |
4.1939 | 0.1214 | 0.1217 | 0.940 | 4.1935 | 0.1214 | 0.1216 | 0.940 | |
4.4935 | 0.1212 | 0.1222 | 0.936 | 4.4939 | 0.1212 | 0.1214 | 0.934 | |
4.0976 | 0.1234 | 0.1240 | 0.948 | 4.0968 | 0.1234 | 0.1238 | 0.944 | |
4.4911 | 0.1307 | 0.1316 | 0.944 | 4.4922 | 0.1308 | 0.1315 | 0.946 | |
4.1955 | 0.1353 | 0.1357 | 0.948 | 4.1950 | 0.1352 | 0.1354 | 0.946 | |
6.3959 | 0.1277 | 0.1278 | 0.950 | 6.3969 | 0.1278 | 0.1277 | 0.948 | |
4.4951 | 0.1209 | 0.1218 | 0.934 | 3.0124 | 0.1209 | 0.1218 | 0.934 | |
4.5925 | 0.1208 | 0.1217 | 0.936 | 4.5931 | 0.1208 | 0.1217 | 0.936 | |
4.0972 | 0.1246 | 0.1243 | 0.940 | 4.0961 | 0.1246 | 0.1245 | 0.940 | |
4.4901 | 0.1331 | 0.1330 | 0.942 | 4.4915 | 0.1332 | 0.1329 | 0.946 | |
4.2920 | 0.1331 | 0.1335 | 0.936 | 4.2914 | 0.1331 | 0.1335 | 0.938 | |
–0.0495 | 0.0084 | 0.0085 | 0.952 | –0.0496 | 0.0084 | 0.0085 | 0.952 | |
0.0297 | 0.0124 | 0.0111 | 0.948 | 0.0297 | 0.0124 | 0.0112 | 0.948 | |
0.0907 | 0.0172 | 0.0175 | 0.942 | 0.0908 | 0.0172 | 0.0175 | 0.940 | |
0.0801 | 0.0042 | 0.0042 | 0.948 | 0.0799 | 0.0042 | 0.0042 | 0.978 | |
0.1993 | 0.0062 | 0.0063 | 0.942 | 0.1995 | 0.0062 | 0.0064 | 0.946 | |
0.1994 | 0.0070 | 0.0069 | 0.954 | 0.1997 | 0.0071 | 0.0069 | 0.958 | |
0.3988 | 0.0160 | 0.0170 | 0.952 | 0.3993 | 0.0160 | 0.0170 | 0.952 | |
0.4975 | 0.0268 | 0.0263 | 0.954 | 0.4971 | 0.0268 | 0.0264 | 0.950 | |
0.2975 | 0.0320 | 0.0322 | 0.952 | 0.2976 | 0.0320 | 0.0323 | 0.952 | |
0.1764 | 0.0010 | 0.0010 | 0.930 | 0.1764 | 0.0010 | 0.0010 | 0.930 |
Simulation results of the JM and TS methods in case 2. Average is the average value of parameter estimates in 500 MC replications; SD is the MC standard deviation of the estimates across simulated data sets; is the mean of bootstrap standard deviations calculated on bootstrap samples for each MC sample; CP is the 95% coverage probability defined as the percentage of repetitions in which true value falls into the calculated confidence interval.
. | JM . | TS . | ||||||
---|---|---|---|---|---|---|---|---|
True . | . | SD . | . | CP . | . | SD . | . | CP . |
Survival | ||||||||
–0.4190 | 0.1564 | 0.1549 | 0.948 | –0.4222 | 0.1556 | 0.1537 | 0.936 | |
–0.1180 | 0.1397 | 0.1417 | 0.944 | –0.1202 | 0.1393 | 0.1410 | 0.942 | |
0.7195 | 0.1016 | 0.1013 | 0.946 | 0.7288 | 0.1015 | 0.1012 | 0.940 | |
0.2025 | 0.1327 | 0.1319 | 0.950 | 0.1994 | 0.1326 | 0.1319 | 0.948 | |
0.3221 | 0.2036 | 0.2138 | 0.946 | 0.3157 | 0.2032 | 0.2137 | 0.944 | |
0.3416 | 0.1441 | 0.1384 | 0.934 | 0.3236 | 0.1389 | 0.1332 | 0.920 | |
0.2037 | 0.0844 | 0.0827 | 0.932 | 0.1758 | 0.0845 | 0.0823 | 0.870 | |
Longitudinal | ||||||||
6.1932 | 0.1241 | 0.1242 | 0.946 | 6.1944 | 0.1242 | 0.1240 | 0.948 | |
4.4954 | 0.1212 | 0.1221 | 0.946 | 4.4947 | 0.1211 | 0.1221 | 0.948 | |
4.9946 | 0.1199 | 0.1223 | 0.940 | 4.9950 | 0.1199 | 0.1222 | 0.940 | |
4.6951 | 0.1231 | 0.1226 | 0.944 | 4.6936 | 0.1231 | 0.1228 | 0.944 | |
4.9950 | 0.1260 | 0.1264 | 0.944 | 4.9907 | 0.1262 | 0.1262 | 0.946 | |
4.4860 | 0.1278 | 0.1276 | 0.946 | 4.4851 | 0.1278 | 0.1277 | 0.946 | |
6.7988 | 0.1301 | 0.1276 | 0.942 | 6.7887 | 0.1301 | 0.1275 | 0.942 | |
4.1939 | 0.1214 | 0.1217 | 0.940 | 4.1935 | 0.1214 | 0.1216 | 0.940 | |
4.4935 | 0.1212 | 0.1222 | 0.936 | 4.4939 | 0.1212 | 0.1214 | 0.934 | |
4.0976 | 0.1234 | 0.1240 | 0.948 | 4.0968 | 0.1234 | 0.1238 | 0.944 | |
4.4911 | 0.1307 | 0.1316 | 0.944 | 4.4922 | 0.1308 | 0.1315 | 0.946 | |
4.1955 | 0.1353 | 0.1357 | 0.948 | 4.1950 | 0.1352 | 0.1354 | 0.946 | |
6.3959 | 0.1277 | 0.1278 | 0.950 | 6.3969 | 0.1278 | 0.1277 | 0.948 | |
4.4951 | 0.1209 | 0.1218 | 0.934 | 3.0124 | 0.1209 | 0.1218 | 0.934 | |
4.5925 | 0.1208 | 0.1217 | 0.936 | 4.5931 | 0.1208 | 0.1217 | 0.936 | |
4.0972 | 0.1246 | 0.1243 | 0.940 | 4.0961 | 0.1246 | 0.1245 | 0.940 | |
4.4901 | 0.1331 | 0.1330 | 0.942 | 4.4915 | 0.1332 | 0.1329 | 0.946 | |
4.2920 | 0.1331 | 0.1335 | 0.936 | 4.2914 | 0.1331 | 0.1335 | 0.938 | |
–0.0495 | 0.0084 | 0.0085 | 0.952 | –0.0496 | 0.0084 | 0.0085 | 0.952 | |
0.0297 | 0.0124 | 0.0111 | 0.948 | 0.0297 | 0.0124 | 0.0112 | 0.948 | |
0.0907 | 0.0172 | 0.0175 | 0.942 | 0.0908 | 0.0172 | 0.0175 | 0.940 | |
0.0801 | 0.0042 | 0.0042 | 0.948 | 0.0799 | 0.0042 | 0.0042 | 0.978 | |
0.1993 | 0.0062 | 0.0063 | 0.942 | 0.1995 | 0.0062 | 0.0064 | 0.946 | |
0.1994 | 0.0070 | 0.0069 | 0.954 | 0.1997 | 0.0071 | 0.0069 | 0.958 | |
0.3988 | 0.0160 | 0.0170 | 0.952 | 0.3993 | 0.0160 | 0.0170 | 0.952 | |
0.4975 | 0.0268 | 0.0263 | 0.954 | 0.4971 | 0.0268 | 0.0264 | 0.950 | |
0.2975 | 0.0320 | 0.0322 | 0.952 | 0.2976 | 0.0320 | 0.0323 | 0.952 | |
0.1764 | 0.0010 | 0.0010 | 0.930 | 0.1764 | 0.0010 | 0.0010 | 0.930 |
. | JM . | TS . | ||||||
---|---|---|---|---|---|---|---|---|
True . | . | SD . | . | CP . | . | SD . | . | CP . |
Survival | ||||||||
–0.4190 | 0.1564 | 0.1549 | 0.948 | –0.4222 | 0.1556 | 0.1537 | 0.936 | |
–0.1180 | 0.1397 | 0.1417 | 0.944 | –0.1202 | 0.1393 | 0.1410 | 0.942 | |
0.7195 | 0.1016 | 0.1013 | 0.946 | 0.7288 | 0.1015 | 0.1012 | 0.940 | |
0.2025 | 0.1327 | 0.1319 | 0.950 | 0.1994 | 0.1326 | 0.1319 | 0.948 | |
0.3221 | 0.2036 | 0.2138 | 0.946 | 0.3157 | 0.2032 | 0.2137 | 0.944 | |
0.3416 | 0.1441 | 0.1384 | 0.934 | 0.3236 | 0.1389 | 0.1332 | 0.920 | |
0.2037 | 0.0844 | 0.0827 | 0.932 | 0.1758 | 0.0845 | 0.0823 | 0.870 | |
Longitudinal | ||||||||
6.1932 | 0.1241 | 0.1242 | 0.946 | 6.1944 | 0.1242 | 0.1240 | 0.948 | |
4.4954 | 0.1212 | 0.1221 | 0.946 | 4.4947 | 0.1211 | 0.1221 | 0.948 | |
4.9946 | 0.1199 | 0.1223 | 0.940 | 4.9950 | 0.1199 | 0.1222 | 0.940 | |
4.6951 | 0.1231 | 0.1226 | 0.944 | 4.6936 | 0.1231 | 0.1228 | 0.944 | |
4.9950 | 0.1260 | 0.1264 | 0.944 | 4.9907 | 0.1262 | 0.1262 | 0.946 | |
4.4860 | 0.1278 | 0.1276 | 0.946 | 4.4851 | 0.1278 | 0.1277 | 0.946 | |
6.7988 | 0.1301 | 0.1276 | 0.942 | 6.7887 | 0.1301 | 0.1275 | 0.942 | |
4.1939 | 0.1214 | 0.1217 | 0.940 | 4.1935 | 0.1214 | 0.1216 | 0.940 | |
4.4935 | 0.1212 | 0.1222 | 0.936 | 4.4939 | 0.1212 | 0.1214 | 0.934 | |
4.0976 | 0.1234 | 0.1240 | 0.948 | 4.0968 | 0.1234 | 0.1238 | 0.944 | |
4.4911 | 0.1307 | 0.1316 | 0.944 | 4.4922 | 0.1308 | 0.1315 | 0.946 | |
4.1955 | 0.1353 | 0.1357 | 0.948 | 4.1950 | 0.1352 | 0.1354 | 0.946 | |
6.3959 | 0.1277 | 0.1278 | 0.950 | 6.3969 | 0.1278 | 0.1277 | 0.948 | |
4.4951 | 0.1209 | 0.1218 | 0.934 | 3.0124 | 0.1209 | 0.1218 | 0.934 | |
4.5925 | 0.1208 | 0.1217 | 0.936 | 4.5931 | 0.1208 | 0.1217 | 0.936 | |
4.0972 | 0.1246 | 0.1243 | 0.940 | 4.0961 | 0.1246 | 0.1245 | 0.940 | |
4.4901 | 0.1331 | 0.1330 | 0.942 | 4.4915 | 0.1332 | 0.1329 | 0.946 | |
4.2920 | 0.1331 | 0.1335 | 0.936 | 4.2914 | 0.1331 | 0.1335 | 0.938 | |
–0.0495 | 0.0084 | 0.0085 | 0.952 | –0.0496 | 0.0084 | 0.0085 | 0.952 | |
0.0297 | 0.0124 | 0.0111 | 0.948 | 0.0297 | 0.0124 | 0.0112 | 0.948 | |
0.0907 | 0.0172 | 0.0175 | 0.942 | 0.0908 | 0.0172 | 0.0175 | 0.940 | |
0.0801 | 0.0042 | 0.0042 | 0.948 | 0.0799 | 0.0042 | 0.0042 | 0.978 | |
0.1993 | 0.0062 | 0.0063 | 0.942 | 0.1995 | 0.0062 | 0.0064 | 0.946 | |
0.1994 | 0.0070 | 0.0069 | 0.954 | 0.1997 | 0.0071 | 0.0069 | 0.958 | |
0.3988 | 0.0160 | 0.0170 | 0.952 | 0.3993 | 0.0160 | 0.0170 | 0.952 | |
0.4975 | 0.0268 | 0.0263 | 0.954 | 0.4971 | 0.0268 | 0.0264 | 0.950 | |
0.2975 | 0.0320 | 0.0322 | 0.952 | 0.2976 | 0.0320 | 0.0323 | 0.952 | |
0.1764 | 0.0010 | 0.0010 | 0.930 | 0.1764 | 0.0010 | 0.0010 | 0.930 |
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